Article
Biochemistry & Molecular Biology
Alexandra Grieb, Angelika Schmitt, Annunziata Fragasso, Manuel Widmann, Felipe Mattioni Maturana, Christof Burgstahler, Gunnar Erz, Philipp Schellhorn, Andreas M. Niess, Barbara Munz
Summary: microRNAs (miRs) in skeletal muscle of sedentary young healthy females were analyzed before and after endurance exercise. Downregulation of specific miRs and their involvement in fatty acid metabolism were observed. The expression of certain miRs was also correlated with training adaptation.
Article
Immunology
Catherine M. Jankowski, Melissa P. Wilson, Samantha MaWhinney, Jane Reusch, Leslie Knaub, Sara Hull, Kristine M. Erlandson
Summary: The study found that individuals with HIV had blunted mitochondrial adaptations to exercise compared to uninfected controls, suggesting the need for different types of exercise-induced stimulation to improve mitochondrial function in this population.
JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Cell Biology
Yan Zheng, Ting Liu, Qun Li, Jie Li
Summary: This study identified lncRNAs involved in skeletal muscle aging, revealing important lncRNAs and their functional role in a muscle atrophy cell model. The findings provide new insights into the pathogenesis of aging-related diseases.
Review
Medicine, Research & Experimental
Colin Harper, Venkatesh Gopalan, Jorming Goh
Summary: This review examines the cellular and molecular changes in skeletal muscle mitochondria during aging, particularly focusing on the efficiency of mitochondrial coupling and its impact on muscle function decline. It also discusses how different exercise modalities can potentially reverse these changes and delay the onset of sarcopenia. Additional concepts such as mitophagy and the implications of muscle fiber type changes with sarcopenia on mitochondrial function are also integrated in this review.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Article
Physiology
Elisabeth Skoglund, Per Stal, Tommy R. Lundberg, Thomas Gustafsson, Per A. Tesch, Lars -Eric Thornell
Summary: This study compared muscle morphology in three advanced aging cohorts, including a unique cohort of lifelong endurance athletes. The findings suggest that lifelong endurance training is associated with higher muscle oxidative capacity, even in individuals over the age of 80.
JOURNAL OF APPLIED PHYSIOLOGY
(2023)
Article
Geriatrics & Gerontology
Alessio Molfino, Marc Beltra, Maria Ida Amabile, Roberta Belli, Giovanni Birolo, Elena Belloni, Serena De Lucia, Lorena Garcia-Castillo, Fabio Penna, Giovanni Imbimbo, Giuseppe Nigri, Barbara Pardini, Paola Costelli, Maurizio Muscaritoli
Summary: This study analyzed small non-coding RNAs (sncRNAs) in patients with gastrointestinal cancer and found dysregulation of muscle-specific microRNAs in cancer-induced muscle wasting. The study also discovered an association between changes in circulating microRNAs and the level of muscularity at body composition analysis. SncRNAs in muscle were assessed by RNAseq, while circulating microRNAs were evaluated by qPCR.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2023)
Article
Medicine, Research & Experimental
Milad Azad, Neda Khaledi, Mehdi Hedayati, Mohammadreza Karbalaie
Summary: The study revealed that the apoptotic response to exercise depends on the type and intensity of exercise, as well as the sensitivity and susceptibility of the muscle. Acute and chronic exercise can significantly affect apoptotic responses in different types of muscles.
Article
Biochemistry & Molecular Biology
Svitlana Drozdovska, Nadege Zanou, Jessica Lavier, Lucia Mazzolai, Gregoire P. Millet, Maxime Pellegrin
Summary: This study investigated the effect of low- and supramaximal-intensity hypoxic training on muscle metabolic gene expression in mice. The results indicated that hypoxic training, regardless of exercise intensity, has a moderate effect on muscle metabolic gene expression in healthy mice.
Article
Biochemistry & Molecular Biology
Javier Botella, Nicholas A. Jamnick, Cesare Granata, Amanda J. Genders, Enrico Perri, Tamim Jabar, Andrew Garnham, Michael Lazarou, David J. Bishop
Summary: Autophagy is an important mechanism for cells to degrade old or dysfunctional proteins and organelles. The effects of exercise on autophagosome content markers differ between rodents and humans. The decrease in LC3B-II protein levels induced by exercise in humans does not reflect a decreased autophagy flux.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Public, Environmental & Occupational Health
Junmin Mi, Litao Zhang, Wei Sun, Zhen Wang, Pengbo Yang, Jiachen Zhang, Yani Zhang
Summary: This study identifies the research hotspots of resistance training (RT) intervention in aging and predicts the research frontiers and development trends using bibliometric analysis. The research results can provide references for further exploration and government policies.
FRONTIERS IN PUBLIC HEALTH
(2023)
Article
Biotechnology & Applied Microbiology
Jingbao Kan, Yifang Hu, Yaoqi Ge, WenSong Zhang, Shan Lu, Cuiping Zhao, Rihua Zhang, Yun Liu
Summary: The research revealed that the reduced expression of mitochondrial functional genes may be the main cause of skeletal muscle aging, with CYCS and ESRRA potentially playing significant roles in this process.
