Article
Immunology
Rosanna Leuzzi, Margherita Bodini, Isaac P. Thomsen, Elisabetta Soldaini, Erika Bartolini, Alessandro Muzzi, Bruna Clemente, Bruno Galletti, Andrea Guido Oreste Manetti, Cinzia Giovani, Stefano Censini, Sonia Budroni, Fabiana Spensieri, Erica Borgogni, Silvia Rossi Paccani, Immaculada Margarit, Fabio Bagnoli, Giuseppe Del Giudice, Clarence B. Creech
Summary: The study identified specific cytokine and functional antibody signatures in patients with different primary invasive diseases caused by Staphylococcus aureus. These data provide insights into human responses to invasive staphylococcal infections and are important for guiding the identification of novel preventive and therapeutic interventions against S. aureus. Our findings showed distinct differences in inflammatory responses and antibody levels between patients with invasive S. aureus disease and healthy donors.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Virology
Agniva Majumdar, Ritubrita Saha, Ananya Chatterjee, Rudrak Gupta, Ratul Datta Chaudhuri, Alok Kumar Chakrabarti, Mamta Chawla-Sarkar, Shanta Dutta
Summary: A sudden increase in respiratory adenovirus positivity among hospitalized children with acute respiratory infection in Kolkata and surrounding districts of West Bengal, India, is reported. The positivity rate ranged from 22.1% in December 2022 to 52.6% in March 2023, with an overall positivity of 40.4% during the period. Children aged 2 to <5 years were most affected, and single infection with adenovirus accounted for 72.4% of cases. Regular monitoring of circulating strains is warranted.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Article
Virology
Yiman Huang, Chao Wang, Fenlian Ma, Qiong Guo, Lihong Yao, Aijun Chen, Xiaoyi Luo, Lishu Zheng
Summary: The study described the epidemiology and genotypic diversity of HAdV in hospitalized children with RTIs in Beijing, China. The main epidemic strains were found to be HAdV-B3 and HAdV-B7, with a recombinant HAdV-C strain CBJ113 forming an epidemic trend.
Article
Microbiology
Shunhang Wen, Zupan Lin, Yue Zhang, Fangfang Lv, Haiyan Li, Xueya Zhang, Li Lin, Hui-Hui Zhu, Zhi Xu, Changchong Li, Hailin Zhang
Summary: In hospitalized children with acute respiratory infections in Wenzhou, HAdV-3, -7, -2, and -1 were the most common types. Outbreaks of HAdV-3 and -7 occurred from December 2018 to August 2019. There were significant differences in HAdV types among children with pneumonia, tonsillitis, bronchitis, and URTI. HAdV-7 can cause more severe pneumonia in children than HAdV-3.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Virology
Kenichiro Takahashi, Tsuguto Fujimoto, Nozomu Hanaoka, Mariko Tamura, Yoko Suzuki, Shigetaka Sugihara
Summary: This study aims to investigate the usefulness of clinical manifestations in deciding the use of adenovirus IC kits for children with upper respiratory infections (URI). The study found that when patients lack the clinical manifestations of fever, rhinorrhea, and tonsillar exudate, the results of adenovirus IC kits are often negative.
JOURNAL OF MEDICAL VIROLOGY
(2022)
Article
Biochemistry & Molecular Biology
Magda Marchetti, Barbara De Berardis, Irene Bigioni, Alessia Mariano, Fabiana Superti, Anna Scotto d'Abusco
Summary: Viral respiratory tract infections, such as SARS-CoV-2 infection, cause significant morbidity and mortality. N-acetylglucosamine (GlcNAc), an immunomodulatory and anti-inflammatory drug, shows potential for controlling respiratory virus infections. This study investigated the inhibitory effects of GlcNAc on viral infectivity and the inflammatory response in two different cell lines infected with Influenza A virus and Human adenovirus type 2.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Immunology
Kristen K. Coleman, Emily R. Robie, Anfal Abdelgadir, Arthi S. Kozhumam, Raquel A. Binder, Gregory C. Gray
Summary: A systematic review found that HAdV-E4 has caused thousands of infections worldwide, predominantly leading to respiratory and ocular diseases. The majority of deaths were reported in the United States, China, and Singapore. There has been an increase in the number of civilian infections reported over the past decade, with recent epidemics among US college students.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Multidisciplinary Sciences
Eric H. Y. Lau, Owen T. Y. Tsang, David S. C. Hui, Mike Y. W. Kwan, Wai-hung Chan, Susan S. Chiu, Ronald L. W. Ko, Kin H. Chan, Samuel M. S. Cheng, Ranawaka A. P. M. Perera, Benjamin J. Cowling, Leo L. M. Poon, Malik Peiris
Summary: In this study, researchers quantified SARS-CoV-2 specific neutralizing antibodies using plaque reduction neutralization (PRNT) assays on 195 patients in different disease states. They found that patients with severe disease had higher peaks of neutralizing antibody titres than patients with mild or asymptomatic infections, and that serum neutralizing antibody persists for over 6 months in most people.
