Article
Biochemistry & Molecular Biology
Mattias Berglin, Jorunn Pauline Cavanagh, Josefin Seth Caous, Balmukund Sureshkumar Thakkar, Jeddah Marie Vasquez, Wenche Stensen, Benny Lyven, John-Sigurd Svendsen, Johan Svenson
Summary: This paper describes the development of polyurethane materials with the capability to attach antibacterial compounds. The materials exhibit robustness and flexibility, and the attached antimicrobial peptides effectively reduce bacterial colonization and growth. The findings indicate the potential for medical applications in reducing the impact of bacterial biofilms.
MACROMOLECULAR BIOSCIENCE
(2023)
Article
Chemistry, Medicinal
Huaxing Shen, Nan Zhang, Xianglong Kong, Nan Wang, Hong-Gang Hu, Wei Cong, Chao Liu
Summary: In this study, a series of benzyl-stapled derivatives of A4K14-Citropin 1.1 were designed and synthesized, and their physical and chemical properties, as well as biological activity, were compared with the prototype peptide. The results showed that two of the derivatives exhibited higher helicity and stronger anti-cancer activity, with no significant difference in hemolytic effect compared to the prototype peptide. These derivatives could serve as promising lead compounds for the development of novel anti-cancer drugs.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2023)
Article
Nanoscience & Nanotechnology
Qin Yao, Jinyi Zhang, Guoqing Pan, Binghai Chen
Summary: Long-term indwelling catheters or stents often cause complications such as infection and encrustation. This study developed an antibacterial coating on urinary stents/catheters using a clickable mussel-inspired peptide and antimicrobial peptide. The coating exhibited excellent stability, bactericidal properties, and improved biological compatibility.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Chemistry, Multidisciplinary
Zunwei Ma, Huaiming Wang, Zhifeng Shi, Fengying Yan, Qingtao Li, Junjian Chen, Zhong-Kai Cui, Yunjiao Zhang, Xin Jin, Yong-Guang Jia, Lin Wang
Summary: We demonstrated that mesoporous silica nanoparticles loaded with DOX and AMP can effectively kill bacteria and tumor cells, modulate the tumor microenvironment, treat bacterial infections, and eliminate lung tumors. The MSN@DOX-AMP system can be inhaled and accumulate in the lung, leading to better therapeutic outcomes. This platform holds promise for treating bacterial infections in tumors and advancing the clinical treatment of lung cancer.
Article
Polymer Science
Jinkang Dou, Minghui Xu, Bojun Tan, Hongchang Mo, Xianming Lu, Bozhou Wang, Ning Liu
Summary: Nitrile N-oxide-based click ligation is a promising technique for polymer crosslinking due to its catalyst-free and byproduct-free reactions. In this study, methyl groups were introduced to enhance the stability and reactivity of phenyl nitrile N-oxides. Novel aromatic nitrile N-oxides were synthesized and used as efficient reagents for catalyst-free crosslinking of natural rubber, resulting in elastomers with good mechanical properties.
Article
Chemistry, Analytical
Laura Sola, Dario Brambilla, Alessandro Mussida, Roberto Consonni, Francesco Damin, Marina Cretich, Alessandro Gori, Marcella Chiari
Summary: A new polymeric coating was introduced to co-immobilize proteins and oriented peptides on the same substrate, facilitating the phenotype characterization of extracellular vesicles. Through NMR characterization and post polymerization modification, the strategy could reduce the number of analysis, save time, reagents, and costs.
ANALYTICA CHIMICA ACTA
(2021)
Review
Pharmacology & Pharmacy
Bruna Costa, Guillermo Martinez-de-Tejada, Paula A. C. Gomes, M. Cristina L. Martins, Fabiola Costa
Summary: The prevention of orthopedic implant-related infections is a major medical challenge, and antimicrobial peptides (AMPs) are considered promising alternatives to conventional antibiotics due to their broad-spectrum activity and low propensity for resistance. Research strategies involving AMP-releasing and immobilization onto surfaces show potential for preventing infections, with a focus needed on clinical validation and translation efforts.
