Renal Tubule Repair: Is Wnt/β-Catenin a Friend or Foe?

Redirecting TGF-βSignaling through theβ-Catenin/Foxo Complex Prevents Kidney Fibrosis

(2017) Xi Qiao et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Blocking TGF-βandβ-Catenin Epithelial Crosstalk Exacerbates CKD

(2017) Stellor Nlandu-Khodo et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

(Pro)renin Receptor Is an Amplifier of Wnt/ β -Catenin Signaling in Kidney Injury and Fibrosis

(2017) Zhen Li et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Tubule-Derived Wnts Are Required for Fibroblast Activation and Kidney Fibrosis

(2017) Dong Zhou et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Experimental inhibition of porcupine-mediated Wnt O-acylation attenuates kidney fibrosis

(2016) Babita Madan et al.   KIDNEY INTERNATIONAL

Developmental signalling pathways in renal fibrosis: the roles of Notch, Wnt and Hedgehog

(2016) Maria Edeling et al.   Nature Reviews Nephrology

Global Prevalence of Chronic Kidney Disease – A Systematic Review and Meta-Analysis

(2016) Nathan R. Hill et al.   PLoS One

FOXO3a modulates WNT/β-catenin signaling and suppresses epithelial-to-mesenchymal transition in prostate cancer cells

(2015) Hao Liu et al.   CELLULAR SIGNALLING

Sustained Activation of Wnt/ -Catenin Signaling Drives AKI to CKD Progression

(2015) L. Xiao et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Failed Tubule Recovery, AKI-CKD Transition, and Kidney Disease Progression

(2015) M. A. Venkatachalam et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Paracrine Wnt1 Drives Interstitial Fibrosis without Inflammation by Tubulointerstitial Cross-Talk

(2015) O. H. Maarouf et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Kidney organoids from human iPS cells contain multiple lineages and model human nephrogenesis

(2015) Minoru Takasato et al.   NATURE

Snail1-induced partial epithelial-to-mesenchymal transition drives renal fibrosis in mice and can be targeted to reverse established disease

(2015) M Teresa Grande et al.   NATURE MEDICINE

Epithelial-to-mesenchymal transition induces cell cycle arrest and parenchymal damage in renal fibrosis

(2015) Sara Lovisa et al.   NATURE MEDICINE

WNT/β-Catenin Signaling Is Required for Integration of CD24+Renal Progenitor Cells into Glycerol-Damaged Adult Renal Tubules

(2015) Zhao Zhang et al.   Stem Cells International

β-Catenin Overexpression in the Metanephric Mesenchyme Leads to Renal Dysplasia Genesis via Cell-Autonomous and Non–Cell-Autonomous Mechanisms

(2014) Sanjay Sarin et al.   AMERICAN JOURNAL OF PATHOLOGY

Delayed Administration of a Single Dose of Lithium Promotes Recovery from AKI

(2014) H. Bao et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Multiple Genes of the Renin-Angiotensin System Are Novel Targets of Wnt/ -Catenin Signaling

(2014) L. Zhou et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Report on ISN Forefronts, Florence, Italy, 12–15 September 2013: stem cells and kidney regeneration

(2014) Paola Romagnani et al.   KIDNEY INTERNATIONAL

In Vivo Clonal Analysis Reveals Lineage-Restricted Progenitor Characteristics in Mammalian Kidney Development, Maintenance, and Regeneration

(2014) Yuval Rinkevich et al.   Cell Reports

Direct Transcriptional Reprogramming of Adult Cells to Embryonic Nephron Progenitors

(2013) C. E. Hendry et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Rapid and Efficient Differentiation of Human Pluripotent Stem Cells into Intermediate Mesoderm That Forms Tubules Expressing Kidney Proximal Tubular Markers

(2013) A. Q. Lam et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Wnt4/ -Catenin Signaling in Medullary Kidney Myofibroblasts

(2013) D. P. DiRocco et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

FOXOs: signalling integrators for homeostasis maintenance

(2013) Astrid Eijkelenboom et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Differentiated kidney epithelial cells repair injured proximal tubule

(2013) T. Kusaba et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Wnt and planar cell polarity signaling in cystic renal disease

