Article
Oncology
Lingling Xie, Jinhong Wei, Zhihua Gao, Hongming Huang, Shaoqing Ju, Xudong Wang
Summary: Despite progress in myeloma treatment, cell adhesion-mediated drug resistance (CAM-DR) remains a major challenge. This study identified a miRNA-mRNA regulatory network in myeloma cells adherent to bone marrow stromal cells (BMSCs). It was found that BMSCs upregulated miR-30a-5p and downregulated BCL2L11 in the myeloma cells, while activation of NF-KB signaling pathway played a role in the expression of miR-30a-5p. Inhibition of miR-30a-5p or upregulation of BCL2L11 promoted apoptosis of myeloma cells, suggesting the potential clinical significance of miR-30a-5p inhibitor and PLBCL2L11 plasmid in CAM-DR treatment.
EXPERIMENTAL CELL RESEARCH
(2022)
Article
Immunology
Rachel E. Crossland, Jean Norden, Sakhila Ghimire, Mateja Kralj Juric, Kim F. Pearce, Clare Lendrem, Matthew Collin, Eva Mischak-Weissinger, Ernst Holler, Hildegard T. Greinix, Anne M. Dickinson
Summary: The study found that miR-155 and miR-146a were upregulated in gastrointestinal and skin tissue samples of aGvHD patients, and their expression levels in serum and urine samples were also associated with the risk of developing aGvHD. These results support the potential of miR-155 and miR-146a as biomarkers for aGvHD, but further investigation is needed to understand their role in generalized inflammation and specific pathophysiology.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Endocrinology & Metabolism
Ziyi Li, Chang Liu, Shilun Li, Ting Li, Yukun Li, Na Wang, Xiaoxue Bao, Peng Xue, Sijing Liu
Summary: The study revealed that BMSC-derived exosomes attenuate dexamethasone-induced muscle atrophy by upregulating miR-486-5p and inhibiting nuclear translocation of FoxO1. These results suggest that BMSC-Exos have a protective effect on muscles and can inhibit muscle atrophy through the miR486-5p/Foxo1 axis.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Immunology
Yuyu Zhang, Wei Huo, Lidi Sun, Jie Wu, Chengbin Zhang, Huanhuan Wang, Bin Wang, Jinlong Wei, Chao Qu, Hongshi Cao, Xin Jiang
Summary: This study identified miR-148b-5p as downregulated in gastric cancer, with its overexpression inhibiting cell proliferation and invasion, reprogramming metabolic properties, altering the immune microenvironment, and affecting patient prognosis and drug sensitivity. Targeting miR-148b-5p could inhibit immune microenvironment and gastric cancer progression.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
Guohua Lai, Renli Zhao, Weida Zhuang, Zuoxu Hou, Zefeng Yang, Peipei He, Jiachang Wu, Hongxun Sang
Summary: In the bone marrow microenvironment of postmenopausal osteoporosis, BMSC-derived exosomal miRNAs, specifically miR-27a-3p and miR-196b-5p, have been found to play an important regulatory role in bone formation and bone resorption. The study suggests that these miRNAs may have therapeutic potential for the treatment of osteoporosis.
Article
Biochemistry & Molecular Biology
Hui Hu, Xiaowei Hu, Lin Li, Yan Fang, Yan Yang, Jingjing Gu, Jiadong Xu, Lisheng Chu
Summary: Exosomes derived from bone mesenchymal stem cells (BMSC-Exos) can promote angiogenesis and improve neurological functions in ischemic stroke mice via upregulation of miR-21-5p. In vitro experiments show that BMSC-Exos also enhance the functions of human umbilical vein endothelial cells (HUVECs).
Article
Biochemistry & Molecular Biology
Xin Lin, Tianxing Yu, Jianxiong Luo, Lin Chen, Yang Liu, Junping Xu, Lifang Chen, Qiong Lin, Yuwang Bao, Liyu Xu
Summary: In this study, we investigated the effects and mechanism of bone-marrow-derived mesenchymal stem cells (BMSCs) on ventilator-induced lung injury (VILI). The results showed that BMSCs transplantation can mitigate the severity of VILI, reduce lung inflammation, and promote autophagy through upregulating miR-155-5p.
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
(2022)
Article
Cell & Tissue Engineering
Runbi Ji, Jiang Lin, Hongbing Gu, Jichun Ma, Min Fu, Xu Zhang
Summary: This study reveals that resident mesenchymal stem cells (MSCs) in the tumor microenvironment play a crucial role in gastric cancer cell migration. Additionally, miR-374a-5p is found to regulate the expression of inflammatory factors through the NF-κB signaling pathway, promoting the migration ability of gastric cancer cells. Exosomes derived from MSCs carry miR-374a-5p and deliver it to gastric cancer cells, leading to an up-regulation of adhesion molecules by targeting HAPLN1 and further promoting gastric cancer cell migration. This study provides new insights and potential targets for the prevention and treatment of gastric cancer metastasis.
