Computer Simulation of TSP1 Inhibition of VEGF–Akt–eNOS: An Angiogenesis Triple Threat

A computational analysis of pro-angiogenic therapies for peripheral artery disease

(2018) Lindsay E. Clegg et al.   Integrative Biology

Integrative meta-modeling identifies endocytic vesicles, late endosome and the nucleus as the cellular compartments primarily directing RTK signaling

(2017) Jared C. Weddell et al.   Integrative Biology

Transcriptional and Post-Transcriptional Regulation of Thrombospondin-1 Expression: A Computational Model

(2017) Chen Zhao et al.   PLoS Computational Biology

Computational investigation of sphingosine kinase 1 (SphK1) and calcium dependent ERK1/2 activation downstream of VEGFR2 in endothelial cells

(2017) Hojjat Bazzazi et al.   PLoS Computational Biology

Inhibition of VEGFR2 Activation and Its Downstream Signaling to ERK1/2 and Calcium by Thrombospondin-1 (TSP1): In silico Investigation

(2017) Hojjat Bazzazi et al.   Frontiers in Physiology

Mechanisms and regulation of endothelial VEGF receptor signalling

(2016) Michael Simons et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The endothelial adaptor molecule TSAd is required for VEGF-induced angiogenic sprouting through junctional c-Src activation

(2016) E. J. Gordon et al.   Science Signaling

Thrombospondin-1 signaling through CD47 inhibits cell cycle progression and induces senescence in endothelial cells

(2016) Qi Gao et al.   Cell Death & Disease

The endothelial adaptor molecule TSAd is required for VEGF-induced angiogenic sprouting through junctional c-Src activation

(2016) E. J. Gordon et al.   Science Signaling

CD47 Receptor Globally Regulates Metabolic Pathways That Control Resistance to Ionizing Radiation

(2015) Thomas W. Miller et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Site-Specific Phosphorylation of VEGFR2 Is Mediated by Receptor Trafficking: Insights from a Computational Model

(2015) Lindsay Wendel Clegg et al.   PLoS Computational Biology

CD47 Signaling Regulates the Immunosuppressive Activity of VEGF in T Cells

(2014) Sukhbir Kaur et al.   JOURNAL OF IMMUNOLOGY

Thrombospondin-1 Activation of Signal-Regulatory Protein-  Stimulates Reactive Oxygen Species Production and Promotes Renal Ischemia Reperfusion Injury

(2014) M. Yao et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Thrombospondin-1 and CD47 regulation of cardiac, pulmonary and vascular responses in health and disease

(2014) Natasha M. Rogers et al.   MATRIX BIOLOGY

Thrombospondin-1 and CD47 signaling regulate healing of thermal injury in mice

(2014) David R. Soto-Pantoja et al.   MATRIX BIOLOGY

Antiangiogenic VEGF-A in peripheral artery disease

(2014) Joshua M Boucher et al.   NATURE MEDICINE

Quantitative fluorescent profiling of VEGFRs reveals tumor cell and endothelial cell heterogeneity in breast cancer xenografts

(2014) Princess. I. Imoukhuede et al.   Cancer Medicine

Computational model of VEGFR2 pathway to ERK activation and modulation through receptor trafficking

(2013) Wan Hua Tan et al.   CELLULAR SIGNALLING

VEGFA and tumour angiogenesis

(2013) L. Claesson-Welsh et al.   JOURNAL OF INTERNAL MEDICINE

Therapeutic angiogenesis for critical limb ischaemia

(2013) Brian H. Annex   Nature Reviews Cardiology

The Reactome pathway knowledgebase

(2013) David Croft et al.   NUCLEIC ACIDS RESEARCH

Computational Model of Gab1/2-Dependent VEGFR2 Pathway to Akt Activation

(2013) Wan Hua Tan et al.   PLoS One

Thrombospondin-1 Signaling through CD47 Inhibits Self-renewal by Regulating c-Myc and Other Stem Cell Transcription Factors

(2013) Sukhbir Kaur et al.   Scientific Reports

The VEGF Pathway in Cancer and Disease: Responses, Resistance, and the Path Forward

(2013) M. W. Kieran et al.   Cold Spring Harbor Perspectives in Medicine

A Mathematical Model of T Lymphocyte Calcium Dynamics Derived from Single Transmembrane Protein Properties

