期刊
TRENDS IN GENETICS
卷 37, 期 2, 页码 188-200出版社
CELL PRESS
DOI: 10.1016/j.tig.2020.08.011
关键词
-
资金
- UMR9002 CNRS-University of Montpellier
- ANR [ANR-17-CE12-0011-01, ANR-19-CE12-0031]
- FRM
- Fondation ARC
- Labex EpiGenMed
- AFM Telethon
- Agence Nationale de la Recherche (ANR) [ANR-19-CE12-0031, ANR-17-CE12-0011] Funding Source: Agence Nationale de la Recherche (ANR)
piRNAs and PIWI proteins play crucial roles in biological and developmental processes by regulating cellular mRNAs. These functions are ancestral and recent research has expanded our understanding of the mechanisms of action and the conservation of PIWI proteins in distant species.
Piwi-interacting RNAs (piRNAs) and PIWI proteins play key functions in a wide range of biological and developmental processes through the regulation of cellular mRNAs, in addition to their role in transposable element (TE) repression. Evolutionary studies indicate that these PIWI functions in mRNA regulatory programs, occurring in both germ and somatic cells, are ancestral. Recent advances have widely expanded our understanding of these functions of PIWI proteins, identifying new mechanisms of action and strengthening their importance through their conservation in distant species. In this review, we discuss the latest findings regarding piRNA/PIWI-dependent mRNA decay in germ cells and during the maternal-to-zygotic transition in embryos combined with new modes of action of PIWI proteins in mRNA stabilization and translational activation and piRNA-independent roles of PIWI proteins in cancer.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据