Exploring and exploiting the connection between mitochondria and the virulence of human pathogenic fungi

Tracing Genetic Exchange and Biogeography of Cryptococcus neoformans var. grubii at the Global Population Level

(2017) Johanna Rhodes et al.   GENETICS

The ER-mitochondria encounter structure contributes to hyphal growth, mitochondrial morphology and virulence of the pathogenic mold Aspergillus fumigatus

(2017) Bernadette Geißel et al.   INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY

Iron–sulfur cluster biogenesis and trafficking in mitochondria

(2017) Joseph J. Braymer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cryptococcus neoformans Iron-Sulfur Protein Biogenesis Machinery Is a Novel Layer of Protection against Cu Stress

(2017) Sarela Garcia-Santamarina et al.   mBio

Evolutionary conservation and in vitro reconstitution of microsporidian iron–sulfur cluster biosynthesis

(2017) Sven-A. Freibert et al.   Nature Communications

Generational distribution of a Candida glabrata population: Resilient old cells prevail, while younger cells dominate in the vulnerable host

(2017) Tejas Bouklas et al.   PLoS Pathogens

Repurposing Approach Identifies Auranofin with Broad Spectrum Antifungal Activity That Targets Mia40-Erv1 Pathway

(2017) Shankar Thangamani et al.   Frontiers in Cellular and Infection Microbiology

Tracing Genetic Exchange and Biogeography of Cryptococcus neoformans var. grubii at the Global Population Level

(2017) Johanna Rhodes et al.   GENETICS

TheCandidaGenome Database (CGD): incorporation of Assembly 22, systematic identifiers and visualization of high throughput sequencing data

(2016) Marek S. Skrzypek et al.   NUCLEIC ACIDS RESEARCH

F901318 represents a novel class of antifungal drug that inhibits dihydroorotate dehydrogenase

(2016) Jason D. Oliver et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Aspergillus fumigatus Damage Resistance Protein Family Coordinately Regulates Ergosterol Biosynthesis and Azole Susceptibility

(2016) Jinxing Song et al.   mBio

Separating mitochondrial protein assembly and endoplasmic reticulum tethering by selective coupling of Mdm10

(2016) Lars Ellenrieder et al.   Nature Communications

Exploiting mitochondria as targets for the development of new antifungals

(2016) Dongmei Li et al.   Virulence

A Putative Mitochondrial Iron Transporter MrsA in Aspergillus fumigatus Plays Important Roles in Azole-, Oxidative Stress Responses and Virulence

(2016) Nanbiao Long et al.   Frontiers in Microbiology

The Zinc Finger Protein Mig1 Regulates Mitochondrial Function and Azole Drug Susceptibility in the Pathogenic Fungus Cryptococcus neoformans

(2016) Mélissa Caza et al.   mSphere

The Endoplasmic Reticulum-Mitochondrion Tether ERMES Orchestrates Fungal Immune Evasion, Illuminating Inflammasome Responses to Hyphal Signals

(2016) Timothy M. Tucey et al.   mSphere

Mitochondrial Complex I Is a Global Regulator of Secondary Metabolism, Virulence and Azole Sensitivity in Fungi

(2016) Mike Bromley et al.   PLoS One

Mechanism of Action of ME1111, a Novel Antifungal Agent for Topical Treatment of Onychomycosis

(2015) Sho Takahata et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Structure and mechanism of ATP-dependent phospholipid transporters

(2015) Rosa L. López-Marqués et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

An Essential Role of the Mitochondrial Electron Transport Chain in Cell Proliferation Is to Enable Aspartate Synthesis

(2015) Kıvanç Birsoy et al.   CELL

Sedaxane, Isopyrazam and Solatenol™: Novel Broad-spectrum Fungicides Inhibiting Succinate Dehydrogenase (SDH) – Synthesis Challenges and Biological Aspects

(2015) Harald Walter et al.   CHIMIA

Host–pathogen interactions in malaria: cross-kingdom signaling and mitochondrial regulation

(2015) Shirley Luckhart et al.   CURRENT OPINION IN IMMUNOLOGY

Compartmentalization of iron between mitochondria and the cytosol and its regulation

(2015) Ulrich Mühlenhoff et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

System-level impact of mitochondria on fungal virulence: to metabolism and beyond

(2015) Richard Calderone et al.   FEMS YEAST RESEARCH

Unisexual versus bisexual mating in Cryptococcus neoformans: Consequences and biological impacts

