Article
Biotechnology & Applied Microbiology
Caroline R. Garcia, Armin T. Rad, Farnoosh Saeedinejad, Arvind Manojkumar, Deepa Roy, Hansapani Rodrigo, Sue Anne Chew, Ziyaur Rahman, Mu-Ping Nieh, Upal Roy
Summary: This study investigated the safety and extended release of a combination antiretroviral therapy drug (tenofovir)-loaded nanodiscs for HIV-1 treatment in the brain. The results showed that the nanodiscs entrapped the drug in their interior and released it in a controlled manner at the desired location.
Article
Biophysics
Divya Soundararajan, Lakshmi Narashimhan Ramana, Prakash Shankaran, Uma Maheswari Krishnan
Summary: Nanotechnology-based interventions have the potential to improve the therapeutic efficacy of antiretroviral drugs for HIV infections. The use of nanocarriers for drug delivery is gaining momentum, offering the possibility to overcome some of the disadvantages associated with conventional drugs.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2022)
Review
Chemistry, Multidisciplinary
Santosh Bashyal, Chhitij Thapa, Sangkil Lee
Summary: This article provides an overview of recent exosome-based drug delivery nanoplatforms and discusses the potential of using exosomes as drug delivery vehicles for treating brain diseases. Exosomes possess advantages such as barrier penetration, targeting capability, and stability, but also face challenges that need to be addressed through future research efforts.
JOURNAL OF CONTROLLED RELEASE
(2022)
Review
Chemistry, Analytical
Goutam Pramanik, Soumabha Bag, Sabyasachi Chakrabortty
Summary: The interest in utilizing nanodiamonds as nanotheranostics has been growing rapidly due to their unique properties, such as high refractive index, low toxicity, inertness, and magneto-optical properties. Current research focuses on the combination of diagnostics/imaging and therapy using nanodiamonds, with an emphasis on surface engineering for bioactive interactions. Customized nanodiamonds with diagnostic and therapeutic features hold great potential for advancing personalized medicine.
Article
Chemistry, Multidisciplinary
Lili Ren, Lirong Qiu, Binbin Huang, Jun Yin, Yaning Li, Xiaolong Yang, Guoguang Chen
Summary: The simple and functional modification of nanoparticle surfaces is used for efficient delivery of chemotherapeutic drugs for cancer treatment. Constructing a nanocrystalline drug delivery system with doxorubicin wrapped in red blood cell membranes shows superior properties compared to traditional free drug treatments, providing a promising foundation for further development and clinical trials of anti-cancer drug nanocarriers in the future.
Article
Chemistry, Multidisciplinary
Jun-Yong Wu, Yong-Jiang Li, Xiong-Bin Hu, Si Huang, Shilin Luo, Tiantian Tang, Da-Xiong Xiang
Summary: The study compared Exos and BNVs for brain tumor drug delivery, finding that BNVs derived from brain-derived endothelial cells are a promising alternative with higher yield and similar drug-loading capacity to natural exosomes. Despite different mechanisms, BNV/DOX showed similar therapeutic effects to Exo/DOX in inhibiting the progression of glioblastoma, with minimal systemic toxicity. The findings suggest that autologous BNVs are an effective alternative to Exos for brain tumor nanomedicine.
JOURNAL OF CONTROLLED RELEASE
(2021)
Review
Pharmacology & Pharmacy
Anna Froelich, Tomasz Osmalek, Barbara Jadach, Vinam Puri, Bozena Michniak-Kohn
Summary: Nose-to-brain drug delivery has gained significant attention as a route to deliver drugs directly to the central nervous system, bypassing the blood-brain barrier. Challenges include the small volume of the nasal cavity and limited drug absorption, which can be addressed by using drug carriers to enhance delivery efficiency.
Review
Pharmacology & Pharmacy
Amir Barzegar Behrooz, Zahra Talaie, Amir Syahir
Summary: Aggressive glioblastoma (GBM) is a primary brain tumor with no known treatment. However, drug delivery based on nanotechnology holds the potential to address the challenges of treating GBM. Combination therapies have shown better efficacy in GBM treatment, and nanotechnology can enhance the effectiveness of combination treatments.
Article
Pharmacology & Pharmacy
Siaka Fadera, Chinwendu Chukwu, Andrew H. Stark, Yimei Yue, Lu Xu, Chih-Yen Chien, Jinyun Yuan, Hong Chen
Summary: This study demonstrates the potential of focused ultrasound combined with microbubble-mediated blood-brain barrier opening as a safe and effective method for delivering immune checkpoint inhibitors to brain tumor cells in large animal models.