Article
Biochemistry & Molecular Biology
Anjali Bhat, Rafay Abu, Sankarasubramanian Jagadesan, Neetha Nanoth Vellichirammal, Ved Vasishtha Pendyala, Li Yu, Tara L. Rudebush, Chittibabu Guda, Irving H. Zucker, Vikas Kumar, Lie Gao
Summary: Exercise training improves skeletal muscle health through various adaptative pathways. Nrf2, an important antioxidant transcription factor, is crucial for the adaptative responses and beneficial effects of exercise on muscle. The study suggests that Nrf2 plays a critical role in the adaptive effects of skeletal muscle and its response to exercise training.
Article
Nutrition & Dietetics
Reza Bagheri, Abolfazl Shakibaee, Donny M. Camera, Vahid Sobhani, Hamid Ghobadi, Eisa Nazar, Hadi Fakhari, Fred Dutheil
Summary: This study compared the effects of a high protein diet and a low protein diet combined with resistance training on skeletal muscle adaptation in untrained older ex-military men. The results showed that a daily intake of 1.6 g/kg/d protein was more effective in improving skeletal muscle mass and muscle strength, and it was well tolerated by healthy older ex-military males.
FRONTIERS IN NUTRITION
(2023)
Article
Cell Biology
Donato A. Rivas, Fei Peng, Townsend Benard, Adelino Sanchez Ramos da Silva, Roger A. Fielding, Lee M. Margolis
Summary: The study found that miR-19b-3p plays a crucial role in regulating muscle synthesis, contributing to understanding the varied responses of mobility-limited older adults to anabolic stimuli.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2021)
Review
Geriatrics & Gerontology
Hawley E. Kunz, Ian R. Lanza
Summary: Aging is associated with various changes in skeletal muscle, including muscle mass loss, local inflammation, and reduced response to exercise. The chronic inflammation associated with aging, known as inflammaging, may contribute to these age-related muscle impairments. Inflammation and exercise have a complex relationship, as exercise can induce acute inflammation necessary for muscle repair, while chronic inflammation in aging may hinder this response. However, exercise training has anti-inflammatory effects and can target the underlying causes of inflammaging. This review explores the interplay between inflammation and exercise in aging and discusses potential therapeutic targets for enhancing exercise responsiveness in older adults.
EXPERIMENTAL GERONTOLOGY
(2023)
Letter
Pathology
Benjamin Champion, Siaw Ming Chai, Mayank Bhandari, Dilini Gunawardena
Article
Automation & Control Systems
Ali Ahmadi Dastjerdi, Alessandro Astolfi, Niranjan Saikumar, Nima Karbasizadeh, Duarte Valerio, S. Hassan HosseinNia
Summary: This article presents a closed-loop frequency analysis tool for reset control systems. It provides sufficient conditions for the existence of steady-state response and shows that the steady-state response for periodic inputs is periodic with the same period as the input. The framework presented in this article allows for the computation of steady-state response and defines a notion of closed-loop frequency response, including high order harmonics.
IEEE TRANSACTIONS ON AUTOMATIC CONTROL
(2023)
Article
Medicine, General & Internal
Livia Gozzellino, Margherita Nannini, Carmine Pizzi, Ornella Leone, Barbara Corti, Valentina Indio, Chiara Baldovini, Pasquale Paolisso, Alberto Foa, Davide Pacini, Gianluca Folesani, Angela Schipani, Alice Costa, Gianandrea Pasquinelli, Maria Abbondanza Pantaleo, Annalisa Astolfi
Summary: Primary cardiac sarcomas are rare malignant tumors with poor prognosis. This study aimed to investigate the gene mutations and expression profiles of two types of cardiac sarcomas, osteosarcoma and leiomyosarcoma, using whole-transcriptome sequencing. The results revealed specific genetic alterations and differential gene expression in these two types of sarcomas compared to other cardiac histotypes, which could be associated with tumorigenesis mechanisms. These findings provide insights for further research on targeted therapies and improving the prognosis of patients with primary cardiac sarcomas.
