Review
Engineering, Manufacturing
Osezua Ibhadode, Zhidong Zhang, Jeffrey Sixt, Ken M. Nsiempba, Joseph Orakwe, Alexander Martinez-Marchese, Osazee Ero, Shahriar Imani Shahabad, Ali Bonakdar, Ehsan Toyserkani
Summary: Metal additive manufacturing is actively researched, focusing on physics, statistical and AI-driven process modeling and optimization, structure-property characterization, design optimization, and equipment enhancements. This review specifically addresses the utilization of topology optimization in metal additive manufacturing, including its applications in aerospace, medical, automotive, and other industries, support structure design for thermal-based powder-bed processes, manufacturing constraints and porous feature generation in topology optimization, as well as the adoption of AI models. Open-source and commercial software for topology optimization and metal additive manufacturing are also explored, with considerations given to future research directions and challenges.
VIRTUAL AND PHYSICAL PROTOTYPING
(2023)
Article
Engineering, Biomedical
Markus Laubach, Philipp Kobbe, Dietmar W. Hutmacher
Summary: Lumbar fusion is a common treatment for spinal diseases, but current cage materials have limitations. Recently, biodegradable cages and scaffold-guided bone regeneration have shown potential for better outcomes. Surface modification of implants can also enhance tissue integration and reduce infections. Further research is needed to improve these techniques.
Review
Engineering, Mechanical
Kashif Ishfaq, Zafar Abas, M. Saravana Kumar, Muhammad Arif Mahmood
Summary: This study outlines the challenges in ultrasonic additive manufacturing (AM) and discusses the importance of process parameters in ultrasonic additive manufacturing (UAM). The study also presents methods for improving the UAM process and identifies current challenges in UAM.
RAPID PROTOTYPING JOURNAL
(2023)
Review
Automation & Control Systems
Swati Jindal, Faisal Manzoor, Niall Haslam, Elena Mancuso
Summary: Millions of craniofacial surgeries are performed annually worldwide for bone replacement and augmentation, which impose significant economic burden and aesthetic expectations. Autografts and allografts are the first choice for treatment but their limited availability and shaping difficulty have led to alternative strategies. Biomaterial-based approaches have been explored due to ample supply but conventional processing technologies have drawbacks, especially in producing patient-specific implants. Additive manufacturing has gained attention as it allows customization according to patient needs, however, biomaterial implants have limitations such as stress shielding and limited bone integration. Composites have been investigated in recent decades to overcome these limitations and improve bone integration. The use of polymeric composite-based biomaterials in combination with 3D printing technology for patient-specific craniofacial implants is reviewed in this article, along with challenges and future perspectives associated with 3D printing of polymer-based composites.
INTERNATIONAL JOURNAL OF ADVANCED MANUFACTURING TECHNOLOGY
(2021)
Review
Materials Science, Multidisciplinary
Hong Wei Tan, Yu Ying Clarrisa Choong, Che Nan Kuo, Hong Yee Low, Chee Kai Chua
Summary: In recent years, the 3D printed electronics technology has attracted significant attention from industries and researchers due to its unique features. This review provides an in-depth overview of the latest 3D electronic printing techniques, innovative practical technologies, and upcoming application trends in advanced functional materials for fabricating 3D printed electronics devices.
PROGRESS IN MATERIALS SCIENCE
(2022)
Article
Engineering, Biomedical
Victor M. Villapun, Luke N. Carter, Steven Avery, Alba Gonzalez-Alvarez, James W. Andrews, Sophie Cox
Summary: Additive manufacturing technologies have great potential in healthcare, allowing for complex customization. However, different stakeholders have different priorities for its implementation, highlighting the need for collaboration and communication to establish common standards.
INTERNATIONAL JOURNAL OF BIOPRINTING
(2022)
Review
Engineering, Civil
Bassiouny Saleh, Reham Fathi, Yinbao Tian, N. Radhika, Jinghua Jiang, Aibin Ma
Summary: This paper provides a comprehensive analysis of the recent advancements in wire arc additive manufacturing (WAAM) technology, focusing on microstructure, mechanical properties, materials used, process-related defects, and post-process treatments. The results highlight the strengths and limitations of WAAM and offer insights into its future prospects. This information is valuable for academics, designers, and manufacturers in the field, serving as a milestone for future WAAM research and application.
