标题
Gene Therapy for Parkinson’s Disease, An Update
作者
关键词
-
出版物
Journal of Parkinsons Disease
Volume 8, Issue 2, Pages 195-215
出版商
IOS Press
发表日期
2018-04-29
DOI
10.3233/jpd-181331
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Effect of optogenetic modulation on entopeduncular input affects thalamic discharge and behavior in an AAV2-α-synuclein-induced hemiparkinson rat model
- (2018) Hyeong Cheol Moon et al. NEUROSCIENCE LETTERS
- Long-term protective effects of AAV9-mesencephalic astrocyte-derived neurotrophic factor gene transfer in parkinsonian rats
- (2017) Fei Hao et al. EXPERIMENTAL NEUROLOGY
- Exploring the potential of genome editing CRISPR-Cas9 technology
- (2017) Vijai Singh et al. GENE
- Regulation of human GDNF gene expression in nigral dopaminergic neurons using a new doxycycline-regulated NTS-polyplex nanoparticle system
- (2017) Armando J. Espadas-Alvarez et al. Nanomedicine-Nanotechnology Biology and Medicine
- Intracerebral injections of DNA nanoparticles encoding for a therapeutic gene provide partial neuroprotection in an animal model of neurodegeneration
- (2017) David Yurek et al. Nanomedicine-Nanotechnology Biology and Medicine
- Unconventional neurotrophic factors CDNF and MANF: Structure, physiological functions and therapeutic potential
- (2017) Maria Lindahl et al. NEUROBIOLOGY OF DISEASE
- Early Insights from Commercialization of Gene Therapies in Europe
- (2017) Nicolas Touchot et al. Genes
- Persistent Expression of Dopamine-Synthesizing Enzymes 15 Years After Gene Transfer in a Primate Model of Parkinson's Disease
- (2017) Yoshihide Sehara et al. Human Gene Therapy Clinical Development
- Titer and Product Affect the Distribution of Gene Expression after Intraputaminal Convection-Enhanced Delivery
- (2017) Marina E. Emborg et al. STEREOTACTIC AND FUNCTIONAL NEUROSURGERY
- The genetic background of Parkinson's disease: current progress and future prospects
- (2016) K. Kalinderi et al. ACTA NEUROLOGICA SCANDINAVICA
- Optogenetic Approaches for Controlling Seizure Activity
- (2016) Jack K. Tung et al. Brain Stimulation
- Nurr1-Based Therapies for Parkinson's Disease
- (2016) Jie Dong et al. CNS Neuroscience & Therapeutics
- Surgical Treatment of Parkinson’s Disease
- (2016) Leo Verhagen Metman et al. Current Treatment Options in Neurology
- Combined Nurr1 and Foxa2 roles in the therapy of Parkinson's disease
- (2016) S.-M. Oh et al. EMBO Molecular Medicine
- Parkinson Disease-linked Vps35 R524W Mutation Impairs the Endosomal Association of Retromer and Induces α-Synuclein Aggregation
- (2016) Jordan Follett et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Tyrosine hydroxylase (TH), its cofactor tetrahydrobiopterin (BH4), other catecholamine-related enzymes, and their human genes in relation to the drug and gene therapies of Parkinson’s disease (PD): historical overview and future prospects
- (2016) Toshiharu Nagatsu et al. JOURNAL OF NEURAL TRANSMISSION
- Teaching neurons to respond to placebos
- (2016) Fabrizio Benedetti et al. JOURNAL OF PHYSIOLOGY-LONDON
- Chinese scientists to pioneer first human CRISPR trial
- (2016) David Cyranoski NATURE
- Neuropeptide Y (NPY) as a therapeutic target for neurodegenerative diseases
- (2016) Joana Duarte-Neves et al. NEUROBIOLOGY OF DISEASE
- Optogenetic stimulation of cortico-subthalamic projections is sufficient to ameliorate bradykinesia in 6-ohda lesioned mice
- (2016) Teresa H. Sanders et al. NEUROBIOLOGY OF DISEASE
- Developing therapeutically more efficient Neurturin variants for treatment of Parkinson's disease
- (2016) Pia Runeberg-Roos et al. NEUROBIOLOGY OF DISEASE
- DREADDs for Neuroscientists
- (2016) Bryan L. Roth NEURON
- Probing pain pathways with light
- (2016) Feng Wang et al. NEUROSCIENCE
- Human striatal recordings reveal abnormal discharge of projection neurons in Parkinson’s disease
