Production of Plant Secondary Metabolites: Examples, Tips and Suggestions for Biotechnologists

Biotechnological production of pharmaceuticals and biopharmaceuticals in plant cell and organ cultures

(2018) Diego Hidalgo et al.   CURRENT MEDICINAL CHEMISTRY

Expression of artemisinin biosynthesis and trichome formation genes in five Artemisia species

(2018) Maryam Salehi et al.   INDUSTRIAL CROPS AND PRODUCTS

Relationship between aluminum stress and caffeine biosynthesis in suspension cells of Coffea arabica L

(2018) Roberto Pech-Kú et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Plant cell wall-mediated immunity: cell wall changes trigger disease resistance responses

(2018) Laura Bacete et al.   PLANT JOURNAL

In vitro regeneration of Artemisia abrotanum L. by means of somatic organogenesis

(2017) Mark Bolyard   IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-PLANT

Phytochemical identification of volatile fraction, essential oil and screening of antioxidant, antibacterial, allelopathic and insecticidal potential from Artemisia herba-alba leaves

(2017) Sana Bellili et al.   MAIN GROUP CHEMISTRY

Determination of lignans, phenolic acids and antioxidant capacity in transformed hairy root culture of Linum usitatissimum

(2017) Ahmed M. M. Gabr et al.   NATURAL PRODUCT RESEARCH

Promotion of artemisinin content in Artemisia annua by overexpression of multiple artemisinin biosynthetic pathway genes

(2017) Pu Shi et al.   PLANT CELL TISSUE AND ORGAN CULTURE

Overexpression of a type-I isopentenyl pyrophosphate isomerase of Artemisia annua in the cytosol leads to high arteannuin B production and artemisinin increase

(2017) Dongming Ma et al.   PLANT JOURNAL

AaMYB1 and its orthologue AtMYB61 affect terpene metabolism and trichome development in Artemisia annua and Arabidopsis thaliana

(2017) Luis Matías-Hernández et al.   PLANT JOURNAL

CRISPR-Cas9 based plant genome editing: Significance, opportunities and recent advances

(2017) Neelam Soda et al.   PLANT PHYSIOLOGY AND BIOCHEMISTRY

A Review of Biotechnological Artemisinin Production in Plants

(2017) Nur K. B. K. Ikram et al.   Frontiers in Plant Science

Silicon and Plants: Current Knowledge and Technological Perspectives

(2017) Marie Luyckx et al.   Frontiers in Plant Science

Poaceae vs. Abiotic Stress: Focus on Drought and Salt Stress, Recent Insights and Perspectives

(2017) Simone Landi et al.   Frontiers in Plant Science

Deletion of the celA gene in Aspergillus nidulans triggers overexpression of secondary metabolite biosynthetic genes

(2017) Gea Guerriero et al.   Scientific Reports

Glycosyltransferase engineering for carbohydrate synthesis

(2016) J. B. McArthur et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Relationship Between the Different Aspects Related to Coffee Quality and Their Volatile Compounds

(2016) Paulo R.A.B. Toledo et al.   COMPREHENSIVE REVIEWS IN FOOD SCIENCE AND FOOD SAFETY

Chemical Composition of the Essential Oils from the Aerial Parts ofArtemisia sieberiby Using Conventional Hydrodistillation and Microwave Assisted Hydrodistillation: A Comparative Study

(2016) Majid Mohammadhosseini et al.   Journal of Essential Oil Bearing Plants

Identification and Comparison of Essential Oil Composition ofArtemisia sieberiandArtemisia aucheriCultivated in the South of Iran

(2016) Najmeh Asgharpour et al.   Journal of Essential Oil Bearing Plants

Engineering a microbial platform for de novo biosynthesis of diverse methylxanthines

(2016) Maureen McKeague et al.   METABOLIC ENGINEERING

Compartmentalized Metabolic Engineering for Artemisinin Biosynthesis and Effective Malaria Treatment by Oral Delivery of Plant Cells