(2013) Paraskevi Goggolidou   Organogenesis

Kidney tubular β-catenin signaling controls interstitial fibroblast fate via epithelial-mesenchymal communication

(2013) Dong Zhou et al.   Scientific Reports

Wnt/β-Catenin Signaling and Disease

(2012) Hans Clevers et al.   CELL

Six2 and Wnt Regulate Self-Renewal and Commitment of Nephron Progenitors through Shared Gene Regulatory Networks

(2012) Joo-Seop Park et al.   DEVELOPMENTAL CELL

Wnt signalling in kidney diseases: dual roles in renal injury and repair

(2012) Takahisa Kawakami et al.   JOURNAL OF PATHOLOGY

Specific deletion of glycogen synthase kinase-3β in the renal proximal tubule protects against acute nephrotoxic injury in mice

(2012) Christiana Howard et al.   KIDNEY INTERNATIONAL

Targeted proximal tubule injury triggers interstitial fibrosis and glomerulosclerosis

(2012) Ivica Grgic et al.   KIDNEY INTERNATIONAL

Tubule-specific ablation of endogenous β-catenin aggravates acute kidney injury in mice

(2012) Dong Zhou et al.   KIDNEY INTERNATIONAL

Activation of canonical Wnt signalling is required for TGF-β-mediated fibrosis

(2012) Alfiya Akhmetshina et al.   Nature Communications

A sensitive and bright single-cell resolution live imaging reporter of Wnt/ß-catenin signaling in the mouse

(2011) Anna Ferrer-Vaquer et al.   BMC DEVELOPMENTAL BIOLOGY

Secreted Wnt antagonist Dickkopf-1 controls kidney papilla development coordinated by Wnt-7b signalling

(2011) Ilkka Pietilä et al.   DEVELOPMENTAL BIOLOGY

Wnt4 induces nephronic tubules in metanephric mesenchyme by a non-canonical mechanism

(2011) Shunsuke Tanigawa et al.   DEVELOPMENTAL BIOLOGY

 -Catenin Causes Renal Dysplasia via Upregulation of Tgf 2 and Dkk1

(2011) D. Bridgewater et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Targeted Inhibition of  -Catenin/CBP Signaling Ameliorates Renal Interstitial Fibrosis

(2011) S. Hao et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Neutrophil transmigration triggers repair of the lung epithelium via  -catenin signaling

(2011) R. L. Zemans et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Wnt Signaling Regulates Hepatic Metabolism

(2011) H. Liu et al.   Science Signaling

GSK3  Promotes Apoptosis after Renal Ischemic Injury

(2010) Z. Wang et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Macrophage Wnt7b is critical for kidney repair and regeneration

(2010) S.-L. Lin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inhibition of Wnt/ -catenin/CREB binding protein (CBP) signaling reverses pulmonary fibrosis

(2010) W. R. Henderson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Fate Tracing Reveals the Pericyte and Not Epithelial Origin of Myofibroblasts in Kidney Fibrosis

(2009) Benjamin D. Humphreys et al.   AMERICAN JOURNAL OF PATHOLOGY

 -Catenin Promotes Survival of Renal Epithelial Cells by Inhibiting Bax

(2009) Z. Wang et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Wnt/ -Catenin Signaling Promotes Renal Interstitial Fibrosis

(2009) W. He et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Intrinsic Epithelial Cells Repair the Kidney after Injury

(2008) Benjamin D. Humphreys et al.   Cell Stem Cell

Canonical WNT/β-catenin signaling is required for ureteric branching

(2008) Darren Bridgewater et al.   DEVELOPMENTAL BIOLOGY

Epithelial cell α3β1 integrin links β-catenin and Smad signaling to promote myofibroblast formation and pulmonary fibrosis

(2008) Kevin K. Kim et al.   JOURNAL OF CLINICAL INVESTIGATION

WNT/β-catenin signaling in nephron progenitors and their epithelial progeny

(2008) Kai M. Schmidt-Ott et al.   KIDNEY INTERNATIONAL

The FoxO code

(2008) D R Calnan et al.   ONCOGENE

β-Catenin is necessary to keep cells of ureteric bud/Wolffian duct epithelium in a precursor state

(2007) Thomas D. Marose et al.   DEVELOPMENTAL BIOLOGY