Review
Biochemistry & Molecular Biology
Klaudia Krzyzaniak, Robert Krion, Aleksandra Szymczyk, Ewelina Stepniewska, Mariusz Sieminski
Summary: Sepsis is a life-threatening condition triggered by an inflammatory response to infection, leading to multi-organ failure. Sepsis-associated encephalopathy (SAE) is a common complication of sepsis, causing acute cognitive and consciousness disorders without specific diagnostic criteria. The mechanisms of SAE involve neuroinflammation, blood-brain barrier disruption, altered cerebral microcirculation, neurotransmission changes, calcium homeostasis alterations, and oxidative stress. This review discusses substances with neuroprotective properties and their potential in treating SAE, providing valuable insights for clinicians and researchers in sepsis and SAE.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Clinical Neurology
Yihao Chen, Yan Hu, Xufeng Li, Peiling Chen, Chun Wang, Jing Wang, Jiaxing Wu, Yueyu Sun, Guilang Zheng, Yiyun Lu, Yuxiong Guo
Summary: This study retrospectively analyzed the data of children with sepsis and found a high incidence and poor prognosis of sepsis-associated encephalopathy (SAE) in children. Significant differences were observed between the SAE and non-SAE groups in various indicators, and several risk factors and protective factors for SAE in pediatric patients were identified.
FRONTIERS IN NEUROLOGY
(2022)
Article
Mathematical & Computational Biology
Lina Zhao, Yunying Wang, Zengzheng Ge, Huadong Zhu, Yi Li
Summary: The study developed a machine learning model for predicting sepsis-associated encephalopathy (SAE) with satisfactory performance. The nomogram showed good discrimination and clinical utility in individualized prediction, aiding in early detection and management of SAE.
FRONTIERS IN COMPUTATIONAL NEUROSCIENCE
(2021)
Article
Microbiology
Heng Fang, Yirong Wang, Jia Deng, Huidan Zhang, Qingrui Wu, Linling He, Jing Xu, Xin Shao, Xin Ouyang, Zhimei He, Qiuping Zhou, Huifang Wang, Yiyu Deng, Chunbo Chen
Summary: The gut microbiota plays a crucial role in the development of sepsis-associated encephalopathy (SAE). The disruption of gut microbiota is more severe in SAE-susceptible mice compared to SAE-resistant mice. Microbially derived compound, indole-3-propionic acid (IPA), is found to be enriched in SAE-resistant mice and can alleviate SAE symptoms. The protective effect of IPA may be mediated through the inhibition of NLRP3 inflammasome activation and IL-1 beta secretion in microglia.
Article
Multidisciplinary Sciences
Xiao Lu, Hongyu Kang, Dawei Zhou, Qin Li
Summary: This study aimed to develop interpretable machine learning models to predict the occurrence of Sepsis-associated encephalopathy (SAE) after ICU admission and quantitative evaluation of the model interpretability by professional physicians. The study found significant differences in the incidence of SAE among patients with pathogen infection, as well as significant differences in physical indicators and laboratory results. The optimal classification model identified important risk factors for predicting SAE, including creatinine, respiratory rate, and age.
SCIENTIFIC REPORTS
(2022)
Article
Medicine, General & Internal
Naoki Moriyama, Masafumi Saito, Yuko Ono, Kimihiro Yamashita, Takashi Aoi, Joji Kotani
Summary: Gammadelta T cells expressing CCR6(+)CXCR6(+)IL-17 were found in the brains and meninges, and were found to exacerbate sepsis-associated encephalopathy and sepsis-induced psychological disorders in mice.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Immunology
Jiaming Liu, Yangjie Jin, Yanglie Ye, Yahui Tang, Shanshan Dai, Mengfang Li, Guangju Zhao, Guangliang Hong, Zhong-Qiu Lu
Summary: The study found that SCFAs significantly alleviated behavioral impairments and neuronal degeneration in SAE mice, reduced levels of IL-1 beta and IL-6 in the brain, and modulated the expressions of TJ proteins, inflammatory factors, and phosphorylation of specific proteins in the brain, indicating a neuroprotective effect of SCFAs against SAE in mice.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Neurosciences
Rebeca Osca-Verdegal, Jesus Beltran-Garcia, Federico V. Pallardo, Jose Luis Garcia-Gimenez
Summary: Sepsis-associated encephalopathy is a common neurological complication in septic patients, but its diagnosis remains challenging. miRNAs have shown potential as biomarkers for improving diagnosis and prognosis in SAE.
MOLECULAR NEUROBIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Mariusz Sieminski, Karolina Szaruta-Raflesz, Jacek Szypenbejl, Klaudia Krzyzaniak
Summary: Sepsis-associated encephalopathy (SAE) is a brain injury caused by a dysregulated host response to infection, which can lead to various clinical symptoms and chronic cognitive dysfunction. Melatonin, with its anti-inflammatory and antioxidant properties, is considered a potential therapeutic factor in SAE, as it may exert a neuroprotective effect.
Article
Immunology
Yun Li, Lina Zhao, Yang Yu, Kai Zhang, Yi Jiang, Zhiwei Wang, Keliang Xie, Yonghao Yu
Summary: This study examined the relationship between oxygen therapy and SAE patients. The results showed that conservative oxygen therapy should be maintained in SAE patients in the ICU, including the perioperative period, with a target range of SPO2 ≥ 93%, PaO2 (97-339) mmHg, and PaO2/FiO(2) (189-619).
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Plant Sciences
Shao-Peng Lin, Lidong Zhu, Hongjian Shi, Shan Ye, Qi Li, Xiaofang Yin, Qiangda Xie, Qizhong Xu, Jue-Xian Wei, Fen Mei, Yongcheng Zhu, Pei-Yi Lin, Xiao-Hui Chen
Summary: This study demonstrates that puerarin can reduce the production of inflammatory cytokines in the peripheral blood and improve sepsis-associated cognitive impairment in mice. Puerarin also inhibits the release of inflammatory cytokines from microglia, thereby preventing neuronal cell death. Network pharmacology analysis identifies AKT1 as a potential therapeutic target for puerarin in sepsis-associated encephalopathy treatment.
Article
Immunology
Lina Zhao, Yu Song, Ying Zhang, Haiying Liu, Yuehao Shen, Yan Fan, Yun Li, Keliang Xie
Summary: This study explores the role of the HIF-1a/BNIP3L signaling pathway in Sepsis Associated Encephalopathy (SAE). The results show that HIF-1a and BNIP3L promote mitochondrial damage, neuronal apoptosis, and the expression of inflammatory factors, which may be the mechanisms of SAE in critically ill patients and the perioperative period.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Bin Mei, Jun Li, Zhiyi Zuo
Summary: Sepsis-associated encephalopathy (SAE) is a significant clinical issue associated with increased mortality and healthcare costs. Dexmedetomidine, an alpha 2 adrenoceptor agonist, has been shown to induce neuroprotection in septic mice by reducing systemic inflammation, neuroinflammation, blood-brain barrier injury, and cognitive dysfunction, possibly through activation of alpha 2A adrenoceptors in astrocytes.
BRAIN BEHAVIOR AND IMMUNITY
(2021)
Article
Neurosciences
Anderson Velasque Catarina, Gisele Branchini, Lais Bettoni, Jarbas Rodrigues De Oliveira, Fernanda Bordignon Nunes
Summary: Sepsis, a major cause of morbidity and mortality in ICUs worldwide, can lead to severe brain injuries. Sepsis-associated encephalopathy is primarily caused by inflammatory and oxidative processes, with damage to the blood-brain barrier playing a significant role. Further studies and experimental advancements are crucial for understanding the complex pathophysiology of SAE and developing effective treatments and therapies.
MOLECULAR NEUROBIOLOGY
(2021)
Article
Health Care Sciences & Services
Lina Zhao, Bin Liu, Yunying Wang, Zhiwei Wang, Keliang Xie, Yun Li
Summary: Hemodynamic indicators are associated with Sepsis-associated encephalopathy (SAE). Maintaining certain levels of hemodynamic indicators can reduce the incidence and mortality of SAE.
JOURNAL OF PERSONALIZED MEDICINE
(2022)