(2016) Karan Malhotra et al.   Molecular Plant

The genus Artemisia L. in the northern region of Saudi Arabia: essential oil variability and antibacterial activities

(2016) Arbi Guetat et al.   NATURAL PRODUCT RESEARCH

Identification of a residue responsible for UDP-sugar donor selectivity of a dihydroxybenzoic acid glycosyltransferase from Arabidopsis natural accessions

(2016) Han-Yi Chen et al.   PLANT JOURNAL

Native Phytoremediation Potential of Urtica dioica for Removal of PCBs and Heavy Metals Can Be Improved by Genetic Manipulations Using Constitutive CaMV 35S Promoter

(2016) Jitka Viktorova et al.   PLoS One

In vitro regeneration and transient expression of recombinant sesquiterpene cyclase (SQC) in Artemisia annua L.

(2016) H. Mirzaee et al.   SOUTH AFRICAN JOURNAL OF BOTANY

Prediction of specialty coffee cup quality based on near infrared spectra of green coffee beans

(2016) Kassaye Tolessa et al.   TALANTA

Si-Accumulation In Artemisia annua Glandular Trichomes Increases Artemisinin Concentration, but Does Not Interfere In the Impairment of Toxoplasma gondii Growth

(2016) Cristina Rostkowska et al.   Frontiers in Plant Science

Silicon and the Plant Extracellular Matrix

(2016) Gea Guerriero et al.   Frontiers in Plant Science

Glycosylation Is a Major Regulator of Phenylpropanoid Availability and Biological Activity in Plants

(2016) Julien Le Roy et al.   Frontiers in Plant Science

Cannabis sativa: The Plant of the Thousand and One Molecules

(2016) Christelle M. Andre et al.   Frontiers in Plant Science

In vitro regeneration and optimization of factors affecting Agrobacterium mediated transformation in Artemisia Pallens, an important medicinal plant

(2016) Anshu Alok et al.   PHYSIOLOGY AND MOLECULAR BIOLOGY OF PLANTS

Efficient in vitro propagation of Artemisia nilagirica var. nilagirica (Indian wormwood) and assessment of genetic fidelity of micropropagated plants

(2016) Smita Shinde et al.   PHYSIOLOGY AND MOLECULAR BIOLOGY OF PLANTS

Transcriptional regulation of artemisinin biosynthesis in Artemisia annua L.

(2016) Qian Shen et al.   Science Bulletin

Protoplasts: a friendly tool to study aluminum toxicity and coffee cell viability

(2016) Wilberth Poot-Poot et al.   SpringerPlus

Accumulation of dibenzocyclooctadiene lignans in agar cultures and in stationary and agitated liquid cultures of Schisandra chinensis (Turcz.) Baill

(2015) Agnieszka Szopa et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Application of magnetic nanoparticles in smart enzyme immobilization

(2015) Hamideh Vaghari et al.   BIOTECHNOLOGY LETTERS

Chemical Composition and Antipathogenic Activity ofArtemisia annuaEssential Oil from Romania

(2015) Ioana C. Marinas et al.   CHEMISTRY & BIODIVERSITY

Advance on the FlavonoidC-glycosides and Health Benefits

(2015) Jianbo Xiao et al.   CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION

Lignocellulosic biomass: Biosynthesis, degradation, and industrial utilization

(2015) Gea Guerriero et al.   ENGINEERING IN LIFE SCIENCES

Role of phospholipid signalling in plant environmental responses

(2015) E. Ruelland et al.   ENVIRONMENTAL AND EXPERIMENTAL BOTANY

Essential Oil and Phenolic Compounds ofArtemisia herba-alba(Asso.): Composition, Antioxidant, Antiacetylcholinesterase, and Antibacterial Activities

