Article
Cell Biology
Fatma Saaoud, Laisel Martinez, Yifan Lu, Keman Xu, Ying Shao, Jia L. Zhuo, Avrum Gillespie, Hong Wang, Marwan Tabbara, Alghidak Salama, Xiaofeng Yang, Roberto I. I. Vazquez-Padron
Summary: Most patients with end-stage renal disease (ESRD) and advanced chronic kidney disease (CKD) choose hemodialysis as their treatment of choice. This study examined the transcriptome of veins in CKD patients and found that CKD converts veins into immune organs, increases innate immune responses, impairs mitochondrial bioenergetics, reprograms fibrogenic processes, alters cell death and survival programs, and upregulates protein kinase signal transduction pathways and transcription factors for embryonic organ development, positive regulation of developmental growth, and muscle structure development in veins. These findings provide novel insights on the roles of veins as immune endocrine organs and the effect of CKD in upregulating secretomes and driving immune and vascular cell differentiation.
Review
Pharmacology & Pharmacy
Jonatan Barrera-Chimal, Frederic Jaisser, Hans-Joachim Anders
Summary: Chronic kidney disease is a major public health concern globally, with MR antagonists emerging as a potential therapeutic approach against various forms of kidney disease. Experimental and clinical studies have shown the protective effects of MRAs in reducing albuminuria and slowing disease progression. Recent evidence also suggests that MRAs can reduce hard kidney outcomes, particularly in CKD associated with type 2 diabetes, highlighting their potential benefit in maximizing organ protection through combination therapy.
BRITISH JOURNAL OF PHARMACOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Paul M. Ridker, Katherine R. Tuttle, Vlado Perkovic, Peter Libby, Jean G. MacFadyen
Summary: This study found that residual inflammatory risk plays a significant role in determining the risk of recurrent major adverse cardiovascular events among post-myocardial infarction patients already treated with statins, especially in those with impaired kidney function.
EUROPEAN HEART JOURNAL
(2022)
Article
Biochemistry & Molecular Biology
Nicholas A. Maksimowski, Xuewen Song, Eun Hui Bae, Heather Reich, Rohan John, York Pei, James W. Scholey
Summary: The study revealed that FSTL1 is a fibroblast-derived cytokine associated with the progression of chronic kidney disease. Its expression levels are positively correlated with age, eGFR, proteinuria, interstitial fibrosis, and tubular atrophy. High baseline FSTL1 mRNA levels were also linked to a greater risk of clinical disease progression in CKD patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Anna Gluba-Sagr, Beata Franczyk, Magdalena Rysz-Gorzynska, Janusz Lawinski, Jacek Rysz
Summary: Chronic kidney disease is a significant health concern, with renal fibrosis being a major mechanism of renal dysfunction. MicroRNAs play important roles in the development of fibrosis and chronic kidney disease. However, the effects and regulation of miRNAs may vary in different tissues and cells.
Article
Pharmacology & Pharmacy
Priyal Patel, Sandip Patel, Piyush Chudasama, Shailesh Soni, Manan Raval
Summary: The present investigation explored the potential treatment option of roflumilast as a PDE4 inhibitor for chronic kidney disease. The results demonstrated that roflumilast significantly reduced serum creatinine, urea, uric acid levels, increased serum calcium, and regulated protein expression of inflammatory markers. Moreover, roflumilast noticeably improved the structure and functioning of glomeruli, tubules, and cells. Therefore, roflumilast has the potential to ameliorate renal injury.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Xin-Yue Ge, Zhong-Kai Lan, Qiao-Qing Lan, Hua-Shan Lin, Guo-Dong Wang, Jing Chen
Summary: This study used radiomics of B-mode ultrasound and Sound Touch Elastography (STE) images in combination with clinical features to predict kidney fibrosis in patients with chronic kidney disease. A nomogram based on multiple logistic regression analyses was constructed, combining clinical and radiomics, and it showed good performance in differentiating kidney fibrosis of different severities.
EUROPEAN RADIOLOGY
(2023)
Article
Endocrinology & Metabolism
Benjamin P. Larkin, Long T. Nguyen, Miao Hou, Sarah J. Glastras, Hui Chen, Alen Faiz, Jason Chen, Rosy Wang, Carol A. Pollock, Sonia Saad
Summary: Using a mouse model of obesity, it was found that low-dose hydralazine can prevent obesity-related chronic kidney disease independently of alterations in biometric and metabolic variables or blood pressure regulation. This discovery provides a basis for repurposing hydralazine as a novel therapy to prevent CKD progression in obese patients.