- (2016) Arun Singh et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Leucine-rich repeat kinase 2 and Parkinson's disease
- (2016) Un-Beom Kang et al. PROTEOMICS
- Optogenetic Inhibition of the Subthalamic Nucleus Reduces Levodopa-Induced Dyskinesias in a Rat Model of Parkinson's Disease
- (2016) Hyung Ho Yoon et al. STEREOTACTIC AND FUNCTIONAL NEUROSURGERY
- Spinal Plasticity and Behavior: BDNF-Induced Neuromodulation in Uninjured and Injured Spinal Cord
- (2016) Sandra M. Garraway et al. NEURAL PLASTICITY
- CRISPR/Cas9: Implications for Modeling and Therapy of Neurodegenerative Diseases
- (2016) Weili Yang et al. Frontiers in Molecular Neuroscience
- Gene delivery of neurturin to putamen and substantia nigra in Parkinson disease: A double-blind, randomized, controlled trial
- (2015) C. Warren Olanow et al. ANNALS OF NEUROLOGY
- Optogenetics
- (2015) Jens Duebel et al. CURRENT OPINION IN OPHTHALMOLOGY
- Global, regional, and national incidence, prevalence, and years lived with disability for 301 acute and chronic diseases and injuries in 188 countries, 1990–2013: a systematic analysis for the Global Burden of Disease Study 2013
- (2015) Theo Vos et al. LANCET
- Lewy body dementias
- (2015) Zuzana Walker et al. LANCET
- Pharmacogenetic stimulation of cholinergic pedunculopontine neurons reverses motor deficits in a rat model of Parkinson’s disease
- (2015) Ilse S. Pienaar et al. Molecular Neurodegeneration
- Enhanced Efficacy of the CDNF/MANF Family by Combined Intranigral Overexpression in the 6-OHDA Rat Model of Parkinson's Disease
- (2015) Óscar Cordero-Llana et al. MOLECULAR THERAPY
- CRISPR, the disruptor
- (2015) Heidi Ledford NATURE
- Post-mortem assessment of the short and long-term effects of the trophic factor neurturin in patients with α-synucleinopathies
- (2015) R.T. Bartus et al. NEUROBIOLOGY OF DISEASE
- Role of two sequence motifs of mesencephalic astrocyte-derived neurotrophic factor in its survival-promoting activity
- (2015) K Mätlik et al. Cell Death & Disease
- Transgenic Expression of Human Glial Cell Line-Derived Neurotrophic Factor from Integration-Deficient Lentiviral Vectors is Neuroprotective in a Rodent Model of Parkinson's Disease
- (2014) Ngoc B. Lu-Nguyen et al. HUMAN GENE THERAPY
- Long-term safety and tolerability of ProSavin, a lentiviral vector-based gene therapy for Parkinson's disease: a dose escalation, open-label, phase 1/2 trial
- (2014) Stéphane Palfi et al. LANCET
- The medical treatment of Parkinson disease from James Parkinson to George Cotzias
- (2014) Stanley Fahn MOVEMENT DISORDERS
- DNAJC13genetic variants in parkinsonism
- (2014) Emil K. Gustavsson et al. MOVEMENT DISORDERS
- Noninvasive optical inhibition with a red-shifted microbial rhodopsin
- (2014) Amy S Chuong et al. NATURE NEUROSCIENCE
- Optogenetic Inactivation of the Subthalamic Nucleus Improves Forelimb Akinesia in a Rat Model of Parkinson Disease
- (2014) Hyung Ho Yoon et al. NEUROSURGERY
- Cardiac optogenetics
- (2013) Emilia Entcheva AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
- Roles of long noncoding RNAs in brain development, functional diversification and neurodegenerative diseases
- (2013) Ping Wu et al. BRAIN RESEARCH BULLETIN
- An animal model mimicking pedunculopontine nucleus cholinergic degeneration in Parkinson’s disease
- (2013) Ilse S. Pienaar et al. Brain Structure & Function
- AAV2-mediated striatum delivery of human CDNF prevents the deterioration of midbrain dopamine neurons in a 6-hydroxydopamine induced parkinsonian rat model
- (2013) Xinmiao Ren et al. EXPERIMENTAL NEUROLOGY
- Regeneration of the MPTP-Lesioned Dopaminergic System after Convection-Enhanced Delivery of AAV2-GDNF
- (2013) A. P. Kells et al. JOURNAL OF NEUROSCIENCE
- Control of Basal Ganglia Output by Direct and Indirect Pathway Projection Neurons
- (2013) B. S. Freeze et al. JOURNAL OF NEUROSCIENCE
- Safety/feasibility of targeting the substantia nigra with AAV2-neurturin in Parkinson patients