(2015) Ci Fu et al.   FUNGAL GENETICS AND BIOLOGY

The mitochondrial protein Mcu1 plays important roles in carbon source utilization, filamentation, and virulence in Candida albicans

(2015) Guobo Guan et al.   FUNGAL GENETICS AND BIOLOGY

Recognition of seven species in the Cryptococcus gattii/Cryptococcus neoformans species complex

(2015) Ferry Hagen et al.   FUNGAL GENETICS AND BIOLOGY

Mitochondrial fission protein MoFis1 mediates conidiation and is required for full virulence of the rice blast fungus Magnaporthe oryzae

(2015) Irshad Ali Khan et al.   MICROBIOLOGICAL RESEARCH

Mitochondrial dynamics in the pathogenic moldAspergillus fumigatus: therapeutic and evolutionary implications

(2015) Michael Neubauer et al.   MOLECULAR MICROBIOLOGY

Essential Gene Discovery in the Basidiomycete Cryptococcus neoformans for Antifungal Drug Target Prioritization

(2015) Giuseppe Ianiri et al.   mBio

Genome Evolution and Innovation across the Four Major Lineages of Cryptococcus gattii

(2015) Rhys A. Farrer et al.   mBio

The Genomic Aftermath of Hybridization in the Opportunistic Pathogen Candida metapsilosis

(2015) Leszek P. Pryszcz et al.   PLoS Genetics

Genetic Analysis Using an Isogenic Mating Pair of Aspergillus fumigatus Identifies Azole Resistance Genes and Lack of MAT Locus’s Role in Virulence

(2015) Liliana Losada et al.   PLoS Pathogens

Efficient Mitochondrial Genome Editing by CRISPR/Cas9

(2015) Areum Jo et al.   Biomed Research International

Identification of Genomic Binding Sites for Candida glabrata Pdr1 Transcription Factor in Wild-Type and ρ0Cells

(2014) Sanjoy Paul et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Mitochondrial UPR-regulated innate immunity provides resistance to pathogen infection

(2014) Mark W. Pellegrino et al.   NATURE

Unisexual Reproduction of Cryptococcus gattii

(2014) Sujal S. Phadke et al.   PLoS One

Stress-responsive regulation of mitochondria through the ER unfolded protein response

(2014) T. Kelly Rainbolt et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Phenotypic consequences ofLYS4gene disruption inCandida albicans

(2014) Iwona Gabriel et al.   YEAST

‘Division of labour’ in response to host oxidative burst drives a fatal Cryptococcus gattii outbreak

(2014) Kerstin Voelz et al.   Nature Communications

Mitochondria InfluenceCDR1Efflux Pump Activity, Hog1-Mediated Oxidative Stress Pathway, Iron Homeostasis, and Ergosterol Levels in Candida albicans

(2013) Edwina Thomas et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Highly divergent mitochondrion-related organelles in anaerobic parasitic protozoa

(2013) Takashi Makiuchi et al.   BIOCHIMIE

Cell surface changes in theCandida albicansmitochondrial mutantgoa1Δ are associated with reduced recognition by innate immune cells

(2013) Xiaodong She et al.   CELLULAR MICROBIOLOGY

Sex Determination Directs Uniparental Mitochondrial Inheritance in Phycomyces

(2013) Viplendra P. S. Shakya et al.   EUKARYOTIC CELL

The heme-binding protein Dap1 links iron homeostasis to azole resistance via the P450 protein Erg11 inCandida glabrata

(2013) Naoki Hosogaya et al.   FEMS YEAST RESEARCH

Congenic Strains for Genetic Analysis of Virulence Traits in Cryptococcus gattii

(2013) Pinkuan Zhu et al.   INFECTION AND IMMUNITY

Heme Sensor Proteins

(2013) Hazel M. Girvan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Acetolactate synthases MoIlv2 and MoIlv6 are required for infection-related morphogenesis inMagnaporthe oryzae

(2013) Yan Du et al.   MOLECULAR PLANT PATHOLOGY

A Review of Current Knowledge of Resistance Aspects for the Next-Generation Succinate Dehydrogenase Inhibitor Fungicides

(2013) Helge Sierotzki et al.   PHYTOPATHOLOGY

Old Cryptococcus neoformans Cells Contribute to Virulence in Chronic Cryptococcosis

(2013) T. Bouklas et al.   mBio

Prezygotic and Postzygotic Control of Uniparental Mitochondrial DNA Inheritance in Cryptococcus neoformans

