Article
Nanoscience & Nanotechnology
Jingcui Peng, Sa Li, Bin Li, Wenxia Hu, Cuimin Ding
Summary: This study found that miR-486-5p inhibits lung cancer progression by regulating the expression of MIER3, and this effect is mediated by exosomes carried by mesenchymal stem cells.
JOURNAL OF BIOMEDICAL NANOTECHNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Jing Xu, Peng Chen, Chaoqun Yu, Qiangqiang Shi, Susu Wei, Yaxin Li, Hongzhao Qi, Qilong Cao, Chuanlong Guo, Xianggen Wu, Guohu Di
Summary: Hypoxia preconditioning of mesenchymal stromal cells (Hp-MSCs) enhances liver regeneration through secreted exosomes (Hp-Exo), which mediate M2 macrophage polarization by modulating the FOXO1/TLR4 signaling pathway.
Article
Cell & Tissue Engineering
Jingwen Wang, Jiale Wang, Ying Wang, Ruiyang Ma, Shucong Zhang, Jin Zheng, Wujun Xue, Xiaoming Ding
Summary: We demonstrated that bone marrow mesenchymal stem cells (BMSCs) can deliver exosomes containing miR-21-5p into islet cells. Overexpression of miR-21-5p reduced apoptosis in islets and rat insulinoma (INS-1) cells, while inhibition of miR-21-5p significantly promoted apoptosis. The upregulated miR-21-5p directly binds to the 3'UTR of programmed cell death 4 (PDCD4), thereby reducing apoptosis in transplanted islets. This study suggests that miR-21-5p can be used as a therapeutic agent in islet transplantation to minimize beta-cell apoptosis and improve transplantation outcome.
Article
Multidisciplinary Sciences
Guohua Lai, Renli Zhao, Weida Zhuang, Zuoxu Hou, Zefeng Yang, Peipei He, Jiachang Wu, Hongxun Sang
Summary: In the bone marrow microenvironment of postmenopausal osteoporosis, BMSC-derived exosomal miRNAs, specifically miR-27a-3p and miR-196b-5p, have been found to play an important regulatory role in bone formation and bone resorption. The study suggests that these miRNAs may have therapeutic potential for the treatment of osteoporosis.
Article
Immunology
Xinglong Zheng, Feng Zhang, Fengzhi Zhao, Longzhu Li, Haiyan Huang, Lijun Li, Yuhu Yi, Haiyan Yin, Jun Xu
Summary: Exosomes derived from BMSCs carrying miR-127-5p can inhibit the formation of NETs in sepsis-related ALI. The protective effect of exosomes is dependent on miR-127-5p, which targets CD64 to reduce tissue damage and inflammatory response. These findings suggest the potential of exosomal miR-127-5p as a therapeutic agent for sepsis-induced ALI.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Heidi M. Namlos, Magne Skarn, Deeqa Ahmed, Iwona Grad, Kim Andresen, Stine H. Kresse, Else Munthe, Massimo Serra, Katia Scotlandi, Antonio Llombart-Bosch, Ola Myklebost, Guro E. Lind, Leonardo A. Meza-Zepeda
Summary: miR-486-5p is an epigenetically regulated miRNA in osteosarcoma, playing a significant role in the biology of the disease.
Article
Biotechnology & Applied Microbiology
Qingqing Xia, Quan Wang, Feng Lin, Junjuan Wang
Summary: The study revealed that miR-125a-5p can regulate chondrocyte migration and inhibit cartilage degradation, showing a negative correlation in traumatic OA. Exosomes derived from BMSCs are rich in miR-125a-5p, promoting internalization by chondrocytes and alleviating extracellular matrix degradation. These findings suggest that transferring exosomal miR-125a-5p could be a potential strategy for OA treatment.
Article
Cell Biology
Kyung-Ah Cho, Da-Won Choi, Yu-Hee Kim, Jungwoo Kim, Kyung-Ha Ryu, So-Youn Woo
Summary: This study investigated the role of T-MSC exosomes in recovery of body weight and skeletal muscle mass in chemotherapy-treated mice. The results showed that T-MSC exosomes rescued muscle atrophy both in vivo and in vitro via a miR-145-5p dependent manner, suggesting therapeutic potential in maintaining or improving skeletal muscle mass under various activin A elevated pathologic conditions.