Article
Pharmacology & Pharmacy
Jiangtao Wu, Xiangbin Du, Dongmei Zhang, Jicheng Cui, Xiaoxia Zhang, Xine Duan, John F. Trant, Yingqi Li
Summary: This study developed a dual-gated folate-functionalized nanodiamond drug delivery system that selectively delivers drugs to cancer cells, reducing side effects. The system has activatable fluorescence and cytotoxicity and releases drugs through high levels of glutathione.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Chemistry, Multidisciplinary
Hoi Man Leung, Hoi Ching Chu, Zheng-Wei Mao, Pik Kwan Lo
Summary: Nanodiamonds are carbon-based nanoparticles in nanomedicine that have gained attention for their unique features including versatility, opto-magnetic properties, stability, low cytotoxicity, affinity to biomolecules, and biocompatibility. This article discusses the opto-magnetic properties of negatively charged nitrogen vacancy (NV-) centers in nanodiamonds as fluorescence probes. It also explores the chemical methods for surface modification of nanodiamonds relevant to biomedical applications and highlights their biocompatibility. Furthermore, it provides an overview of recent biomedical applications of nanodiamonds as tools for bioimaging, targeting nanocarriers, and various therapies.
CHEMICAL COMMUNICATIONS
(2023)
Article
Biophysics
Marwa H. Abdallah, Amr S. Abu Lila, Rahamat Unissa, Heba S. Elsewedy, Hanaa A. Elghamry, Mahmoud S. Soliman
Summary: This study aimed to formulate and evaluate a nanoemulgel formulation of Brucine for enhanced topical anti-inflammatory and anti-nociceptive activities. The nanoemulgel showed higher drug release and skin permeation, efficiently inhibiting inflammation and pain.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2021)
Article
Pharmacology & Pharmacy
Ghazal Naseri Kouzehgarani, Pankaj Kumar, Susan E. Bolin, Edward B. Reilly, Didier R. Lefebvre
Summary: Cerebrospinal fluid (CSF) microcirculation is the flow of CSF through the brain or spinal parenchyma. This study demonstrates that ABT-806, a specific antibody, can reach different layers of the brain through CSF circulation, highlighting the potential of using CSF circulation as a drug delivery system. This finding offers hope for the treatment of brain diseases.
Article
Chemistry, Multidisciplinary
Songhang Li, Yuhao Liu, Tao Zhang, Shiyu Lin, Sirong Shi, Jiajun He, Yu Xie, Xiaoxiao Cai, Taoran Tian, Yunfeng Lin
Summary: MicroRNA-based therapy shows great potential, but its biomedical functionality is limited by structural challenges. A novel bioswitchable miR inhibitor delivery system (BiRDS) is designed using a tetrahedral framework DNA (tFNA) as a vehicle to maximize miR inhibitor loading capacity and improve delivery efficacy.
ADVANCED MATERIALS
(2022)
Article
Medicine, Research & Experimental
Aleksandra Krajcer, Ewelina Grzywna, Joanna Lewandowska-Lancucka
Summary: This article discusses the treatment of glioblastoma (GBL). Current chemotherapy methods have been shown to prolong overall survival, but the serious side effects and limited effectiveness call for the exploration of novel treatments and innovative drug formulations to improve efficacy and reduce side effects.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Chemistry, Multidisciplinary
Kaige Shi, Logesh Mathivathanan, Vadym A. Drozd, Raphael G. Raptis
CRYSTAL GROWTH & DESIGN
(2019)
Article
Nanoscience & Nanotechnology
Shah Najiba, Stephen J. Juhl, Manik Mandal, Cong Liu, Andriy Durygin, Jiuhua Chen, Yingwei Fei, Nasim Alem, Kai Landskron
SCRIPTA MATERIALIA
(2019)
Article
Chemistry, Physical
Hooman Sabarou, Vadym Drozd, Osama Awadallah, Andriy Durygin, Shadi Darvish, Dehua Huang, Yu Zhong
JOURNAL OF ALLOYS AND COMPOUNDS
(2019)
Review
Immunology
Roberto De La Garza, Hansapani Rodrigo, Francisco Fernandez, Upal Roy
CURRENT HIV RESEARCH
(2019)
Article
Biotechnology & Applied Microbiology
Arti Vashist, Venkata Atluri, Andrea Raymond, Ajeet Kaushik, Tiyash Parira, Zaohua Huang, Andriy Durygin, Asahi Tomitaka, Roozbeh Nikkhah-Moshaiel, Atul Vashist, Marisela Agudelo, Hitendra S. Chand, Ilyas Saytashev, Jessica C. Ramella-Roman, Madhavan Nair
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2020)
Article
Engineering, Chemical
Eduin Yesid Mora Mendoza, Armando Sarmiento Santos, Enrique Vera Lopez, Vadym Drozd, Andriy Durygin, Jiuhua Chen, Surendra K. Saxena
Summary: The kinetics of synthetic siderite decomposition under room temperature conditions were studied, showing the influence of water and air atmosphere in the formation of magnetite and hematite.
