Article
Cell Biology
Han Dai, Wenjing Hu, Lianying Zhang, Feiyu Jiang, Xiongmin Mao, Gangyi Yang, Ling Li
Summary: Research showed that FGF21 was significantly downregulated in prostate cancer tissues and cell lines, and inhibited PCa cell proliferation and promoted apoptosis through facilitated autophagy.
CELL DEATH & DISEASE
(2021)
Article
Cell & Tissue Engineering
Longwei Hu, Yang Wang, Hongya Pan, Kathreena Kadir, Jin Wen, Siyi Li, Chenping Zhang
Summary: ARC promotes BMSC proliferation, inhibits cell apoptosis, and enhances BMSC osteogenic differentiation in vitro. In vivo, ARC can inhibit BMSC apoptosis and increase new bone formation. ARC mainly regulates BMSCs by activating the Fgf-2/PI3K/Akt pathway, providing a promising method for bone tissue engineering.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Biochemistry & Molecular Biology
Henry F. Thomas, Elena Kotova, Swathi Jayaram, Axel Pilz, Merrit Romeike, Andreas Lackner, Thomas Penz, Christoph Bock, Martin Leeb, Florian Halbritter, Joanna Wysocka, Christa Buecker
Summary: Multiple enhancers regulate the expression of Fgf5 gene, with a poised enhancer located in the first intron playing a crucial role at every time point. These elements are essential for the formation of a super-enhancer, which acts in a collaborative manner to induce Fgf5 expression.
Article
Orthopedics
Pei Lu, Yi-min Shen, Ting Hua, Ting Pan, Gang Chen, Teng Dai, Ke-qin Shi
Summary: In this study, it was found that FGF-2 is downregulated in DEX-treated cells, leading to decreased cell viability and increased apoptosis. The anti-apoptotic effect of FGF-2 is mediated through the PI3K/Akt signaling pathway. Overexpression of FGF-2 can reverse DEX-induced apoptosis and delay osteonecrosis of the femoral head progression.
JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
(2021)
Article
Cell & Tissue Engineering
Elise C. Jeffery, Terry L. A. Mann, Jade A. Pool, Zhiyu Zhao, Sean J. Morrison
Summary: The contribution of skeletal stem/progenitor cells (SSCs) from bone marrow and periosteum to bone repair has been investigated. During steady-state conditions, new bone primarily arises from bone marrow SSCs. However, after bone injuries, different populations of SSCs play distinct roles in bone repair, with periosteal cells primarily involved in non-stabilized fracture repair.
Article
Oncology
Cedrik Labreche, David P. Cook, John Abou-Hamad, Julia Pascoal, Benjamin R. Pryce, Khalid N. Al-Zahrani, Luc A. Sabourin
Summary: Breast cancer is a highly heterogeneous disease with multiple drivers and complex regulatory networks. Postn plays a crucial role in tumor development, with about 50% of breast tumors acquiring Postn expression in epithelial tumor cells. The regulation of Postn expression involves cross-talk between FGFR, TGF beta, and PI3K/AKT pathways.
BREAST CANCER RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Hsin-Wei Tseng, Anthony Mota-Sydor, Rania Leventis, Predrag Jovanovic, Ivan Topisirovic, Thomas F. Duchaine
Summary: This study reveals the direct regulation of Pten alternative polyadenylation (APA) by the mammalian cleavage factor I (CFIm) complex, impacting PTEN protein dosage and having widespread effects on APA in transcriptomes. Differential regulation of Pten APA by CFIm59 and CFIm68 is uncovered, with their divergent functions having broad impact on APA in transcriptomes.
NUCLEIC ACIDS RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Xian Wu, Ruiying Tong, Xiuli Chen, Xinying Jiang, Xiaoying He, Libing Ma
Summary: The miR-302s/367 family can inhibit the proliferation and apoptosis of sheep fetal fibroblasts by targeting key molecules in the cell cycle and PI3K-Akt pathways, but cannot reprogram these cells into pluripotent stem cells.
Article
Genetics & Heredity
Staci E. Hammer, Michael Polymenis
Summary: Enzymes involved in one-carbon metabolism play crucial roles in regulating cell division. Loss of these enzymes leads to abnormalities in cell size and cell cycle kinetics, affecting cell proliferation. Loss of Ade17p specifically delays the START phase, while loss of Shm2p reduces growth rate. Furthermore, the inability to synthesize phosphatidylcholine in cho2 Delta cells delays START and decreases nuclear elongation coherence, accompanied by metabolite changes.
G3-GENES GENOMES GENETICS
(2023)