ARCHIVES OF CIVIL AND MECHANICAL ENGINEERING
(2023)
Review
Materials Science, Multidisciplinary
Yahya Bozkurt, Elif Karayel
Summary: 3D printing technology, a miracle manufacturing method widely used in the medical field in recent years, is applied in surgery, pharmaceutical industry, disease modeling, development of customized implants and prostheses, organ printing, vet medicine, and tissue engineering applications.
JOURNAL OF MATERIALS RESEARCH AND TECHNOLOGY-JMR&T
(2021)
Review
Automation & Control Systems
Ugur M. Dilberoglu, Bahar Gharehpapagh, Ulas Yaman, Melik Dolen
Summary: Despite the rapid growth in the past decade, industrial adoption of additive manufacturing has not yet been achieved due to limitations. A recent trend is to integrate additive manufacturing with secondary production techniques to alleviate its inherent drawbacks. Hybrid additive manufacturing solutions can help overcome current barriers by leveraging the combined merits of merging technologies.
INTERNATIONAL JOURNAL OF ADVANCED MANUFACTURING TECHNOLOGY
(2021)
Review
Engineering, Manufacturing
Gustavo Gonzalez, Ignazio Roppolo, Candido Fabrizio Pirri, Annalisa Chiappone
Summary: In the past two decades, 3D printing technology has emerged as an alternative for producing microfluidic devices, making their production cheaper, faster, and easier. However, there are still barriers to overcome in terms of technology and materials. This review evaluates the current state of polymeric 3D printing techniques and materials for manufacturing microfluidic chips, highlighting the latest innovations, materials, and applications.
ADDITIVE MANUFACTURING
(2022)
Review
Computer Science, Interdisciplinary Applications
Niharika Karnik, Urvi Bora, Karan Bhadri, Prasanna Kadambi, Pankaj Dhatrak
Summary: This paper discusses the characteristics, enablers, and future prospects of the Industry 4.0 paradigm, emphasizing its advantages of changing production line dynamics and increasing profitability through virtualization and predictive manufacturing.
JOURNAL OF INDUSTRIAL INFORMATION INTEGRATION
(2022)
Review
Materials Science, Multidisciplinary
Amir A. Elhadad, Ana Rosa-Sainz, Raquel Canete, Estela Peralta, Belen Begines, Mario Balbuena, Ana Alcudia, Y. Torres
Summary: This article explores recent advancements and emerging trends in 3D printing from a novel multidisciplinary perspective. It provides an overview of various 3D printing techniques and their applications, with a focus on materials such as composites, hybrids, and smart materials. The article also discusses the latest developments in 4D bioprinting technology and outlines present challenges and future regulations.
MATERIALS SCIENCE & ENGINEERING R-REPORTS
(2023)
Article
Business
Jaya Priyadarshini, Rajesh Kr Singh, Ruchi Mishra, Manoj Dora
Summary: This study presents a systematic review of additive manufacturing (AM) literature in the healthcare sector, analyzing the current state of the art and providing future research directions. The study provides an analysis of AM applications in healthcare, key trends in literature, benefits of AM adoption, and barriers to implementation. It also offers an AM capabilities framework and identifies gaps in the literature using the TCCM framework to guide future research.
TECHNOLOGICAL FORECASTING AND SOCIAL CHANGE
(2023)
Article
Chemistry, Multidisciplinary
Ali Doryab, Juergen Groll
Summary: As chronic respiratory diseases become one of the leading causes of mortality post-COVID, the lack of predictive in vitro lung models hinders pulmonary preclinical drug development. Current cutting-edge models are compromised in technological and biological aspects, with limited translation to clinical settings. On the other hand, cellular and molecular studies mostly rely on simplistic and unrealistic in vitro models. This article discusses the current challenges and potential strategies for developing truly biomimetic lung models.
ADVANCED MATERIALS
(2023)
Review
Materials Science, Composites
Shrutika Sharma, Vishal Gupta, Deepa Mudgal
Summary: The healing of bone fractures relies heavily on the compatibility, stability, degradability, functionality, and shelf-life of biomaterials. Metallic biomaterials offer good mechanical properties and biocompatibility, but come with issues like stress shielding and corrosion. Polymer materials are being explored for bone implants due to their lightweight and biocompatible nature, but additive manufacturing has made it possible to create customized implants with minimal waste. However, polymer implants lack in terms of mechanical strength and biological properties.
