SARS-CoV-2 infection drives an inflammatory response in human adipose tissue through infection of adipocytes and macrophages
出版年份 2022 全文链接
标题
SARS-CoV-2 infection drives an inflammatory response in human adipose tissue through infection of adipocytes and macrophages
作者
关键词
-
出版物
Science Translational Medicine
Volume -, Issue -, Pages -
出版商
American Association for the Advancement of Science (AAAS)
发表日期
2022-09-23
DOI
10.1126/scitranslmed.abm9151
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Adipose tissue in COVID-19: detection of SARS-CoV-2 in adipocytes and activation of the interferon-alpha response
- (2022) A. Basolo et al. JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
- A single-cell atlas of human and mouse white adipose tissue
- (2022) Margo P. Emont et al. NATURE
- Inflammasome activation in infected macrophages drives COVID-19 pathology
- (2022) Esen Sefik et al. NATURE
- FcγR-mediated SARS-CoV-2 infection of monocytes activates inflammation
- (2022) Caroline Junqueira et al. NATURE
- Neuroinvasion of SARS-CoV-2 in human and mouse brain
- (2021) Eric Song et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Circuits between infected macrophages and T cells in SARS-CoV-2 pneumonia
- (2021) Rogan A. Grant et al. NATURE
- A novel ACE2 isoform is expressed in human respiratory epithelia and is upregulated in response to interferons and RNA respiratory virus infection
- (2021) Cornelia Blume et al. NATURE GENETICS
- Interplay of Antibody and Cytokine Production Reveals CXCL13 as a Potential Novel Biomarker of Lethal SARS-CoV-2 Infection
- (2021) Alexander M. Horspool et al. mSphere
- ICU Admission Levels of Endothelial Biomarkers as Predictors of Mortality in Critically Ill COVID-19 Patients
- (2021) Alice G. Vassiliou et al. Cells
- Characterizing the molecular regulation of inhibitory immune checkpoints with multimodal single-cell screens
- (2021) Efthymia Papalexi et al. NATURE GENETICS
- Preexisting and inducible endotoxemia as crucial contributors to the severity of COVID-19 outcomes
- (2021) Ilja L. Kruglikov et al. PLoS Pathogens
- Macrophage Migration Inhibitory Factor (MIF) Plasma Concentration in Critically Ill COVID-19 Patients: A Prospective Observational Study
- (2021) Christian Bleilevens et al. Diagnostics
- Role of interleukin 6 as a predictive factor for a severe course of Covid-19: retrospective data analysis of patients from a long-term care facility during Covid-19 outbreak
- (2021) P. Sabaka et al. BMC INFECTIOUS DISEASES
- A molecular single-cell lung atlas of lethal COVID-19
- (2021) Johannes C. Melms et al. NATURE
- COVID-19 tissue atlases reveal SARS-CoV-2 pathology and cellular targets
- (2021) Toni M. Delorey et al. NATURE
- Single-cell sequencing of human white adipose tissue identifies new cell states in health and obesity
- (2021) Andrew D. Hildreth et al. NATURE IMMUNOLOGY
- Systemic and organ-specific immune-related manifestations of COVID-19
- (2021) Manuel Ramos-Casals et al. Nature Reviews Rheumatology
- Distinct uptake, amplification, and release of SARS-CoV-2 by M1 and M2 alveolar macrophages
- (2021) Jiadi Lv et al. Cell Discovery
- Characterisation of cardiac pathology in 23 autopsies of lethal COVID ‐19
- (2021) Jasmin D Haslbauer et al. Journal of Pathology Clinical Research
- FNDC4 and FNDC5 reduce SARS-CoV-2 entry points and spike glycoprotein S1-induced pyroptosis, apoptosis, and necroptosis in human adipocytes
- (2021) Gema Frühbeck et al. Cellular & Molecular Immunology
- An Overview of Adipose Tissue ACE2 Modulation by Diet and Obesity. Potential Implications in COVID-19 Infection and Severity
- (2021) Saioa Gómez-Zorita et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Multi-omic profiling reveals widespread dysregulation of innate immunity and hematopoiesis in COVID-19
- (2021) Aaron J. Wilk et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Activation of NF-κB and induction of proinflammatory cytokine expressions mediated by ORF7a protein of SARS-CoV-2
- (2021) Chia-Ming Su et al. Scientific Reports
- SARS-CoV-2 Subgenomic RNA Kinetics in Longitudinal Clinical Samples
- (2021) Renu Verma et al. Open Forum Infectious Diseases
- Replication of SARS-CoV-2 in adipose tissue determines organ and systemic lipid metabolism in hamsters and humans
- (2021) Martin Zickler et al. Cell Metabolism
- Hyperglycemia in acute COVID-19 is characterized by insulin resistance and adipose tissue infectivity by SARS-CoV-2
- (2021) Moritz Reiterer et al. Cell Metabolism
- Upregulated miR-200c is associated with downregulation of the functional receptor for severe acute respiratory syndrome coronavirus 2 ACE2 in individuals with obesity
- (2021) Jayanthi Bellae Papannarao et al. INTERNATIONAL JOURNAL OF OBESITY
