The pharmacological perturbation of brain zinc impairs BDNF-related signaling and the cognitive performances of young mice

Exenatide exerts cognitive effects by modulating the BDNF-TrkB neurotrophic axis in adult mice

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Neurobiology of local and intercellular BDNF signaling

(2017) Manju Sasi et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

PBT2 Rapidly Improves Cognition in Alzheimer's Disease: Additional Phase II Analyses

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Overexpression of matrix metalloproteinase-9 (MMP-9) rescues insulin-mediated impairment in the 5XFAD model of Alzheimer’s disease

(2017) Archontia Kaminari et al.   Scientific Reports

Control of spine maturation and pruning through proBDNF synthesized and released in dendrites

(2016) Lauren L. Orefice et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Autocrine BDNF–TrkB signalling within a single dendritic spine

(2016) Stephen C. Harward et al.   NATURE

Higher brainBDNFgene expression is associated with slower cognitive decline in older adults

(2016) Aron S. Buchman et al.   NEUROLOGY

Neurobiological actions by three distinct subtypes of brain-derived neurotrophic factor: Multi-ligand model of growth factor signaling

(2016) Toshiyuki Mizui et al.   PHARMACOLOGICAL RESEARCH

Altered Kv2.1 functioning promotes increased excitability in hippocampal neurons of an Alzheimer’s disease mouse model

(2016) V Frazzini et al.   Cell Death & Disease

Regulation of hippocampal synaptic plasticity by BDNF

(2015) Graciano Leal et al.   BRAIN RESEARCH

Metalloproteinases: A parade of functions in matrix biology and an outlook for the future

(2015) Suneel S. Apte et al.   MATRIX BIOLOGY

Pyruvate prevents the development of age-dependent cognitive deficits in a mouse model of Alzheimer's disease without reducing amyloid and tau pathology

(2015) Elisa Isopi et al.   NEUROBIOLOGY OF DISEASE

Metal chaperones prevent zinc-mediated cognitive decline

(2015) Paul A. Adlard et al.   NEUROBIOLOGY OF DISEASE

Clioquinol rescues Parkinsonism and dementia phenotypes of the tau knockout mouse

(2015) Peng Lei et al.   NEUROBIOLOGY OF DISEASE

Intracellular zinc is a critical intermediate in the excitotoxic cascade

(2015) Alberto Granzotto et al.   NEUROBIOLOGY OF DISEASE

Left hippocampus-amygdala complex macro- and microstructural variation is associated with BDNF plasma levels in healthy elderly individuals

(2015) Antonietta Manna et al.   Brain and Behavior

ERK5/KLF4 signaling as a common mediator of the neuroprotective effects of both nerve growth factor and hydrogen peroxide preconditioning

(2014) Chang Su et al.   AGE

Neurotrophin receptor p75NTR mediates Huntington’s disease–associated synaptic and memory dysfunction

(2014) Verónica Brito et al.   JOURNAL OF CLINICAL INVESTIGATION

Brain-derived neurotrophic factor but not vesicular zinc promotes TrkB activation within mossy fibers of mouse hippocampus in vivo

(2014) Jeffrey Helgager et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Genetic Activation of ERK5 MAP Kinase Enhances Adult Neurogenesis and Extends Hippocampus-Dependent Long-Term Memory

(2014) W. Wang et al.   JOURNAL OF NEUROSCIENCE

Zinc chelation reduces traumatic brain injury-induced neurogenesis in the subgranular zone of the hippocampal dentate gyrus

(2014) Bo Young Choi et al.   JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY

Neuroprotective role of MMP-9 overexpression in the brain of Alzheimer's 5xFAD mice

(2014) Apostolia Fragkouli et al.   NEUROBIOLOGY OF DISEASE

Zinc Dynamics and Action at Excitatory Synapses

(2014) Angela Maria Vergnano et al.   NEURON

Long-Term Memory Deficits are Associated with Elevated Synaptic ERK1/2 Activation and Reversed by mGluR5 Antagonism in an Animal Model of Autism

(2014) Ronald R Seese et al.   NEUROPSYCHOPHARMACOLOGY

Synaptically Released Matrix Metalloproteinase Activity in Control of Structural Plasticity and the Cell Surface Distribution of GluA1-AMPA Receptors

(2014) Zsuzsanna Szepesi et al.   PLoS One

Matrix metalloproteinase-9 involvement in the structural plasticity of dendritic spines

(2014) Michal Stawarski et al.   Frontiers in Neuroanatomy

proBDNF Negatively Regulates Neuronal Remodeling, Synaptic Transmission, and Synaptic Plasticity in Hippocampus

(2014) Jianmin Yang et al.   Cell Reports

The role of intracellular zinc release in aging, oxidative stress, and Alzheimer’s disease

(2014) Meghan C. McCord et al.   Frontiers in Aging Neuroscience

Form follows function: BDNF and its involvement in sculpting the function and structure of synapses

(2013) Marta Zagrebelsky et al.   NEUROPHARMACOLOGY

High Dose Zinc Supplementation Induces Hippocampal Zinc Deficiency and Memory Impairment with Inhibition of BDNF Signaling

