Past Life and Future Effects—How Heterologous Infections Alter Immunity to Influenza Viruses

Influenza-specific lung-resident memory T cells are proliferative and polyfunctional and maintain diverse TCR profiles

(2018) Angela Pizzolla et al.   JOURNAL OF CLINICAL INVESTIGATION

High-throughput immune repertoire analysis with IGoR

(2018) Quentin Marcou et al.   Nature Communications

Memory CD8 T cells mediate severe immunopathology following respiratory syncytial virus infection

(2018) Megan E. Schmidt et al.   PLoS Pathogens

Intrinsic 4-1BB signals are indispensable for the establishment of an influenza-specific tissue-resident memory CD8 T-cell population in the lung

(2017) A C Zhou et al.   Mucosal Immunology

Severity of Acute Infectious Mononucleosis Correlates with Cross-Reactive Influenza CD8 T-Cell Receptor Repertoires

(2017) Nuray Aslan et al.   mBio

Polymicrobial sepsis impairs bystander recruitment of effector cells to infected skin despite optimal sensing and alarming function of skin resident memory CD8 T cells

(2017) Derek B. Danahy et al.   PLoS Pathogens

A constant companion: immune recognition and response to cytomegalovirus with aging and implications for immune fitness

(2017) Aisha Souquette et al.   GeroScience

Sequential Infection with Common Pathogens Promotes Human-like Immune Gene Expression and Altered Vaccine Response

(2016) Tiffany A. Reese et al.   Cell Host & Microbe

A Novel Vaccination Strategy Mediating the Induction of Lung-Resident Memory CD8 T Cells Confers Heterosubtypic Immunity against Future Pandemic Influenza Virus

(2016) Yu-Na Lee et al.   JOURNAL OF IMMUNOLOGY

Heterologous Immunity and Persistent Murine Cytomegalovirus Infection

(2016) Jenny W. Che et al.   JOURNAL OF VIROLOGY

Programs for the persistence, vigilance and control of human CD8+ lung-resident memory T cells

(2016) Pleun Hombrink et al.   NATURE IMMUNOLOGY

Human influenza viruses and CD8 + T cell responses

(2016) Emma J Grant et al.   Current Opinion in Virology

Balancing Immune Protection and Immune Pathology by CD8+ T-Cell Responses to Influenza Infection

(2016) Susu Duan et al.   Frontiers in Immunology

Avian Influenza Viruses, Inflammation, and CD8+ T Cell Immunity

(2016) Zhongfang Wang et al.   Frontiers in Immunology

T cell responses in hepatitis C virus infection: Historical overview and goals for future research

(2015) Lauren Holz et al.   ANTIVIRAL RESEARCH

Out-of-Sequence Signal 3 Paralyzes Primary CD4+ T-Cell-Dependent Immunity

(2015) Gail D. Sckisel et al.   IMMUNITY

Airway-Resident Memory CD8 T Cells Provide Antigen-Specific Protection against Respiratory Virus Challenge through Rapid IFN-γ Production

(2015) Sean R. McMaster et al.   JOURNAL OF IMMUNOLOGY

Antibody-targeted vaccination to lung dendritic cells generates tissue-resident memory CD8 T cells that are highly protective against influenza virus infection

(2015) L M Wakim et al.   Mucosal Immunology

Cytomegalovirus infection enhances the immune response to influenza

(2015) David Furman et al.   Science Translational Medicine

Antigen-dependent and –independent contributions to primary memory CD8 T cell activation and protection following infection

(2015) Matthew D. Martin et al.   Scientific Reports

Diverse Heterologous Primary Infections Radically Alter Immunodominance Hierarchies and Clinical Outcomes Following H7N9 Influenza Challenge in Mice

(2015) Susu Duan et al.   PLoS Pathogens

Bystander hyperactivation of preimmune CD8+ T cells in chronic HCV patients

(2015) Cécile Alanio et al.   eLife

Large-Scale and Comprehensive Immune Profiling and Functional Analysis of Normal Human Aging

(2015) Chan C. Whiting et al.   PLoS One

Distinct Dendritic Cell Subsets Dictate the Fate Decision between Effector and Memory CD8+ T Cell Differentiation by a CD24-Dependent Mechanism

(2014) Taeg S. Kim et al.   IMMUNITY

Bystander Chronic Infection Negatively Impacts Development of CD8+ T Cell Memory

(2014) Erietta Stelekati et al.   IMMUNITY

Tissue-Resident Memory T Cells

(2014) Jason M. Schenkel et al.   IMMUNITY

CD4+ T Cell Help Guides Formation of CD103+ Lung-Resident Memory CD8+ T Cells during Influenza Viral Infection

(2014) Brian J. Laidlaw et al.   IMMUNITY

The Influenza Virus-Specific CTL Immunodominance Hierarchy in Mice Is Determined by the Relative Frequency of High-Avidity T Cells

(2014) T. Cukalac et al.   JOURNAL OF IMMUNOLOGY

Resident memory CD8 T cells trigger protective innate and adaptive immune responses

(2014) J. M. Schenkel et al.   SCIENCE

Skin-resident memory CD8+ T cells trigger a state of tissue-wide pathogen alert

(2014) S. Ariotti et al.   SCIENCE

Influenza infection results in local expansion of memory CD8+T cells with antigen non-specific phenotype and function

(2013) Gail D. Sckisel et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Human CD1c+ Dendritic Cells Drive the Differentiation of CD103+ CD8+ Mucosal Effector T Cells via the Cytokine TGF-β

