Macrophage-targeting and reactive oxygen species (ROS)-responsive nanopolyplexes mediate anti-inflammatory siRNA delivery against acute liver failure (ALF)

Multifunctional PEI-entrapped gold nanoparticles enable efficient delivery of therapeutic siRNA into glioblastoma cells

(2017) Lingdan Kong et al.   Biomaterials Science

Serum-resistant, reactive oxygen species (ROS)-potentiated gene delivery in cancer cells mediated by fluorinated, diselenide-crosslinked polyplexes

(2017) Qiurong Deng et al.   Biomaterials Science

Enhanced bioreduction-responsive biodegradable diselenide-containing poly(ester urethane) nanocarriers

(2017) Chao Wei et al.   Biomaterials Science

Synergistic therapy of chemotherapeutic drugs and MTH1 inhibitors using a pH-sensitive polymeric delivery system for oral squamous cell carcinoma

(2017) Xiao Li et al.   Biomaterials Science

Defined pH-sensitive nanogels as gene delivery platform for siRNA mediated in vitro gene silencing

(2017) Mathias Dimde et al.   Biomaterials Science

Suppression of Hepatic Inflammation via Systemic siRNA Delivery by Membrane-Disruptive and Endosomolytic Helical Polypeptide Hybrid Nanoparticles

(2016) Hua He et al.   ACS Nano

Optimizing the Size of Micellar Nanoparticles for Efficient siRNA Delivery

(2015) Shi Liang et al.   ADVANCED FUNCTIONAL MATERIALS

Reversibly Cross-Linked Polyplexes Enable Cancer-Targeted Gene Delivery via Self-Promoted DNA Release and Self-Diminished Toxicity

(2015) Hua He et al.   BIOMACROMOLECULES

Dendrimer-Inspired Nanomaterials for the in Vivo Delivery of siRNA to Lung Vasculature

(2015) Omar F. Khan et al.   NANO LETTERS

Peptide-like Polymers Exerting Effective Glioma-Targeted siRNA Delivery and Release for Therapeutic Application

(2015) Sai An et al.   Small

Supramolecular Self-Assembled Nanoparticles Mediate Oral Delivery of Therapeutic TNF-α siRNA against Systemic Inflammation

(2013) Lichen Yin et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Hydrophobic modification of low molecular weight polyethylenimine for improved gene transfection

(2013) Pei Yun Teo et al.   BIOMATERIALS

Macrophage specific delivery of TNF-α siRNA complexed with β-1,3-glucan inhibits LPS-induced cytokine production in a murine acute hepatitis model

(2013) Shinichi Mochizuki et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Combined delivery of HMGB-1 box A peptide and S1PLyase siRNA in animal models of acute lung injury

(2013) Binna Oh et al.   JOURNAL OF CONTROLLED RELEASE

Acute Liver Failure

(2013) William Bernal et al.   NEW ENGLAND JOURNAL OF MEDICINE

miR-15b and miR-16 regulate TNF mediated hepatocyte apoptosis via BCL2 in acute liver failure

(2012) Fangmei An et al.   APOPTOSIS

Well-Defined Degradable Cationic Polylactide as Nanocarrier for the Delivery of siRNA to Silence Angiogenesis in Prostate Cancer

(2012) Chih-Kuang Chen et al.   Advanced Healthcare Materials

Protective effect of melittin on inflammation and apoptosis in acute liver failure

(2011) Ji-Hyun Park et al.   APOPTOSIS

Differences in DNA Condensation and Release by Lysine and Arginine Homopeptides Govern Their DNA Delivery Efficiencies

(2011) Anita Mann et al.   MOLECULAR PHARMACEUTICS

Lipoic Acid Modified Low Molecular Weight Polyethylenimine Mediates Nontoxic and Highly Potentin VitroGene Transfection

(2011) Meng Zheng et al.   MOLECULAR PHARMACEUTICS

Intratracheal siRNA for the in vivo silencing of caspase-3: A novel therapy for acute lung injury?*

(2010) Yu Ru Kou et al.   CRITICAL CARE MEDICINE

Efficient and targeted delivery of siRNA in vivo

(2010) Min Suk Shim et al.   FEBS Journal

Orally delivered thioketal nanoparticles loaded with TNF-α–siRNA target inflammation and inhibit gene expression in the intestines

(2010) D. Scott Wilson et al.   NATURE MATERIALS

Strategies in the design of nanoparticles for therapeutic applications

(2010) Robby A. Petros et al.   NATURE REVIEWS DRUG DISCOVERY

Orally delivered siRNA targeting macrophage Map4k4 suppresses systemic inflammation

(2009) Myriam Aouadi et al.   NATURE

Controlled cytoplasmic and nuclear localization of plasmid DNA and siRNA by differentially tailored polyethylenimine

(2008) Min Suk Shim et al.   JOURNAL OF CONTROLLED RELEASE

Origin and physiological roles of inflammation

(2008) Ruslan Medzhitov   NATURE