- Clinical predictors of mortality due to COVID-19 based on an analysis of data of 150 patients from Wuhan, China
- (2020) Qiurong Ruan et al. INTENSIVE CARE MEDICINE
- Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China
- (2020) Chaolin Huang et al. LANCET
- COVID-19, ACE2, and the cardiovascular consequences
- (2020) Andrew M. South et al. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
- Structural and Functional Basis of SARS-CoV-2 Entry by Using Human ACE2
- (2020) Qihui Wang et al. CELL
- Post‐mortem examination of COVID19 patients reveals diffuse alveolar damage with severe capillary congestion and variegated findings of lungs and other organs suggesting vascular dysfunction
- (2020) T. Menter et al. HISTOPATHOLOGY
- Plasma IP-10 and MCP-3 levels are highly associated with disease severity and predict the progression of COVID-19
- (2020) Yang Yang et al. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
- Obesity could shift severe COVID-19 disease to younger ages
- (2020) David A Kass et al. LANCET
- Proteomics of SARS-CoV-2-infected host cells reveals therapy targets
- (2020) Denisa Bojkova et al. NATURE
- Virological assessment of hospitalized patients with COVID-2019
- (2020) Roman Wölfel et al. NATURE
- High prevalence of obesity in severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) requiring invasive mechanical ventilation
- (2020) Arthur Simonnet et al. Obesity
- Factors associated with hospital admission and critical illness among 5279 people with coronavirus disease 2019 in New York City: prospective cohort study
- (2020) Christopher M Petrilli et al. BMJ-British Medical Journal
- Tropism, replication competence, and innate immune responses of the coronavirus SARS-CoV-2 in human respiratory tract and conjunctiva: an analysis in ex-vivo and in-vitro cultures
- (2020) Kenrie P Y Hui et al. Lancet Respiratory Medicine
- Vascular Endothelial Growth Factor (VEGF) as a Vital Target for Brain Inflammation during the COVID-19 Outbreak
- (2020) Xi-Xi Yin et al. ACS Chemical Neuroscience
- Obesity and Mortality Among Patients Diagnosed With COVID-19: Results From an Integrated Health Care Organization
- (2020) Sara Y. Tartof et al. ANNALS OF INTERNAL MEDICINE
- Is Acetylsalicylic Acid a Safe and Potentially Useful Choice for Adult Patients with COVID-19 ?
- (2020) Vanessa Bianconi et al. DRUGS
- Extrapulmonary manifestations of COVID-19
- (2020) Aakriti Gupta et al. NATURE MEDICINE
- Obesity as a Potential Predictor of Disease Severity in Young COVID‐19 Patients: A Retrospective Study
- (2020) Ming Deng et al. Obesity
- Obesity prolongs the hospital stay in patients affected by COVID-19, and may impact on SARS-COV-2 shedding
- (2020) Diego Moriconi et al. Obesity Research & Clinical Practice
- The evolution of pulmonary pathology in fatal COVID-19 disease: an autopsy study with clinical correlation
- (2020) Hans Bösmüller et al. VIRCHOWS ARCHIV
- Small molecule therapeutics for COVID-19: repurposing of inhaled furosemide
- (2020) Zhiyu Wang et al. PeerJ
- Antigen-Specific Adaptive Immunity to SARS-CoV-2 in Acute COVID-19 and Associations with Age and Disease Severity
- (2020) Carolyn Rydyznski Moderbacher et al. CELL
- Characterization of the cytokine storm reflects hyperinflammatory endothelial dysfunction in COVID-19
- (2020) Jonathan T. Sims et al. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
- Cytokine release syndrome in COVID-19: Innate immune, vascular, and platelet pathogenic factors differ in severity of disease and sex
- (2020) Aaron C. Petrey et al. JOURNAL OF LEUKOCYTE BIOLOGY
- Tissue-specific and interferon-inducible expression of nonfunctional ACE2 through endogenous retroelement co-option
- (2020) Kevin W. Ng et al. NATURE GENETICS
- Interferons and viruses induce a novel truncated ACE2 isoform and not the full-length SARS-CoV-2 receptor
- (2020) Olusegun O. Onabajo et al. NATURE GENETICS
- Individuals with obesity and COVID‐19: A global perspective on the epidemiology and biological relationships
- (2020) Barry M. Popkin et al. Obesity Reviews
- Neuropilin-1 facilitates SARS-CoV-2 cell entry and infectivity
- (2020) Ludovico Cantuti-Castelvetri et al. SCIENCE
- Two distinct immunopathological profiles in autopsy lungs of COVID-19
- (2020) Ronny Nienhold et al. Nature Communications
- Obesity and diabetes as comorbidities for COVID-19: Underlying mechanisms and the role of viral–bacterial interactions
- (2020) Ilja L Kruglikov et al. eLife
- Regulation of Angiotensin- Converting Enzyme 2 in Obesity: Implications for COVID-19
- (2020) Saba Al Heialy et al. Frontiers in Physiology
- Severe Acute Respiratory Syndrome Coronavirus 2–Induced Immune Activation and Death of Monocyte-Derived Human Macrophages and Dendritic Cells