Article
Engineering, Environmental
Guansong Hu, Junjian Chen, Yan Fan, Haiyan Zhou, Kunzhong Guo, Zhou Fang, Liangxu Xie, Lin Wang, Yingjun Wang
Summary: This study established a facile and efficient CuAAC-Bor system, finding that CuNCs showed stronger efficiency in immobilizing multiple peptides on titanium implants. Mechanistic insights into the significance of peptide size on CuAAC efficiency were revealed through all-atom molecular dynamics simulation and machine learning.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Agricultural Engineering
Xiao-Man Fan, Jia-Jia Shen, Yuan-Yuan Xu, Jian Gao, Ye-Wang Zhang
Summary: A method for specific immobilization of whole-cell was developed through a click reaction between alkyne and azide groups, showing significantly higher activity, operational stability, and reusability compared to free cells.
BIORESOURCE TECHNOLOGY
(2021)
Article
Agriculture, Multidisciplinary
Cecilia Pinna, Piera Anna Martino, Gabriele Meroni, Valerio Massimo Sora, Lucia Tamborini, Sabrina Dallavalle, Martina L. Contente, Andrea Pinto
Summary: A series of vanillamides were synthesized and found to be more effective towards Pseudomonas aeruginosa than the vanillic acid precursor. These molecules could be the basis for new nature-inspired antimicrobials. Increased process productivity and stability were achieved through a tailored flow biocatalyzed strategy and immobilization technology.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Review
Chemistry, Analytical
Cristina-Virginia Topor, Mihaela Puiu, Camelia Bala
Summary: Surface plasmon resonance (SPR) is a surface-sensitive technique that enables trace and ultra-trace detection of various analytes through affinity pairing. Despite its label-free, sensitive detection and real-time monitoring capabilities, challenges such as poor stability, non-specific adsorption, and loss of biomolecular activity need to be addressed. This review discusses progress in sensor modification, immobilization techniques, and the use of novel 2D nanomaterials, gold nanostructures, and magnetic nanoparticles for signal amplification. The advantages and disadvantages of each design strategy are provided, along with recent achievements.
Article
Chemistry, Organic
Mannem Adinarayana, Kumar Siddhant, Moulali Vaddamanu, Arruri Sathyanarayana, Aravind Kumar Rengan, Kyohei Hisano, Osamu Tsutsumi, Ganesan Prabusankar
Summary: In this study, a new super bulky compound was synthesized and used in click reaction for the synthesis of a super bulky triazole. A rare intermolecular interaction was also discovered. Various techniques were used to analyze and detect these compounds, and their thermal stability and photophysical properties were investigated.
JOURNAL OF HETEROCYCLIC CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Irina Yu Strobykina, Alexandra D. Voloshina, Olga Andreeva, Anastasiia S. Sapunova, Anna P. Lyubina, Syumbelya K. Amerhanova, Mayya G. Belenok, Liliya F. Saifina, Vyacheslav E. Semenov, Vladimir E. Kataev
Summary: Four new TPP conjugates of 1,2,3-triazolyl nucleoside analogues were synthesized and evaluated for their antibacterial, antifungal, and cytotoxic activities. Two lead compounds showed high antibacterial activity against MRSA strains resistant to Ciprofloxacin and Amoxicillin, as well as high cytotoxicity against human cancer cell lines. The bactericidal effect of the lead compounds was not caused by a violation of the integrity of the cytoplasmic membrane of bacteria and their cytotoxic activity is likely associated with apoptosis induction and cell cycle arrest.
BIOORGANIC CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Tony Rady, Michel Mosser, Marc Nothisen, Stephane Erb, Igor Dovgan, Sarah Cianferani, Alain Wagner, Guilhem Chaubet
Summary: BCN alcohol is a significant strained-alkyne scaffold in chemical biology. This study presents the synthesis of an oxidized analogue - BCN acid - which can be easily functionalized via amide bond formation, resulting in more stable derivatives than traditionally encountered carbamates.
