Article
Cell Biology
Qi Zhu, Feng Liang, Shufang Cai, Xiaorong Luo, Tianqi Duo, Ziyun Liang, Zuyong He, Yaosheng Chen, Delin Mo
Summary: KDM4A deficiency in skeletal muscle impairs muscle formation and regeneration, and inhibits myogenic cell proliferation and differentiation.
CELL DEATH & DISEASE
(2021)
Article
Biochemistry & Molecular Biology
Hee-Seok Lee, Jaewook Lee, Seok-Hee Lee, Hyeyeong Seo, Kwang-Geun Lee, Yooheon Park
Summary: 3-Monochloro-1,2-propanediol (3-MCPD) is a chemical compound unintentionally produced during food processing, which has been linked to reproductive toxicity, genotoxicity, neurotoxicity, and kidney toxicity. In this study, it was found that 3-MCPD inhibits muscle differentiation in C2C12 myoblasts by suppressing the expression of genetic factors related to muscle differentiation.
CHEMICO-BIOLOGICAL INTERACTIONS
(2021)
Review
Cell Biology
Tomohiko Shirakawa, Takashi Toyono, Asako Inoue, Takuma Matsubara, Tatsuo Kawamoto, Shoichiro Kokabu
Summary: This review summarizes the myogenic regulatory factors (MRFs) and their regulatory factors and target genes, discussing their roles and potential applications in stem cell differentiation and muscle-related disease treatment.
Article
Biochemistry & Molecular Biology
Shuang Gu, Chaoliang Wen, Junying Li, Honghong Liu, Qiang Huang, Jiangxia Zheng, Congjiao Sun, Ning Yang
Summary: This study selected four different breeds of chickens to investigate the temporal expression patterns of key regulatory genes during embryonic muscle development, providing a foundation for understanding the regulation mechanisms. The highest expression level of Myomaker, a crucial gene for myoblast fusion, occurred from embryonic days 13 to 15, with Cornish breed showing the highest expression level. The MYOD gene may play an important role after hatching. Histomorphology analysis suggested that the myofibers were largely complete by embryonic day 17 due to increased expression of MSTN and decreased expression of Myomaker.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Agriculture, Dairy & Animal Science
Miquel Perello-Amoros, Isabel Garcia-Perez, Albert Sanchez-Moya, Arnau Innamorati, Emilio J. Velez, Isabel Achaerandio, Montserrat Pujola, Josep Calduch-Giner, Jaume Perez-Sanchez, Jaume Fernandez-Borras, Josefina Blasco, Joaquim Gutierrez
Summary: The study showed that exercise can improve fish growth and enhance the utilization of nutrients, leading to increased aquaculture production efficiency. Feeding fish with a high-lipid diet resulted in slower growth, but exercise could mitigate this effect, preventing protein deficiency.
Article
Geriatrics & Gerontology
Rianne D. W. Vaes, David P. J. van Dijk, Elham Aida Farshadi, Steven W. M. Olde Damink, Sander S. Rensen, Ramon C. Langen
Summary: The study revealed that factors derived from pancreatic tumor organoids alter the kinetics of myogenesis, potentially contributing to impaired muscle mass maintenance in cancer cachexia.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2022)
Article
Agriculture, Dairy & Animal Science
Dong-Hwan Kim, Young Min Choi, Yeunsu Suh, Sangsu Shin, Joonbum Lee, Seongsoo Hwang, Sang Suk Lee, Kichoon Lee
Summary: The study investigated the expression levels of myostatin and myogenic regulatory factors in a low-weight Japanese quail line with muscle hypoplasia, indicating that high levels of Mstn and low levels of MRFs during embryonic stages may be associated with muscle hypoplasia and delayed growth.