CURRENT STEM CELL RESEARCH & THERAPY
(2023)
Article
Oncology
Lin Wang, Chen Wu, Juan Xu, Zhen Gong, Xiaoli Cao, Jiaying Huang, Haibo Dong, Wei Zhu, Feng Huang, Chenglin Zhou, Mei Wang
Summary: In this study, it was found that gastric cancer tissue-derived mesenchymal stem cells (GC-MSCs) play a critical role in promoting gastric cancer metastasis. The researchers also discovered the involvement of circular RNAs (circRNAs) and metabolic reprogramming in the malignant progression of gastric cancer. Specifically, circ_0024107 was identified as a mediator of GC-MSCs promoting gastric cancer lymphatic metastasis by inducing fatty acid oxidation (FAO) metabolic reprogramming. Mechanistically, circ_0024107 acted as a sponge for miR-5572 and miR-6855-5p, thereby upregulating carnitine palmitoyltransferase 1A (CPT1A) to induce FAO metabolic reprogramming in GC-MSCs.
Article
Cell & Tissue Engineering
Jingwen Wang, Jiale Wang, Ying Wang, Ruiyang Ma, Shucong Zhang, Jin Zheng, Wujun Xue, Xiaoming Ding
Summary: We demonstrated that bone marrow mesenchymal stem cells (BMSCs) can deliver exosomes containing miR-21-5p into islet cells. Overexpression of miR-21-5p reduced apoptosis in islets and rat insulinoma (INS-1) cells, while inhibition of miR-21-5p significantly promoted apoptosis. The upregulated miR-21-5p directly binds to the 3'UTR of programmed cell death 4 (PDCD4), thereby reducing apoptosis in transplanted islets. This study suggests that miR-21-5p can be used as a therapeutic agent in islet transplantation to minimize beta-cell apoptosis and improve transplantation outcome.
Article
Endocrinology & Metabolism
Yuewen Gao, Yanqin Wang, Lingxin Meng, Kai Wang, Xiaoyong Liu, Lei Chen
Summary: In this study, the levels of miR-155-5p in gastric cancer tissues and cells were analyzed, and it was found that miR-155-5p was highly expressed in gastric cancer. Further experiments showed that miR-155-5p promotes the growth of NCI-N87 cells, and its enrichment can reverse the inhibitory effects of lobaplatin treatment on gastric cancer cells.
JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS
(2023)
Article
Clinical Neurology
Rukiye Tekdemir, Yavuz Selvi, Kursat Altinbas, Nadir Kocak
Summary: This study found that miRNAs play an important role in the pathogenesis of bipolar disorder and may serve as biomarkers for diagnosis and screening of the disorder.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Cell Biology
Zixu Bao, Ning Zhang, Wanxiang Niu, Maolin Mu, Xiaoming Zhang, Shanshan Hu, Chaoshi Niu
Summary: Exosomes released from glioma stem-like cells (GSCs) containing miR-155-5p can be horizontally transferred to surrounding glioma cells, promoting tumor progression and mesenchymal transition by targeting ACOT12. High expression of miR-155-5p in plasma exosomes is associated with glioma diagnosis and grading, suggesting its potential as a predictive biomarker for glioma.
CELL DEATH & DISEASE
(2022)
Article
Biochemistry & Molecular Biology
Karolina Golabek, Dorota Hudy, Agata Swietek, Jadwiga Gazdzicka, Natalia Dabrowska, Katarzyna Miskiewicz-Orczyk, Natalia Zieba, Maciej Misiolek, Joanna Katarzyna Strzelczyk
Summary: This study analyzed the expression of E2F2 gene and protein, as well as the miRNAs candidate targets (miR-125b-5p, miR-155-3p, and miR-214-5p) in oral squamous cell carcinoma (OSCC) tumor and margin samples. The results showed that E2F2 gene is not the target for analyzed miRNAs in OSCC, while miR-155-3p and miR-125b-5p may play roles in the pathogenesis of OSCC. Additionally, miRNAs expression in response to tobacco smoke and HPV status showed differences.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biotechnology & Applied Microbiology
Qingqing Xia, Quan Wang, Feng Lin, Junjuan Wang
Summary: The study revealed that miR-125a-5p can regulate chondrocyte migration and inhibit cartilage degradation, showing a negative correlation in traumatic OA. Exosomes derived from BMSCs are rich in miR-125a-5p, promoting internalization by chondrocytes and alleviating extracellular matrix degradation. These findings suggest that transferring exosomal miR-125a-5p could be a potential strategy for OA treatment.