Plasmacytoid dendritic cell activation is dependent on coordinated expression of distinct amino acid transporters

Long-Tailed Unconventional Class I Myosins in Health and Disease

(2020) A. Navinés-Ferrer et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Plasmacytoid Dendritic Cells: Development, Regulation, and Function

(2019) Boris Reizis   IMMUNITY

Clinical Experience of Sirolimus Regarding Efficacy and Safety in Systemic Lupus Erythematosus

(2019) Per Eriksson et al.   Frontiers in Pharmacology

snakePipes: facilitating flexible, scalable and integrative epigenomic analysis

(2019) Vivek Bhardwaj et al.   BIOINFORMATICS

GM-CSF, IL-3, and IL-5 Family of Cytokines: Regulators of Inflammation

(2019) Michael Dougan et al.   IMMUNITY

Antigen receptor control of methionine metabolism in T cells

(2019) Linda V Sinclair et al.   eLife

Genetic Ablation of the Cystine Transporter xCT in PDAC Cells Inhibits mTORC1, Growth, Survival, and Tumor Formation via Nutrient and Oxidative Stresses

(2019) Boutaina Daher et al.   CANCER RESEARCH

Comprehensive Integration of Single-Cell Data

(2019) Tim Stuart et al.   CELL

The immune cell landscape in kidneys of patients with lupus nephritis

(2019) Arnon Arazi et al.   NATURE IMMUNOLOGY

New therapies for systemic lupus erythematosus — past imperfect, future tense

(2019) Grainne Murphy et al.   Nature Reviews Rheumatology

Nutrient regulation of mTORC1 at a glance

(2019) Kendall J. Condon et al.   JOURNAL OF CELL SCIENCE

Trial of Anifrolumab in Active Systemic Lupus Erythematosus

(2019) Eric F. Morand et al.   NEW ENGLAND JOURNAL OF MEDICINE

Erastin Inhibits Septic Shock and Inflammatory Gene Expression via Suppression of the NF-κB Pathway

(2019) Byung Moo Oh et al.   Journal of Clinical Medicine

Genetic deletion of xCT attenuates peripheral and central inflammation and mitigates LPS-induced sickness and depressive-like behavior in mice

(2018) Giulia Albertini et al.   GLIA

Sirolimus in patients with clinically active systemic lupus erythematosus resistant to, or intolerant of, conventional medications: a single-arm, open-label, phase 1/2 trial

(2018) Zhi-Wei Lai et al.   LANCET

Baricitinib for systemic lupus erythematosus: a double-blind, randomised, placebo-controlled, phase 2 trial

(2018) Daniel J Wallace et al.   LANCET

Single cell analysis of kynurenine and System L amino acid transport in T cells

(2018) Linda V. Sinclair et al.   Nature Communications

Human Dendritic Cell Subsets Undergo Distinct Metabolic Reprogramming for Immune Response

(2018) Farhan Basit et al.   Frontiers in Immunology

Discovery of 2-[[2-Ethyl-6-[4-[2-(3-hydroxyazetidin-1-yl)-2-oxoethyl]piperazin-1-yl]-8-methylimidazo[1,2-a]pyridin-3-yl]methylamino]-4-(4-fluorophenyl)thiazole-5-carbonitrile (GLPG1690), a First-in-Class Autotaxin Inhibitor Undergoing Clinical Evaluation for the Treatment of Idiopathic Pulmonary Fibrosis

(2017) Nicolas Desroy et al.   JOURNAL OF MEDICINAL CHEMISTRY

Absence of system xc − on immune cells invading the central nervous system alleviates experimental autoimmune encephalitis

(2017) Ellen Merckx et al.   Journal of Neuroinflammation

Twenty-five years of mTOR: Uncovering the link from nutrients to growth

(2017) David M. Sabatini   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

JAK-inhibitor tofacitinib suppresses interferon alfa production by plasmacytoid dendritic cells and inhibits arthrogenic and antiviral effects of interferon alfa

(2017) Patrick P.C. Boor et al.   Translational Research

mTORC1 Balances Cellular Amino Acid Supply with Demand for Protein Synthesis through Post-transcriptional Control of ATF4

(2017) Yeonwoo Park et al.   Cell Reports

Comparing the effects of tofacitinib, methotrexate and the combination, on bone marrow oedema, synovitis and bone erosion in methotrexate-naive, early active rheumatoid arthritis: results of an exploratory randomised MRI study incorporating semiquantitative and quantitative techniques

(2016) Philip G Conaghan et al.   ANNALS OF THE RHEUMATIC DISEASES

Type 1 Interferons Induce Changes in Core Metabolism that Are Critical for Immune Function

(2016) Duojiao Wu et al.   IMMUNITY

Fluorescence-based measurement of cystine uptake through xCT shows requirement for ROS detoxification in activated lymphocytes