Article
Biochemistry & Molecular Biology
Zihao Zhang, Shudai Lin, Wen Luo, Tuanhui Ren, Xing Huang, Wangyu Li, Xiquan Zhang
Summary: Adult skeletal muscle is divided into fast and slow-type muscles, and satellite cells play a crucial role in their development. The expression of Sox6 and Nfix partially explain the differences in development between satellite cells derived from fast and slow muscles.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Chuan-Che Wu, Wei-Cheng Chen, Wen-Po Hsiao, Kai-Fan Huang, Yi-Shiuan Liao, Huang-Bin Lin, Yi-Ju Wu, Chien-Han Kao, Shen-Liang Chen
Summary: Mitochondria and peroxisomes are involved in the oxidative metabolism of cells, but their dynamics and functional adaptations during skeletal muscle development are still lacking. In this study, increased MITO DNA, ROS level, and redox ratio were observed in myotubes, suggesting a reduction in MITO efficiency during myogenesis. The number and density of peroxisomes increased during myogenesis, likely due to their accumulation and increased biogenesis. Knockdown of Pex3, a biogenesis factor, not only reduced peroxisome density and function but also affected MITO genes and functions, indicating a close coupling between peroxisome biogenesis and MITO functions. Surprisingly, Pex3 knockdown inhibited myogenic differentiation, highlighting the critical role of peroxisome biogenesis in myogenesis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Agriculture, Multidisciplinary
Dingding Zhang, Jingli Tao, Xuan Zhang, Xiangfei Ma, Chengyu Li, Hongmin Li, Weijian Li, Jie Chen, Honglin Liu
Summary: This study reveals the role of neoruscogenin in muscle growth by inhibiting MSTN maturation and promoting protein synthesis metabolism. It also shows its potential in repairing muscle injuries. These findings have important implications for the treatment of muscle disorders and the livestock industry.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Pharmacology & Pharmacy
Hiroshi Todaka, Mikihiko Arikawa, Tatsuya Noguchi, Atsushi Ichikawa, Takayuki Sato
Summary: The study demonstrated that donepezil enhances muscle regeneration by promoting muscle differentiation independently of its acetylcholinesterase-inhibitory action. This finding suggests that donepezil could be a useful therapeutic agent for injured skeletal muscle treatment.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Multidisciplinary Sciences
Yaolu Zhao, Elke Albrecht, Katja Stange, Zeyang Li, Johannes Schregel, Quentin L. Sciascia, Cornelia C. Metges, Steffen Maak
Summary: This study found that glutamine supplementation can improve muscle growth in low birth weight piglets by stimulating cell proliferation both in muscle tissue and in vitro myogenic cell culture, with minimal impact on the expression of muscle growth regulatory genes.
SCIENTIFIC REPORTS
(2021)
Article
Genetics & Heredity
Lin-Lin Shi, Ke-Cheng Zhu, Huan-Ling Wang
Summary: This study characterized the sequences and expression patterns of Myod and Myf5 in Megalobrama amblycephala. The results showed that these genes were predominantly expressed in skeletal muscle, with highest expression in white muscle. Additionally, the effects of LPS on muscle-related gene expression and satellite cell proliferation and differentiation were evaluated.
Article
Biotechnology & Applied Microbiology
Sukanya Srivastava, Richa Rathor, Som Nath Singh, Geetha Suryakumar
Summary: This study analyzed the role of myokines and the regeneration capacity of skeletal muscle during chronic hypobaric hypoxia. The results indicated impairment in the levels of myokines and myogenesis during prolonged hypoxia. Myokine levels could be a predictive biomarker for evaluating skeletal muscle performance and loss at high altitudes.
Article
Geriatrics & Gerontology
Sebastiaan Dalle, Jolan Dupont, Lenore Dedeyne, Sabine Verschueren, Jos Tournoy, Evelien Gielen, Katrien Koppo
Summary: This study compared the protein expression profiles between older adults with preserved and low muscle strength, and found differences in catabolic, mitochondrial, stress-related, and myogenic pathways. The increased stress factors in the low muscle strength group may reflect the deterioration of tissue homeostasis, while the upregulation of myogenic markers in this group may be an attempt to compensate for the gradual loss in muscle quantity and quality.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2022)
Article
Environmental Sciences
Jieyu Chen, Jie Wang, Xiaoning Wang, Yabing Lv, Dapeng Li, Jie Hou, Xugang He
Summary: Cooperation between Phosphate and Glycogen Accumulating Organisms (PAOs and GAOs) in SNEDPR systems is crucial for nutrient removal. Regulating competition between PAOs and GAOs through operational mode adjustment is key to achieving desired nutrient removal performance in CW systems.
