T315I mutation of BCR-ABL1 into human Philadelphia chromosome-positive leukemia cell lines by homologous recombination using the CRISPR/Cas9 system

How introns enhance gene expression

(2017) Orit Shaul   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Enhanced CRISPR/Cas9-mediated precise genome editing by improved design and delivery of gRNA, Cas9 nuclease, and donor DNA

(2017) Xiquan Liang et al.   JOURNAL OF BIOTECHNOLOGY

Gene expression and mutation-guided synthetic lethality eradicates proliferating and quiescent leukemia cells

(2017) Margaret Nieborowska-Skorska et al.   JOURNAL OF CLINICAL INVESTIGATION

Drugging the Cancers Addicted to DNA Repair

(2017) Jac A. Nickoloff et al.   JNCI-Journal of the National Cancer Institute

Simplified CRISPR tools for efficient genome editing and streamlined protocols for their delivery into mammalian cells and mouse zygotes

(2017) Ashley M. Jacobi et al.   METHODS

PARP inhibitors: Synthetic lethality in the clinic

(2017) Christopher J. Lord et al.   SCIENCE

Drugging the Cancers Addicted to DNA Repair

(2017) Jac A. Nickoloff et al.   JNCI-Journal of the National Cancer Institute

RNA-Guided CRISPR-Cas9 System-Mediated Engineering of Acute Myeloid Leukemia Mutations

(2017) Oliver Brabetz et al.   Molecular Therapy-Nucleic Acids

Genetic and Epigenetic Silencing of MicroRNA-203 Enhances ABL1 and BCR - ABL1 Oncogene Expression

(2016) María J. Bueno et al.   CANCER CELL

Efficient introduction of specific homozygous and heterozygous mutations using CRISPR/Cas9

(2016) Dominik Paquet et al.   NATURE

Tyrosine kinase inhibitors in chronic myeloid leukaemia: which, when, for whom?

(2016) Gianantonio Rosti et al.   Nature Reviews Clinical Oncology

Restoration of miR-424 suppresses BCR–ABL activity and sensitizes CML cells to imatinib treatment

(2015) Oshrat Hershkovitz-Rokah et al.   CANCER LETTERS

MiR-30e induces apoptosis and sensitizes K562 cells to imatinib treatment via regulation of the BCR–ABL protein

(2015) Oshrat Hershkovitz-Rokah et al.   CANCER LETTERS

Increasing the efficiency of precise genome editing with CRISPR-Cas9 by inhibition of nonhomologous end joining

(2015) Takeshi Maruyama et al.   NATURE BIOTECHNOLOGY

Increasing the efficiency of homology-directed repair for CRISPR-Cas9-induced precise gene editing in mammalian cells

(2015) Van Trung Chu et al.   NATURE BIOTECHNOLOGY

Regulation of Gene Editing Activity Directed by Single-Stranded Oligonucleotides and CRISPR/Cas9 Systems

(2015) Pawel Bialk et al.   PLoS One

Downregulation of BRCA1 protein in BCR-ABL1 leukemia cells depends on stress-triggered TIAR-mediated suppression of translation

(2014) Paulina Podszywalow-Bartnicka et al.   CELL CYCLE

CRISPR-Cas systems for editing, regulating and targeting genomes

(2014) Jeffry D Sander et al.   NATURE BIOTECHNOLOGY

RNA-Guided Human Genome Engineering via Cas9

(2013) P. Mali et al.   SCIENCE

Multiplex Genome Engineering Using CRISPR/Cas Systems

(2013) L. Cong et al.   SCIENCE

Targeting RAD51 phosphotyrosine-315 to prevent unfaithful recombination repair in BCR-ABL1 leukemia

(2011) A. Slupianek et al.   BLOOD

AP24534, a Pan-BCR-ABL Inhibitor for Chronic Myeloid Leukemia, Potently Inhibits the T315I Mutant and Overcomes Mutation-Based Resistance

(2009) Thomas O'Hare et al.   CANCER CELL

Widespread Shortening of 3′UTRs by Alternative Cleavage and Polyadenylation Activates Oncogenes in Cancer Cells

(2009) Christine Mayr et al.   CELL

BCR-ABLGene Expression Is Required for Its Mutations in a Novel KCL-22 Cell Culture Model for Acquired Resistance of Chronic Myelogenous Leukemia

(2009) Hongfeng Yuan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inhibition of Poly(ADP-Ribose) Polymerase in Tumors fromBRCAMutation Carriers

(2009) Peter C. Fong et al.   NEW ENGLAND JOURNAL OF MEDICINE

Hypersensitivity of Ph-positive lymphoid cell lines to rapamycin: Possible clinical application of mTOR inhibitor

(2008) Chikara Hirase et al.   LEUKEMIA RESEARCH

Proliferating Cells Express mRNAs with Shortened 3' Untranslated Regions and Fewer MicroRNA Target Sites

(2008) R. Sandberg et al.   SCIENCE