Article
Biochemistry & Molecular Biology
Yang Liu, Fei Wang, Zhe Li, Yanling Mu, Voon Wee Yong, Mengzhou Xue
Summary: This study found that chlorogenic acid (CGA) can provide neuroprotection in intracerebral hemorrhage (ICH) by inhibiting the expression of EMMPRIN and MMP-2/9, alleviating neuroinflammation, blood-brain barrier disruption, cell death, and brain injury.
Article
Environmental Sciences
Carlos Ramos, Rebeca Canedo-Mondragon, Carina Becerril, Georgina Gonzalez-Avila, Ana Laura Esquivel, Ana Lilia Torres-Machorro, Martha Montano
Summary: Exposure to short-term wood smoke was found to significantly increase total cells, macrophages, neutrophils, and collagen in the respiratory system of guinea pigs, leading to overexpression of pro-inflammatory cytokines, MMPs, and TIMPs in lung tissue.
Review
Medical Laboratory Technology
Hai-Yang Liao, Chao-Ming Da, Bei Liao, Hai-Hong Zhang
Summary: MMP-7 is a crucial proteolytic enzyme involved in regulating various human pathophysiological processes, especially in the occurrence and development of cancers. It could serve as a potential tumor biomarker and therapeutic target, providing new diagnostic and prognostic considerations for cancer patients.
CLINICAL BIOCHEMISTRY
(2021)
Article
Toxicology
Ali Hasanvand, Azam Hosseinzadeh, Morteza Saeedavi, Mehdi Goudarzi, Zahra Basir, Saeed Mehrzadi
Summary: This study found that tannic acid has a suppressive effect on Kainic acid-induced seizures, and it can improve epileptic symptoms by regulating oxidative stress, inflammation, and apoptosis.
HUMAN & EXPERIMENTAL TOXICOLOGY
(2022)
Article
Toxicology
Ali Hasanvand, Azam Hosseinzadeh, Morteza Saeedavi, Mehdi Goudarzi, Zahra Basir, Saeed Mehrzadi
Summary: Tannic acid (TA) was found to significantly increase seizure latency and decrease seizure duration and activity in KA-induced seizures in mice. The effects were associated with the reduction of oxidative stress, inflammation, and apoptosis. Additionally, TA treatment improved KA-induced pyramidal cell loss and changes in the CA1 molecular layer arrangement.
HUMAN & EXPERIMENTAL TOXICOLOGY
(2022)
Article
Cell Biology
Jingya Guo, Yong Liang, Diyuan Xue, Jiao Shen, Yueqi Cai, Jiankun Zhu, Yang-Xin Fu, Hua Peng
Summary: A next-generation IL-15 cytokine has been developed in this study, which can be activated inside the tumor microenvironment without causing systemic toxicity by avoiding peripheral expansion of NK and T cells. The anti-tumor effect of pro-IL-15 depends on intratumoral CD8(+) T cells and IFN-gamma, and it helps overcome immune checkpoint blockade resistance and synergizes with current targeted-therapy. This novel IL-15 cytokine shows potent anti-tumor activity while minimizing severe toxicity.
Article
Endocrinology & Metabolism
Christoph Klenk, Leif Hommers, Martin J. Lohse
Summary: This study reveals that the extracellular domain of PTH1R is cleaved by metalloproteinases, leading to impaired stability of the receptor. The cleavage site is located in the first loop of the extracellular domain. A receptor mutant resistant to proteolytic cleavage showed reduced signaling to G(s) and increased activation of G(q).