Article
Environmental Sciences
Wang Lin, Honghui Guo, Liping Yang, Yu Kuang, Dapeng Li, Pinhong Yang, Li Li
Summary: This study conducted a comprehensive investigation on lipid metabolism and its regulation mechanism of female zebrafish exposed to MC-LR and BC for the first time. The results indicated that BC may solely function as an absorbent agent to reduce MC-LR bioaccumulation in zebrafish liver and alleviate MC-LR-induced hepatotoxicity.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Article
Fisheries
Weitong Xu, Qiushi Yang, Yin Wang, Rong Tang, Dapeng Li
Summary: This study explored the performance of the recirculating pond aquaculture system (RPAS) on grass carp. The results showed that RPAS had lower concentrations of nitrogen compounds in the water and led to higher growth rates and lower feed conversion rates in the fish. The expression of growth-related genes was also increased in the fish cultured in RPAS ponds. Additionally, RPAS helped reduce oxidative stress and enhance muscle umami flavor in the fish.
Article
Fisheries
Honghao Zhao, Jasmine Chong, Dapeng Li, Jianguo Xia
Summary: This study investigates the molecular mechanisms underlying the effects of artificial formula feed and grass-feeding on muscle quality and growth in grass carp. The results suggest that artificial formula feed promotes myofiber differentiation and protein synthesis for more muscle mass gain, while grass-feeding promotes muscle cell proliferation and hypertrophy for muscle growth. The study also highlights the significant impact of muscle fiber types on muscle tenderness and quality.
Article
Environmental Sciences
Zhenyi Hu, Dengfeng Han, Tingting Zhang, Dapeng Li, Rong Tang
Summary: Under unfavorable agricultural conditions, ammonia toxicity has become a major problem, resulting in a large number of deaths. This study found that ammonia has toxic effects on normal grass carp hepatocytes by inducing oxidative stress and endoplasmic reticulum stress, leading to cell injury and apoptosis.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Engineering, Environmental
Xiaoning Wang, Jie Wang, Jingyi Chen, Jieyu Chen, Yabing Lv, Ruiya Chen, Juchen Xu, Dapeng Li, Xugang He, Jie Hou
Summary: To control eutrophication in aquatic ecosystems, upgrading conventional constructed wetlands to aeration wetlands is common. However, efforts to reduce dissolved inorganic nitrogen (DIN) discharge have overshadowed the importance of dissolved organic nitrogen (DON). This study found that intermittent aeration in aeration wetlands introduces large amounts of DON and bioavailable DON in effluents, while decreasing total nitrogen (TN). The increase in DON discharge can influence phytoplankton composition and stimulate harmful species, indicating the need to regulate DON discharge alongside DIN.
Article
Environmental Sciences
Jun Xie, Caiyan Wang, Lu Liu, Yuanshuai Duan, Bin Huo, Dapeng Li
Summary: Long-term ecological restoration can partially restore aquatic ecosystems and alleviate the crisis of freshwater fish biodiversity. The distribution of fish communities in the Hun River Basin showed spatial differences along the longitudinal gradient and was influenced by agricultural land, urban land, and grassland. The health status of the Hun River varied, with the upper and middle reaches being in better health and the lower reaches being poorer, mainly due to different levels of human activities.
Article
Environmental Sciences
Weitong Xu, Fengyue Zhu, Dengqiang Wang, Daqing Chen, Xinbin Duan, Mingdian Liu, Dapeng Li
Summary: Metabolomics studies were used to investigate the influence of the high-altitude aquatic environment on indigenous fish metabolites. Different metabolite concentrations were found in the livers of fish at high and low altitudes, indicating different metabolic processes such as oxidative stress, energy metabolism, carbohydrate metabolism, and lipid metabolism. The mTOR signaling pathway, apoptosis, and lysosome were enriched between groups to ensure energy supply and limit tissue damage in fish at high altitudes. Nicotine and methoprene, two organic pollutants, showed different effects in fish at different altitudes. Overall, this study provides important insights into fish adaptation to high-altitude environments and organic contaminants pollution.