DIABETES OBESITY & METABOLISM
(2022)
Review
Biochemistry & Molecular Biology
Liang-Ti Huang, Chung-Ming Chen
Summary: Preterm birth and hyperoxia exposure disrupt the development and function of the kidneys, leading to the pathogenesis of chronic kidney disease. Hyperoxia-induced kidney injuries are mediated by various molecular factors, including hypoxia-inducible factor-1 alpha, interleukin-6/Smad2/transforming growth factor-beta, and Wnt/beta-catenin signaling pathways.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Fatimah K. Khalaf, Chrysan J. Mohammed, Prabhatchandra Dube, Jacob A. Connolly, Apurva Lad, Usman M. Ashraf, Joshua D. Breidenbach, Robin C. Su, Andrew L. Kleinhenz, Deepak Malhotra, Amira F. Gohara, Steven T. Haller, David J. Kennedy
Summary: This study found that decreased PON-1 is associated with the progression of renal inflammation and fibrosis independent of blood pressure. By knockout of the Pon1 gene in a rat model, it was discovered that the absence of PON-1 leads to increased renal fibrosis, sclerosis, and tubular injury, as well as increased recruitment of immune cells in the renal interstitium and the expression of inflammatory genes. Furthermore, the absence of PON-1 also results in a decline in renal function and increased renal oxidative stress.
Article
Medicine, Research & Experimental
Jing Pan, Min Shi, Fan Guo, Liang Ma, Ping Fu
Summary: The study demonstrated that the use of STAT3 inhibitor can delay the progression of hyperuricemia-induced CKD renal fibrosis, improve renal function, and lower serum uric acid levels. Additionally, the inhibitor can suppress multiple fibrotic signaling pathways and cytokine expressions.
Article
Plant Sciences
Shubo Zhou, Yifeng He, Weiping Zhang, Yin Xiong, Li Jiang, Juan Wang, Xiuming Cui, Yuan Qu, Feng Ge
Summary: O. lanpingensis polysaccharides (OLP) can significantly alleviate chronic kidney disease in mice by reducing oxidative stress, inflammation, apoptosis, and fibrosis in the kidneys, providing evidence for the potential application of OLP in alleviating CKD.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Review
Medicine, General & Internal
Bin Wang, Zuo-Lin Li, Yi-Lin Zhang, Yi Wen, Yue-Ming Gao, Bi-Cheng Liu
Summary: This review outlines the characteristics, mechanisms, complications, potential therapeutic approaches, and challenges of chronic hypoxia in chronic kidney disease (CKD).
Article
Dentistry, Oral Surgery & Medicine
Youn Soo Lee, Ae Ri Kim, Yeong-Eui Jeon, Eun-Jung Bak, Yun-Jung Yoo
Summary: The objective of this study was to examine the effect of periodontitis on renal function and morphology in rats with or without nephrectomy-induced chronic kidney disease. The results showed that periodontitis increased renal fibrosis and inflammation, but did not affect renal function. In the presence of chronic kidney disease, periodontitis also increased TNFa expression in the kidneys.
Article
Food Science & Technology
Hyoungnae Kim, Bo Young Nam, Jimin Park, Seokcheon Song, Woon-Ki Kim, Kiuk Lee, Tae-Wook Nam, Jung Tak Park, Tae-Hyun Yoo, Shin-Wook Kang, GwangPyo Ko, Seung Hyeok Han
Summary: This study aimed to evaluate the protective effects of probiotic supplement KBL409 against kidney injury in an animal model of chronic kidney disease (CKD). The results showed that KBL409 supplementation had beneficial immunomodulating effects and protected against kidney injury.
MOLECULAR NUTRITION & FOOD RESEARCH
(2022)
Review
Pharmacology & Pharmacy
Zheng Zhong, David M. Virshup
MOLECULAR PHARMACOLOGY
(2020)
Article
Biology
Jonathan M. Philpott, Rajesh Narasimamurthy, Clarisse G. Ricci, Alfred M. Freeberg, Sabrina R. Hunt, Lauren E. Yee, Rebecca S. Pelofsky, Sarvind Tripathi, David M. Virshup, Carrie L. Partch
Article
Oncology
Kyunghee Lee, Mayumi Kitagawa, Pei Ju Liao, David M. Virshup, Sang Hyun Lee
Review
Oncology
Zheng Zhong, Jia Yu, David M. Virshup, Babita Madan
CANCER AND METASTASIS REVIEWS
(2020)
Article
Multidisciplinary Sciences
Shusaku Masuda, Rajesh Narasimamurthy, Hikari Yoshitane, Jae Kyoung Kim, Yoshitaka Fukada, David M. Virshup
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2020)
Article
Oncology
Jia Yu, Permeen A. Mohamed Yusoff, Danielle T. J. Woutersen, Pamela Goh, Nathan Harmston, Ron Smits, David M. Epstein, David M. Virshup, Babita Madan
Article
Genetics & Heredity
Shiyang Liu, Nathan Harmston, Trudy Lee Glaser, Yunka Wong, Zheng Zhong, Babita Madan, David M. Virshup, Enrico Petretto
Article
Biochemistry & Molecular Biology
Rie Nygaard, Jia Yu, Jonathan Kim, Daniel R. Ross, Giacomo Parisi, Oliver B. Clarke, David M. Virshup, Filippo Mancia
Summary: Wnts are evolutionarily conserved ligands that regulate morphogenesis, cell fate, and stem cell renewal. The secretion of Wnts involves O-palmitoleation and loading onto WLS. The cryo-EM structure of palmitoleated human WNT8A in complex with WLS reveals molecular insights into their physiological implications and central mechanisms in animal body plan development and stem cell biology.
