Self-Triggered Apoptosis Enzyme Prodrug Therapy (STAEPT): Enhancing Targeted Therapies via Recurrent Bystander Killing Effect by Exploiting Caspase-Cleavable Linker

Albumin-binding caspase-cleavable prodrug that is selectively activated in radiation exposed local tumor

(2016) Seung Woo Chung et al.   BIOMATERIALS

Intracellular Released Payload Influences Potency and Bystander-Killing Effects of Antibody-Drug Conjugates in Preclinical Models

(2016) F. Li et al.   CANCER RESEARCH

Optimization of a Stable Linker Involved DEVD Peptide-Doxorubicin Conjugate That Is Activated upon Radiation-Induced Caspase-3-Mediated Apoptosis

(2015) Seung Woo Chung et al.   JOURNAL OF MEDICINAL CHEMISTRY

Gene-Directed Enzyme Prodrug Therapy

(2014) Jin Zhang et al.   AAPS Journal

FITC-Conjugated Cyclic RGD Peptides as Fluorescent Probes for Staining Integrin αvβ3/αvβ5 in Tumor Tissues

(2014) Yumin Zheng et al.   BIOCONJUGATE CHEMISTRY

Tumor Heterogeneity Confounds and Illuminates: Assessing the implications

(2014) Maria Kleppe et al.   NATURE MEDICINE

Cancer heterogeneity: implications for targeted therapeutics

(2013) R Fisher et al.   BRITISH JOURNAL OF CANCER

Extraction protocol and mass spectrometry method for quantification of doxorubicin released locally from prodrugs in tumor tissue

(2013) Stuart Ibsen et al.   JOURNAL OF MASS SPECTROMETRY

Tumour heterogeneity in the clinic

(2013) Philippe L. Bedard et al.   NATURE

Tumor heterogeneity and its implication for drug delivery

(2012) Tracy A. Denison et al.   JOURNAL OF CONTROLLED RELEASE

Species Difference of Esterase Expression and Hydrolase Activity in Plasma

(2012) Fatma Goksin Bahar et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Doxorubicin: an update on anticancer molecular action, toxicity and novel drug delivery systems

(2012) Oktay Tacar et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

Clonal evolution in cancer

(2012) Mel Greaves et al.   NATURE

Intratumor Heterogeneity and Branched Evolution Revealed by Multiregion Sequencing

(2012) Marco Gerlinger et al.   NEW ENGLAND JOURNAL OF MEDICINE

Integrin Targeted Delivery of Chemotherapeutics

(2012) Kai Chen et al.   Theranostics

Integrin-assisted drug delivery of nano-scaled polymer therapeutics bearing paclitaxel

(2011) Anat Eldar-Boock et al.   BIOMATERIALS

A simple HPLC method for doxorubicin in plasma and tissues of nude mice

(2009) Ahmed M. Al-Abd et al.   ARCHIVES OF PHARMACAL RESEARCH

Caspase-3 is activated and rapidly released from human umbilical vein endothelial cells in response to lipopolysaccharide

(2009) Toshikazu Shioiri et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE