Sepsis-Induced Gut Dysbiosis Mediates the Susceptibility to Sepsis-Associated Encephalopathy in Mice

Rapid gut dysbiosis induced by stroke exacerbates brain infarction in turn

(2021) Kaiyu Xu et al.   GUT

Therapeutic Methods for Gut Microbiota Modification in Lipopolysaccharide-Associated Encephalopathy

(2021) Suyan Li et al.   SHOCK

Aberrant gut-microbiota-immune-brain axis development in premature neonates with brain damage

(2021) David Seki et al.   Cell Host & Microbe

Systemic inflammation induced the delayed reduction of excitatory synapses in the CA3 during ageing

(2021) Tatsuya Manabe et al.   JOURNAL OF NEUROCHEMISTRY

NU9056, a KAT 5 Inhibitor, Treatment Alleviates Brain Dysfunction by Inhibiting NLRP3 Inflammasome Activation, Affecting Gut Microbiota, and Derived Metabolites in LPS-Treated Mice

(2021) Lu Chen et al.   Frontiers in Nutrition

Surviving sepsis campaign: international guidelines for management of sepsis and septic shock 2021

(2021) Laura Evans et al.   INTENSIVE CARE MEDICINE

Indole-3-Propionic Acid, a Functional Metabolite of Clostridium sporogenes, Promotes Muscle Tissue Development and Reduces Muscle Cell Inflammation

(2021) Lei Du et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Melatonin Reduces Neuroinflammation and Improves Axonal Hypomyelination by Modulating M1/M2 Microglia Polarization via JAK2-STAT3-Telomerase Pathway in Postnatal Rats Exposed to Lipopolysaccharide

(2021) Qiuping Zhou et al.   MOLECULAR NEUROBIOLOGY

The role of microbiota-gut-brain axis in neuropsychiatric and neurological disorders

(2021) Katarzyna Socała et al.   PHARMACOLOGICAL RESEARCH

Gut microbiota profiles in critically ill patients, potential biomarkers and risk variables for sepsis

(2020) Gloria M. Agudelo-Ochoa et al.   Gut Microbes

Gut microbiota-derived indole 3-propionic acid protects against radiation toxicity via retaining acyl-CoA-binding protein

(2020) Hui-wen Xiao et al.   Microbiome

Ethyl pyruvate protects against sepsis-associated encephalopathy through inhibiting the NLRP3 inflammasome

(2020) Xiaoli Zhong et al.   MOLECULAR MEDICINE

Probiotics Exert Protective Effect against Sepsis-Induced Cognitive Impairment by Reversing Gut Microbiota Abnormalities

(2020) Jiaming Liu et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Polyphenol Microbial Metabolites Exhibit Gut and Blood–Brain Barrier Permeability and Protect Murine Microglia against LPS-Induced Inflammation

(2019) Shelby L. Johnson et al.   Metabolites

Enteric dysbiosis is associated with sepsis in patients

(2019) Zhanguo Liu et al.   FASEB JOURNAL

The Microbiota-Gut-Brain Axis

(2019) John F. Cryan et al.   PHYSIOLOGICAL REVIEWS

Microglial control of astrocytes in response to microbial metabolites

(2018) Veit Rothhammer et al.   NATURE

Sepsis-associated encephalopathy

(2018) Dario-Lucas Helbing et al.   CANADIAN MEDICAL ASSOCIATION JOURNAL

Intestinal microbiota mediates the susceptibility to polymicrobial sepsis-induced liver injury by granisetron generation in mice

(2018) Shenhai Gong et al.   HEPATOLOGY

NLRP3/Caspase-1 Pathway-Induced Pyroptosis Mediated Cognitive Deficits in a Mouse Model of Sepsis-Associated Encephalopathy

(2018) Qun Fu et al.   INFLAMMATION

Inhibiting antibiotic-resistant Enterobacteriaceae by microbiota-mediated intracellular acidification

(2018) Matthew T. Sorbara et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Potentially modifiable factors contributing to sepsis-associated encephalopathy

(2017) Romain Sonneville et al.   INTENSIVE CARE MEDICINE

Characterization of Sepsis and Sepsis-Associated Encephalopathy

(2017) Qing Feng et al.   JOURNAL OF INTENSIVE CARE MEDICINE

Progress in Drug Treatment of Cerebral Edema

(2016) Y. Y. Deng et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Type I interferons and microbial metabolites of tryptophan modulate astrocyte activity and central nervous system inflammation via the aryl hydrocarbon receptor

(2016) Veit Rothhammer et al.   NATURE MEDICINE

Extreme Dysbiosis of the Microbiome in Critical Illness

(2016) Daniel McDonald et al.   mSphere

Systemic inflammation and multiple organ injury in traumatic hemorrhagic shock

(2015) Mingshi Yang   Frontiers in Bioscience-Landmark

Aryl hydrocarbon receptor negatively regulates NLRP3 inflammasome activity by inhibiting NLRP3 transcription

(2014) Wanwan Huai et al.   Nature Communications

Calming the cytokine storm

(2010) Charlotte Harrison   NATURE REVIEWS DRUG DISCOVERY

Indole-3-propionic acid attenuates neuronal damage and oxidative stress in the ischemic hippocampus

(2009) In Koo Hwang et al.   JOURNAL OF NEUROSCIENCE RESEARCH