Article
Medicine, Research & Experimental
Amanpreet Kaur, Jun Yi Stanley Lim, Sugunavathi Sepramaniam, Siddhi Patnaik, Nathan Harmston, May Ann Lee, Enrico Petretto, David M. Virshup, Babita Madan
Summary: The study reveals that Wnt signaling plays a critical role in regulating DNA repair genes in stem cells and cancer, maintaining genomic integrity. Blocking Wnt signaling may sensitize cancers to radiation and other DNA damaging agents.
EMBO MOLECULAR MEDICINE
(2021)
Article
Pathology
Kenon Chua, David M. Virshup, Eugene G. Odono, Kenneth Tou En Chang, Nicholas Jin Hong Tan, Susan Swee-Shan Hue, Arthur Yi Loong Sim, Victor Kwan Min Lee
Summary: The study evaluated WLS expression in bone and soft tissue tumours using the YJ5 antibody, finding strong YJ5 immunoreactivity in almost all osteosarcomas, chondroblastomas, osteoblastomas, and osteoid osteomas. This marker may be useful in determining the osteogenic lineage in malignant bone tumours, especially in distinguishing osteosarcomas with unusual features.
Article
Multidisciplinary Sciences
Lucy Brunt, Gediminas Greicius, Sally Rogers, Benjamin D. Evans, David M. Virshup, Kyle C. A. Wedgwood, Steffen Scholpp
Summary: Vangl2 regulates Wnt ligand distribution by controlling cytoneme behavior, enhancing paracrine Wnt/β-catenin signaling. This study reveals the crucial role of Vangl2 in intercellular Wnt signal transduction through cytonemes.
NATURE COMMUNICATIONS
(2021)
Article
Cell Biology
Jia Yu, Pei-Ju Liao, Weijun Xu, Julie R. Jones, David B. Everman, Heather Flanagan-Steet, Thomas H. Keller, David M. Virshup
Summary: Wnt signaling is essential for normal development and a therapeutic target in cancer. PORCN is a crucial enzyme for the post-translational modification of Wnts and slowing the growth of Wnt-dependent cancers. A structural model of human PORCN has been developed to enhance the understanding of its catalytic mechanism and pharmacologic inhibition, facilitating the development of improved inhibitors.
JOURNAL OF CELL SCIENCE
(2021)
Article
Peripheral Vascular Disease
Xiaohan Lu, Jiandong Zhang, Yi Wen, Jiafa Ren, Robert Griffiths, Nathan P. Rudemiller, Shintaro Ide, Tomokazu Souma, Steven D. Crowley
Summary: In this study, the researchers investigated the role of AT(1) receptors on CD11c(+) cells in the development of hypertension. They found that AT(1) receptor stimulation on dendritic cells (DCs) suppresses renal DC maturation and T cell activation, resulting in protection from sodium retention and blood pressure elevation. These findings provide insights into the pathogenesis of hypertension and offer new possibilities for its treatment.
Review
Biochemistry & Molecular Biology
Jia Yu, David M. Virshup
Summary: Wnts are lipid-modified signaling glycoproteins that play critical roles in development and homeostasis. Their function is regulated by post-translational modifications, such as O-linked palmitoleation. The abundance and activity of Wnt are controlled by intracellular recycling, ubiquitylation-mediated degradation, and cleavage by metalloprotease TIKI. Understanding these modifications provides insights into the regulation of Wnt signaling.
BIOCHEMICAL SOCIETY TRANSACTIONS
(2022)
Article
Medicine, Research & Experimental
Zheng Zhong, Nathan Harmston, Kris C. Wood, Babita Madan, David M. Virshup
Summary: Wnt signaling plays a crucial role in regulating the balance between stemness and differentiation. RNF43-mutant pancreatic cancers are resistant to PORCN inhibitors due to genetic alterations that silence EP300 and downregulate GATA6 expression, leading to a shift in phenotype and resistance to Wnt inhibition.
JOURNAL OF CLINICAL INVESTIGATION
(2022)