(2015) Faten Younsi et al.   INTERNATIONAL JOURNAL OF FOOD PROPERTIES

Essential Oil of the Aerial Parts ofArtemisia annua(Asteraceae) from Iran

(2015) M. Kazemi   Journal of Essential Oil Bearing Plants

Volatile constituents of AlgerianArtemisia herba-albaessential oils

(2015) Nacéra Dahmani-Hamzaoui et al.   JOURNAL OF ESSENTIAL OIL RESEARCH

Artemisia herba-alba essential oil from Buseirah (South Jordan): Chemical characterization and assessment of safe antifungal and anti-inflammatory doses

(2015) M.S. Abu-Darwish et al.   JOURNAL OF ETHNOPHARMACOLOGY

Cellulose biosynthesis inhibitors – a multifunctional toolbox

(2015) Mizuki Tateno et al.   JOURNAL OF EXPERIMENTAL BOTANY

Enhanced artemisinin yield by expression of rol genes in Artemisia annua

(2015) Erum Dilshad et al.   MALARIA JOURNAL

TRICHOME AND ARTEMISININ REGULATOR 1 Is Required for Trichome Development and Artemisinin Biosynthesis in Artemisia annua

(2015) Hexin Tan et al.   Molecular Plant

Tilting Plant Metabolism for Improved Metabolite Biosynthesis and Enhanced Human Benefit

(2015) Bhekumthetho Ncube et al.   MOLECULES

The I-TASSER Suite: protein structure and function prediction

(2015) Jianyi Yang et al.   NATURE METHODS

The plant cell wall integrity maintenance mechanism – A case study of a cell wall plasma membrane signaling network

(2015) Thorsten Hamann   PHYTOCHEMISTRY

Moss-made pharmaceuticals: from bench to bedside

(2015) Ralf Reski et al.   PLANT BIOTECHNOLOGY JOURNAL

Lignan enhancement in hairy root cultures of Linum album using coniferaldehyde and methylenedioxycinnamic acid

(2015) Najmeh Ahmadian Chashmi et al.   PREPARATIVE BIOCHEMISTRY & BIOTECHNOLOGY

Gene-to-metabolite network for biosynthesis of lignans in MeJA-elicited Isatis indigotica hairy root cultures

(2015) Ruibing Chen et al.   Frontiers in Plant Science

Cell wall remodeling under abiotic stress

(2015) Raimund Tenhaken   Frontiers in Plant Science

Generation of Triple-Transgenic Forsythia Cell Cultures as a Platform for the Efficient, Stable, and Sustainable Production of Lignans

(2015) Jun Murata et al.   PLoS One

Genetic Transformation of Artemisia carvifolia Buch with rol Genes Enhances Artemisinin Accumulation

(2015) Erum Dilshad et al.   PLoS One

Pollen morphology of Centaurea L. (Asteraceae) in Iran

(2014) Elaheh Sadat Bagheri Shabestari et al.   Acta Botanica Brasilica

Enhancement of artemisinin content and relative expression of genes of artemisinin biosynthesis in Artemisia annua by exogenous MeJA treatment

(2014) Lien Xiang et al.   PLANT GROWTH REGULATION

Unraveling the Mechanism Underlying the Glycosylation and Methylation of Anthocyanins in Peach

(2014) J. Cheng et al.   PLANT PHYSIOLOGY

Metabolic Engineering of Saccharomyces cerevisiae for Caffeine and Theobromine Production

(2014) Lu Jin et al.   PLoS One

Screening antimicrobial activity of various extracts of Urtica dioica

(2014) Amir Modarresi-Chahardehi et al.   REVISTA DE BIOLOGIA TROPICAL

Micropropagation of an antidiabetic medicinal plant, Artemisia pallens

(2014) Varsha Nitin NATHAR et al.   TURKISH JOURNAL OF BOTANY

The role of silicon in plant tissue culture

(2014) Iyyakkannu Sivanesan et al.   Frontiers in Plant Science

In vitro regeneration and Agrobacterium mediated genetic transformation of Artemisia aucheri Boiss

