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FGF21 promotes non-small cell lung cancer progression by SIRT1/PI3K/AKT signaling

(2020) Xiaofeng Yu et al.   LIFE SCIENCES

The cGAS-cGAMP-STING Pathway: A Molecular Link Between Immunity and Metabolism

(2019) Juli Bai et al.   DIABETES

Dysregulation of histone deacetylases in carcinogenesis and tumor progression: a possible link to apoptosis and autophagy

(2019) Srimanta Patra et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Osteoprotegerin Promotes Liver Steatosis by Targeting the ERK-PPARγ-CD36 Pathway

(2019) Cheng Zhang et al.   DIABETES

Association between Circulating Fibroblast Growth Factor 21 and Aggressiveness in Thyroid Cancer

(2019) Yea Eun Kang et al.   Cancers

DOCK5 regulates energy balance and hepatic insulin sensitivity by targeting mTORC1 signaling

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Diabetes as risk factor for pancreatic cancer: Hyperglycemia promotes epithelial-mesenchymal-transition and stem cell properties in pancreatic ductal epithelial cells

(2018) Sascha Rahn et al.   CANCER LETTERS

Investigation of miR-136-5p key target genes and pathways in lung squamous cell cancer based on TCGA database and bioinformatics analysis

(2018) Zu-cheng Xie et al.   PATHOLOGY RESEARCH AND PRACTICE

Deficiency of fibroblast growth factor 21 (FGF21) promotes hepatocellular carcinoma (HCC) in mice on a long term obesogenic diet

(2018) Garima Singhal et al.   Molecular Metabolism

MiR-146b inhibits autophagy in prostate cancer by targeting the PTEN/Akt/mTOR signaling pathway

(2018) Song Gao et al.   Aging-US

Palmitic acid induces human osteoblast-like Saos-2 cell apoptosis via endoplasmic reticulum stress and autophagy

(2018) Lei Yang et al.   CELL STRESS & CHAPERONES

Fibroblast growth factor 21 as a circulating biomarker at various stages of colorectal carcinogenesis

(2018) Jing Qian et al.   BRITISH JOURNAL OF CANCER

MicroRNA-20a regulates cell proliferation, apoptosis and autophagy by targeting thrombospondin 2 in cervical cancer

(2018) Qinghong Zhou et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Glucagon and Insulin Cooperatively Stimulate Fibroblast Growth Factor 21 Gene Transcription by Increasing the Expression of Activating Transcription Factor 4

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The 2016 WHO Classification of Tumours of the Urinary System and Male Genital Organs—Part A: Renal, Penile, and Testicular Tumours

(2016) Holger Moch et al.   EUROPEAN UROLOGY

Fibroblast growth factor 21 improves hepatic insulin sensitivity by inhibiting mammalian target of rapamycin complex 1 in mice

(2016) Qi Gong et al.   HEPATOLOGY

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mTORC1 Is a Major Regulatory Node in the FGF21 Signaling Network in Adipocytes

(2016) Annabel Y. Minard et al.   Cell Reports

Fibroblast Growth Factor 21 (FGF21) Protects against High Fat Diet Induced Inflammation and Islet Hyperplasia in Pancreas

(2016) Garima Singhal et al.   PLoS One

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MiR-144 Inhibits Proliferation and Induces Apoptosis and Autophagy in Lung Cancer Cells by Targeting TIGAR

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Activation of ERK1/2 Ameliorates Liver Steatosis in Leptin Receptor–Deficient (db/db) Mice via Stimulating ATG7-Dependent Autophagy

(2015) Yuzhong Xiao et al.   DIABETES

FGF19 promotes progression of prostate cancer

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A novel functional interplay between Progesterone Receptor-B and PTEN, via AKT, modulates autophagy in breast cancer cells

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(2014) Zhiping Hu et al.   MOLECULAR NEUROBIOLOGY

Activation of Liver FGF21 in hepatocarcinogenesis and during hepatic stress

(2013) Chaofeng Yang et al.   BMC GASTROENTEROLOGY

Rottlerin induces autophagy and apoptosis in prostate cancer stem cells via PI3K/Akt/mTOR signaling pathway

(2013) Dhruv Kumar et al.   CANCER LETTERS

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(2013) Ryan C Russell et al.   CELL RESEARCH

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(2013) Christoph Plass et al.   NATURE REVIEWS GENETICS

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(2012) Catherine S. Grasso et al.   NATURE

Progesterone is neuroprotective against ischemic brain injury through its effects on the phosphoinositide 3-kinase/protein kinase B signaling pathway

(2012) T. Ishrat et al.   NEUROSCIENCE

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(2012) Andrew C. Adams et al.   PLoS One

The breadth of FGF21's metabolic actions are governed by FGFR1 in adipose tissue

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(2011) Jørgen Wesche et al.   BIOCHEMICAL JOURNAL

The effects of fibroblast growth factor-21 knockdown and over-expression on its signaling pathway and glucose–lipid metabolism in vitro

(2011) Ke Li et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

The Role of Autophagy in Cancer: Therapeutic Implications

(2011) Z. J. Yang et al.   MOLECULAR CANCER THERAPEUTICS

Autophagy as a target for anticancer therapy

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Lysosomal membrane proteins: life between acid and neutral conditions: Figure 1

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Acute glucose-lowering and insulin-sensitizing action of FGF21 in insulin-resistant mouse models—association with liver and adipose tissue effects

(2009) Jing Xu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Targeting the PI3K signaling pathway in cancer

(2009) Kwok-Kin Wong et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Fibroblast Growth Factor 21 Controls Glycemia via Regulation of Hepatic Glucose Flux and Insulin Sensitivity

(2009) Eric D. Berglund et al.   ENDOCRINOLOGY

Fibroblast Growth Factor-19, a Novel Factor That Inhibits Hepatic Fatty Acid Synthesis

(2009) Sushant Bhatnagar et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

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(2009) Andrew Beenken et al.   NATURE REVIEWS DRUG DISCOVERY

Fibroblast Growth Factor 21 Reverses Hepatic Steatosis, Increases Energy Expenditure, and Improves Insulin Sensitivity in Diet-Induced Obese Mice

(2008) J. Xu et al.   DIABETES

Fibroblast Growth Factor 21 Corrects Obesity in Mice

(2008) Tamer Coskun et al.   ENDOCRINOLOGY

Bile acids activate fibroblast growth factor 19 signaling in human hepatocytes to inhibit cholesterol 7α-hydroxylase gene expression

(2008) Kwang-Hoon Song et al.   HEPATOLOGY

Autophagy fights disease through cellular self-digestion

(2008) Noboru Mizushima et al.   NATURE