(2013) R. Gyawali et al.   mBio

The Role of Mitochondria in Cellular Iron-Sulfur Protein Biogenesis: Mechanisms, Connected Processes, and Diseases

(2013) O. Stehling et al.   Cold Spring Harbor Perspectives in Biology

The Uve1 Endonuclease Is Regulated by the White Collar Complex to Protect Cryptococcus neoformans from UV Damage

(2013) Surbhi Verma et al.   PLoS Genetics

Transmission of Hypervirulence Traits via Sexual Reproduction within and between Lineages of the Human Fungal Pathogen Cryptococcus gattii

(2013) Kerstin Voelz et al.   PLoS Genetics

Azole Susceptibility and Transcriptome Profiling in Candida albicans Mitochondrial Electron Transport Chain Complex I Mutants

(2012) Nuo Sun et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

The ERMES complex and ER–mitochondria connections

(2012) Agnès H. Michel et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Sequencing of mitochondrial genomes of nine Aspergillus and Penicillium species identifies mobile introns and accessory genes as main sources of genome size variability

(2012) Vinita Joardar et al.   BMC GENOMICS

Mitochondrial Sorting and Assembly Machinery Subunit Sam37 in Candida albicans: Insight into the Roles of Mitochondria in Fitness, Cell Wall Integrity, and Virulence

(2012) Yue Qu et al.   EUKARYOTIC CELL

Defects in Mitochondrial and Peroxisomal β-Oxidation Influence Virulence in the Maize Pathogen Ustilago maydis

(2012) Matthias Kretschmer et al.   EUKARYOTIC CELL

Mitochondrial genome variability within the Candida parapsilosis species complex

(2012) Matus Valach et al.   MITOCHONDRION

Mitochondrial β-oxidation regulates organellar integrity and is necessary for conidial germination and invasive growth inMagnaporthe oryzae

(2012) Rajesh N. Patkar et al.   MOLECULAR MICROBIOLOGY

BRG1 and NRG1 form a novel feedback circuit regulating Candida albicans hypha formation and virulence

(2012) Ian A. Cleary et al.   MOLECULAR MICROBIOLOGY

Fungal Mitochondrial DNases: Effectors with the Potential to Activate Plant Defenses in Nonhost Resistance

(2012) Lee A. Hadwiger et al.   PHYTOPATHOLOGY

HapX-Mediated Iron Homeostasis Is Essential for Rhizosphere Competence and Virulence of the Soilborne Pathogen Fusarium oxysporum

(2012) M. S. Lopez-Berges et al.   PLANT CELL

Comparative Lipidomics in Clinical Isolates of Candida albicans Reveal Crosstalk between Mitochondria, Cell Wall Integrity and Azole Resistance

(2012) Ashutosh Singh et al.   PLoS One

A model system for mitochondrial biogenesis reveals evolutionary rewiring of protein import and membrane assembly pathways

(2012) V. L. Hewitt et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitochondrial Fission, Fusion, and Stress

(2012) R. J. Youle et al.   SCIENCE

Hidden Killers: Human Fungal Infections

(2012) G. D. Brown et al.   Science Translational Medicine

Loss of Mitochondrial Functions Associated with Azole Resistance in Candida glabrata Results in Enhanced Virulence in Mice

(2011) Sélène Ferrari et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Mitochondria and Fungal Pathogenesis: Drug Tolerance, Virulence, and Potential for Antifungal Therapy

(2011) Miguel Shingu-Vazquez et al.   EUKARYOTIC CELL

ER Tubules Mark Sites of Mitochondrial Division

(2011) J. R. Friedman et al.   SCIENCE

ER Stress and Its Functional Link to Mitochondria: Role in Cell Survival and Death

(2011) J. D. Malhotra et al.   Cold Spring Harbor Perspectives in Biology

Cytochrome P450 enzymes in the fungal kingdom

(2010) B. Črešnar et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Regulation of the CgPdr1 Transcription Factor from the Pathogen Candida glabrata

(2010) Sanjoy Paul et al.   EUKARYOTIC CELL

Candida albicans Hap43 Is a Repressor Induced under Low-Iron Conditions and Is Essential for Iron-Responsive Transcriptional Regulation and Virulence

(2010) Po-Chen Hsu et al.   EUKARYOTIC CELL

Cell wall integrity is linked to mitochondria and phospholipid homeostasis in Candida albicans through the activity of the post-transcriptional regulator Ccr4-Pop2

