Reversing allosteric communication: From detecting allosteric sites to inducing and tuning targeted allosteric response

An engineered photoswitchable mammalian pyruvate kinase

(2017) Stefanie Gehrig et al.   FEBS Journal

Exploring the limits of the usefulness of mutagenesis in studies of allosteric mechanisms

(2017) Qingling Tang et al.   HUMAN MUTATION

Improved Method for the Identification and Validation of Allosteric Sites

(2017) Kun Song et al.   Journal of Chemical Information and Modeling

Allosteric sites: remote control in regulation of protein activity

(2016) Enrico Guarnera et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Predicting Allosteric Effects from Orthosteric Binding in Hsp90-Ligand Interactions: Implications for Fragment-Based Drug Design

(2016) Arun Chandramohan et al.   PLoS Computational Biology

Structure-Based Statistical Mechanical Model Accounts for the Causality and Energetics of Allosteric Communication

(2016) Enrico Guarnera et al.   PLoS Computational Biology

Computational Advances for the Development of Allosteric Modulators and Bitopic Ligands in G Protein-Coupled Receptors

(2015) Zhiwei Feng et al.   AAPS Journal

ASBench: benchmarking sets for allosteric discovery: Fig. 1.

(2015) Wenkang Huang et al.   BIOINFORMATICS

Parallel Allostery by cAMP and PDE Coordinates Activation and Termination Phases in cAMP Signaling

(2015) Srinath Krishnamurthy et al.   BIOPHYSICAL JOURNAL

The Role of Protein-Ligand Contacts in Allosteric Regulation of theEscherichia coliCatabolite Activator Protein

(2015) Philip D. Townsend et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Protein Sectors: Statistical Coupling Analysis versus Conservation

(2015) Tiberiu Teşileanu et al.   PLoS Computational Biology

Recent computational advances in the identification of allosteric sites in proteins

(2014) Shaoyong Lu et al.   DRUG DISCOVERY TODAY

Harnessing Allostery: A Novel Approach to Drug Discovery

(2014) Shaoyong Lu et al.   MEDICINAL RESEARCH REVIEWS

Computing protein dynamics from protein structure with elastic network models

(2014) Ugo Bastolla   Wiley Interdisciplinary Reviews-Computational Molecular Science

A structure-guided fragment-based approach for the discovery of allosteric inhibitors targeting the lipophilic binding site of transcription factor EthR

(2013) Sachin Surade et al.   BIOCHEMICAL JOURNAL

Thermodynamics of allostery paves a way to allosteric drugs

(2013) Igor N. Berezovsky   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Allosite: a method for predicting allosteric sites

(2013) Wenkang Huang et al.   BIOINFORMATICS

Allostery in Disease and in Drug Discovery

(2013) Ruth Nussinov et al.   CELL

γ-Secretase Modulator (GSM) Photoaffinity Probes Reveal Distinct Allosteric Binding Sites on Presenilin

(2013) Nikolay Pozdnyakov et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Covalent and allosteric inhibitors of the ATPase VCP/p97 induce cancer cell death

(2013) Paola Magnaghi et al.   Nature Chemical Biology

Emerging paradigms in GPCR allostery: implications for drug discovery

(2013) Denise Wootten et al.   NATURE REVIEWS DRUG DISCOVERY

Strategies for the Selective Regulation of Kinases with Allosteric Modulators: Exploiting Exclusive Structural Features

(2012) Zhizhou Fang et al.   ACS Chemical Biology

Drugs for Allosteric Sites on Receptors

(2011) Cody J. Wenthur et al.   Annual Review of Pharmacology and Toxicology

The structure and allosteric regulation of mammalian glutamate dehydrogenase

(2011) Ming Li et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Impact of high-throughput screening in biomedical research

(2011) Ricardo Macarron et al.   NATURE REVIEWS DRUG DISCOVERY

Turning a protein kinase on or off from a single allosteric site via disulfide trapping

(2011) J. D. Sadowsky et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Coherent Conformational Degrees of Freedom as a Structural Basis for Allosteric Communication

(2011) Simon Mitternacht et al.   PLoS Computational Biology

Binding Leverage as a Molecular Basis for Allosteric Regulation

(2011) Simon Mitternacht et al.   PLoS Computational Biology

Cyclic AMP Analog Blocks Kinase Activation by Stabilizing Inactive Conformation: Conformational Selection Highlights a New Concept in Allosteric Inhibitor Design

(2010) Suguna Badireddy et al.   MOLECULAR & CELLULAR PROTEOMICS

Structural basis for a reciprocating mechanism of negative cooperativity in dimeric phosphagen kinase activity

(2009) Xiaoai Wu et al.   FASEB JOURNAL

Probing Allosteric Binding Sites of the Maize Endosperm ADP-Glucose Pyrophosphorylase

(2009) S. K. Boehlein et al.   PLANT PHYSIOLOGY

Structural basis for cAMP-mediated allosteric control of the catabolite activator protein

(2009) N. Popovych et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Allosteric modulators of GPCRs: a novel approach for the treatment of CNS disorders

(2008) P. Jeffrey Conn et al.   NATURE REVIEWS DRUG DISCOVERY

Untangling the glutamate dehydrogenase allosteric nightmare

(2008) Thomas J. Smith et al.   TRENDS IN BIOCHEMICAL SCIENCES