Chemokine interactome mapping enables tailored intervention in acute and chronic inflammation

Probing Functional Heteromeric Chemokine Protein-Protein Interactions through Conformation-Assisted Oxime Ligation

(2016) Stijn M. Agten et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Adaptive Response of T and B Cells in Atherosclerosis

(2016) Daniel F.J. Ketelhuth et al.   CIRCULATION RESEARCH

Interaction of chemokine receptor CXCR4 in monomeric and dimeric state with its endogenous ligand CXCL12: coarse-grained simulations identify differences

(2016) Pasquale Cutolo et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

Structure-Based Design of Peptidic Inhibitors of the Interaction between CC Chemokine Ligand 5 (CCL5) and Human Neutrophil Peptides 1 (HNP1)

(2016) Kanin Wichapong et al.   JOURNAL OF MEDICINAL CHEMISTRY

Structural basis for oligomerization and glycosaminoglycan binding of CCL5 and CCL3

(2016) Wenguang G. Liang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

How much of the human protein interactome remains to be mapped?

(2016) Marc Vidal   Science Signaling

How much of the human protein interactome remains to be mapped?

(2016) Marc Vidal   Science Signaling

Structures of Human CCL18, CCL3, and CCL4 Reveal Molecular Determinants for Quaternary Structures and Sensitivity to Insulin-Degrading Enzyme

(2015) Wenguang G. Liang et al.   JOURNAL OF MOLECULAR BIOLOGY

Exploring the binding mechanisms of MIF to CXCR2 using theoretical approaches

(2015) Lei Xu et al.   PHYSICAL CHEMISTRY CHEMICAL PHYSICS

Crystal structure of the chemokine receptor CXCR4 in complex with a viral chemokine

(2015) L. Qin et al.   SCIENCE

Recruitment of classical monocytes can be inhibited by disturbing heteromers of neutrophil HNP1 and platelet CCL5

(2015) Jean-Eric Alard et al.   Science Translational Medicine

Chemokines in Atherosclerosis

(2014) Alma Zernecke et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

A rationally designed monomeric peptide triagonist corrects obesity and diabetes in rodents

(2014) Brian Finan et al.   NATURE MEDICINE

Identification of platelet function defects by multi-parameter assessment of thrombus formation

(2014) Susanne M. de Witt et al.   Nature Communications

Dynamic conformational switching in the chemokine ligand is essential for G-protein-coupled receptor activation

(2013) Prem Raj B. Joseph et al.   BIOCHEMICAL JOURNAL

Chemoselective Oxime Reactions in Proteins and Peptides by Using an Optimized Oxime Strategy: The Demise of Levulinic Acid

(2013) Stijn M. Agten et al.   CHEMBIOCHEM

Alternative C-Terminal Helix Orientation Alters Chemokine Function

(2013) Je-Hung Kuo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Chemokine CXCL1 Dimer Is a Potent Agonist for the CXCR2 Receptor

(2013) Aishwarya Ravindran et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Exchange of extracellular domains of CCR1 and CCR5 reveals confined functions in CCL5-mediated cell recruitment

(2013) Birgit K. Kramp et al.   THROMBOSIS AND HAEMOSTASIS

Disruption of Platelet-derived Chemokine Heteromers Prevents Neutrophil Extravasation in Acute Lung Injury

(2012) Jochen Grommes et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

The heterodimerization of platelet-derived chemokines

(2012) James Carlson et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

The Chemokine Superfamily Revisited

(2012) Albert Zlotnik et al.   IMMUNITY

Measurement of whole blood thrombus formation using parallel-plate flow chambers – a practical guide

(2012) Roger Van Kruchten et al.   PLATELETS

Helix 8 Plays a Crucial Role in Bradykinin B2Receptor Trafficking and Signaling

(2011) Jens Feierler et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

CCL17-expressing dendritic cells drive atherosclerosis by restraining regulatory T cell homeostasis in mice

(2011) Christian Weber et al.   JOURNAL OF CLINICAL INVESTIGATION

Atherosclerosis: current pathogenesis and therapeutic options

(2011) Christian Weber et al.   NATURE MEDICINE

Monomeric and dimeric CXCL12 inhibit metastasis through distinct CXCR4 interactions and signaling pathways

(2011) L. J. Drury et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Polymerization of MIP-1 chemokine (CCL3 and CCL4) and clearance of MIP-1 by insulin-degrading enzyme

(2010) Min Ren et al.   EMBO JOURNAL

MIF-chemokine receptor interactions in atherogenesis are dependent on an N-loop-based 2-site binding mechanism

(2010) Sandra Kraemer et al.   FASEB JOURNAL

Therapeutic targeting of chemokine interactions in atherosclerosis

(2010) Rory R. Koenen et al.   NATURE REVIEWS DRUG DISCOVERY

Prolonged RXFP1 and RXFP2 signaling can be explained by poor internalization and a lack of β-arrestin recruitment

(2009) Gabrielle E. Callander et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Structural Basis for Differential Binding of the Interleukin-8 Monomer and Dimer to the CXCR1 N-Domain: Role of Coupled Interactions and Dynamics

(2009) Aishwarya Ravindran et al.   BIOCHEMISTRY

Chemokine receptor oligomerization: functional considerations

(2009) Marcus Thelen et al.   CURRENT OPINION IN PHARMACOLOGY

Synergy-inducing chemokines enhance CCR2 ligand activities on monocytes

(2009) Katrin Kuscher et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Disrupting functional interactions between platelet chemokines inhibits atherosclerosis in hyperlipidemic mice

(2009) Rory R Koenen et al.   NATURE MEDICINE

CXC and CC Chemokines Form Mixed Heterodimers

(2008) Irina V. Nesmelova et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural Basis of CXCR4 Sulfotyrosine Recognition by the Chemokine SDF-1/CXCL12

(2008) C. T. Veldkamp et al.   Science Signaling