Article
Physiology
Ching-Yan Chloe Yeung, Annesofie T. Olesen, Richard Wilson, Shireen R. Lamande, John F. Bateman, Rene B. Svensson, S. Peter Magnusson, Michael Kjaer
Summary: Both aging and physical activity can affect the amount of intramuscular connective tissue in skeletal muscle. This study investigated the impact on specific extracellular matrix (ECM) proteins and found that aging is associated with an increased abundance of these proteins. However, regular physical activity did not alter the ECM protein levels. These findings indicate that age-related changes in the intramuscular ECM solubility can occur, but physical training does not have the same effect.
JOURNAL OF APPLIED PHYSIOLOGY
(2023)
Article
Nutrition & Dietetics
J. Max Michel, Kristy K. Lievense, Sam C. Norton, Juliana V. Costa, Kathryn H. Alphin, Lydia A. Bailey, Gary D. Miller
Summary: This study examined the effects of resistance training (RT) and protein intake on muscle in older adults. The results showed that RT improved muscle quality and function, and the type of protein intake did not have a significant impact on the outcomes.
Article
Biotechnology & Applied Microbiology
Jingbao Kan, Yifang Hu, Yaoqi Ge, WenSong Zhang, Shan Lu, Cuiping Zhao, Rihua Zhang, Yun Liu
Summary: The research revealed that the reduced expression of mitochondrial functional genes may be the main cause of skeletal muscle aging, with CYCS and ESRRA potentially playing significant roles in this process.
Article
Cell Biology
Jacob G. Smith, Kevin B. Koronowski, Thomas Mortimer, Tomoki Sato, Carolina M. Greco, Paul Petrus, Amandine Verlande, Siwei Chen, Muntaha Samad, Ekaterina Deyneka, Lavina Mathur, Ronnie Blazev, Jeffrey Molendijk, Arun Kumar, Oleg Deryagin, Mireia Vaca-Dempere, Valentina Sica, Peng Liu, Valerio Orlando, Benjamin L. Parker, Pierre Baldi, Patrick-Simon Welz, Cholsoon Jang, Selma Masri, Salvador Aznar Benitah, Pura Munoz-Canoves, Paolo Sassone-Corsi
Summary: Physiology is regulated by interconnected cell and tissue circadian clocks. Disruption of these clocks' activity is associated with metabolic disease. In this study, the interactions between clocks in liver and skeletal muscle were tested. The results showed that individual clocks have partial effects on tissue glucose metabolism, but the connection between both tissue clocks, coupled with daily feeding rhythms, supports systemic glucose tolerance. This synergy relies on local transcriptional control, feeding-responsive signals, and metabolic cycles between the muscle and liver. The study highlights the importance of spatiotemporal mechanisms in maintaining systemic glucose homeostasis and the potential role of disrupting this diurnal coordination in metabolic disease.
Article
Public, Environmental & Occupational Health
Junmin Mi, Litao Zhang, Wei Sun, Zhen Wang, Pengbo Yang, Jiachen Zhang, Yani Zhang
Summary: This study identifies the research hotspots of resistance training (RT) intervention in aging and predicts the research frontiers and development trends using bibliometric analysis. The research results can provide references for further exploration and government policies.
FRONTIERS IN PUBLIC HEALTH
(2023)
Article
Multidisciplinary Sciences
Konxhe Kulaj, Alexandra Harger, Michaela Bauer, Oezuem S. Caliskan, Tilak Kumar Gupta, Dapi Menglin Chiang, Edward Milbank, Josefine Reber, Angelos Karlas, Petra Kotzbeck, David N. Sailer, Francesco Volta, Dominik Lutter, Sneha Prakash, Juliane Merl-Pham, Vasilis Ntziachristos, Hans Hauner, Michael W. Pfaffl, Matthias H. Tschoep, Timo D. Mueller, Stefanie M. Hauck, Benjamin D. Engel, Jantje M. Gerdes, Paul T. Pfluger, Natalie Krahmer, Kerstin Stemmer
Summary: Extracellular vesicles (EVs) derived from adipocytes transfer insulinotropic proteins to pancreatic β-cells, enhancing insulin secretion and glucose tolerance. This process is observed in insulin-resistant obese mice, suggesting that AdEVs play a role in informing β-cells about insulin resistance and increasing insulin demand.
