Epigenetic modulation of inflammation and synaptic plasticity promotes resilience against stress in mice

Sex-specific transcriptional signatures in human depression

(2017) Benoit Labonté et al.   NATURE MEDICINE

Social stress induces neurovascular pathology promoting depression

(2017) Caroline Menard et al.   NATURE NEUROSCIENCE

Nucleus Accumbens Medium Spiny Neuron Subtypes Mediate Depression-Related Outcomes to Social Defeat Stress

(2015) T. Chase Francis et al.   BIOLOGICAL PSYCHIATRY

Sex Differences in Nucleus Accumbens Transcriptome Profiles Associated with Susceptibility versus Resilience to Subchronic Variable Stress

(2015) G. E. Hodes et al.   JOURNAL OF NEUROSCIENCE

Excitatory transmission at thalamo-striatal synapses mediates susceptibility to social stress

(2015) Daniel J Christoffel et al.   NATURE NEUROSCIENCE

Chronic variable stress activates hematopoietic stem cells

(2014) Timo Heidt et al.   NATURE MEDICINE

Individual differences in the peripheral immune system promote resilience versus susceptibility to social stress

(2014) Georgia E. Hodes et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Enhancing Depression Mechanisms in Midbrain Dopamine Neurons Achieves Homeostatic Resilience

(2014) A. K. Friedman et al.   SCIENCE

Natural polyphenols in the management of major depression

(2013) Lokesh Pathak et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Role of standardized grape polyphenol preparation as a novel treatment to improve synaptic plasticity through attenuation of features of metabolic syndrome in a mouse model

(2013) Jun Wang et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Epigenetic regulation of RAC1 induces synaptic remodeling in stress disorders and depression

(2013) Sam A Golden et al.   NATURE MEDICINE

Identification of brain-targeted bioactive dietary quercetin-3-O-glucuronide as a novel intervention for Alzheimer's disease

(2012) Lap Ho et al.   FASEB JOURNAL

Automated design of ligands to polypharmacological profiles

(2012) Jérémy Besnard et al.   NATURE

Decreased expression of synapse-related genes and loss of synapses in major depressive disorder

(2012) Hyo Jung Kang et al.   NATURE MEDICINE

Rac1 is essential in cocaine-induced structural plasticity of nucleus accumbens neurons

(2012) David M Dietz et al.   NATURE NEUROSCIENCE

Effects of Inhibitor of κB Kinase Activity in the Nucleus Accumbens on Emotional Behavior

(2012) Daniel J Christoffel et al.   NEUROPSYCHOPHARMACOLOGY

Enzymatic synthesis of substituted epicatechins for bioactivity studies in neurological disorders

(2011) Jack W. Blount et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

I B Kinase Regulates Social Defeat Stress-Induced Synaptic and Behavioral Plasticity

(2011) D. J. Christoffel et al.   JOURNAL OF NEUROSCIENCE

Major depressive disorder: new clinical, neurobiological, and treatment perspectives

(2011) David J Kupfer et al.   LANCET

A standardized protocol for repeated social defeat stress in mice

(2011) Sam A Golden et al.   Nature Protocols

Epigenetic Status of Gdnf in the Ventral Striatum Determines Susceptibility and Adaptation to Daily Stressful Events

(2011) Shusaku Uchida et al.   NEURON

Structural and synaptic plasticity in stress-related disorders

(2011) Daniel J. Christoffel et al.   REVIEWS IN THE NEUROSCIENCES

AMP-activated Protein Kinase Signaling Activation by Resveratrol Modulates Amyloid-β Peptide Metabolism

(2010) Valérie Vingtdeux et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of Synaptic Rac1 Activity, Long-Term Potentiation Maintenance, and Learning and Memory by BCR and ABR Rac GTPase-Activating Proteins

(2010) D. Oh et al.   JOURNAL OF NEUROSCIENCE

Disrupted-in-Schizophrenia 1 (DISC1) regulates spines of the glutamate synapse via Rac1

(2010) Akiko Hayashi-Takagi et al.   NATURE NEUROSCIENCE

Cell Type-Specific Loss of BDNF Signaling Mimics Optogenetic Control of Cocaine Reward

(2010) M. K. Lobo et al.   SCIENCE

Role of Nuclear Factor κB in Ovarian Hormone-Mediated Stress Hypersensitivity in Female Mice

(2009) Quincey LaPlant et al.   BIOLOGICAL PSYCHIATRY

A Meta-Analysis of Cytokines in Major Depression

(2009) Yekta Dowlati et al.   BIOLOGICAL PSYCHIATRY

Use of Planar Array Electrophysiology for the Development of Robust Ion Channel Cell Lines

(2009) Jeffrey Clare et al.   COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING

Antidepressant Actions of Histone Deacetylase Inhibitors

(2009) H. E. Covington et al.   JOURNAL OF NEUROSCIENCE

CREB regulation of nucleus accumbens excitability mediates social isolation–induced behavioral deficits

(2009) Deanna L Wallace et al.   NATURE NEUROSCIENCE

Gender and the relationship between marital status and first onset of mood, anxiety and substance use disorders

(2009) K. M. Scott et al.   PSYCHOLOGICAL MEDICINE

Associations of Depression With C-Reactive Protein, IL-1, and IL-6: A Meta-Analysis

(2009) M Bryant Howren et al.   PSYCHOSOMATIC MEDICINE

Methylation status of a single CpG site in theIL6promoter is related toIL6messenger RNA levels and rheumatoid arthritis

(2008) Christoper J. Nile et al.   ARTHRITIS AND RHEUMATISM

Drug-Dependent Requirement of Hippocampal Neurogenesis in a Model of Depression and of Antidepressant Reversal

(2008) Alexandre Surget et al.   BIOLOGICAL PSYCHIATRY

Grape-Derived Polyphenolics Prevent A  Oligomerization and Attenuate Cognitive Deterioration in a Mouse Model of Alzheimer's Disease

(2008) J. Wang et al.   JOURNAL OF NEUROSCIENCE

Natural products to drugs: natural product-derived compounds in clinical trials

(2008) Mark S. Butler   NATURAL PRODUCT REPORTS

Cellular Imaging Predictions of Clinical Drug-Induced Liver Injury

(2008) Jinghai J. Xu et al.   TOXICOLOGICAL SCIENCES