Ras/ERK-signalling promotes tRNA synthesis and growth via the RNA polymerase III repressor Maf1 in Drosophila

Investigation of protein synthesis inDrosophilalarvae using puromycin labelling

(2017) Lisa P. Deliu et al.   Biology Open

Modulated Expression of Specific tRNAs Drives Gene Expression and Cancer Progression

(2016) Hani Goodarzi et al.   CELL

The Initiator Methionine tRNA Drives Secretion of Type II Collagen from Stromal Fibroblasts to Promote Tumor Growth and Angiogenesis

(2016) Cassie J. Clarke et al.   CURRENT BIOLOGY

The initiator methionine tRNA drives cell migration and invasion leading to increased metastatic potential in melanoma

(2016) Joanna Birch et al.   Biology Open

Why should cancer biologists care about tRNAs? tRNA synthesis, mRNA translation and the control of growth

(2015) Savraj S. Grewal   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

The Levels of a Universally Conserved tRNA Modification Regulate Cell Growth

(2015) Diego Rojas-Benitez et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

EGFR/Ras Signaling Controls Drosophila Intestinal Stem Cell Proliferation via Capicua-Regulated Genes

(2015) Yinhua Jin et al.   PLoS Genetics

A Dual Program for Translation Regulation in Cellular Proliferation and Differentiation

(2014) Hila Gingold et al.   CELL

A Functional Screen Reveals an Extensive Layer of Transcriptional and Splicing Control Underlying RAS/MAPK Signaling in Drosophila

(2014) Dariel Ashton-Beaucage et al.   PLOS BIOLOGY

The RASopathies

(2013) Katherine A. Rauen   Annual Review of Genomics and Human Genetics

mTORC1 Controls Mitochondrial Activity and Biogenesis through 4E-BP-Dependent Translational Regulation

(2013) Masahiro Morita et al.   Cell Metabolism

Drosophila Myc integrates multiple signaling pathways to regulate intestinal stem cell proliferation during midgut regeneration

(2013) Fangfang Ren et al.   CELL RESEARCH

Regulation of Hippo Signaling by EGFR-MAPK Signaling through Ajuba Family Proteins

(2013) B.V.V.G. Reddy et al.   DEVELOPMENTAL CELL

Inhibition of Myc family proteins eradicates KRas-driven lung cancer in mice

(2013) L. Soucek et al.   GENES & DEVELOPMENT

Overexpression of initiator methionine tRNA leads to global reprogramming of tRNA expression and increased proliferation in human epithelial cells

(2013) M. Pavon-Eternod et al.   RNA

Mutual Repression by Bantam miRNA and Capicua Links the EGFR/MAPK and Hippo Pathways in Growth Control

(2012) Héctor Herranz et al.   CURRENT BIOLOGY

Non-autonomous crosstalk between the Jak/Stat and Egfr pathways mediates Apc1-driven intestinal stem cell hyperplasia in the Drosophila adult midgut

(2012) J. B. Cordero et al.   DEVELOPMENT

Nutrient/TOR-dependent regulation of RNA polymerase III controls tissue and organismal growth inDrosophila

(2012) Lynne Marshall et al.   EMBO JOURNAL

PP4 dephosphorylates Maf1 to couple multiple stress conditions to RNA polymerase III repression

(2012) Andrew J Oler et al.   EMBO JOURNAL

Oncogenic cooperation between SOCS family proteins and EGFR identified using a Drosophila epithelial transformation model

(2012) H. Herranz et al.   GENES & DEVELOPMENT

A unifying model for mTORC1-mediated regulation of mRNA translation

(2012) Carson C. Thoreen et al.   NATURE

The translational landscape of mTOR signalling steers cancer initiation and metastasis

(2012) Andrew C. Hsieh et al.   NATURE

RSK regulates activated BRAF signalling to mTORC1 and promotes melanoma growth

(2012) Y Romeo et al.   ONCOGENE

Drosophila RNA polymerase III repressor Maf1 controls body size and developmental timing by modulating tRNAiMet synthesis and systemic insulin signaling

(2012) E. J. Rideout et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Drosophila EGFR pathway coordinates stem cell proliferation and gut remodeling following infection

(2011) Nicolas Buchon et al.   BMC BIOLOGY

EGF signaling regulates the proliferation of intestinal stem cells in Drosophila

(2011) B. Biteau et al.   DEVELOPMENT

EGFR, Wingless and JAK/STAT signaling cooperatively maintain Drosophila intestinal stem cells

(2011) Na Xu et al.   DEVELOPMENTAL BIOLOGY

EGFR/Ras/MAPK Signaling Mediates Adult Midgut Epithelial Homeostasis and Regeneration in Drosophila

(2010) Huaqi Jiang et al.   Cell Stem Cell

Paving the way for targeting RSK in cancer

(2010) Yves Romeo et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Requirement of the mTOR Kinase for the Regulation of Maf1 Phosphorylation and Control of RNA Polymerase III-dependent Transcription in Cancer Cells

(2010) Boris Shor et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

mTORC1 Directly Phosphorylates and Regulates Human MAF1

(2010) A. A. Michels et al.   MOLECULAR AND CELLULAR BIOLOGY

Combined deficiency for MAP kinase-interacting kinase 1 and 2 (Mnk1 and Mnk2) delays tumor development

(2010) T. Ueda et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

mTOR associates with TFIIIC, is found at tRNA and 5S rRNA genes, and targets their repressor Maf1

(2010) T. Kantidakis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

mTORC1-Mediated Cell Proliferation, But Not Cell Growth, Controlled by the 4E-BPs

(2010) R. J. O. Dowling et al.   SCIENCE

High levels of tRNA abundance and alteration of tRNA charging by bortezomib in multiple myeloma

(2009) Ying Zhou et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

EGFR signaling regulates the proliferation of Drosophila adult midgut progenitors

(2009) H. Jiang et al.   DEVELOPMENT

Mechanisms of regulation of RNA polymerase III-dependent transcription by TORC1

(2009) Yuehua Wei et al.   EMBO JOURNAL

Characterization of the rapamycin-sensitive phosphoproteome reveals that Sch9 is a central coordinator of protein synthesis

(2009) A. Huber et al.   GENES & DEVELOPMENT

tRNA over-expression in breast cancer and functional consequences

(2009) Mariana Pavon-Eternod et al.   NUCLEIC ACIDS RESEARCH

Dynamic Control of Cell Cycle and Growth Coupling by Ecdysone, EGFR, and PI3K Signaling in Drosophila Histoblasts

(2009) Nikolay Ninov et al.   PLOS BIOLOGY

A Drosophila Model for EGFR-Ras and PI3K-Dependent Human Glioma

(2009) Renee D. Read et al.   PLoS Genetics

Max-independent functions of Myc in Drosophila melanogaster

(2008) Dominik Steiger et al.   NATURE GENETICS