NATURE COMMUNICATIONS
(2023)
Article
Nutrition & Dietetics
Reza Bagheri, Abolfazl Shakibaee, Donny M. Camera, Vahid Sobhani, Hamid Ghobadi, Eisa Nazar, Hadi Fakhari, Fred Dutheil
Summary: This study compared the effects of a high protein diet and a low protein diet combined with resistance training on skeletal muscle adaptation in untrained older ex-military men. The results showed that a daily intake of 1.6 g/kg/d protein was more effective in improving skeletal muscle mass and muscle strength, and it was well tolerated by healthy older ex-military males.
FRONTIERS IN NUTRITION
(2023)
Article
Biochemistry & Molecular Biology
Paola De Sanctis, Giuseppe Filardo, Provvidenza Maria Abruzzo, Annalisa Astolfi, Alessandra Bolotta, Valentina Indio, Alessandro Di Martino, Christian Hofer, Helmut Kern, Stefan Loefler, Maurilio Marcacci, Marina Marini, Sandra Zampieri, Cinzia Zucchini
Summary: The study found that exercise training helped skeletal muscle counteract age-related sarcopenia by inducing a wide range of adaptations, sustained by the expression of protein-coding genes. Non-coding RNAs also play a crucial role in orchestrating gene expression during this process.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Geriatrics & Gerontology
Navneet N. Lal, Jon Cornwall, Philip W. Sheard
Summary: Age-related loss of skeletal muscle mass in mice is mainly due to fiber shortening rather than fiber loss, with alterations in muscle morphology playing a significant role in muscle wasting. Tendon length and pennation angle remain consistent across the lifespan, while changes in connective tissue selectively impact muscle structure.
EXPERIMENTAL GERONTOLOGY
(2021)
Article
Physiology
Maya Hioki, Hiroko Takahashi, Akira Saito, Mizuka Imai, Hideki Yasuda
Summary: This study aimed to investigate the effects of EMS training on intramuscular fat index and biochemical parameters in older adults. The results showed that EMS training did not improve intramuscular fat content but increased the concentrations of free fatty acid and glucose.
EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY
(2023)
Review
Sport Sciences
Brad S. Currier, Jonathan C. Mcleod, Laura Banfield, Joseph Beyene, Nicky J. Welton, Alysha C. D'Souza, Joshua A. J. Keogh, Lydia Lin, Giulia Coletta, Antony Yang, Lauren Colenso-Semple, Kyle J. Lau, Alexandria Verboom, Stuart M. Phillips
Summary: This study aimed to determine the effects of distinct combinations of resistance training prescription variables (load, sets, and frequency) on muscle strength and hypertrophy. A systematic review and Bayesian network meta-analysis were conducted, and it was found that higher-load, multiset, thrice-weekly training was the most effective for strength gains, while higher-load, multiset, twice-weekly training was the best for hypertrophy.
BRITISH JOURNAL OF SPORTS MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Nick Gaulton, Griffen Wakelin, Laura V. Young, Scott Wotherspoon, Michael Kamal, Gianni Parise, Joshua P. Nederveen, Andy Holwerda, Lex B. Verdijk, Luc J. C. van Loon, Tim Snijders, Adam P. Johnston
Summary: Twist2-expressing cells are a population of myogenic progenitors in human skeletal muscle that respond to aging and exercise. They are similar to fibro-adipogenic progenitors (FAPs) and distinct from satellite cells. These cells are more prevalent in aged muscle and increase following resistance exercise training (RET).
Article
Orthopedics
Ching-Fang Hu, Carl Pai-Chu Chen, Po-Hsiang Tsui, Chiao-Nan Chen, Chih-Chin Hsu
Summary: This research studied the antifibrotic and myogenic responses of injured muscles to stretching exercise, and confirmed the feasibility of using ultrasonic Nakagami parametric index (NPI) to assess muscle morphology. Stretching can decrease muscle fibrosis and promote myogenesis.