(2013) Yang Yang et al.   PLoS One

Exenatide promotes cognitive enhancement and positive brain metabolic changes in PS1-KI mice but has no effects in 3xTg-AD animals

(2013) M Bomba et al.   Cell Death & Disease

Serum Brain-Derived Neurotrophic Factor and the Risk for Dementia

(2013) Galit Weinstein et al.   JAMA Neurology

Altered Balance of Proteolytic Isoforms of Pro-Brain-Derived Neurotrophic Factor in Autism

(2012) Kristine L.P. Garcia et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Matrix Metalloproteinase-7 Regulates Cleavage of Pro-Nerve Growth Factor and Is Neuroprotective following Kainic Acid-Induced Seizures

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Fiji: an open-source platform for biological-image analysis

(2012) Johannes Schindelin et al.   NATURE METHODS

Role of pro-brain-derived neurotrophic factor (proBDNF) to mature BDNF conversion in activity-dependent competition at developing neuromuscular synapses

(2012) H. S. Je et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Matrix Metalloproteinase-9 Contributes to Kindled Seizure Development in Pentylenetetrazole-Treated Mice by Converting Pro-BDNF to Mature BDNF in the Hippocampus

(2011) H. Mizoguchi et al.   JOURNAL OF NEUROSCIENCE

The Neurophysiology and Pathology of Brain Zinc

(2011) S. L. Sensi et al.   JOURNAL OF NEUROSCIENCE

Metal Ionophore Treatment Restores Dendritic Spine Density and Synaptic Protein Levels in a Mouse Model of Alzheimer's Disease

(2011) Paul A. Adlard et al.   PLoS One

New therapeutic targets in Alzheimer's disease: brain deregulation of calcium and zinc

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Cognitive Loss in Zinc Transporter-3 Knock-Out Mice: A Phenocopy for the Synaptic and Memory Deficits of Alzheimer's Disease?

(2010) P. A. Adlard et al.   JOURNAL OF NEUROSCIENCE

Impairment of recognition memory and hippocampal long-term potentiation after acute exposure to clioquinol

(2010) A. Takeda et al.   NEUROSCIENCE

Clioquinol Inhibits Zinc-Triggered Caspase Activation in the Hippocampal CA1 Region of a Global Ischemic Gerbil Model

(2010) Tao Wang et al.   PLoS One

Dietary zinc supplementation of 3xTg-AD mice increases BDNF levels and prevents cognitive deficits as well as mitochondrial dysfunction

(2010) C Corona et al.   Cell Death & Disease

Decreased Brain Zinc Availability Reduces Hippocampal Neurogenesis in Mice and Rats

(2009) Sang Won Suh et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

New Insights in the Biology of BDNF Synthesis and Release: Implications in CNS Function

(2009) M. E. Greenberg et al.   JOURNAL OF NEUROSCIENCE

Neuronal release of proBDNF

(2009) Jianmin Yang et al.   NATURE NEUROSCIENCE

Zinc in the physiology and pathology of the CNS

(2009) Stefano L. Sensi et al.   NATURE REVIEWS NEUROSCIENCE

Zinc-Mediated Transactivation of TrkB Potentiates the Hippocampal Mossy Fiber-CA3 Pyramid Synapse

(2009) Yang Z. Huang et al.   NEURON

Control of extracellular cleavage of ProBDNF by high frequency neuronal activity

(2009) G. Nagappan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Distinct Role of Long 3′ UTR BDNF mRNA in Spine Morphology and Synaptic Plasticity in Hippocampal Neurons

(2008) Juan Ji An et al.   CELL

Important role of matrix metalloproteinase 9 in epileptogenesis

(2008) Grzegorz M. Wilczynski et al.   JOURNAL OF CELL BIOLOGY

Safety, efficacy, and biomarker findings of PBT2 in targeting Aβ as a modifying therapy for Alzheimer's disease: a phase IIa, double-blind, randomised, placebo-controlled trial

(2008) Lars Lannfelt et al.   LANCET NEUROLOGY

Biosynthesis and processing of endogenous BDNF: CNS neurons store and secrete BDNF, not pro-BDNF

(2008) Tomoya Matsumoto et al.   NATURE NEUROSCIENCE

Rapid Restoration of Cognition in Alzheimer's Transgenic Mice with 8-Hydroxy Quinoline Analogs Is Associated with Decreased Interstitial Aβ

(2008) Paul A. Adlard et al.   NEURON

The hippocampal region of rats and mice after a single i.p. dose of clioquinol: Loss of synaptic zinc, cell death and c-Fos induction

(2008) T. Ismail et al.   NEUROSCIENCE

Zinc at glutamatergic synapses

(2008) P. Paoletti et al.   NEUROSCIENCE

Extracellular proteolysis by matrix metalloproteinase-9 drives dendritic spine enlargement and long-term potentiation coordinately

(2008) X.-b. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

BDNF is essential to promote persistence of long-term memory storage

(2008) P. Bekinschtein et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The toxicology of Clioquinol☆

(2008) X MAO et al.   TOXICOLOGY LETTERS