Exploiting mitochondria as targets for the development of new antifungals

Cell Wall N-Linked Mannoprotein Biosynthesis Requires Goa1p, a Putative Regulator of Mitochondrial Complex I in Candida albicans

(2016) Xiaodong She et al.   PLoS One

Antifungal Activities of SCY-078 (MK-3118) and Standard Antifungal Agents against Clinical Non-Aspergillus Mold Isolates

(2015) Frédéric Lamoth et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Fungal-specific subunits of theCandida albicansmitochondrial complex I drive diverse cell functions including cell wall synthesis

(2015) Xiaodong She et al.   CELLULAR MICROBIOLOGY

Functional diversity of complex I subunits in Candida albicans mitochondria

(2015) Dongmei Li et al.   CURRENT GENETICS

System-level impact of mitochondria on fungal virulence: to metabolism and beyond

(2015) Richard Calderone et al.   FEMS YEAST RESEARCH

The mitochondrial protein Mcu1 plays important roles in carbon source utilization, filamentation, and virulence in Candida albicans

(2015) Guobo Guan et al.   FUNGAL GENETICS AND BIOLOGY

Two-component phosphorelays in fungal mitochondria and beyond

(2015) Neeraj Chauhan   MITOCHONDRION

Mitochondrial dynamics in the pathogenic moldAspergillus fumigatus: therapeutic and evolutionary implications

(2015) Michael Neubauer et al.   MOLECULAR MICROBIOLOGY

Hybrid histidine kinases in pathogenic fungi

(2015) Tatiana A. Defosse et al.   MOLECULAR MICROBIOLOGY

Burden of serious fungal infections in Mexico

(2015) D. E. Corzo-León et al.   MYCOSES

How to bolster the antifungal pipeline

(2015) D. W. Denning et al.   SCIENCE

Mitochondrial Activity and Cyr1 Are Key Regulators of Ras1 Activation of C. albicans Virulence Pathways

(2015) Nora Grahl et al.   PLoS Pathogens

The evolution of drug resistance in clinical isolates of Candida albicans

(2015) Christopher B Ford et al.   eLife

The Rbf1, Hfl1 and Dbp4 of Candida albicans regulate common as well as transcription factor-specific mitochondrial and other cell activities

(2014) Kasra Khamooshi et al.   BMC GENOMICS

Novel Antifungal Mechanism of Resveratrol: Apoptosis Inducer in Candida albicans

(2014) Juneyoung Lee et al.   CURRENT MICROBIOLOGY

Antifungal drug discovery: the process and outcomes

(2014) Richard Calderone et al.   Future Microbiology

Emerging drugs and vaccines for Candidemia

(2014) Brad Moriyama et al.   MYCOSES

Mitochondria InfluenceCDR1Efflux Pump Activity, Hog1-Mediated Oxidative Stress Pathway, Iron Homeostasis, and Ergosterol Levels in Candida albicans

(2013) Edwina Thomas et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Multidrug-Resistant Transporter Mdr1p-Mediated Uptake of a Novel Antifungal Compound

(2013) Nuo Sun et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Structure–activity relationship of cytochrome bc1 reductase inhibitor broad spectrum antifungal ilicicolin H

(2013) Sheo B. Singh et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Cell surface changes in theCandida albicansmitochondrial mutantgoa1Δ are associated with reduced recognition by innate immune cells

(2013) Xiaodong She et al.   CELLULAR MICROBIOLOGY

Novel Insights into the Role of Neurospora crassa NDUFAF2, an Evolutionarily Conserved Mitochondrial Complex I Assembly Factor

(2013) B. Pereira et al.   MOLECULAR AND CELLULAR BIOLOGY

Spatial and functional organization of mitochondrial protein network

(2013) Jae-Seong Yang et al.   Scientific Reports

Inhibiting GPI Anchor Biosynthesis in Fungi Stresses the Endoplasmic Reticulum and Enhances Immunogenicity

(2012) Catherine A. McLellan et al.   ACS Chemical Biology

Azole Susceptibility and Transcriptome Profiling in Candida albicans Mitochondrial Electron Transport Chain Complex I Mutants

(2012) Nuo Sun et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Mitochondrial Sorting and Assembly Machinery Subunit Sam37 in Candida albicans: Insight into the Roles of Mitochondria in Fitness, Cell Wall Integrity, and Virulence

(2012) Yue Qu et al.   EUKARYOTIC CELL

Caloric restriction restores the chronological life span of the goa1 null mutant of Candida albicans in spite of high cell levels of ROS

(2012) Hui Chen et al.   FUNGAL GENETICS AND BIOLOGY

Hidden Killers: Human Fungal Infections

(2012) G. D. Brown et al.   Science Translational Medicine

Antifungal Drug Resistance: Mechanisms, Epidemiology, and Consequences for Treatment

(2011) Michael A. Pfaller   AMERICAN JOURNAL OF MEDICINE

E1210, a New Broad-Spectrum Antifungal, Suppresses Candida albicans Hyphal Growth through Inhibition of Glycosylphosphatidylinositol Biosynthesis

(2011) Nao-aki Watanabe et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Mitochondria and Fungal Pathogenesis: Drug Tolerance, Virulence, and Potential for Antifungal Therapy

(2011) Miguel Shingu-Vazquez et al.   EUKARYOTIC CELL

Enzymatic Dysfunction of Mitochondrial Complex I of the Candida albicansgoa1Mutant Is Associated with Increased Reactive Oxidants and Cell Death

(2011) Dongmei Li et al.   EUKARYOTIC CELL

Candida albicans SRR1 , a Putative Two-Component Response Regulator Gene, Is Required for Stress Adaptation, Morphogenesis, and Virulence

(2011) Chirayu Desai et al.   EUKARYOTIC CELL

The Subunit Composition of Mitochondrial NADH:Ubiquinone Oxidoreductase (Complex I) FromPichia pastoris

(2010) Hannah R. Bridges et al.   MOLECULAR & CELLULAR PROTEOMICS

Cell wall integrity is linked to mitochondria and phospholipid homeostasis in Candida albicans through the activity of the post-transcriptional regulator Ccr4-Pop2

(2010) Michael J. Dagley et al.   MOLECULAR MICROBIOLOGY

Pathway analysis of Candida albicans survival and virulence determinants in a murine infection model

(2010) J. M. Becker et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The respiratory complexes I from the mitochondria of twoPichiaspecies

(2009) Hannah R. Bridges et al.   BIOCHEMICAL JOURNAL

Goa1p ofCandida albicansLocalizes to the Mitochondria during Stress and Is Required for Mitochondrial Function and Virulence

(2009) Adrienne Bambach et al.   EUKARYOTIC CELL

Ilicicolin Inhibition and Binding at Center N of the Dimeric Cytochromebc1Complex Reveal Electron Transfer and Regulatory Interactions between Monomers

(2009) Raul Covian et al.   JOURNAL OF BIOLOGICAL CHEMISTRY