AMERICAN JOURNAL OF SPORTS MEDICINE
(2022)
Article
Sport Sciences
Babak Hooshmand-Moghadam, Monika Johne, Fateme Golestani, Katarzyna Lorenz, Monireh Asadi, Ewelina Maculewicz, Andrzej Mastalerz
Summary: We evaluated the effects of soy milk ingestion on changes in body composition, strength, power, and muscular-related biomarkers following 12 weeks of resistance training in older men. The results showed that the intervention group who consumed soy milk had significant improvements in muscle mass, strength, power, and skeletal muscle regulatory markers compared to the control group. This suggests that the ingestion of soy milk during resistance training can enhance lean mass, strength, and power in older men.
Article
Physiology
Rocio Zapata-Bustos, Jean Finlayson, Paul R. Langlais, Dawn K. Coletta, Moulun Luo, Danielle Grandjean, Elena A. De Filippis, Lawrence Mandarino
Summary: This study identified new candidate transcription factors that respond differently to exercise in insulin resistant individuals, compared to healthy individuals. The analysis of muscle proteome and transcription factors showed that abnormal responses to exercise may be responsible for differences in protein abundances in insulin resistant muscle.
FRONTIERS IN PHYSIOLOGY
(2021)
Review
Rehabilitation
Karenina Arrais Guida Modesto, Julia Aguillar Ivo Bastos, Marco Aurelio Vaz, Joao Luiz Quagliotti Durigan
Summary: This study investigated the effects of Kilohertz-frequency alternating current on muscle performance. Results showed that carrier frequencies up to 1 kHz elicited higher torque, while carrier frequencies between 2.5 and 5 kHz resulted in lower perceived discomfort. Shorter burst duty cycles (10%-50%) induced higher evoked torque and lower perceived discomfort. The study concludes that Kilohertz-frequency alternating current with carrier frequencies between 1 and 2.5 kHz and burst duty cycles less than 50% can generate greater evoked torque, while frequencies between 2.5 and 5 kHz along with burst duty cycles less than 50% can reduce perceived discomfort.
AMERICAN JOURNAL OF PHYSICAL MEDICINE & REHABILITATION
(2023)
Article
Clinical Neurology
Larissa Santana, Emerson Fachin-Martins, David Lobato Borges, Jonathan Galvao Tenorio Cavalcante, Nicolas Babault, Frederico Ribeiro Neto, Joao Luiz Quagliotti Durigan, Rita de Cassia Marqueti
Summary: This study compared the association between neuromuscular function, motor function impairment, and muscle and tendon structures in individuals with spinal cord injury (SCI) and a non-disabled control group. The results showed that individuals with SCI had abnormalities in muscle and tendon structures, as well as a higher prevalence of neuromuscular electrophysiological disorders.
JOURNAL OF SPINAL CORD MEDICINE
(2023)
Article
Anatomy & Morphology
Henrique Mansur, Joao Luiz Quagliotti Durigan, Marcos de Noronha, Michael Kjaer, S. Peter Magnusson, Bruno Abdo Santana de Araujo, Rita de Cassia Marqueti
Summary: Increasing age affects morphologic changes in major tendons, but its effects on the cross-sectional area (CSA) of different ankle tendons are less understood. This study found significant differences in CSA among age groups and along different tendon regions. However, there were no differences in tendon CSA between sexes.
JOURNAL OF ANATOMY
(2023)
Article
Engineering, Electrical & Electronic
Alvaro Ventura, Leandro Gomes, Jonathan Cavalcante, Denis Vieira, Caio Victor Sousa, Rita de Cassia Marqueti, Nicolas Babault, Joao Luiz Durigan
Summary: This study aimed to investigate the changes in muscle architecture of quadriceps femoris constituents with sensor electrodes placed over VL and VM motor points during a neuromuscular electrical stimulation session. The results showed no difference in the muscle architecture changes when the electrodes were placed on VL and VM motor points. Therefore, clinicians can choose either VL or VM motor points for sensor electrode positioning and expect similar muscle architecture adaptation.
