期刊
NEUROBIOLOGY OF DISEASE
卷 95, 期 -, 页码 210-224出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.nbd.2016.07.022
关键词
Neuropeptide Y; NPY; NPY receptors; Neurodegenerative diseases; Alzheimer's disease; Parkinson's disease; Huntington's disease; Machado-Joseph disease; Neurogenesis; Trophic factors; Autophagy; Excitotoxicity; Neuroinflammation; Neuroprotection
资金
- Richard Chin and Lily Lock Research Fund
- FEDER funds through the Operational Program Competitiveness Factors - COMPETE
- national funds through the Portuguese Foundation for Science and Technology (FCT) [SFRH/BD/74993/2010]
- QREN Programa Mais Centro: New Strategies to Manage Brain Diseases [CENTRO-07-ST24-FEDER-002002, 002006, 002008]
- [UID/NEU/04539/2013]
- [E-Rare4/0003/2012]
- Fundação para a Ciência e a Tecnologia [E-Rare4/0003/2012, SFRH/BD/74993/2010] Funding Source: FCT
Neuropeptide Y (NPY) and NPY receptors are widely expressed in the mammalian central nervous system. Studies in both humans and rodent models revealed that brain NPY levels are altered in some neurodegenerative disorders, such as Alzheimer's disease, Parkinson's disease, Huntington's disease and Machado-Joseph_disease. In this review, we will focus on the roles of NPY in the pathological mechanisms of these disorders, highlighting NPY as a neuroprotective agent, as a neural stem cell proliferative agent, as an agent that increases trophic support, as a stimulator of autophagy and as an inhibitor of excitotoxicity and neuroinflammation. Moreover, the effect of NPY in some clinical manifestations commonly observed in Alzheimer's disease, Parkinson's disease, Huntington's disease and Machado Joseph disease, such as depressive symptoms and body weight loss, are also discussed. In conclusion, this review highlights NPY system as a potential therapeutic target in neurodegenerative diseases. (C) 2016 Elsevier Inc. All rights reserved.
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