Exploring the limits of the usefulness of mutagenesis in studies of allosteric mechanisms

What Mutagenesis Can and Cannot Reveal About Allostery

(2016) Gerald M. Carlson et al.   BIOPHYSICAL JOURNAL

Distinguishing the Interactions in the Fructose 1,6-Bisphosphate Binding Site of Human Liver Pyruvate Kinase That Contribute to Allostery

(2015) Arjun Ishwar et al.   BIOCHEMISTRY

M2 pyruvate kinase provides a mechanism for nutrient sensing and regulation of cell proliferation

(2013) H. P. Morgan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Energetic Coupling between an Oxidizable Cysteine and the Phosphorylatable N-Terminus of Human Liver Pyruvate Kinase

(2012) Todd Holyoak et al.   BIOCHEMISTRY

Monitoring allostery in D2O: a necessary control in studies using hydrogen/deuterium exchange to characterize allosteric regulation

(2011) Charulata B. Prasannan et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Effector Analogues Detect Varied Allosteric Roles for Conserved Protein−Effector Interactions in Pyruvate Kinase Isozymes

(2011) Aileen Y. Alontaga et al.   BIOCHEMISTRY

Changes in Small-Angle X-ray Scattering Parameters Observed upon Binding of Ligand to Rabbit Muscle Pyruvate Kinase Are Not Correlated with Allosteric Transitions

(2010) Aron W. Fenton et al.   BIOCHEMISTRY

The pyruvate kinase model system, a cautionary tale for the use of osmolyte perturbations to support conformational equilibria in allostery

(2010) Aron W. Fenton et al.   PROTEIN SCIENCE

The pH dependence of the allosteric response of human liver pyruvate kinase to fructose-1,6-bisphosphate, ATP, and alanine

(2009) Aron W. Fenton et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

An Activating Interaction between the Unphosphorylated N-Terminus of Human Liver Pyruvate Kinase and the Main Body of the Protein Is Interrupted by Phosphorylation

(2009) Aron W. Fenton et al.   BIOCHEMISTRY

Disentangling the Web of Allosteric Communication in a Homotetramer: Heterotropic Inhibition in Phosphofructokinase fromEscherichia coli

(2009) Aron W. Fenton et al.   BIOCHEMISTRY

Modulation of allostery of pyruvate kinase by shifting of an ensemble of microstates

(2008) J. Ching Lee   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

Allostery: an illustrated definition for the ‘second secret of life’

(2008) Aron W. Fenton   TRENDS IN BIOCHEMICAL SCIENCES