JOURNAL OF SENSORS
(2023)
Review
Cell Biology
Ivo Vieira de Sousa Neto, Ana Paula Pinto, Vitor Rosetto Munoz, Rita de Cassia Marqueti, Jose Rodrigo Pauli, Eduardo Rochete Ropelle, Adelino Sanchez Ramos da Silva
Summary: Physical training can improve mitochondrial health through PGC-1a signaling pathways. However, the impact of physical training on PGC-1a in different physiological systems with advancing age is not well understood. This review provides comprehensive information on the effects of exercise on PGC-1a signaling pathways in rodents and humans, addressing molecular mechanisms and highlighting the importance of further investigation in certain human tissues. PGC-1a functions as more than a transcriptional coactivator, playing a role in mitochondrial dynamics and various physiological processes.
AGEING RESEARCH REVIEWS
(2023)
Article
Medicine, Research & Experimental
Graziele F. Deriggi-Pisani, Uliana S. Stotzer, Rita C. Marqueti, Maria F. C. Rodrigues, Bruna G. Biffe, Karina A. Silva, Victor Fabricio, Clifford J. Rosen, Heloisa Sobreiro Selistre-de-Araujo
Summary: This study evaluated the effects of resistance training on bone properties, morphology, and bone extracellular matrix remodeling markers in an ovariectomy rat model. The results showed that resistance training could reverse the negative effects of ovariectomy on bone mineral density, stiffness, maximal load, and calcium content. Additionally, resistance training was effective in increasing trabecular thickness and cortical bone volume, improving bone resistance.
Article
Biophysics
Isabella da Silva Almeida, Leandro Gomes de Jesus Ferreira, Alvaro de Almeida Ventura, Henrique Mansur, Nicolas Babault, Rita de Cassia Marqueti, Joao Luiz Quagliotti Durigan
Summary: This study aimed to verify the reliability and agreement of the stimulus electrodiagnostic test (SET) in post-COVID-19 patients. The results showed high intra- and inter-rater reliability of SET measurements in assessing neuromuscular electrophysiological disorders (NED) in post-COVID-19 participants. The SET was found to be a reliable tool for evaluating NED in post-COVID-19 patients.
PHYSIOLOGICAL MEASUREMENT
(2023)
Article
Biology
Rebecca Salomao, Victoria Assis, Ivo Vieira de Sousa Neto, Bernardo Petriz, Nicolas Babault, Joao Luiz Quaglioti Durigan, Rita de Cassia Marqueti
Summary: The costs of COVID-19 worldwide have been enormous, and understanding biomarkers is crucial in reducing the disease burden. This review summarizes the role of increasing MMPs during SARS-CoV-2 infection and their association with complications and severity of COVID-19. Better understanding of MMPs could provide new insights into the symptoms, pathogenesis, and treatment of COVID-19.
Article
Rehabilitation
Isabel de Almeida Paz, Francesca Chaida Sonda, Matias Frohlich, Joao Luiz Quagliotti Durigan, Marco Aurelio Vaz
Summary: This study compared the effects of pulsed current and kilohertz frequency alternating current on healthy individuals. The results showed that pulsed current generated higher torque, had higher neuromuscular efficiency, and similar discomfort levels. Therefore, the study suggests that pulsed current is the best choice for clinicians to use in NMES-based protocols.
JOURNAL OF SPORT REHABILITATION
(2023)
Article
Critical Care Medicine
Luciana Vieira, Paulo Eugenio Silva, Priscilla Flavia de Melo, Vinicius Maldaner, Joao Q. Durigan, Rita de Cassia Marqueti, Otavio Nobrega, Sunita Mathur, Chris Burtin, Fabricio Barin, Wilcelly Machado-Silva, Sergio Ramalho, Gaspar R. Chiappa, Nadia Oliveira Gomes, Celso R. F. Carvalho, Graziella F. B. Cipriano, Gerson Cipriano
Summary: This study aimed to investigate the effects of early neuromuscular electrical stimulation (NMES) on muscle quality and size in patients with traumatic brain injury (TBI). The results showed that NMES intervention preserved muscle size and quality and maintained normal levels of signaling mediators of muscle growth and inflammation in TBI patients. Therefore, early NMES can be beneficial for TBI patients.
CRITICAL CARE RESEARCH AND PRACTICE
(2023)