(2014) Ali Sharafi et al.   PHYSIOLOGY AND MOLECULAR BIOLOGY OF PLANTS

Iterative Saturation Mutagenesis of −6 Subsite Residues in Cyclodextrin Glycosyltransferase from Paenibacillus macerans To Improve Maltodextrin Specificity for 2-O-d-Glucopyranosyl-l-Ascorbic Acid Synthesis

(2013) Ruizhi Han et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Toxic essential oils. Part II: Chemical, toxicological, pharmacological and microbiological profiles of Artemisia annua L. volatiles

(2013) Niko S. Radulović et al.   FOOD AND CHEMICAL TOXICOLOGY

Identification of a Bifunctional MaizeC- andO-Glucosyltransferase

(2013) María Lorena Falcone Ferreyra et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Evidence for ‘silicon’ within the cell walls of suspension-cultured rice cells

(2013) Congwu He et al.   NEW PHYTOLOGIST

The metabolite chemotype ofNicotiana benthamianatransiently expressing artemisinin biosynthetic pathway genes is a function ofCYP71AV1type and relative gene dosage

(2013) Hieng-Ming Ting et al.   NEW PHYTOLOGIST

The carbohydrate-active enzymes database (CAZy) in 2013

(2013) Vincent Lombard et al.   NUCLEIC ACIDS RESEARCH

Phytochemical, phylogenetic, and anti-inflammatory evaluation of 43 Urtica accessions (stinging nettle) based on UPLC–Q-TOF-MS metabolomic profiles

(2013) Mohamed A. Farag et al.   PHYTOCHEMISTRY

Short term UV-B radiation-mediated transcriptional responses and altered secondary metabolism of in vitro propagated plantlets of Artemisia annua L.

(2013) Neha Pandey et al.   PLANT CELL TISSUE AND ORGAN CULTURE

Engineering flavonoid glycosyltransferases for enhanced catalytic efficiency and extended sugar-donor selectivity

(2013) Hye Soo Kim et al.   PLANTA

Enzymatic C-glycosylation: Insights from the study of a complementary pair of plant O- and C-glucosyltransferases

(2013) Alexander Gutmann et al.   PURE AND APPLIED CHEMISTRY

Putting bugs to the blush

(2013) Philana V van Summeren-Wesenhagen et al.   Bioengineered

Chemical composition and antioxidant and antimicrobial activity of essential oil of Artemisia annua L. from Bosnia

(2012) Sanja Ćavar et al.   INDUSTRIAL CROPS AND PRODUCTS

Towards establishing broad-spectrum disease resistance in plants: silicon leads the way

(2012) Jonas Van Bockhaven et al.   JOURNAL OF EXPERIMENTAL BOTANY

Effect of growth regulators on in vitro germination of Artemisia absinthium

(2012) A. Mannan   Scientific Research and Essays

Essential oil from Artemisia herba-alba Asso grown wild in Algeria: Variability assessment and comparison with an updated literature survey

(2012) Rachid Belhattab et al.   Arabian Journal of Chemistry

Effect of external stress on density and size of glandular trichomes in full-grown Artemisia annua, the source of anti-malarial artemisinin

(2012) Anders Kjær et al.   AoB Plants

Plant cell wall integrity maintenance as an essential component of biotic stress response mechanisms

(2012) Thorsten Hamann   Frontiers in Plant Science

Changes in Cinnamic Acid Derivatives Associated with the Habituation of Maize Cells to Dichlobenil

(2011) Hugo Mélida et al.   Molecular Plant

Generation of the potent anti-malarial drug artemisinin in tobacco

(2011) Moran Farhi et al.   NATURE BIOTECHNOLOGY

Artemisinin Biosynthesis Enhancement in TransgenicArtemisia annuaPlants by Downregulation of theβ-Caryophyllene Synthase Gene