- (2020) Jian Zheng et al. JOURNAL OF INFECTIOUS DISEASES
- The dysregulated innate immune response in severe COVID-19 pneumonia that could drive poorer outcome
- (2020) Mathieu Blot et al. Journal of Translational Medicine
- A Potential Role of Interleukin 10 in COVID-19 Pathogenesis
- (2020) Ligong Lu et al. TRENDS IN IMMUNOLOGY
- SARS-CoV-2 Spike protein binds to bacterial lipopolysaccharide and boosts proinflammatory activity
- (2020) Ganna Petruk et al. Journal of Molecular Cell Biology
- Upper airway gene expression reveals suppressed immune responses to SARS-CoV-2 compared with other respiratory viruses
- (2020) Eran Mick et al. Nature Communications
- Two distinct interstitial macrophage populations coexist across tissues in specific subtissular niches
- (2019) Svetoslav Chakarov et al. SCIENCE
- Fast, sensitive and accurate integration of single-cell data with Harmony
- (2019) Ilya Korsunsky et al. NATURE METHODS
- OUP accepted manuscript
- (2018) JOURNAL OF INFECTIOUS DISEASES
- Identification of functionally distinct fibro-inflammatory and adipogenic stromal subpopulations in visceral adipose tissue of adult mice
- (2018) Chelsea Hepler et al. eLife
- STRING v11: protein–protein association networks with increased coverage, supporting functional discovery in genome-wide experimental datasets
- (2018) Damian Szklarczyk et al. NUCLEIC ACIDS RESEARCH
- Role of innate and adaptive immunity in obesity-associated metabolic disease
- (2017) Tracey McLaughlin et al. JOURNAL OF CLINICAL INVESTIGATION
- Inhibition of cytosolic phospholipase A2α impairs an early step of coronavirus replication in cell culture
- (2017) Christin Müller et al. JOURNAL OF VIROLOGY
- IL-6 Improves Energy and Glucose Homeostasis in Obesity via Enhanced Central IL-6 trans -Signaling
- (2017) Katharina Timper et al. Cell Reports
- Antiviral activity of aspirin against RNA viruses of the respiratory tract-an in vitro study
- (2016) Bernadette Glatthaar-Saalmüller et al. Influenza and Other Respiratory Viruses
- Human adipose tissue as a reservoir for memory CD4+ T cells and HIV
- (2015) Jacob Couturier et al. AIDS
- Intestinal CD169+ macrophages initiate mucosal inflammation by secreting CCL8 that recruits inflammatory monocytes
- (2015) Kenichi Asano et al. Nature Communications
- Adipose Tissue Is a Neglected Viral Reservoir and an Inflammatory Site during Chronic HIV and SIV Infection
- (2015) Abderaouf Damouche et al. PLoS Pathogens
- Endotoxemia, nutrition, and cardiometabolic disorders
- (2014) K. A. Elisa Kallio et al. ACTA DIABETOLOGICA
- Metabolic Dysfunction Drives a Mechanistically Distinct Proinflammatory Phenotype in Adipose Tissue Macrophages
- (2014) Mario Kratz et al. Cell Metabolism
- Elevated Muscle TLR4 Expression and Metabolic Endotoxemia in Human Aging
- (2014) S. Ghosh et al. JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
- Visceral and subcutaneous fat have different origins and evidence supports a mesothelial source
- (2014) You-Ying Chau et al. NATURE CELL BIOLOGY
- Salicylate (Salsalate) in Patients With Type 2 Diabetes
- (2013) Allison B. Goldfine ANNALS OF INTERNAL MEDICINE
- Active Replication of Middle East Respiratory Syndrome Coronavirus and Aberrant Induction of Inflammatory Cytokines and Chemokines in Human Macrophages: Implications for Pathogenesis
- (2013) Jie Zhou et al. JOURNAL OF INFECTIOUS DISEASES
- Pregravid Obesity Associates With Increased Maternal Endotoxemia and Metabolic Inflammation
- (2010) Subhabrata Basu et al. Obesity
- High sucrose intake in rats is associated with increased ACE2 and angiotensin-(1–7) levels in the adipose tissue
- (2010) Michella Soares Coelho et al. REGULATORY PEPTIDES
- Inflammation and impaired adipogenesis in hypertrophic obesity in man
- (2009) Birgit Gustafson et al. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
- A two-pronged strategy to suppress host protein synthesis by SARS coronavirus Nsp1 protein
- (2009) Wataru Kamitani et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Adipogenic Cascade Can Be Induced Without Adipogenic Media by a Human Adenovirus
- (2009) Miloni A. Rathod et al. Obesity
- ACE2 is expressed in mouse adipocytes and regulated by a high-fat diet
- (2008) Manisha Gupte et al. AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
- CC Chemokine and CC Chemokine Receptor Profiles in Visceral and Subcutaneous Adipose Tissue Are Altered in Human Obesity
- (2008) Joakim Huber et al. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
Become a Peeref-certified reviewer
The Peeref Institute provides free reviewer training that teaches the core competencies of the academic peer review process.
Get StartedAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started