(2013) Christine Schmeitz et al.   Frontiers in Immunology

VEGF-A engages at least three tyrosine kinases to activate PI3K/Akt

(2012) Guo-Xiang Ruan et al.   CELL CYCLE

Axl is essential for VEGF-A-dependent activation of PI3K/Akt

(2012) Guo-Xiang Ruan et al.   EMBO JOURNAL

VEGFR2 induces c-Src signaling and vascular permeability in vivo via the adaptor protein TSAd

(2012) Zuyue Sun et al.   JOURNAL OF EXPERIMENTAL MEDICINE

NIH Image to ImageJ: 25 years of image analysis

(2012) Caroline A Schneider et al.   NATURE METHODS

Expression of VEGF Receptors on Endothelial Cells in Mouse Skeletal Muscle

(2012) Princess I. Imoukhuede et al.   PLoS One

Annotating Cancer Variants and Anti-Cancer Therapeutics in Reactome

(2012) Marija Milacic et al.   Cancers

Neuropilin-1 promotes VEGFR-2 trafficking through Rab11 vesicles thereby specifying signal output

(2011) K. Ballmer-Hofer et al.   BLOOD

Orai1 and CRAC Channel Dependence of VEGF-Activated Ca 2+ Entry and Endothelial Tube Formation

(2011) Jing Li et al.   CIRCULATION RESEARCH

Phosphorylation of Akt and ERK1/2 Is Required for VEGF-A/VEGFR2-Induced Proliferation and Migration of Lymphatic Endothelium

(2011) Michael T. Dellinger et al.   PLoS One

Thrombospondin-1 Is a Plasmatic Marker of Peripheral Arterial Disease That Modulates Endothelial Progenitor Cell Angiogenic Properties

(2010) David M. Smadja et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Thrombospondin-1 supports blood pressure by limiting eNOS activation and endothelial-dependent vasorelaxation

(2010) Eileen M. Bauer et al.   CARDIOVASCULAR RESEARCH

A Novel Ca2+/Calmodulin Antagonist HBC Inhibits Angiogenesis and Down-regulates Hypoxia-inducible Factor

(2010) Hye Jin Jung et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Thrombospondin-1 Inhibits VEGF Receptor-2 Signaling by Disrupting Its Association with CD47

(2010) Sukhbir Kaur et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Vascular endothelial growth factor and age-related macular degeneration: from basic science to therapy

(2010) Napoleone Ferrara   NATURE MEDICINE

Systems biology of pro-angiogenic therapies targeting the VEGF system

(2010) Feilim Mac Gabhann et al.   Wiley Interdisciplinary Reviews-Systems Biology and Medicine

Blockade of Thrombospondin-1-CD47 Interactions Prevents Necrosis of Full Thickness Skin Grafts

(2009) Jeff S. Isenberg et al.   ANNALS OF SURGERY

eNOS Activation by Physical Forces: From Short-Term Regulation of Contraction to Chronic Remodeling of Cardiovascular Tissues

(2009) J.-L. Balligand et al.   PHYSIOLOGICAL REVIEWS

Ligand-Stimulated VEGFR2 Signaling is Regulated by Co-Ordinated Trafficking and Proteolysis

(2009) Alexander F. Bruns et al.   TRAFFIC

Inhibition of Vascular Endothelial Growth Factor-A Signaling Induces Hypertension: Examining the Effect of Cediranib (Recentin; AZD2171) Treatment on Blood Pressure in Rat and the Use of Concomitant Antihypertensive Therapy

(2008) J. O. Curwen et al.   CLINICAL CANCER RESEARCH

The Role of Vascular Endothelial Growth Factor in Wound Healing

(2008) Philip Bao et al.   JOURNAL OF SURGICAL RESEARCH

A methodology for performing global uncertainty and sensitivity analysis in systems biology

(2008) Simeone Marino et al.   JOURNAL OF THEORETICAL BIOLOGY

New Role for the Protein Tyrosine Phosphatase DEP-1 in Akt Activation and Endothelial Cell Survival

(2008) C. Chabot et al.   MOLECULAR AND CELLULAR BIOLOGY

Treatment of liver ischemia–reperfusion injury by limiting thrombospondin-1/CD47 signaling

(2008) Jeff S. Isenberg et al.   SURGERY

Thrombospondin-1 stimulates platelet aggregation by blocking the antithrombotic activity of nitric oxide/cGMP signaling

(2007) J. S. Isenberg et al.   BLOOD