Article
Biochemistry & Molecular Biology
Michele Fiore, Alberto Taddia, Valentina Indio, Salvatore Nicola Bertuccio, Daria Messelodi, Salvatore Serravalle, Jessica Bandini, Filippo Spreafico, Daniela Perotti, Paola Collini, Andrea Di Cataldo, Gianandrea Pasquinelli, Francesca Chiarini, Maura Fois, Fraia Melchionda, Andrea Pession, Annalisa Astolfi
Summary: Clear cell sarcoma of the kidney (CCSK) is a rare pediatric renal tumor with worse prognosis than Wilms' tumor. This study aims to investigate the molecular differences between metastatic and localized BCOR-ITD-positive CCSK at diagnosis. The findings suggest that metastatic CCSKs have an overexpression of genes related to the MAPK signaling pathway, and FGF3 may play a role in the acquisition of a more aggressive phenotype.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Carmen Ciavarella, Ilenia Motta, Francesco Vasuri, Teresa Palumbo, Anthony Paul Lisi, Alice Costa, Annalisa Astolfi, Sabrina Valente, Piera Versura, Eugenio F. Fornasiero, Raffaella Mauro, Mauro Gargiulo, Gianandrea Pasquinelli
Summary: The failure of arteriovenous fistulas due to intimal hyperplasia is a serious problem for patients undergoing hemodialysis. This study investigated the role of the PPAR-gamma in regulating intimal hyperplasia and found that the PPAR-gamma agonist pioglitazone had a negative effect on cell proliferation and migration.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Sara Mongiorgi, Alessia De Stefano, Stefano Ratti, Valentina Indio, Annalisa Astolfi, Irene Casalin, Andrea Pellagatti, Stefania Paolini, Sarah Parisi, Michele Cavo, Andrea Pession, James A. McCubrey, Pann-Ghill Suh, Lucia Manzoli, Jacqueline Boultwood, Carlo Finelli, Lucio Cocco, Matilde Y. Follo
Summary: This study found that high levels of miR-192-5p are associated with higher overall survival and leukemia-free survival in myelodysplastic syndromes responding to azacitidine and lenalidomide. Moreover, miR-192-5p specifically targets and inhibits BCL2, possibly regulating proliferation and apoptosis and leading to the identification of new therapeutic targets.
CLINICAL EPIGENETICS
(2023)
Review
Genetics & Heredity
Angela Schipani, Margherita Nannini, Annalisa Astolfi, Maria A. Pantaleo
Summary: Loss of function of succinate dehydrogenase complex is a characteristic of 20-40% of KIT/PDGFRA-negative GIST. Half of SDH-deficient GIST patients lack SDHx mutations and are caused by hypermethylation of SDHC promoter. The remaining 50% have mutations in SDH subunits, with SDHA mutations being the most common.
Article
Food Science & Technology
Wafa Mkadem, Valentina Indio, Khaoula Belguith, Olfa Oussaief, Federica Savini, Federica Giacometti, Halima El Hatmi, Andrea Serraino, Alessandra De Cesare, Nourhene Boudhrioua
Summary: This research compared the physicochemical properties, fatty acids, phenolic acids, and microbiota of fermented goat and cow milk. The results showed significant differences between the two types of milk in these parameters, highlighting the need for further investigation into fermented goat milk.
Article
Veterinary Sciences
Silva Rubini, Matilde Baruffaldi, Roberta Taddei, Giulia D'Annunzio, Erika Scaltriti, Martina Tambassi, Ilaria Menozzi, Giulia Bondesan, Sandro Mazzariol, Cinzia Centelleghe, Giorgia Corazzola, Federica Savini, Valentina Indio, Andrea Serraino, Federica Giacometti
Summary: This study describes a lethal case of L. monocytogenes infection in a loggerhead sea turtle. The autopsy examination revealed multiple nodular lesions in the heart, lung, liver, spleen, and urinary bladder. Analysis of the isolates confirmed the presence of L. monocytogenes belonging to Sequence Type 6 (ST 6). These findings highlight the need for caution when handling loggerhead sea turtles and the role of wildlife animals as potential carriers of virulent strains of L. monocytogenes.
VETERINARY SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Cinzia Zucchini, Carmela Serpe, Paola De Sanctis, Alessandro Ghezzo, Paola Visconti, Annio Posar, Federica Facchin, Marina Marini, Provvidenza Maria Abruzzo
Summary: This study found that in individuals with autism spectrum disorder (ASD), proteins with the TLDc domain and their associated mRNAs and noncoding RNAs are significantly increased. These increased levels are positively correlated with inflammatory gene expression and scores on the Childhood Autism Rating Scale. This suggests a new biological pathway involved in the oxidative stress response in individuals with ASD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Alice Costa, Livia Gozzellino, Margherita Nannini, Annalisa Astolfi, Maria Abbondanza Pantaleo, Gianandrea Pasquinelli
Summary: Visceral sarcomas are a rare subtype of soft tissue sarcomas, and understanding their development mechanisms and developing personalized therapies are urgent clinical needs. However, the complex genomic profiles and lack of reliable preclinical models present challenges.
Article
Food Science & Technology
Federica Savini, Federica Giacometti, Sean Alberto Cuomo, Federico Tomasello, Yitagele Terefe Mekonnen, Fulvia Troja, Valentina Indio, Marco Tassinari, Alessandra De Cesare, Andrea Serraino
Summary: Dry aging is a meat processing method that improves tenderness and flavor through low temperature and low humidity storage. Through exposure to the atmosphere and proper cleaning procedures, the survival of foodborne pathogens can be reduced.
ITALIAN JOURNAL OF FOOD SAFETY
(2023)
Article
Geriatrics & Gerontology
Kaja Kastelic, Stefan Lofler, Spela Matko, Nejc Sarabon
Summary: The German version of the DABQ has demonstrated satisfactory validity for use in epidemiological research and population surveillance among older adults.
JOURNAL OF AGING AND PHYSICAL ACTIVITY
(2023)