NATURE COMMUNICATIONS
(2021)
Article
Virology
Guohong Zhu, Dan Xu, Yuanyuan Zhang, Tianlin Wang, Lingyan Zhang, Weizhong Gu, Meiping Shen
Summary: The study found that the rates of viral infection in children vary by different ages and seasons, with the highest positivity rate of adenovirus appearing in the preschool period, respiratory syncytial virus being highest in infants, and influenza virus increasing with age. The total positive rate of viral infection in different seasons is highest in winter, with influenza positivity rate also being highest in winter.
Article
Virology
Gabriel Gonzalez, Matthew Hayes, Melinda Balansay, Ryan Underwood, Caroline Balagot, Roger Pan, Kyle Pineda, Esmeralda Iniguez-Stevens, Paula Kriner, Irais Estrada, Christopher A. Myers, Adriana E. Kajon
Summary: Two new genotypes of human mastadenovirus D, designated 109 and 110, were isolated from unrelated cases of acute respiratory disease detected at the California/Mexico border in January 2018. Both genotypes are examples of intertypic recombination and contribute to the understanding of the expanded tissue tropism of certain members of species HAdV-D.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Article
Medicine, General & Internal
Zhan Wu, Rong Zhang, Dongdong Liu, Xuesong Liu, Jierong Zhang, Zhihui Zhang, Sibei Chen, Weiqun He, Yimin Li, Yonghao Xu, Xiaoqing Liu
Summary: This study found that adenovirus is an important cause of virus-related ARDS, with a higher positivity rate in lower respiratory tract secretions than in upper respiratory tract secretions. Age, lower CD3+CD4+ T cells, and higher serum creatinine may be associated with adenovirus-induced ARDS in adults requiring mechanical ventilation. Early identification and intervention to prevent disease progression are essential for reducing the mortality rate in these patients.
FRONTIERS IN MEDICINE
(2022)
Article
Virology
Varvara Probst, Emily K. Datyner, Zaid Haddadin, Danielle A. Rankin, Lubna Hamdan, Herdi K. Rahman, Andrew Spieker, Laura S. Stewart, Claudia Guevara, Erin Yepsen, Jonathan E. Schmitz, Natasha B. Halasa
Summary: This retrospective cohort study investigated the association between HAdV species and acute respiratory illnesses in children. The results showed that HAdV-C and HAdV-B were the most common species detected, with differences in clinical characteristics and outcomes noted. Further research with larger sample sizes focusing on high-risk pediatric populations is necessary to guide future type-specific HAdV vaccine development.
JOURNAL OF CLINICAL VIROLOGY
(2021)
Article
Cell Biology
Giovanny J. Martinez-Colon, Kalani Ratnasiri, Heping Chen, Sizun Jiang, Elizabeth Zanley, Arjun Rustagi, Renu Verma, Han Chen, Jason R. Andrews, Kirsten D. Mertz, Alexandar Tzankov, Dan Azagury, Jack Boyd, Garry P. Nolan, Christian M. Schuerch, Matthias S. Matter, Catherine A. Blish, Tracey L. McLaughlin
Summary: This study found that adipocytes in COVID-19 autopsy cases were infected by SARS-CoV-2, accompanied by inflammatory infiltrate. The study also revealed that SARS-CoV-2 infected adipose tissue-resident macrophages and initiated inflammatory responses. These findings suggest that SARS-CoV-2 infection in adipose tissue could contribute to the severity of COVID-19 through viral replication and induction of inflammation.
SCIENCE TRANSLATIONAL MEDICINE
(2022)
Article
Microbiology
Wen Xu, Cheng-Jun Wu, Yan-Mei Jiao, Xiao-Le Mei, Lei Huang, En-Qiang Qin, Bo Tu, Peng Zhao, Li-Feng Wang, Wei-Wei Chen
Summary: Human adenovirus infection causes inflammation and tissue injury. The study found that sRAGE is involved in adenovirus-induced inflammatory responses and may be a potential therapeutic target to alleviate excessive inflammation.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Infectious Diseases
Xinye Wang, Dawei Wang, Sajid Umar, Sheng Qin, Qiong Ling, Gregory C. Gray, Yuntao Liu
Summary: The study in Guangzhou, China revealed a circulation of at least three species of HAdVs (species B, C, and E) with a consistent detection of HAdV infections throughout the year, and a relatively higher prevalence in summer. The most prevalent genotypes identified were HAdV-B3 and HAdV-B7, with common symptoms including fever, cough, and rhinorrhea.
BMC INFECTIOUS DISEASES
(2021)