BRAZILIAN JOURNAL OF CHEMICAL ENGINEERING
(2021)
Article
Materials Science, Ceramics
Jose Belisario, Santanu Mondal, Iman Khakpour, Alexander Franco Hernandez, Andriy Durygin, Zhe Cheng
Summary: (Hf1-xZrx)B-2 solid solution powders were synthesized by two methods, characterized, sintered into ceramics, and their properties were studied. The influence of different parameters on product characteristics was examined, and implications of the study were discussed for future research.directions.
JOURNAL OF THE EUROPEAN CERAMIC SOCIETY
(2021)
Article
Materials Science, Multidisciplinary
Paniz Foroughi, Andriy Durygin, Shichen Sun, Zhe Cheng
Summary: This study demonstrates the flash sintering of single-phase Ta0.5Hf0.5B2 solid solution powder. The effects of limiting current density on microstructure and hardness of the flash-sintered samples were investigated. Higher limiting current density, deagglomerated powders, higher applied pressure, and better thermal insulation should be considered for future studies to achieve full densification of high-temperature ceramics using flash sintering.
JOURNAL OF MATERIALS RESEARCH
(2022)
Article
Materials Science, Ceramics
Suprabha Das, Diego Dubois, Md Shariful Islam Sozal, Yusuf Emirov, Borzooye Jafarizadeh, Chunlei Wang, Vadym Drozd, Andriy Durygin, Zhe Cheng
Summary: This study successfully synthesized ZrN powder via a urea route and sintered it into near fully dense single-phase ceramics using a flash sintering setup. The effects of processing parameters on the synthesis method were investigated.
JOURNAL OF THE AMERICAN CERAMIC SOCIETY
(2022)
Review
Biochemistry & Molecular Biology
Nagesh Kolishetti, Arti Vashist, Adriana Yndart Arias, Venkata Atluri, Shanta Dhar, Madhavan Nair
Summary: Magneto-electric nanomaterials with core-shell architecture have emerged as promising tools in biomedical fields, offering controlled on-demand cargo transport and release. They show coupling of magnetic and electric properties and have been successfully utilized for therapeutic delivery, sensing, and neuromodulation.
MOLECULAR ASPECTS OF MEDICINE
(2022)
Article
Chemistry, Physical
Md Shariful Islam Sozal, Wei Tang, Suprabha Das, Wenhao Li, Andriy Durygin, Vadym Drozd, Cheng Zhang, Borzooye Jafarizadeh, Chunlei Wang, Arvind Agarwal, Dong Ding, Zhe Cheng
Summary: PNC exhibits good electrical conductivity and stability at high temperatures, but it shows significant poisoning from H2O and CO2 in symmetric cells with the specific electrolyte BZCYYb4411. In contrast, PNC does not suffer from H2O and CO2 poisoning in symmetric cells with GDC electrolyte.
INTERNATIONAL JOURNAL OF HYDROGEN ENERGY
(2022)
Proceedings Paper
Engineering, Electrical & Electronic
Omena Okpowe, Andriy Durygin, Vadym Drozd, Temitayo Olowu, Nezih Pala, Chunlei Wang
Summary: "This paper describes a modeling work on gradient refractive index (GRIN) lenses fabricated from a mixture of photocurable hydroxyethyl methacrylate and epoxy prepolymer resins, with simulations showing measurable and tunable optical properties."
2021 ANNUAL CONFERENCE OF THE IEEE PHOTONICS SOCIETY (IPC)
(2021)
Article
Engineering, Electrical & Electronic
Osama Awadallah, Andriy Durygin, Zhe Cheng
Summary: Understanding the reaction process governing the formation of CZTS films and growth of secondary sulfide phases at different temperatures is important for optimizing the process. The study showed that at intermediate temperature no binary or ternary sulfide phases were formed, while at lower temperature simple sulfides like Cu2-xS and SnS2 were formed.
JOURNAL OF ELECTRONIC MATERIALS
(2021)
Article
Materials Science, Multidisciplinary
Francy Mayoli Casallas Caicedo, Enrique Vera Lopez, Arvind Agarwal, Vadym Drozd, Andriy Durygin, Alexander Franco Hernandez, Chunlei Wang
DIAMOND AND RELATED MATERIALS
(2020)