- (2013) R. T. Bartus et al. NEUROLOGY
- TFEB-mediated autophagy rescues midbrain dopamine neurons from -synuclein toxicity
- (2013) M. Decressac et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- An ERcentric view of Parkinson's disease
- (2013) Gabriela Mercado et al. TRENDS IN MOLECULAR MEDICINE
- Novel designer receptors to probe GPCR signaling and physiology
- (2013) Jürgen Wess et al. TRENDS IN PHARMACOLOGICAL SCIENCES
- Gene therapy with AAV2-CDNF provides functional benefits in a rat model of Parkinson's disease
- (2013) Susanne Bäck et al. Brain and Behavior
- Glial Cell Line-Derived Neurotrophic Factor Partially Ameliorates Motor Symptoms without Slowing Neurodegeneration in Mice with Respiratory Chain-Deficient Dopamine Neurons
- (2012) Fredrik H. Sterky et al. CELL TRANSPLANTATION
- Simvastatin Induces Neuroprotection in 6-OHDA-Lesioned PC12 via the PI3K/AKT/Caspase 3 Pathway and Anti-Inflammatory Responses
- (2012) Yun-Qi Xu et al. CNS Neuroscience & Therapeutics
- Comparison of the behavioural and histological characteristics of the 6-OHDA and α-synuclein rat models of Parkinson's disease
- (2012) M. Decressac et al. EXPERIMENTAL NEUROLOGY
- Long-Term Evaluation of a Phase 1 Study of AADC Gene Therapy for Parkinson's Disease
- (2012) Gabriele Mittermeyer et al. HUMAN GENE THERAPY
- Mesencephalic Astrocyte-derived Neurotrophic Factor Protects the Heart from Ischemic Damage and Is Selectively Secreted upon Sarco/endoplasmic Reticulum Calcium Depletion
- (2012) Christopher C. Glembotski et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Design of a Single AAV Vector for Coexpression of TH and GCH1 to Establish Continuous DOPA Synthesis in a Rat Model of Parkinson's Disease
- (2012) Erik Cederfjäll et al. MOLECULAR THERAPY
- NTS-Polyplex: a potential nanocarrier for neurotrophic therapy of Parkinson's disease
- (2012) Daniel Martinez-Fong et al. Nanomedicine-Nanotechnology Biology and Medicine
- NRSF/REST neuronal deficient mice are more vulnerable to the neurotoxin MPTP
- (2012) Mei Yu et al. NEUROBIOLOGY OF AGING
- Multifaces of neuropeptide Y in the brain – Neuroprotection, neurogenesis and neuroinflammation
- (2012) J.O. Malva et al. NEUROPEPTIDES
- GDNF fails to exert neuroprotection in a rat -synuclein model of Parkinson's disease
- (2011) M. Decressac et al. BRAIN
- Signaling of Glial Cell Line-Derived Neurotrophic Factor and Its Receptor GFRα1 Induce Nurr1 and Pitx3 to Promote Survival of Grafted Midbrain-Derived Neural Stem Cells in a Rat Model of Parkinson Disease
- (2011) Zhinian Lei et al. JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY
- AAV2-GAD gene therapy for advanced Parkinson's disease: a double-blind, sham-surgery controlled, randomised trial
- (2011) Peter A LeWitt et al. LANCET NEUROLOGY
- An optogenetic toolbox designed for primates
- (2011) Ilka Diester et al. NATURE NEUROSCIENCE
- Neuroprotection by neuropeptide Y in cell and animal models of Parkinson's disease
- (2011) Mickael Decressac et al. NEUROBIOLOGY OF AGING
- Properly scaled and targeted AAV2-NRTN (neurturin) to the substantia nigra is safe, effective and causes no weight loss: Support for nigral targeting in Parkinson's disease
- (2011) Raymond T. Bartus et al. NEUROBIOLOGY OF DISEASE
- Viral vectors for gene delivery to the central nervous system
- (2011) Thomas B. Lentz et al. NEUROBIOLOGY OF DISEASE
- The TrkB-Positive Dopaminergic Neurons are Less Sensitive to MPTP Insult in the Substantia Nigra of Adult C57/BL Mice
- (2011) Yin-Xiu Ding et al. NEUROCHEMICAL RESEARCH
- TFEB Links Autophagy to Lysosomal Biogenesis
- (2011) C. Settembre et al. SCIENCE
- The Yin and Yang of VEGF and PEDF: Multifaceted Neurotrophic Factors and Their Potential in the Treatment of Parkinson’s Disease
- (2010) Torsten Falk et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Pathogenic Lysosomal Depletion in Parkinson's Disease