(2013) Chun I. Yu et al.   IMMUNITY

T-cell memory differentiation: insights from transcriptional signatures and epigenetics

(2013) Ben Youngblood et al.   IMMUNOLOGY

MHV68 Latency Modulates the Host Immune Response to Influenza A Virus

(2013) Fumitake Saito et al.   INFLAMMATION

Lung-resident memory CD8 T cells (TRM ) are indispensable for optimal cross-protection against pulmonary virus infection

(2013) Tao Wu et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Lung niches for the generation and maintenance of tissue-resident memory T cells

(2013) D L Turner et al.   Mucosal Immunology

The developmental pathway for CD103+CD8+ tissue-resident memory T cells of skin

(2013) Laura K Mackay et al.   NATURE IMMUNOLOGY

Enhanced survival of lung tissue-resident memory CD8+ T cells during infection with influenza virus due to selective expression of IFITM3

(2013) Linda M Wakim et al.   NATURE IMMUNOLOGY

Bystander-Activated Memory CD8 T Cells Control Early Pathogen Load in an Innate-like, NKG2D-Dependent Manner

(2013) Talyn Chu et al.   Cell Reports

The T-Cell Response to HIV

(2013) B. Walker et al.   Cold Spring Harbor Perspectives in Medicine

Role of T cell immunity in hepatitis C virus infections

(2013) Mark AA Claassen et al.   Current Opinion in Virology

The impact of CMV infection on survival in older humans

(2012) Graham Pawelec et al.   CURRENT OPINION IN IMMUNOLOGY

Skin infection generates non-migratory memory CD8+ TRM cells providing global skin immunity

(2012) Xiaodong Jiang et al.   NATURE

NKG2D signaling on CD8+ T cells represses T-bet and rescues CD4-unhelped CD8+ T cell memory recall but not effector responses

(2012) Andrew Zloza et al.   NATURE MEDICINE

Regulation of innate CD8+ T-cell activation mediated by cytokines

(2012) B. E. Freeman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Age-related changes in CD8 T cell homeostasis and immunity to infection

(2012) Janko Nikolich-Žugich et al.   SEMINARS IN IMMUNOLOGY

T Cell Memory in the Context of Persistent Herpes Viral Infections

(2012) Nicole Torti et al.   Viruses-Basel

The narrowing of the CD8 T cell repertoire in old age

(2011) Marcia A Blackman et al.   CURRENT OPINION IN IMMUNOLOGY

Exhaustive T-cell repertoire sequencing of human peripheral blood samples reveals signatures of antigen selection and a directly measured repertoire size of at least 1 million clonotypes

(2011) R. L. Warren et al.   GENOME RESEARCH

CD8+ T cells with an intraepithelial phenotype upregulate cytotoxic function upon influenza infection in human lung

(2011) Berber Piet et al.   JOURNAL OF CLINICAL INVESTIGATION

Cutting Edge: Tissue-Retentive Lung Memory CD4 T Cells Mediate Optimal Protection to Respiratory Virus Infection

(2011) J. R. Teijaro et al.   JOURNAL OF IMMUNOLOGY

Resident Memory T Cells (TRM) Are Abundant in Human Lung: Diversity, Function, and Antigen Specificity

(2011) Rahul Purwar et al.   PLoS One

Influenza Virus Evolution, Host Adaptation, and Pandemic Formation

(2010) Jeffery K. Taubenberger et al.   Cell Host & Microbe

Cytomegalovirus Seroprevalence in the United States: The National Health and Nutrition Examination Surveys, 1988–2004

(2010) Sheri Lewis Bate et al.   CLINICAL INFECTIOUS DISEASES

Type I Interferons Regulate Cytolytic Activity of Memory CD8+ T Cells in the Lung Airways during Respiratory Virus Challenge

(2010) Jacob E. Kohlmeier et al.   IMMUNITY

Primary CTL response magnitude in mice is determined by the extent of naive T cell recruitment and subsequent clonal expansion

(2010) Nicole L. La Gruta et al.   JOURNAL OF CLINICAL INVESTIGATION

Broad Cross-Reactive TCR Repertoires Recognizing Dissimilar Epstein-Barr and Influenza A Virus Epitopes

(2010) S. C. Clute et al.   JOURNAL OF IMMUNOLOGY

T Cell Immunity in Acute HIV‐1 Infection

(2010) Hendrik Streeck et al.   JOURNAL OF INFECTIOUS DISEASES

Contribution of Herpesvirus Specific CD8 T Cells to Anti-Viral T Cell Response in Humans

(2010) Elena Sandalova et al.   PLoS Pathogens

Comprehensive assessment of T-cell receptor  -chain diversity in    T cells

(2009) H. S. Robins et al.   BLOOD

Redefining Chronic Viral Infection

(2009) Herbert W. Virgin et al.   CELL

Estimates of US influenza-associated deaths made using four different methods

(2009) William W. Thompson et al.   Influenza and Other Respiratory Viruses

Respiratory Dendritic Cell Subsets Differ in Their Capacity to Support the Induction of Virus-Specific Cytotoxic CD8+ T Cell Responses

(2009) Taeg S. Kim et al.   PLoS One

Endogenous Naive CD8+ T Cell Precursor Frequency Regulates Primary and Memory Responses to Infection

(2008) Joshua J. Obar et al.   IMMUNITY

Memory CD8 T-cell compartment grows in size with immunological experience

(2008) Vaiva Vezys et al.   NATURE