(2010) Michael J. Dagley et al.   MOLECULAR MICROBIOLOGY

Interactions between bacterial pathogens and mitochondrial cell death pathways

(2010) Thomas Rudel et al.   NATURE REVIEWS MICROBIOLOGY

Pathway analysis of Candida albicans survival and virulence determinants in a murine infection model

(2010) J. M. Becker et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitochondria and the regulation of hypervirulence in the fatal fungal outbreak on Vancouver Island

(2010) Hansong Ma et al.   Virulence

HapX-Mediated Adaption to Iron Starvation Is Crucial for Virulence of Aspergillus fumigatus

(2010) Markus Schrettl et al.   PLoS Pathogens

Emergence and Pathogenicity of Highly Virulent Cryptococcus gattii Genotypes in the Northwest United States

(2010) Edmond J. Byrnes et al.   PLoS Pathogens

HapX Positively and Negatively Regulates the Transcriptional Response to Iron Deprivation in Cryptococcus neoformans

(2010) Won Hee Jung et al.   PLoS Pathogens

Hypersusceptibility to Azole Antifungals in a Clinical Isolate of Candida glabrata with Reduced Aerobic Growth

(2009) P. Vandeputte et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Mitochondrial Dysfunction in Diabetes: From Molecular Mechanisms to Functional Significance and Therapeutic Opportunities

(2009) William I. Sivitz et al.   ANTIOXIDANTS & REDOX SIGNALING

Importing Mitochondrial Proteins: Machineries and Mechanisms

(2009) Agnieszka Chacinska et al.   CELL

Goa1p ofCandida albicansLocalizes to the Mitochondria during Stress and Is Required for Mitochondrial Function and Virulence

(2009) Adrienne Bambach et al.   EUKARYOTIC CELL

Promiscuous mitochondria inCryptococcus gattii

(2009) Marjan Bovers et al.   FEMS YEAST RESEARCH

The a2 mating-type-locus gene lga2 of Ustilago maydis interferes with mitochondrial dynamics and fusion, partially in dependence on a Dnm1-like fission component

(2009) M. Mahlert et al.   JOURNAL OF CELL SCIENCE

Cytocidal amino acid starvation of Saccharomyces cerevisiae and Candida albicans acetolactate synthase (ilv2 ) mutants is influenced by the carbon source and rapamycin

(2009) J. M. Kingsbury et al.   MICROBIOLOGY-SGM

Divergence, hybridization, and recombination in the mitochondrial genome of the human pathogenic yeastCryptococcus gattii

(2009) JIANPING XU et al.   MOLECULAR ECOLOGY

The fatal fungal outbreak on Vancouver Island is characterized by enhanced intracellular parasitism driven by mitochondrial regulation

(2009) H. Ma et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An ER-Mitochondria Tethering Complex Revealed by a Synthetic Biology Screen

(2009) Benoît Kornmann et al.   SCIENCE

Gain of Function Mutations in CgPDR1 of Candida glabrata Not Only Mediate Antifungal Resistance but Also Enhance Virulence

(2009) Sélène Ferrari et al.   PLoS Pathogens

Functional characterization of the CgPGS1 gene reveals a link between mitochondrial phospholipid homeostasis and drug resistance in Candida glabrata

(2008) Monika Batova et al.   CURRENT GENETICS

How Do Azoles Inhibit Cytochrome P450 Enzymes? A Density Functional Study†

(2008) Philip R. Balding et al.   JOURNAL OF PHYSICAL CHEMISTRY A

Mitochondrial haplotypes and recombination inCandida albicans

(2008) Mette D. Jacobsen et al.   MEDICAL MYCOLOGY

Evidence for the Bifunctional Nature of Mitochondrial Phosphatidylserine Decarboxylase: Role in Pdr3-Dependent Retrograde Regulation of PDR5 Expression

(2008) K. Gulshan et al.   MOLECULAR AND CELLULAR BIOLOGY

Podospora anserina: a model organism to study mechanisms of healthy ageing

(2008) Christian Q. Scheckhuber et al.   MOLECULAR GENETICS AND GENOMICS

SreA-mediated iron regulation in Aspergillus fumigatus

(2008) Markus Schrettl et al.   MOLECULAR MICROBIOLOGY

Discovery of a sexual cycle in the opportunistic fungal pathogen Aspergillus fumigatus

(2008) Céline M. O’Gorman et al.   NATURE

The Parasexual Cycle in Candida albicans Provides an Alternative Pathway to Meiosis for the Formation of Recombinant Strains

(2008) Anja Forche et al.   PLOS BIOLOGY