- (2010) B. Dehay et al. JOURNAL OF NEUROSCIENCE
- Gene delivery of AAV2-neurturin for Parkinson's disease: a double-blind, randomised, controlled trial
- (2010) William J Marks et al. LANCET NEUROLOGY
- Eight Years of Clinical Improvement in MPTP-Lesioned Primates After Gene Therapy With AAV2-hAADC
- (2010) Piotr Hadaczek et al. MOLECULAR THERAPY
- A Phase I Study of Aromatic L-Amino Acid Decarboxylase Gene Therapy for Parkinson's Disease
- (2010) Shin-ichi Muramatsu et al. MOLECULAR THERAPY
- Bioactivity of AAV2-neurturin gene therapy (CERE-120): Differences between Parkinson's disease and nonhuman primate brains
- (2010) Raymond T. Bartus et al. MOVEMENT DISORDERS
- Regulation of parkinsonian motor behaviours by optogenetic control of basal ganglia circuitry
- (2010) Alexxai V. Kravitz et al. NATURE
- α-Synuclein and dopamine at the crossroads of Parkinson's disease
- (2010) Lara Lourenço Venda et al. TRENDS IN NEUROSCIENCES
- Eight-year safety follow-up of coronary artery disease patients after local intracoronary VEGF gene transfer
- (2009) M Hedman et al. GENE THERAPY
- Functional Effects of AAV2-GDNF on the Dopaminergic Nigrostriatal Pathway in Parkinsonian Rhesus Monkeys
- (2009) Jamie L. Eberling et al. HUMAN GENE THERAPY
- Clinically Relevant Effects of Convection-Enhanced Delivery of AAV2-GDNF on the Dopaminergic Nigrostriatal Pathway in Aged Rhesus Monkeys
- (2009) Louisa C. Johnston et al. HUMAN GENE THERAPY
- Safety Evaluation of AAV2-GDNF Gene Transfer into the Dopaminergic Nigrostriatal Pathway in Aged and Parkinsonian Rhesus Monkeys
- (2009) Xiaomin Su et al. HUMAN GENE THERAPY
- Brain-derived neurotrophic factor in neurodegenerative diseases
- (2009) Chiara Zuccato et al. Nature Reviews Neurology
- Safety and tolerability of putaminal AADC gene therapy for Parkinson disease
- (2009) C. W. Christine et al. NEUROLOGY
- Optical Deconstruction of Parkinsonian Neural Circuitry
- (2009) V. Gradinaru et al. SCIENCE
- Dopamine Gene Therapy for Parkinson's Disease in a Nonhuman Primate Without Associated Dyskinesia
- (2009) B. Jarraya et al. Science Translational Medicine
- Armet, a UPR-upregulated protein, inhibits cell proliferation and ER stress-induced cell death
- (2008) A APOSTOLOU et al. EXPERIMENTAL CELL RESEARCH
- Decreased NURR1 gene expression in patients with Parkinson's disease
- (2008) Weidong Le et al. JOURNAL OF THE NEUROLOGICAL SCIENCES
- Safety and tolerability of intraputaminal delivery of CERE-120 (adeno-associated virus serotype 2–neurturin) to patients with idiopathic Parkinson's disease: an open-label, phase I trial
- (2008) William J Marks et al. LANCET NEUROLOGY
- Phenotype, genotype, and worldwide genetic penetrance of LRRK2-associated Parkinson's disease: a case-control study
- (2008) Daniel G Healy et al. LANCET NEUROLOGY
- Transgene Expression, Bioactivity, and Safety of CERE-120 (AAV2-Neurturin) Following Delivery to the Monkey Striatum
- (2008) Christopher D Herzog et al. MOLECULAR THERAPY
- Functional organization of the basal ganglia: Therapeutic implications for Parkinson's disease
- (2008) Jose A. Obeso et al. MOVEMENT DISORDERS
- Engineering GPCR signaling pathways with RASSLs
- (2008) Bruce R Conklin et al. NATURE METHODS
- Results from a phase I safety trial of hAADC gene therapy for Parkinson disease
- (2008) J. L. Eberling et al. NEUROLOGY
- MPTP-induced deficits in striatal synaptic plasticity are prevented by glial cell line-derived neurotrophic factor expressed via an adeno-associated viral vector
- (2007) Yuan-Hao Chen et al. FASEB JOURNAL
Find the ideal target journal for your manuscript
Explore over 38,000 international journals covering a vast array of academic fields.
SearchAdd your recorded webinar
Do you already have a recorded webinar? Grow your audience and get more views by easily listing your recording on Peeref.
Upload Now