The LuxS/AI-2 Quorum-Sensing System of Streptococcus pneumoniae Is Required to Cause Disease, and to Regulate Virulence- and Metabolism-Related Genes in a Rat Model of Middle Ear Infection

Autoinducer 2 Signaling via the Phosphotransferase FruA Drives Galactose Utilization by Streptococcus pneumoniae , Resulting in Hypervirulence

(2017) Claudia Trappetti et al.   mBio

High-throughput Screening of Small Molecule Inhibitors of the Streptococcus Quorum-sensing Signal Pathway

(2017) Seiji Ishii et al.   Scientific Reports

Acid Stress Response Mechanisms of Group B Streptococci

(2017) Sarah Shabayek et al.   Frontiers in Cellular and Infection Microbiology

In vitro Multi-Species Biofilms of Methicillin-Resistant Staphylococcus aureus and Pseudomonas aeruginosa and Their Host Interaction during In vivo Colonization of an Otitis Media Rat Model

(2017) Mukesh K. Yadav et al.   Frontiers in Cellular and Infection Microbiology

Antimicrobial and Antibiofilm Effects of Human Amniotic/Chorionic Membrane Extract on Streptococcus pneumoniae

(2017) Mukesh K. Yadav et al.   Frontiers in Microbiology

ciaR impacts biofilm formation by regulating an arginine biosynthesis pathway in Streptococcus sanguinis SK36

(2017) Bin Zhu et al.   Scientific Reports

Incidence of acute otitis media in children below 6 years of age seen in medical practices in five East European countries

(2016) Vytautas Usonis et al.   BMC Pediatrics

Streptococcus pneumoniae biofilm formation and dispersion during colonization and disease

(2015) Yashuan Chao et al.   Frontiers in Cellular and Infection Microbiology

Host Glycan Sugar-Specific Pathways in Streptococcus pneumonia: Galactose as a Key Sugar in Colonisation and Infection

(2015) Laura Paixão et al.   PLoS One

Review: Current and new generation pneumococcal vaccines

(2014) Charles Feldman et al.   JOURNAL OF INFECTION

Sinefungin, a Natural Nucleoside Analogue of S-Adenosylmethionine, InhibitsStreptococcus pneumoniaeBiofilm Growth

(2014) Mukesh Kumar Yadav et al.   Biomed Research International

Pneumococci in biofilms are non-invasive: implications on nasopharyngeal colonization

(2014) Ryan P. Gilley et al.   Frontiers in Cellular and Infection Microbiology

Quorum-Sensing Systems LuxS/Autoinducer 2 and Com Regulate Streptococcus pneumoniae Biofilms in a Bioreactor with Living Cultures of Human Respiratory Cells

(2013) Jorge E. Vidal et al.   INFECTION AND IMMUNITY

Pneumococcus

(2013) Samuel Y. Ash et al.   MEDICAL CLINICS OF NORTH AMERICA

Otitis Media

(2013) Michael E. Pichichero   PEDIATRIC CLINICS OF NORTH AMERICA

Interkingdom Signaling Induces Streptococcus pneumoniae Biofilm Dispersion and Transition from Asymptomatic Colonization to Disease

(2013) L. R. Marks et al.   mBio

In VitroStreptococcus pneumoniaeBiofilm Formation andIn VivoMiddle Ear Mucosal Biofilm in a Rat Model of Acute Otitis Induced byS. pneumoniae

(2012) Mukesh Kumar Yadav et al.   Clinical and Experimental Otorhinolaryngology

The fundamental link between pneumococcal carriage and disease

(2012) Birgit Simell et al.   Expert Review of Vaccines

Effect of 5-azacytidine on in vitro biofilm formation of Streptococcus pneumoniae

(2012) Mukesh Kumar Yadav et al.   MICROBIAL PATHOGENESIS

Pneumococcal carbohydrate transport: food for thought

(2012) Carolyn M. Buckwalter et al.   TRENDS IN MICROBIOLOGY

Influence of bacterial interactions on pneumococcal colonization of the nasopharynx

(2012) Joshua R. Shak et al.   TRENDS IN MICROBIOLOGY

A High-Resolution View of Genome-Wide Pneumococcal Transformation

(2012) Nicholas J. Croucher et al.   PLoS Pathogens

Quorum Sensing Inhibitors Increase the Susceptibility of Bacterial Biofilms to Antibiotics In Vitro and In Vivo

(2011) Gilles Brackman et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Biofilm and planktonic pneumococci demonstrate disparate immunoreactivity to human convalescent sera

(2011) Carlos J Sanchez et al.   BMC MICROBIOLOGY

The impact of the competence quorum sensing system on Streptococcus pneumoniae biofilms varies depending on the experimental model

(2011) Claudia Trappetti et al.   BMC MICROBIOLOGY

The LuxS-Dependent Quorum-Sensing System Regulates Early Biofilm Formation by Streptococcus pneumoniae Strain D39

(2011) Jorge E. Vidal et al.   INFECTION AND IMMUNITY

Quantitative liquid chromatography–tandem mass spectrometry profiling of activated methyl cycle metabolites involved in LuxS-dependent quorum sensing in Escherichia coli

(2010) N.M. Halliday et al.   ANALYTICAL BIOCHEMISTRY

Otitis media across nine countries: Disease burden and management

(2010) A. Arguedas et al.   INTERNATIONAL JOURNAL OF PEDIATRIC OTORHINOLARYNGOLOGY

Coinfection withHaemophilus influenzaePromotes Pneumococcal Biofilm Formation during Experimental Otitis Media and Impedes the Progression of Pneumococcal Disease

(2010) Kristin E. D. Weimer et al.   JOURNAL OF INFECTIOUS DISEASES

Methylthioadenosine/S-adenosylhomocysteine nucleosidase, a critical enzyme for bacterial metabolism

(2010) Nikhat Parveen et al.   MOLECULAR MICROBIOLOGY

The Pneumococcal Serine-Rich Repeat Protein Is an Intra-Species Bacterial Adhesin That Promotes Bacterial Aggregation In Vivo and in Biofilms

(2010) Carlos J. Sanchez et al.   PLoS Pathogens

Inhibition of S-ribosylhomocysteinase (LuxS) by substrate analogues modified at the ribosyl C-3 position

(2009) Stanislaw F. Wnuk et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Transcriptional Regulation of the Capsular Polysaccharide Biosynthesis Locus of Streptococcus Pneumoniae: a Bioinformatic Analysis

(2009) M. Moscoso et al.   DNA RESEARCH

The Streptococcus pneumoniae Capsule Inhibits Complement Activity and Neutrophil Phagocytosis by Multiple Mechanisms

(2009) C. Hyams et al.   INFECTION AND IMMUNITY

Identification of adenoid biofilms with middle ear pathogens in otitis-prone children utilizing SEM and FISH

(2009) Michael Hoa et al.   INTERNATIONAL JOURNAL OF PEDIATRIC OTORHINOLARYNGOLOGY

Antibiotic Prescription Rates for Acute Respiratory Tract Infections in US Ambulatory Settings

(2009) Carlos G. Grijalva   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION