The establishment of surrogates and correlates of protection: Useful tools for the licensure of effective influenza vaccines?

Whither vaccines?

(2017) Charlene M.C. Rodrigues et al.   JOURNAL OF INFECTION

Efficacy of Recombinant Influenza Vaccine in Adults 50 Years of Age or Older

(2017) Lisa M. Dunkle et al.   NEW ENGLAND JOURNAL OF MEDICINE

Nasal delivery of Protollin-adjuvanted H5N1 vaccine induces enhanced systemic as well as mucosal immunity in mice

(2017) Weiping Cao et al.   VACCINE

Personalized vaccinology: A review

(2017) G.A. Poland et al.   VACCINE

A structural explanation for the low effectiveness of the seasonal influenza H3N2 vaccine

(2017) Nicholas C. Wu et al.   PLoS Pathogens

Surveillance trends of the 2009 influenza A(H1N1) pandemic in Europe

(2017) A Amato-Gauci et al.   Eurosurveillance

Correlates of Protection against Influenza in the Elderly: Results from an Influenza Vaccine Efficacy Trial

(2016) Andrew J. Dunning et al.   Clinical and Vaccine Immunology

Standardization of Hemagglutination Inhibition Assay for Influenza Serology Allows for High Reproducibility between Laboratories

(2016) Mary Zacour et al.   Clinical and Vaccine Immunology

A plant-derived quadrivalent virus like particle influenza vaccine induces cross-reactive antibody and T cell response in healthy adults

(2016) Stéphane Pillet et al.   CLINICAL IMMUNOLOGY

Standardization and quality control for high-dimensional mass cytometry studies of human samples

(2016) Katja Kleinsteuber et al.   CYTOMETRY PART A

Quantifying Protection Against Influenza Virus Infection Measured by Hemagglutination-inhibition Assays in Vaccine Trials

(2016) Xiahong Zhao et al.   EPIDEMIOLOGY

Mutations acquired during cell culture isolation may affect antigenic characterisation of influenza A(H3N2) clade 3C.2a viruses

(2016) Danuta M Skowronski et al.   Eurosurveillance

Influenza immunology evaluation and correlates of protection: a focus on vaccines

(2016) Claudia Maria Trombetta et al.   Expert Review of Vaccines

An overview of the regulation of influenza vaccines in the United States

(2016) Jerry P. Weir et al.   Influenza and Other Respiratory Viruses

Broadly neutralizing anti-influenza antibodies require Fc receptor engagement for in vivo protection

(2016) David J. DiLillo et al.   JOURNAL OF CLINICAL INVESTIGATION

Effects of egg-adaptation on receptor-binding and antigenic properties of recent influenza A (H3N2) vaccine viruses

(2016) Lauren Parker et al.   JOURNAL OF GENERAL VIROLOGY

Generation and Protective Ability of Influenza Virus–Specific Antibody-Dependent Cellular Cytotoxicity in Humans Elicited by Vaccination, Natural Infection, and Experimental Challenge

(2016) Sinthujan Jegaskanda et al.   JOURNAL OF INFECTIOUS DISEASES

Influenza immunization elicits antibodies specific for an egg-adapted vaccine strain

(2016) Donald D Raymond et al.   NATURE MEDICINE

The Ability of a Non-Egg Adapted (Cell-Like) A(H1N1)pdm09 Virus to Egg-Adapt at HA Loci Other than 222 and 223 and Its Effect on the Yield of Viral Protein

(2016) Carolyn Nicolson et al.   PLoS One

Systems vaccinology informs influenza vaccine immunogenicity

(2016) Adolfo García-Sastre   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Evaluation of Antihemagglutinin and Antineuraminidase Antibodies as Correlates of Protection in an Influenza A/H1N1 Virus Healthy Human Challenge Model

(2016) Matthew J. Memoli et al.   mBio

Novel universal influenza virus vaccine approaches

(2016) Florian Krammer   Current Opinion in Virology

T-Cell Immunity to Influenza in Older Adults: A Pathophysiological Framework for Development of More Effective Vaccines

(2016) Janet E. McElhaney et al.   Frontiers in Immunology

Natural T Cell–mediated Protection against Seasonal and Pandemic Influenza. Results of the Flu Watch Cohort Study

(2015) Andrew C. Hayward et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

International Laboratory Comparison of Influenza Microneutralization Assays for A(H1N1)pdm09, A(H3N2), and A(H5N1) Influenza Viruses by CONSISE

(2015) Karen L. Laurie et al.   Clinical and Vaccine Immunology

Approaches for monitoring of non virus-specific and virus-specific T-cell response in solid organ transplantation and their clinical applications

(2015) Sandra A. Calarota et al.   JOURNAL OF CLINICAL VIROLOGY

Human Influenza A Virus–Specific CD8+ T-Cell Response Is Long-lived

(2015) Carolien E. van de Sandt et al.   JOURNAL OF INFECTIOUS DISEASES

Molecular Characterisation of the Haemagglutinin Glycan-Binding Specificity of Egg-Adapted Vaccine Strains of the Pandemic 2009 H1N1 Swine Influenza A Virus

(2015) Vincenzo Carbone et al.   MOLECULES

Advances in the development of influenza virus vaccines

(2015) Florian Krammer et al.   NATURE REVIEWS DRUG DISCOVERY

Virus-specific T cells as correlate of (cross-)protective immunity against influenza

(2015) Arwen F. Altenburg et al.   VACCINE

A framework for T cell assays

(2015) Cedrik M. Britten et al.   Oncotarget

Single dose vaccination of the ASO3-adjuvanted A(H1N1)pdm09 monovalent vaccine in health care workers elicits homologous and cross-reactive cellular and humoral responses to H1N1 strains

(2015) Sarah Lartey et al.   Human Vaccines & Immunotherapeutics

Against vaccine assay secrecy

(2015) Matthew Herder et al.   Human Vaccines & Immunotherapeutics

Cell culture-based influenza vaccines: A necessary and indispensable investment for the future

(2015) Nagendra R Hegde   Human Vaccines & Immunotherapeutics

Microneutralization Assay Titres Correlate with Protection against Seasonal Influenza H1N1 and H3N2 in Children

(2015) Chris P. Verschoor et al.   PLoS One

Influenza virus-like particle vaccines made in Nicotiana benthamiana elicit durable, poly-functional and cross-reactive T cell responses to influenza HA antigens

(2014) Nathalie Landry et al.   CLINICAL IMMUNOLOGY

Association Between Antibody Titers and Protection Against Influenza Virus Infection Within Households

(2014) Tim K. Tsang et al.   JOURNAL OF INFECTIOUS DISEASES

Efficacy of High-Dose versus Standard-Dose Influenza Vaccine in Older Adults

(2014) Carlos A. DiazGranados et al.   NEW ENGLAND JOURNAL OF MEDICINE

Low 2012–13 Influenza Vaccine Effectiveness Associated with Mutation in the Egg-Adapted H3N2 Vaccine Strain Not Antigenic Drift in Circulating Viruses

(2014) Danuta M. Skowronski et al.   PLoS One

Memory CD4 T Cell-Mediated Immunity against Influenza A Virus: More than a Little Helpful

(2013) K. Kai McKinstry et al.   ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS

Egg- or cell culture-derived hemagglutinin mutations impair virus stability and antigen content of inactivated influenza vaccines

(2013) Sabine Nakowitsch et al.   Biotechnology Journal

Complex Correlates of Protection After Vaccination

(2013) S. A. Plotkin   CLINICAL INFECTIOUS DISEASES

Protective CD8 T Cell-Mediated Immunity against Influenza A Virus Infection following Influenza Virus-like Particle Vaccination

(2013) E. A. Hemann et al.   JOURNAL OF IMMUNOLOGY

Estimation of the Association Between Antibody Titers and Protection Against Confirmed Influenza Virus Infection in Children

(2013) Sophia Ng et al.   JOURNAL OF INFECTIOUS DISEASES

Cellular immune correlates of protection against symptomatic pandemic influenza

(2013) Saranya Sridhar et al.   NATURE MEDICINE

Molecular Signature of High Yield (Growth) Influenza A Virus Reassortants Prepared as Candidate Vaccine Seeds

(2013) Manojkumar Ramanunninair et al.   PLoS One

Human circulating influenza-CD4+ ICOS1+IL-21+ T cells expand after vaccination, exert helper function, and predict antibody responses

(2013) F. Spensieri et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Induction of ICOS+CXCR3+CXCR5+ TH Cells Correlates with Antibody Responses to Influenza Vaccination

(2013) S.-E. Bentebibel et al.   Science Translational Medicine

Immune Monitoring in Cancer Vaccine Clinical Trials: Critical Issues of Functional Flow Cytometry-Based Assays

(2013) Iole Macchia et al.   Biomed Research International

Relationship between haemagglutination-inhibiting antibody titres and clinical protection against influenza: development and application of a bayesian random-effects model

