Flavonoid quercetin–methotrexate combination inhibits inflammatory mediators and matrix metalloproteinase expression, providing protection to joints in collagen-induced arthritis

Use of complementary and alternative medicines is associated with delay to initiation of disease-modifying anti-rheumatic drug therapy in early inflammatory arthritis

(2017) Manjari Lahiri et al.   International Journal of Rheumatic Diseases

Cellular and molecular perspectives in rheumatoid arthritis

(2017) Douglas J. Veale et al.   Seminars in Immunopathology

Design and Development of Microsomal Prostaglandin E2 Synthase-1 Inhibitors: Challenges and Future Directions

(2016) Andreas Koeberle et al.   JOURNAL OF MEDICINAL CHEMISTRY

Mechanism of action of methotrexate in rheumatoid arthritis and the search for biomarkers

(2016) Philip M. Brown et al.   Nature Reviews Rheumatology

Role of methotrexate chronotherapy in collagen-induced rheumatoid arthritis in rats

(2016) X. Wang et al.   ZEITSCHRIFT FUR RHEUMATOLOGIE

Quercetin, Inflammation and Immunity

(2016) Yao Li et al.   Nutrients

The effects of tumour necrosis factor inhibitors, methotrexate, non-steroidal anti-inflammatory drugs and corticosteroids on cardiovascular events in rheumatoid arthritis, psoriasis and psoriatic arthritis: a systematic review and meta-analysis

(2015) Camille Roubille et al.   ANNALS OF THE RHEUMATIC DISEASES

Quercetin reduced inflammation and increased antioxidant defense in rat adjuvant arthritis

(2015) C. Gardi et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Key findings from studies of methotrexate tapering and withdrawal in rheumatoid arthritis

(2015) Sujith Subesinghe et al.   Expert Review of Clinical Pharmacology

Role of T Lymphocytes in the Development of Rheumatoid Arthritis. Implications for Treatment

(2014) Erik Lubberts   CURRENT PHARMACEUTICAL DESIGN

Monitoring C-reactive protein levels to predict favourable clinical outcomes from tocilizumab treatment in patients with rheumatoid arthritis

(2014) Toshihisa Kojima et al.   Modern Rheumatology

Interleukin-10 attenuation of collagen-induced arthritis is associated with suppression of interleukin-17 and retinoid-related orphan receptor γt production in macrophages and repression of classically activated macrophages

(2014) Liang Ye et al.   ARTHRITIS RESEARCH & THERAPY

Effect of Citrus Flavonoids, Naringin and Naringenin, on Metabolic Syndrome and Their Mechanisms of Action

(2014) M. Ashraful Alam et al.   Advances in Nutrition

Molecular Basis for Pharmacokinetics and Pharmacodynamics of Methotrexate in Rheumatoid Arthritis Therapy

(2013) Katsuhisa Inoue et al.   Drug Metabolism and Pharmacokinetics

A combination of Sinomenine and Methotrexate reduces joint damage of collagen induced arthritis in rats by modulating osteoclast-related cytokines

(2013) Yue Sun et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Quercetin Protects against Diabetes-Induced Exaggerated Vasoconstriction in Rats: Effect on Low Grade Inflammation

(2013) Mona F. Mahmoud et al.   PLoS One

Extracellular Matrix Degradation and Tissue Remodeling in Periprosthetic Loosening and Osteolysis: Focus on Matrix Metalloproteinases, Their Endogenous Tissue Inhibitors, and the Proteasome

(2013) Spyros A. Syggelos et al.   Biomed Research International

Quercetin Inhibits IL-1β-Induced Proliferation and Production of MMPs, COX-2, and PGE2 by Rheumatoid Synovial Fibroblast

(2012) Myung-Soon Sung et al.   INFLAMMATION

The association between interleukin-6 polymorphisms and rheumatoid arthritis: a meta-analysis

(2012) Young Ho Lee et al.   INFLAMMATION RESEARCH

Quercetin Ameliorates Cardiovascular, Hepatic, and Metabolic Changes in Diet-Induced Metabolic Syndrome in Rats

(2012) Sunil K. Panchal et al.   JOURNAL OF NUTRITION

Pathogenesis of Joint Destruction in Rheumatoid Arthritis

(2011) Shunichi Shiozawa et al.   ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS

Treatment of Early Rheumatoid Arthritis: Concepts in Management

(2011) Boulos Haraoui et al.   SEMINARS IN ARTHRITIS AND RHEUMATISM

State-of-the-art: rheumatoid arthritis

(2010) I. B. McInnes et al.   ANNALS OF THE RHEUMATIC DISEASES

Biological Evaluation and Structural Determinants of p38α Mitogen-Activated-Protein Kinase and c-Jun-N-Terminal Kinase 3 Inhibition by Flavonoids

(2010) Márcia Goettert et al.   CHEMBIOCHEM

Inhibitory effect of quercetin on matrix metalloproteinase 9 activity Molecular mechanism and structure–activity relationship of the flavonoid–enzyme interaction

(2010) Alejandra C. Saragusti et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Rheumatoid arthritis

(2010) David L Scott et al.   LANCET

Flavonols and cardiovascular disease

(2010) Francisco Perez-Vizcaino et al.   MOLECULAR ASPECTS OF MEDICINE

Inhibition of NF-κB signaling by fasudil as a potential therapeutic strategy for rheumatoid arthritis

(2009) Hiroshi Okamoto et al.   ARTHRITIS AND RHEUMATISM

Effects of exposure to hyperbaric oxygen on oxidative stress in rats with type II collagen-induced arthritis

(2009) F. Nagatomo et al.   CLINICAL AND EXPERIMENTAL MEDICINE

Flavonoid quercetin protects against swimming stress-induced changes in oxidative biomarkers in the hypothalamus of rats

(2009) Nagaraja Haleagrahara et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Differential effect of IL-1β and TNF-α on the production of IL-6, IL-8 and PGE2 in fibroblast-like synoviocytes and THP-1 macrophages

(2009) Hyun Mi Choi et al.   RHEUMATOLOGY INTERNATIONAL

The role of interleukin-17 in the pathogenesis of rheumatoid arthritis

(2009) Sarah L. Gaffen   Current Rheumatology Reports

Disease-modifying antirheumatic drugs other than methotrexate in rheumatoid arthritis and seronegative arthritis

(2008) Pradip Nandi et al.   CURRENT OPINION IN RHEUMATOLOGY

Innovative treatment strategies for patients with rheumatoid arthritis

(2008) Sjoerd M van der Kooij et al.   CURRENT OPINION IN RHEUMATOLOGY

Molecular aspects of rheumatoid arthritis: chemokines in the joints of patients

(2008) Takuji Iwamoto et al.   FEBS Journal

Evidence that cytokines play a role in rheumatoid arthritis

(2008) Fionula M. Brennan et al.   JOURNAL OF CLINICAL INVESTIGATION