POLYMER COMPOSITES
(2022)
Article
Microscopy
A. Karali, A. P. Kao, R. Meeson, M. Roldo, G. W. Blunn, G. Tozzi
Summary: This study investigated the strain distribution and load-bearing capacity in regenerating fractures using in situ XCT mechanics and DVC. The results showed significant variation and inhomogeneity in the 3D strain distribution in the regenerating tissues of the fracture gap, which was associated with the presence of unmineralised tissue observed in histological images.
JOURNAL OF MICROSCOPY
(2022)
Article
Engineering, Biomedical
Roxane Bonithon, Alexander Peter Kao, Marta Pena Fernandez, Joseph Nicholas Dunlop, Gordon William Blunn, Frank Witte, Gianluca Tozzi
Summary: This study characterized highly open-porous Mg-based scaffolds at different scales and found that they exhibited a higher connected structure and smaller spacing compared to trabecular bone. The Mg scaffolds showed lower local strain and highly ductile mechanical behavior, making them suitable for use as a treatment for critical-sized bone defects.
ACTA BIOMATERIALIA
(2021)
Article
Surgery
Yazan Ajam, Swati Midha, Arthur C. W. Tan, Gordon Blunn, Deepak M. Kalaskar
Summary: This study developed a polyurethane nanocomposite as an engineered tendon sheath for single-stage surgical treatment of delayed flexor tendon division. Animal experiments showed that the material had good healing effects and gliding movement functionality for tendon repair, providing promising evidence for clinical application.
JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY
(2022)
Article
Polymer Science
Evangelos Daskalakis, Boyang Huang, Cian Vyas, Anil Ahmet Acar, Ali Fallah, Glen Cooper, Andrew Weightman, Bahattin Koc, Gordon Blunn, Paulo Bartolo
Summary: This study proposes a method for preparing polycaprolactone/bioglass scaffolds with pore size gradient by investigating the coupled effect between material composition and scaffold architecture. The results show that the addition of bioglass improves the mechanical properties and biological performance of the scaffolds.
Article
Chemistry, Multidisciplinary
Evangelos Daskalakis, Boyang Huang, Cian Vyas, Anil A. Acar, Fengyuan Liu, Ali Fallah, Glen Cooper, Andrew Weightman, Gordon Blunn, Bahattin Koc, Paulo Bartolo
Summary: The paper proposes novel anatomically designed scaffolds (bone bricks) with nonuniform pore dimensions to address the limitation of existing bone scaffolds. The gradient design and incorporation of ceramic materials enable structures with higher mechanical properties and improved biological characteristics.
Article
Engineering, Biomedical
Ali Fallah, Mine Altunbek, Paulo Bartolo, Glen Cooper, Andrew Weightman, Gordon Blunn, Bahattin Koc
Summary: Treatment of bone defects is challenging, and synthetic bone scaffolds with suitable mechanical and biological properties are highly sought after. This study presents 3D printed polymeric scaffolds with a continuous ZigZag-Spiral pattern, which have uniform pore size distribution and show better mechanical and mass transportation properties compared to conventional scaffold patterns. Human mesenchymal stem cells seeded on the scaffolds demonstrate gradual pore filling in the ZigZag-Spiral pattern, suggesting its potential as a better choice for bone defect treatments.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2022)
Article
Polymer Science
Evangelos Daskalakis, Mohamed H. Hassan, Abdalla M. Omar, Anil A. Acar, Ali Fallah, Glen Cooper, Andrew Weightman, Gordon Blunn, Bahattin Koc, Paulo Bartolo
Summary: This research investigates the accelerated hydrolytic degradation process of anatomically designed bone scaffolds with a pore size gradient and a rectangular shape. The effect of material composition is investigated using poly-epsilon-caprolactone (PCL) as the main scaffold material, reinforced with ceramics such as hydroxyapatite (HA), beta-tricalcium phosphate (TCP), and bioglass. The results show that the PCL/bioglass bone brick scaffolds exhibited faster degradation kinetics compared to other materials, and the degradation kinetics of rectangular scaffolds increased with the pore size. The degradation process was found to be faster on the external regions of the bone brick scaffolds, and the mechanical properties decreased during the degradation process.