(2012) Laurent Coudeville et al.   BMC Medical Research Methodology

Immunological memory ≠ protective immunity

(2012) Rolf M. Zinkernagel   CELLULAR AND MOLECULAR LIFE SCIENCES

Safety and Immunogenicity of Multimeric-001—a Novel Universal Influenza Vaccine

(2012) Jacob Atsmon et al.   JOURNAL OF CLINICAL IMMUNOLOGY

Preexisting influenza-specific CD4+ T cells correlate with disease protection against influenza challenge in humans

(2012) Tom M Wilkinson et al.   NATURE MEDICINE

Immunogenicity, Safety and Reactogenicity of a Mammalian Cell-Culture–Derived Influenza Vaccine in Healthy Children and Adolescents Three to Seventeen Years of Age

(2012) Timo Vesikari et al.   PEDIATRIC INFECTIOUS DISEASE JOURNAL

Influenza viral neuraminidase: the forgotten antigen

(2011) Bert E Johansson et al.   Expert Review of Vaccines

Polyclonal Immunoglobulins and Hyperimmune Globulins in Prevention and Management of Infectious Diseases

(2011) Jennifer L. Hsu et al.   INFECTIOUS DISEASE CLINICS OF NORTH AMERICA

Limited efficacy of inactivated influenza vaccine in elderly individuals is associated with decreased production of vaccine-specific antibodies

(2011) Sanae Sasaki et al.   JOURNAL OF CLINICAL INVESTIGATION

Cross-protective immunity against influenza pH1N1 2009 viruses induced by seasonal influenza A (H3N2) virus is mediated by virus-specific T-cells

(2011) M. L. B. Hillaire et al.   JOURNAL OF GENERAL VIROLOGY

Influenza Hemagglutination-Inhibition Antibody Titer as a Correlate of Vaccine-Induced Protection

(2011) Suzanne E. Ohmit et al.   JOURNAL OF INFECTIOUS DISEASES

Hemagglutination Inhibition Antibody Titers as a Correlate of Protection for Inactivated Influenza Vaccines in Children

(2011) Steven Black et al.   PEDIATRIC INFECTIOUS DISEASE JOURNAL

Humoral and Cell-Mediated Immunity to Pandemic H1N1 Influenza in a Canadian Cohort One Year Post-Pandemic: Implications for Vaccination

(2011) Lisa E. Wagar et al.   PLoS One

Harmonization of Immune Biomarker Assays for Clinical Studies

(2011) S. H. van der Burg et al.   Science Translational Medicine

Reproducibility of serology assays for pandemic influenza H1N1: Collaborative study to evaluate a candidate WHO International Standard

(2011) John M. Wood et al.   VACCINE

Influenza vaccine responses in older adults

(2010) Janet E. McElhaney   AGEING RESEARCH REVIEWS

Clinical Efficacy of Cell Culture–Derived and Egg‐Derived Inactivated Subunit Influenza Vaccines in Healthy Adults

(2010) Sharon Frey et al.   CLINICAL INFECTIOUS DISEASES

Original Article: Highly conserved cross-reactive CD4+ T-cell HA-epitopes of seasonal and the 2009 pandemic influenza viruses

(2010) Venkata R. S. K. Duvvuri et al.   Influenza and Other Respiratory Viruses

Physiological Numbers of CD4 + T Cells Generate Weak Recall Responses Following Influenza Virus Challenge

(2010) Paul G. Thomas et al.   JOURNAL OF IMMUNOLOGY

Lung homing CTLs and their proliferation ability are important correlates of vaccine protection against influenza

(2010) Jianping Lin et al.   VACCINE

Passage in egg culture is a major cause of apparent positive selection in influenza B hemagglutinin

(2009) Derek Gatherer   JOURNAL OF MEDICAL VIROLOGY

Cross-Reactive Antibody Responses to the 2009 Pandemic H1N1 Influenza Virus

(2009) Kathy Hancock et al.   NEW ENGLAND JOURNAL OF MEDICINE

Correlation of Cellular Immune Responses with Protection against Culture-Confirmed Influenza Virus in Young Children

(2008) B. D. Forrest et al.   Clinical and Vaccine Immunology

Vaccines: Correlates of Vaccine‐Induced Immunity

(2008) Stanley A. Plotkin   CLINICAL INFECTIOUS DISEASES

Influenza virus-like particles produced by transient expression inNicotiana benthamianainduce a protective immune response against a lethal viral challenge in mice

(2008) Marc-André D’Aoust et al.   PLANT BIOTECHNOLOGY JOURNAL

Stabilizing the glycosylation pattern of influenza B hemagglutinin following adaptation to growth in eggs

(2007) Zhongying Chen et al.   VACCINE