(2011) Jian-Lin Chen et al.   PLANTA MEDICA

HMG-CoA reductase limits artemisinin biosynthesis and accumulation in Artemisia annua L. plants

(2010) Mauji Ram et al.   ACTA PHYSIOLOGIAE PLANTARUM

Unraveling the Biochemical and Molecular Networks Involved in Maize Cell Habituation to the Cellulose Biosynthesis Inhibitor Dichlobenil

(2010) Hugo Mélida et al.   Molecular Plant

The phenolic profile of maize primary cell wall changes in cellulose-deficient cell cultures

(2010) Hugo Mélida et al.   PHYTOCHEMISTRY

The production of artemisinin precursors in tobacco

(2010) Yansheng Zhang et al.   PLANT BIOTECHNOLOGY JOURNAL

Enhancement of artemisinin content by constitutive expression of the HMG-CoA reductase gene in high-yielding strain of Artemisia annua L.

(2010) Tazyeen Nafis et al.   Plant Biotechnology Reports

Overexpression of farnesyl pyrophosphate synthase (FPS) gene affected artemisinin content and growth of Artemisia annua L.

(2010) Waleerat Banyai et al.   PLANT CELL TISSUE AND ORGAN CULTURE

The Genetic Map of Artemisia annua L. Identifies Loci Affecting Yield of the Antimalarial Drug Artemisinin

(2010) I. A. Graham et al.   SCIENCE

TheC-Glycosylation of Flavonoids in Cereals

(2009) Melissa Brazier-Hicks et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Substrate specificities of family 1 UGTs gained by domain swapping

(2009) Esben Halkjær Hansen et al.   PHYTOCHEMISTRY

Substrate specificity of plant UDP-dependent glycosyltransferases predicted from crystal structures and homology modeling

(2009) Sarah A. Osmani et al.   PHYTOCHEMISTRY

Overexpression of the HMG‐CoA Reductase Gene Leads to Enhanced Artemisinin Biosynthesis in TransgenicArtemisia annuaPlants

(2009) Samina Aquil et al.   PLANTA MEDICA

Isolation and Identification of Novel Genes Involved in Artemisinin Production from Flowers ofArtemisia annuaUsing Suppression Subtractive Hybridization and Metabolite Analysis

(2009) Shuoqian Liu et al.   PLANTA MEDICA

Development of transgenic Artemisia annua (Chinese wormwood) plants with an enhanced content of artemisinin, an effective anti-malarial drug, by hairpin-RNA-mediated gene silencing

(2008) Ling Zhang et al.   BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY

Fiber yield and quality of fiber nettle (Urtica dioica L.) cultivated in Italy

(2008) L. Bacci et al.   INDUSTRIAL CROPS AND PRODUCTS

Extraction and HPLC Analysis of Phenolic Compounds in Leaves, Stalks, and Textile Fibers of Urtica dioica L.

(2008) Patrizia Pinelli et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Quantification of Three Key Enzymes Involved in Artemisinin Biogenesis in Artemisia annua by Polyclonal Antisera-Based ELISA

(2008) Qing-Ping Zeng et al.   PLANT MOLECULAR BIOLOGY REPORTER

Catalytic Key Amino Acids and UDP-Sugar Donor Specificity of a Plant Glucuronosyltransferase, UGT94B1: Molecular Modeling Substantiated by Site-Specific Mutagenesis and Biochemical Analyses

(2008) S. A. Osmani et al.   PLANT PHYSIOLOGY

Glycosyltransferases: Structures, Functions, and Mechanisms

(2007) L.L. Lairson et al.   Annual Review of Biochemistry

Yield enhancement strategies for artemisinin production by suspension cultures of Artemisia annua

(2007) Ashish Baldi et al.   BIORESOURCE TECHNOLOGY

Micropropagation, encapsulation and growth of Artemisia vulgaris node explants for germplasm preservation

(2007) G. Sujatha et al.   SOUTH AFRICAN JOURNAL OF BOTANY