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Environmental Sciences
Ayibaota Bahabayi, Nan Yang, Tong Xu, Yuting Xue, Lijuan Ma, Xunke Gu, Yongqing Wang, Keke Jia
Summary: This study analyzed the serum levels of MMP-2, -7, and -9 in normal pregnant women and pre-eclampsia patients. The results showed that MMP-2 and MMP-7 levels were significantly higher in the pre-eclampsia group, while MMP-9 levels increased in the first trimester and after the onset of pre-eclampsia but decreased in the second and third trimesters. ROC curve analysis indicated that MMP-9, MMP-2, and MMP-7 were the best predictors of pre-eclampsia in the first, second, and third trimesters, respectively.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Chemistry, Medicinal
Damiano Rocchi, Cristina Blazquez-Barbadillo, Mariangela Agamennone, Antonio Laghezza, Paolo Tortorella, David Vicente-Zurdo, Noelia Rosales-Conrado, Paula Moyano, Javier del Pino, Juan F. Gonzalez, J. Carlos Menendez
Summary: Matrix metalloproteinases (MMPs) play a key role in neuroinflammatory events and brain damage associated with stroke. The study revealed a new compound with inhibitory effects on MMPs and potential neuroprotective activity against oxidative stress, providing a promising lead for future drug development. The compounds showed some selectivity for specific MMP enzymes and a noncompetitive inhibition mechanism was observed.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Immunology
Jennifer Vandooren, Rafaela Vaz Sousa Pereira, Estefania Ugarte-Berzal, Vasily Rybakin, Sam Noppen, Melissa R. Stas, Eline Bernaerts, Eva Ganseman, Mieke Metzemaekers, Dominique Schols, Paul Proost, Ghislain Opdenakker
Summary: Interleukin 7 (IL-7) plays a crucial role in T cell development, cancer, and autoimmune diseases. Abnormalities in IL-7 signaling are associated with T cell acute lymphoblastic leukemia (T-ALL) and involve interactions with matrix metalloproteinase-9 (MMP-9).
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Pathology
Hanna Hametoja, Antti Makitie, Leif Back, Ilmo Leivo, Caj Haglund, Timo Sorsa, Jaana Hagstrom
Summary: In this study on adenoid cystic carcinoma (ACC), the expression of MMP-9 in pseudocysts and peritumoural inflammatory cells was found to be associated with better survival and fewer treatment failures. High tumoural MMP-7 and-25 were linked to better survival, while high tumoural MMP-15 was associated with poorer survival and high tumoural MMP-9 with advanced stage and regional recurrences. Tumour cells did not show MMP-8 immunopositivity. These results suggest potential roles for MMPs in ACC carcinogenesis and prognosis.
PATHOLOGY RESEARCH AND PRACTICE
(2021)
Article
Dentistry, Oral Surgery & Medicine
Yujia Cui, Jing Xie, Linyi Cai, Demao Zhang, Jianxun Sun, Xuedong Zhou
Summary: This study suggests that berberine repairs bone destruction caused by apical periodontics by reducing osteoclast activity, promoting osteoblast differentiation, and inhibiting inflammatory response.
Article
Cell Biology
Aleksandra Maksimova, Ekaterina Shevela, Lyudmila Sakhno, Marina Tikhonova, Aleksandr Ostanin, Elena Chernykh
Summary: Apoptosis and removal of dead cells are important for wound healing. Macrophages play a role in phagocytosis and resolving inflammation. However, their involvement in fibrogenesis and its mechanisms are still unclear.
Article
Medicine, Research & Experimental
Cai-Mei Zheng, Kuo-Cheng Lu, Yi-Jie Chen, Chia-Yi Li, Yu-Hsuan Lee, Hui-Wen Chiu
Summary: This study identified the role of MMP7 in the progression of chronic kidney disease (CKD). MMP7 was found to be upregulated in kidney tissues of CKD patients and its overexpression activated inflammasomes and increased fibrosis-related proteins. MMP7 also inhibited apoptosis and induced autophagy. The inhibition of MMP7 decreased fibrosis and inflammasomes and induced autophagy in kidney tissues. These findings suggest that targeting MMP7 could be a therapeutic strategy for CKD.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Biophysics
Qiong Hu, Luofeng Su, Yan Mao, Shiyu Gan, Yu Bao, Dongdong Qin, Wei Wang, Yuwei Zhang, Li Niu
Summary: A novel electrochemical sensor is presented for highly specific interrogation of MMP activities at ultralow levels. The sensor is highly selective with a detection limit as low as 0.27 pg mL(-1) and a linear range from 1 pg mL(-1) to 1 ng mL(-1). Its applicability in complex serum samples and screening of MMP inhibitors is satisfactory, showing great promise in drug discovery and disease diagnosis.
BIOSENSORS & BIOELECTRONICS
(2021)