Article
Biochemistry & Molecular Biology
Yao Lu, Guangyan Zhou, Jessica Ewald, Zhiqiang Pang, Tanisha Shiri, Jianguo Xia
Summary: Microbiome studies have become routine in various scientific fields, requiring user-friendly bioinformatics tools to analyze complex multi-omics datasets. MicrobiomeAnalyst 2.0 is introduced here as a comprehensive tool for statistical analysis, visualization, functional interpretation, and integrative analysis of microbiome data. It features three new modules for data processing, metabolomics profiling, and statistical meta-analysis, along with other improvements such as support for multi-factor analysis and interactive visualizations.
NUCLEIC ACIDS RESEARCH
(2023)
Article
Multidisciplinary Sciences
Lharbi Dridi, Fernando Altamura, Emmanuel Gonzalez, Olivia Lui, Ryszard Kubinski, Reilly Pidgeon, Adrian Montagut, Jasmine Chong, Jianguo Xia, Corinne F. Maurice, Bastien Castagner
Summary: The composition and metabolism of the human gut microbiota are influenced by dietary complex glycans. A functional assay combining metabolic labeling and cell sorting was used to identify gut bacteria that consume different glycans. The results increase our understanding of glycan metabolism by gut bacteria.
NATURE COMMUNICATIONS
(2023)
Article
Environmental Sciences
Bin Xu, Dapeng Li, Kaijin Wei, Xiangyun Zhu, Jin Xu, Baoshan Ma
Summary: Due to a decline in resources, Schizothorax waltoni Regan and Percocypris retrodorslis have been listed as second-class protected wildlife in China. This study examined the early development and allometric growth of these species under culture conditions. Four periods of larval growth were identified, and the development of organs prioritized functions related to respiration, feeding, and swimming. The findings provide valuable perspectives for species conservation.
Article
Environmental Sciences
Qixin Hu, Jiamin Lu, Yu Yang, Dapeng Li, Jieya Liu
Summary: This study examined the effects of acute thermal stress on skeletal muscle growth and quality in gibel carp. Results showed that the muscle nutrient content was significantly higher at 20°C, with the muscle being more tender and elastic. The gene expression levels of the MRFs family were upregulated after 1 hour and gradually decreased. The study suggests that gibel carp can adapt to acute thermal stress to some extent, but it eventually leads to a decrease in muscle growth rate and quality.
Article
Biochemistry & Molecular Biology
Le Chang, Guangyan Zhou, Jianguo Xia
Summary: Metabolomics-based genome-wide association studies (mGWAS) play a crucial role in understanding the genetic regulations of metabolites in complex phenotypes. We introduce mGWAS-Explorer 2.0 to analyze the causal relationships between over 4000 metabolites and various phenotypes, using semantic triples and molecular quantitative trait loci (QTL) data. This tool allows reproducible analysis and has successfully detected potential causal relationships in two case studies.
Article
Biochemistry & Molecular Biology
Tanisha Jean Shiri, Charles Viau, Xue Gu, Lei Xu, Yao Lu, Jianguo Xia
Summary: Aging is the loss of homeostasis that ultimately leads to death. The microbiome, which evolves with the host, has been found to directly influence aging through modulation of important cellular metabolites. One specific microbiome species, Chryseobacterium sp. CHNTR56 MYb120, has beneficial effects on the lifespan and Vitamin B6 production in C. elegans, and studying its metabolic influence on the worm's different life stages may provide further insights into mutualistic interactions.
Article
Food Science & Technology
Kewen Wang, Xiaojun Liao, Jianguo Xia, Cheng Xiao, Jianjun Deng, Zhenzhen Xu
Summary: Metabolomics is an effective tool for studying small molecules in fresh and processed fruits and vegetables, and can help uncover their quality attributes. Its integration into the whole food system has great potential to improve the stable production of high-quality whole food and high-value ingredients in various industries.
TRENDS IN FOOD SCIENCE & TECHNOLOGY
(2023)