Article
Cell Biology
Qingju Li, Yinchuan Xu, Kaiqi Lv, Yingchao Wang, Zhiwei Zhong, Changchen Xiao, Keyang Zhu, Cheng Ni, Kan Wang, Minjian Kong, Xuebiao Li, Youqi Fan, Fengjiang Zhang, Qi Chen, Yi Li, Qian Li, Chengjia Liu, Jinyun Zhu, Shuhan Zhong, Jingyi Wang, Yongjian Chen, Jing Zhao, Dan Zhu, Rongrong Wu, Jinghai Chen, Wei Zhu, Hong Yu, Reza Ardehali, Jianyi (Jay) Zhang, Jian'an Wang, Xinyang Hu
Summary: This study highlights the key role of sEV miR-486-5p in promoting cardiac angiogenesis. miR-486-5p acts on the fibroblastic MMP19-VEGFA signaling pathway to promote cardiac recovery. Delivery of miR-486-5p-engineered sEVs safely enhanced angiogenesis and cardiac function in a nonhuman primate (NHP) MI model, potentially promoting cardiac repair.
SCIENCE TRANSLATIONAL MEDICINE
(2021)
Article
Pharmacology & Pharmacy
Ying Chen, Sheng Wan, Chenchen Zhou, Shengyi Gu, Tianfan Zhou, Liping Yao, Jindan Pei, Xiaolin Hua
Summary: This study demonstrates that exosomes derived from miR-195-5p transfected BMSCs can improve urodynamic function and restore damaged connective tissues in rats with pelvic floor dysfunction (PFD).
ADVANCED THERAPEUTICS
(2023)
Article
Cell Biology
Yongkun Wei, Huiling Ma, Haiqing Zhou, Hanrong Yin, Jie Yang, Yongcai Song, Binhui Yang
Summary: Research indicates that overexpression of miR-424-5p in BMSCs-derived exosomes can regulate osteogenic differentiation of osteoblasts through the WIF1/Wnt/beta-catenin pathway, suggesting miR-424-5p as a potential new biomarker for the treatment of osteoporosis.
Article
Biotechnology & Applied Microbiology
Enrico Ragni, Alessandra Colombini, Paola De Luca, Francesca Libonati, Marco Vigano, Carlotta Perucca Orfei, Luigi Zagra, Laura de Girolamo
Summary: Cells derived from cartilage, adipose tissue, and bone marrow have shown promise for osteoarthritis treatment. Extracellular vesicles containing miRNAs are important for potential therapy, with miR-103a-3p and miR-22-5p identified as reliable reference genes for quantifying therapeutic miRNAs in MSC and CC-derived EVs.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Hui Hu, Xiaowei Hu, Lin Li, Yan Fang, Yan Yang, Jingjing Gu, Jiadong Xu, Lisheng Chu
Summary: Exosomes derived from bone mesenchymal stem cells (BMSC-Exos) can promote angiogenesis and improve neurological functions in ischemic stroke mice via upregulation of miR-21-5p. In vitro experiments show that BMSC-Exos also enhance the functions of human umbilical vein endothelial cells (HUVECs).
Article
Cell & Tissue Engineering
H. Yu, J. Zhang, X. Liu, Y. Li
Summary: BMSC-derived exosomes carrying miR-136-5p inhibit LRP4 and activate the Wnt/beta-catenin pathway, promoting fracture healing by enhancing osteoblast proliferation and differentiation.
BONE & JOINT RESEARCH
(2021)
Article
Respiratory System
Xingyu Rao, Heting Dong, Weili Zhang, Huiming Sun, Wenjing Gu, Xinxing Zhang, Li Huang, Yongdong Yan, Chuangli Hao, Wei Ji, Canhong Zhu, Zhengrong Chen
Summary: This study examined the role of miRNA in asthma and found that miR-493-5p inhibits Th9 cell differentiation by targeting FOXO1, while DC-derived exosomes can inhibit Th9 cell differentiation through miR-493-5p.
RESPIRATORY RESEARCH
(2022)