Facile synthesis of macrocyclic peptide toxins of GpTx-1 and its analogue

Designing macrocyclic disulfide-rich peptides for biotechnological applications

(2018) Conan K. Wang et al.   Nature Chemical Biology

Organic synthesis provides opportunities to transform drug discovery

(2018) David C. Blakemore et al.   Nature Chemistry

The Role of Disulfide Bond Replacements in Analogues of the Tarantula Toxin ProTx-II and Their Effects on Inhibition of the Voltage-Gated Sodium Ion Channel Nav1.7

(2017) Zoë V. F. Wright et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Single Residue Substitutions That Confer Voltage-Gated Sodium Ion Channel Subtype Selectivity in the NaV1.7 Inhibitory Peptide GpTx-1

(2016) Justin K. Murray et al.   JOURNAL OF MEDICINAL CHEMISTRY

Recent advances in the preparation of Fmoc-SPPS-based peptide thioester and its surrogates for NCL-type reactions

(2016) Hongxing Li et al.   Science China-Chemistry

Diaminodiacid Bridges to Improve Folding and Tune the Bioactivity of Disulfide-Rich Peptides

(2015) Ye Guo et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Voltage-Gated Sodium Channels: Structure, Function, Pharmacology, and Clinical Indications

(2015) Manuel de Lera Ruiz et al.   JOURNAL OF MEDICINAL CHEMISTRY

Engineering Potent and Selective Analogues of GpTx-1, a Tarantula Venom Peptide Antagonist of the NaV1.7 Sodium Channel

(2015) Justin K. Murray et al.   JOURNAL OF MEDICINAL CHEMISTRY

Chemical synthesis of proteins using hydrazide intermediates

(2015) Yi-Chao Huang et al.   National Science Review

Recent progress in sodium channel modulators for pain

(2014) Sharan K. Bagal et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

One-pot hydrazide-based native chemical ligation for efficient chemical synthesis and structure determination of toxin Mambalgin-1

(2014) Man Pan et al.   CHEMICAL COMMUNICATIONS

Computational approaches for designing potent and selective analogs of peptide toxins as novel therapeutics

(2014) Serdar Kuyucak et al.   Future Medicinal Chemistry

Semipermanent C-Terminal Carboxylic Acid Protecting Group: Application to Solubilizing Peptides and Fragment Condensation

(2014) Marta Paradís-Bas et al.   ORGANIC LETTERS

Development of New Thioester Equivalents for Protein Chemical Synthesis

(2013) Ji-Shen Zheng et al.   ACCOUNTS OF CHEMICAL RESEARCH

Chemical Synthesis, 3D Structure, and ASIC Binding Site of the Toxin Mambalgin-2

(2013) Christina I. Schroeder et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Multifaceted Roles of Disulfide Bonds. Peptides as Therapeutics

(2013) Miriam Góngora-Benítez et al.   CHEMICAL REVIEWS

Chemical synthesis of proteins using peptide hydrazides as thioester surrogates

(2013) Ji-Shen Zheng et al.   Nature Protocols

Protein chemical synthesis by serine and threonine ligation

(2013) Y. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Discovery of a selective NaV1.7 inhibitor from centipede venom with analgesic efficacy exceeding morphine in rodent pain models

(2013) S. Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Convergent Chemical Synthesis of Proteins by Ligation of Peptide Hydrazides

(2012) Ge-Min Fang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Synthesis of Cyclic Peptides and Cyclic Proteins via Ligation of Peptide Hydrazides

(2012) Ji-Shen Zheng et al.   CHEMBIOCHEM

Black mamba venom peptides target acid-sensing ion channels to abolish pain

(2012) Sylvie Diochot et al.   NATURE

PADLOC: A Powerful Tool to Assign Disulfide Bond Connectivities in Peptides and Proteins by NMR Spectroscopy

(2011) Leszek Poppe et al.   ANALYTICAL CHEMISTRY

Fragment Condensation of C-Terminal Pseudoproline Peptides without Racemization on the Solid Phase

(2011) Christian Heinlein et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Protein Chemical Synthesis by Ligation of Peptide Hydrazides

(2011) Ge-Min Fang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

An Advance in Proline Ligation

(2011) Shiying Shang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Characterization of voltage-dependent calcium channel blocking peptides from the venom of the tarantula Grammostola rosea

(2011) Seigo Ono et al.   TOXICON

Salicylaldehyde Ester-Induced Chemoselective Peptide Ligations: Enabling Generation of Natural Peptidic Linkages at the Serine/Threonine Sites

(2010) Xuechen Li et al.   ORGANIC LETTERS

NMR-Based Mapping of Disulfide Bridges in Cysteine-Rich Peptides: Application to the μ-Conotoxin SxIIIA

(2008) Aleksandra Walewska et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY