Article
Chemistry, Physical
Mariafrancesca Cascione, Loris Rizzello, Daniela Manno, Antonio Serra, Valeria De Matteis
Summary: The use of silver nanoparticles in the biomedical field requires careful analysis of their potential inflammatory response. This study compares the effects of two different synthesis routes, traditional and green, on the activation of inflammation pathways. The results show that green silver nanoparticles are better tolerated by macrophages and exhibit similar antitumor activity as conventional nanoparticles.
Article
Engineering, Biomedical
Dongjian Han, Fuhang Wang, Zhentao Qiao, Bo Wang, Yi Zhang, Qingjiao Jiang, Miaomiao Liu, Yuansong Zhuang, Quanxu An, Yan Bai, Jiahong Shangguan, Jinying Zhang, Gaofeng Liang, Deliang Shen
Summary: Acute myocardial infarction (AMI) triggers an inflammation response, leading to heart cell damage and adverse cardiac remodeling. Interleukin-5 (IL-5) plays a crucial role in developing eosinophils (EOS) and has proangiogenic properties for tissue healing. This study successfully synthesized a biomimetic IL-5 nanoparticle by camouflaging it in a neutrophilic membrane. Administration of these nanoparticles in an in vivo model promoted EOS accumulation, angiogenesis, and limited adverse cardiac remodeling after AMI. The nanoparticles also acted as neutrophil decoys, absorbing and neutralizing elevated neutrophil-related cytokines in the injured heart. Additionally, they protected cardiomyocytes from excessive inflammatory-induced apoptosis and preserved cardiac function.
BIOACTIVE MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Yuki Akanuma, Takane Imaoka, Hiroyasu Sato, Kimihisa Yamamoto
Summary: Controversy surrounds the roles of metal core and shell in photoluminescence of ligand-protected metal nanoclusters. The inclusion of silver ions in a platinum-thiolate complex led to a significant increase in photoluminescent quantum yield. DFT calculations showed that LUMO, with contributions from Ag s-orbital and Pt d-orbitals, played a critical role in suppressing structural distortion in the excited state.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Cell Biology
Francesca Casciaro, Silvia Zia, Mattia Forcato, Manuela Zavatti, Francesca Beretti, Emma Bertucci, Andrea Zattoni, Pierluigi Reschiglian, Francesco Alviano, Laura Bonsi, Matilde Yung Follo, Marco Demaria, Barbara Roda, Tullia Maraldi
Summary: This study utilized Celector® technology to classify and characterize hAFSCs, uncovering deep intra-population differences and validating their impact on stemness properties. The results suggest the importance of selecting cellular fractions with the highest potential for use in regenerative medicine.
Article
Engineering, Environmental
Qianru Chi, Tong Xu, Yujiao He, Zhe Li, Xinyu Tang, Xue Fan, Shu Li
Summary: The use of plastics and nanotechnology has brought convenience to our lives, but it also increases the environmental burden and the risk of exposure to nanoparticles. This study reveals that exposure to polystyrene nanoparticles (PSNPs) leads to neutrophil infiltration and neutrophil extracellular trap (NET) formation in the liver. Further research shows that NET formation is associated with the reactive oxygen species (ROS)-NLRP3 axis. Inhibition of ROS and NLRP3 can alleviate PSNP-induced NET formation. Moreover, the use of DNase I-coated PSNPs can disassemble NET, reduce neutrophil infiltration in the liver, inhibit the ROS-NLRP3 axis, and decrease cytokine expression.
JOURNAL OF HAZARDOUS MATERIALS
(2022)
Article
Nanoscience & Nanotechnology
Zhenyu Luo, Yichao Lu, Yingying Shi, Mengshi Jiang, Xinyu Shan, Xiang Li, Junlei Zhang, Bing Qin, Xu Liu, Xuemeng Guo, Jiaxin Huang, Yu Liu, Sijie Wang, Qingpo Li, Lihua Luo, Jian You
Summary: In this study, the use of neutrophils for targeted delivery of drugs to the bone marrow was reported. The authors demonstrated that drug-loaded nanoparticles can be taken up by neutrophils and transported across the bone marrow-blood barrier, leading to increased drug concentrations in the bone marrow. The application of this approach was validated in two models: delivery of cabazitaxel by neutrophils significantly inhibited tumor growth in a bone metastasis cancer model, while delivery of teriparatide alleviated osteoporosis indicators and increased bone mineral density in an induced osteoporosis model.
NATURE NANOTECHNOLOGY
(2023)
Article
Nanoscience & Nanotechnology
Cui Tang, Hui Wang, Lina Guo, Chan Zou, Jianming Hu, Hanyong Zhang, Wenhu Zhou, Guoping Yang
Summary: Atherosclerosis (AS) is a major contributor to cardiovascular diseases, and novel therapeutic strategies are needed to alleviate plaque burden. This study found that CpG can enhance macrophage efferocytosis and promote plaque regression. CpG conjugated on silver nanoparticles (CpG-AgNPs) showed excellent therapeutic efficacy and biocompatibility.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Biochemistry & Molecular Biology
Michio Okamoto, Rei Mizuno, Kenji Kawada, Yoshiro Itatani, Yoshiyuki Kiyasu, Keita Hanada, Wataru Hirata, Yasuyo Nishikawa, Hideyuki Masui, Naoko Sugimoto, Takuya Tamura, Susumu Inamoto, Yoshiharu Sakai, Kazutaka Obama
Summary: This study investigated the expression and clinical relevance of neutrophil extracellular traps (NETs) in colorectal cancers (CRCs). The results showed that high expression of intratumoral or systemic NETs correlated with poor relapse-free survival (RFS) in CRC patients. In vitro and in vivo experiments demonstrated that NETs promoted CRC cell migration mediated by neutrophil elastase (NE), and NE inhibition suppressed liver metastases in CRC cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Materials Science, Multidisciplinary
Claudiu Bulbucan, Pau Ternero, Calle Preger, Aram Kostanyan, Maria E. Messing, Rasmus Westerstrom
Summary: We investigated the influence of particle size on the formation of antiferromagnetic FexO subdomains and the occurrence of exchange bias in novel ferrimagnetic Cr-substituted Fe3O4 nanoparticles generated using an aerosol technique. Cooling the samples in a magnetizing field at the Néel temperature of the FexO subdomains caused significant shifts in the hysteresis loops. The shift magnitude decreased with decreasing particle diameter for the larger systems, while only minor exchange fields were observed for the smallest system. This reduction in exchange bias was attributed to the lower volume fraction and size of the metastable FexO phase, which readily transformed into the thermodynamically stable (Fe,Cr)3O4 phase with decreasing particle diameter.
JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS
(2023)
Review
Chemistry, Multidisciplinary
Charuksha Walgama, Nikhil Raj
Summary: Nanoparticle-based electrochemical immunosensors show high sensitivity and amplification ability due to their large surface area. Silver nanoparticles (AgNPs) have been widely used in electrochemical sensors for their unique properties. This article describes six approaches for incorporating AgNPs in electrochemical platforms, focusing on the silver-gold galvanic exchange-based detection strategy. These methods utilize AgNP oxidation into Ag+ ions and subsequent electrodeposition of Ag+ ions onto the working electrode. The article also discusses the impact of AgNP size and shape on detection limits and sensitivity, as well as recent developments in lab-on-a-chip immunosensors for Ag-based metalloimmunoassay detection.
CHEMICAL COMMUNICATIONS
(2023)
Article
Environmental Sciences
Leszek Potocki, Malgorzata Karbarz, Jagoda Adamczyk-Grochala, Idalia Kasprzyk, Klaudia Pawlina-Tyszko, Anna Lewinska, Maciej Wnuk
Summary: The study found that microRNAs derived from silver birch pollen may interfere with autophagy, inflammation, and allergy pathways in humans. Silver birch pollen and its derived microRNAs induced NF-Kappa B-mediated proinflammatory response in human lung cells by increasing levels of NF-Kappa B p65, IL-8, and TNF alpha.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Review
Biotechnology & Applied Microbiology
G. R. Tortella, J. C. Pieretti, O. Rubilar, M. Fernandez-Baldo, A. Benavides-Mendoza, M. C. Diez, A. B. Seabra
Summary: The rapid development of nanomedicine has led to a high demand for silver, copper, and copper oxide nanoparticles due to their potent antimicrobial activity. The recent pandemic has highlighted the urgent need for effective alternatives for treating and preventing viral infections. This review discusses the antiviral activity of silver and copper-based nanoparticles, along with the challenges and limitations in their biomedical applications.
CRITICAL REVIEWS IN BIOTECHNOLOGY
(2022)
Article
Chemistry, Physical
Yanli Li, Xunhao Wang, Jie Zhang, Zhichao Wu
Summary: Silver nanoparticles (AgNPs) are widely studied and used due to their antimicrobial and optical properties. When AgNPs encounter physiological environments, they form a protein corona (PC) due to rapid encapsulation by proteins. The type, concentration, and ratio of proteins in the PC were altered during this process. Dynamic light scattering (DLS) and multi-barreled light scattering (Turbiscan) were used to study the physicochemical reactions. The results showed that IgG preferentially adsorbed and increased AgNPs aggregation, while Fib adsorbed and decreased aggregation. Fib had a greater inhibitory effect than IgG when both proteins were present. At high ionic strength, IgG and Fib cooperated to inhibit AgNPs aggregation, with Fib having a greater effect. The presence of a higher amount of protein led to a more vigorous movement of protein molecules around AgNPs corona.
COLLOID AND INTERFACE SCIENCE COMMUNICATIONS
(2023)
Article
Engineering, Environmental
Tin Yan Wong, Neng Yan, Kenneth Kin Leung Kwan, Yanrong Pan, Jingjing Liu, Yao Xiao, Long Wu, Henry Lam
Summary: Silver nanoparticles (AgNPs) have raised concerns due to their potential harmful effects on human beings. This study investigated the hepatotoxic effects of AgNPs using a comparative proteomics approach. The results showed that cancerous liver cells and normal cells respond to AgNPs exposure through different pathways, providing new insights into mechanisms underlying AgNPs-induced hepatotoxicity.
JOURNAL OF HAZARDOUS MATERIALS
(2023)
Article
Immunology
Christof Kaltenmeier, Hamza O. Yazdani, Kristin Morder, David A. Geller, Richard L. Simmons, Samer Tohme
Summary: NETs in the tumor microenvironment promote an immunosuppressive environment by inducing exhaustion and dysfunction of infiltrating T cells, leading to tumor growth. Targeting NETs or PD-L1 with DNAse or anti-PD-L1 during surgery can diminish tumor growth and enhance T cell function in the TME, suggesting a novel strategy to sustain immune competence.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Jennifer A. Fraser, Erin G. Worrall, Yao Lin, Vivien Landre, Susanne Pettersson, Elizabeth Blackburn, Malcolm Walkinshaw, Petr Muller, Borek Vojtesek, Kathryn Ball, Ted R. Hupp
JOURNAL OF MOLECULAR BIOLOGY
(2015)
Article
Biochemistry & Molecular Biology
Nicola J. MacLaine, Bodil Oster, Bettina Bundgaard, Jennifer A. Fraser, Carolyn Buckner, Pedro A. Lazo, David W. Meek, Per Hoellsberg, Ted R. Hupp
JOURNAL OF BIOLOGICAL CHEMISTRY
(2008)
Article
Biochemistry & Molecular Biology
Jennifer A. Fraser, Arumugam Madhumalar, Elizabeth Blackburn, Janice Bramham, Malcolm D. Walkinshaw, Chandra Verma, Ted R. Hupp
JOURNAL OF BIOLOGICAL CHEMISTRY
(2010)
Article
Biochemistry & Molecular Biology
Jennifer A. Fraser, Borivoj Vojtesek, Ted R. Hupp
JOURNAL OF BIOLOGICAL CHEMISTRY
(2010)
Article
Biochemistry & Molecular Biology
G. Girardi, J. Fraser, R. Lennen, R. Vontell, M. Jansen, G. Hutchison
MOLECULAR PSYCHIATRY
(2015)
Article
Multidisciplinary Sciences
Miguel A. S. Martin-Aragon Baudel, Mick T. Rae, Mark G. Darlison, Amy V. Poole, Jennifer A. Fraser
Article
Multidisciplinary Sciences
Jennifer A. Fraser, Joseph E. Sutton, Saba Tazayoni, Isla Bruce, Amy V. Poole
SCIENTIFIC REPORTS
(2019)
Review
Oncology
James Meehan, Mark Gray, Carlos Martinez-Perez, Charlene Kay, Lisa Y. Pang, Jennifer A. Fraser, Amy V. Poole, Ian H. Kunkler, Simon P. Langdon, David Argyle, Arran K. Turnbull
FRONTIERS IN ONCOLOGY
(2020)
Article
Biochemistry & Molecular Biology
Ashley L. Craig, Jennifer A. Chrystal, Jennifer A. Fraser, Nathalie Sphyris, Yao Lin, Ben J. Harrison, Mary T. Scott, Irena Dornreiter, Ted R. Hupp
MOLECULAR AND CELLULAR BIOLOGY
(2007)
Article
Biochemistry & Molecular Biology
Jennifer A. Fraser, Ted R. Hupp
Article
Biochemistry & Molecular Biology
JA Fraser, P Kansagra, C Kotecki, RDC Saunders, LI McLellan
JOURNAL OF BIOLOGICAL CHEMISTRY
(2003)
Article
Biochemistry & Molecular Biology
JA Fraser, RDC Saunders, LI McLellan
JOURNAL OF BIOLOGICAL CHEMISTRY
(2002)