(2016) Peter J. Siska et al.   JOURNAL OF IMMUNOLOGICAL METHODS

Cutting Edge: Critical Role of Glycolysis in Human Plasmacytoid Dendritic Cell Antiviral Responses

(2016) Gagan Bajwa et al.   JOURNAL OF IMMUNOLOGY

Chemokines and Chemokine Receptors in the Development of Lupus Nephritis

(2016) Xiaofeng Liao et al.   MEDIATORS OF INFLAMMATION

An Autotaxin/Lysophosphatidic Acid/Interleukin-6 Amplification Loop Drives Scleroderma Fibrosis

(2016) Flavia V. Castelino et al.   Arthritis & Rheumatology

Activated T cells enhance interferon-α production by plasmacytoid dendritic cells stimulated with RNA-containing immune complexes

(2015) Dag Leonard et al.   ANNALS OF THE RHEUMATIC DISEASES

Type I/II cytokines, JAKs and new strategies for treating autoimmune diseases

(2015) Daniella M. Schwartz et al.   Nature Reviews Rheumatology

Pathogenic Inflammation and Its Therapeutic Targeting in Systemic Lupus Erythematosus

(2015) Timothy A. Gottschalk et al.   Frontiers in Immunology

The enhancer and promoter landscape of human regulatory and conventional T-cell subpopulations

(2014) C. Schmidl et al.   BLOOD

Genetic evidence for the role of plasmacytoid dendritic cells in systemic lupus erythematosus

(2014) Vanja Sisirak et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The Plasmacytoid Dendritic Cell as the Swiss Army Knife of the Immune System: Molecular Regulation of Its Multifaceted Functions

(2014) Julien J. Karrich et al.   JOURNAL OF IMMUNOLOGY

Pharmacological inhibition of cystine–glutamate exchange induces endoplasmic reticulum stress and ferroptosis

(2014) Scott J Dixon et al.   eLife

Control of amino-acid transport by antigen receptors coordinates the metabolic reprogramming essential for T cell differentiation

(2013) Linda V Sinclair et al.   NATURE IMMUNOLOGY

Ribosomal protein S6 kinase activity controls the ribosome biogenesis transcriptional program

(2013) C Chauvin et al.   ONCOGENE

Essential requirement for IRF8 and SLC15A4 implicates plasmacytoid dendritic cells in the pathogenesis of lupus

(2013) R. Baccala et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Cystine/Glutamate Antiporter System xc− in Health and Disease: From Molecular Mechanisms to Novel Therapeutic Opportunities

(2012) Jan Lewerenz et al.   ANTIOXIDANTS & REDOX SIGNALING

A unifying model for mTORC1-mediated regulation of mRNA translation

(2012) Carson C. Thoreen et al.   NATURE

A yeast-based screen reveals that sulfasalazine inhibits tetrahydrobiopterin biosynthesis

(2011) Christopher Chidley et al.   Nature Chemical Biology

Systematic cytokine receptor profiling reveals GM-CSF as a novel TLR-independent activator of human plasmacytoid predendritic cells

(2010) C. Ghirelli et al.   BLOOD

Discovery of 5-Chloro-N2-[(1S)-1-(5-fluoropyrimidin-2-yl)ethyl]-N4-(5-methyl-1H-pyrazol-3-yl)pyrimidine-2,4-diamine (AZD1480) as a Novel Inhibitor of the Jak/Stat Pathway

(2010) Stephanos Ioannidis et al.   JOURNAL OF MEDICINAL CHEMISTRY

Plasmacytoid Dendritic Cells

(2009) Armin G. Jegalian et al.   ADVANCES IN ANATOMIC PATHOLOGY

The JAK2 Inhibitor AZD1480 Potently Blocks Stat3 Signaling and Oncogenesis in Solid Tumors

(2009) Michael Hedvat et al.   CANCER CELL

l-Type amino acid transporter 1 inhibitors inhibit tumor cell growth

(2009) Koji Oda et al.   CANCER SCIENCE

An ATP-competitive Mammalian Target of Rapamycin Inhibitor Reveals Rapamycin-resistant Functions of mTORC1

(2009) Carson C. Thoreen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

EGFR Regulates the Expression of Keratinocyte-Derived Granulocyte/Macrophage Colony-Stimulating Factor In Vitro and In Vivo

(2009) Francesca Mascia et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Toll-like receptor–mediated induction of type I interferon in plasmacytoid dendritic cells requires the rapamycin-sensitive PI(3)K-mTOR-p70S6K pathway

(2008) Weiping Cao et al.   NATURE IMMUNOLOGY

Model-based Analysis of ChIP-Seq (MACS)

(2008) Yong Zhang et al.   GENOME BIOLOGY