Article
Chemistry, Multidisciplinary
Jincai Li, Joseph J. Richardson, Hirotaka Ejima
Summary: This article reports the first synthesis of dithiocatechol-pendant polymers using a novel protection-deprotection strategy. The resulting polymers are soluble in common organic solvents and can be fully characterized by standard spectroscopic methods. The study also demonstrates the possibility of using reversible addition-fragmentation chain-transfer polymerization to synthesize dithiocatechol-pendant polymers.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2022)
Article
Materials Science, Biomaterials
Junjian Chen, Yuchen Zhu, Yancheng Song, Lin Wang, Jiezhao Zhan, Jingcai He, Jian Zheng, Chunting Zhong, Xuetao Shi, Sa Liu, Li Ren, Yingjun Wang
JOURNAL OF MATERIALS CHEMISTRY B
(2017)
Article
Nanoscience & Nanotechnology
Chunting Zhong, Changming Hu, Ravi Kumar, Vanessa Trouillet, Frank Biedermann, Michael Hirtz
Summary: The patterned immobilization of cucurbit[n]urils (CBn) into multiplexed microarrays enhances sensitivity and allows for the detection of small molecule analytes through indicator-displacement assays. Integration of CBn/indicator microarrays into microfluidic channels provides efficient real-time monitoring of the sensing process and reduces the required analyte volume. The concept is further extended to differential sensing of analytes on diplex or multiplex CBn/indicator microarrays, offering a route for multicomponent sensing of small molecule analytes in complex liquids.
ACS APPLIED NANO MATERIALS
(2021)
Article
Materials Science, Biomaterials
Izabela Stupka, Artur P. Biela, Bernard Piette, Agnieszka Kowalczyk, Karolina Majsterkiewicz, Kinga Borzecka-Solarz, Antonina Naskalska, Jonathan G. Heddle
Summary: Artificial protein cages, such as TRAP-cages, have potential applications in vaccines and drug delivery. TRAP-cages have the ability to control the disassembly conditions by modifying the interface between their building blocks. By using TRAP rings with different numbers of monomers, it is possible to predict the formation of other cages.
JOURNAL OF MATERIALS CHEMISTRY B
(2024)
Article
Materials Science, Biomaterials
Guo Zhang, Yu Wang, Hua Qiu, Lei Lu
Summary: This study presents a one-pot synthesis method for flower-like AMPs@EAMP particles by combining antimicrobial peptides with ellagic acid, offering enlarged surface area, excellent biocompatibility, and broad-spectrum antibacterial activity. In vivo studies indicate their potential for tissue repair and immune barrier reconstruction.
JOURNAL OF MATERIALS CHEMISTRY B
(2024)
Article
Materials Science, Biomaterials
Jiamei Zhang, Lingshuang Wang, Cheng Xu, Yingui Cao, Shengsheng Liu, Rui L. Reis, Subhas C. Kundu, Xiao Yang, Bo Xiao, Lian Duan
Summary: Pluronic F127 modified silk fibroin film with different types of antibacterial agents could accelerate wound recovery by promoting fibroblast adhesion, eradicating bacteria, and facilitating angiogenesis and re-epithelialization.
JOURNAL OF MATERIALS CHEMISTRY B
(2024)
Article
Materials Science, Biomaterials
Yinsheng Liu, Mingyue Wang, Yinfei Hui, Lei Sun, Yanrui Hao, Henlong Ren, Hao Guo, Wu Yang
Summary: In this study, a rare-earth hybrid luminescent material was developed for the detection of a biomarker for anthrax. The material showed excellent selectivity and high sensitivity, allowing for the determination of the biomarker in saliva and urine. Additionally, a convenient point-of-care testing method using fluorescent test paper and a smartphone was established for the initial diagnosis of anthrax.
JOURNAL OF MATERIALS CHEMISTRY B
(2024)
Review
Materials Science, Biomaterials
Wenshuai Yang, Jingsi Chen, Ziqian Zhao, Meng Wu, Lu Gong, Yimei Sun, Charley Huang, Bin Yan, Hongbo Zeng
Summary: Injectable hydrogels with shear-thinning and/or in situ formation properties offer distinct advantages in bioengineering applications, as they can be directly delivered to target sites, possess self-healing abilities, and simplify the implantation process.
JOURNAL OF MATERIALS CHEMISTRY B
(2024)