Article
Engineering, Biomedical
Roxane Bonithon, Colin Lupton, Marta Roldo, Joseph Nicholas Dunlop, Gordon William Blunn, Frank Witte, Gianluca Tozzi
Summary: This study investigates the degradation pattern of magnesium (Mg) alloys used as bone substitutes. It found that in situ cyclic compression accelerated the corrosion rate, but no critical failures in mechanical integrity were observed. The accumulation of corrosion products led to structural changes and changes in mechanical properties.
BIOACTIVE MATERIALS
(2023)
Article
Chemistry, Medicinal
Arianna De Mori, Umoru Junior Alasa, Alex Muhlholzl, Gordon Blunn
Summary: This study investigated the potential of slipper limpet shells as a cost-effective source of bone graft substitutes. The shell material was mainly composed of aragonite and released calcium ions at physiological pH. In addition, apatite formation was observed, and the materials supported osteoblastic differentiation. Overall, the mantle of C. fornicata shows potential as a material for fabricating bone graft substitutes and structural biomaterials for bone regeneration.
Article
Engineering, Biomedical
Sarah Davis, Aikaterina Karali, Jurgita Zekonyte, Marta Roldo, Gordon Blunn
Summary: This study assessed the effects of staining with PTA/PBS solution on the mechanical properties of osteochondral tissue and visualized articular cartilage using CECT imaging for strain comparison. The results indicated that PTA/PBS can be used as a contrast agent for CECT imaging, but further research is needed to address the reduction in stiffness of subchondral bone after incubation in PBS.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2023)
Article
Biotechnology & Applied Microbiology
Sarah Davis, Jurgita Zekonyte, Aikaterina Karali, Marta Roldo, Gordon Blunn
Summary: Understanding the early mechanical changes in articular cartilage and subchondral bone is crucial for improved treatment of osteoarthritis. This study developed a method for assessing the mechanical properties of these tissues using nanoindentation, and found that in early-stage osteoarthritis, there was an increase in the mechanical properties of the deep zone of articular cartilage, while in severe osteoarthritis, there was a significant reduction in the mechanical properties of the superficial and middle zones of the cartilage. The stiffness of the subchondral bone also showed changes with age and severity of osteoarthritis.
BIOENGINEERING-BASEL
(2023)
Article
Cell & Tissue Engineering
Tosca Roncada, Roxane Bonithon, Gordon Blunn, Marta Roldo
Summary: Mesenchymal stem cells (MSCs) are a promising treatment for cartilage injuries, but selectively promoting their differentiation in vivo is challenging. This study demonstrates for the first time that stiffness can guide MSC differentiation without the use of growth factors, using collagen and alginate scaffolds. This finding is important for developing tissue engineering scaffolds for the treatment of cartilage defects.
JOURNAL OF TISSUE ENGINEERING
(2022)
Article
Engineering, Biomedical
Maryam Tamaddon, Gordon Blunn, Rongwei Tan, Pan Yang, Xiaodan Sun, Shen-Mao Chen, Jiajun Luo, Ziyu Liu, Ling Wang, Dichen Li, Ricardo Donate, Mario Monzon, Chaozong Liu
Summary: The repair of osteochondral defects is a major challenge in orthopaedics. This study developed a multi-layered osteochondral scaffold using additive manufacturing technologies, which showed promising results for the regeneration of large defects. The scaffold demonstrated safety and efficacy in an animal model.
BIO-DESIGN AND MANUFACTURING
(2022)
Article
Cell & Tissue Engineering
L. Osagie-Clouard, R. Meeson, A. Sanghani-Kerai, M. Bostrom, T. Briggs, G. Blunn
Summary: This study demonstrates the beneficial effect of combining localized MSC injections with low- or high-dose teriparatide on fracture healing, with the efficacy dependent on PTH dose. The high-dose combination therapy group showed the most significant improvement in fracture healing parameters compared to controls.
BONE & JOINT RESEARCH
(2021)
Article
Engineering, Biomedical
Evangelos Daskalakis, Fengyuan Liu, Boyang Huang, Anil A. Acar, Glen Cooper, Andrew Weightman, Gordon Blunn, Bahattin Koc, Paulo Bartolo
Summary: This study explores a novel osseointegrated prosthetic solution using modular bone bricks, investigating the impact of different architectures and material compositions on the performance of the prosthesis. Results showed that reinforced bone bricks with specific filament patterns exhibited improved mechanical and biological properties, with the best outcomes achieved with certain combinations of materials and structures.
INTERNATIONAL JOURNAL OF BIOPRINTING
(2021)
