Impaired β-arrestin recruitment and reduced desensitization by non-catechol agonists of the D1 dopamine receptor

Identification of G Protein-Biased Agonists That Fail To Recruit β-Arrestin or Promote Internalization of the D1 Dopamine Receptor

(2015) Jennie L. Conroy et al.   ACS Chemical Neuroscience

Dopamine D1 receptor-agonist interactions: A mutagenesis and homology modeling study

(2015) Scot Mente et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

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The dopamine theory of addiction: 40 years of highs and lows

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Mutation of Putative GRK Phosphorylation Sites in the Cannabinoid Receptor 1 (CB1R) Confers Resistance to Cannabinoid Tolerance and Hypersensitivity to Cannabinoids in Mice

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Amphetamine Sensitization Alters Reward Processing in the Human Striatum and Amygdala

(2014) Owen G. O’Daly et al.   PLoS One

The Neurobiology of Thought: The Groundbreaking Discoveries of Patricia Goldman-Rakic 1937-2003

(2013) A. F. T. Arnsten   CEREBRAL CORTEX

Structure of active β-arrestin-1 bound to a G-protein-coupled receptor phosphopeptide

(2013) Arun K. Shukla et al.   NATURE

Adrenaline-activated structure of β2-adrenoceptor stabilized by an engineered nanobody

(2013) Aaron M. Ring et al.   NATURE

Structural Features for Functional Selectivity at Serotonin Receptors

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Investigation of D1Receptor-Agonist Interactions and D1/D2Agonist Selectivity Using a Combination of Pharmacophore and Receptor Homology Modeling

(2012) Marcus Malo et al.   ChemMedChem

Shaping a Screening File for Maximal Lead Discovery Efficiency and Effectiveness: Elimination of Molecular Redundancy

(2012) Gregory A. Bakken et al.   Journal of Chemical Information and Modeling

Prefrontal D1 dopamine signaling is required for temporal control

(2012) N. S. Narayanan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Knowledge-Based, Central Nervous System (CNS) Lead Selection and Lead Optimization for CNS Drug Discovery

(2011) Arup K. Ghose et al.   ACS Chemical Neuroscience

Molecular Mechanism of β-Arrestin-Biased Agonism at Seven-Transmembrane Receptors

(2011) Eric Reiter et al.   Annual Review of Pharmacology and Toxicology

Mapping the Catechol Binding Site in Dopamine D1 Receptors: Synthesis and Evaluation of Two Parallel Series of Bicyclic Dopamine Analogues

(2011) Lisa A. Bonner et al.   ChemMedChem

Synopsis of Some Recent Tactical Application of Bioisosteres in Drug Design

(2011) Nicholas A. Meanwell   JOURNAL OF MEDICINAL CHEMISTRY

Impact of Recovery on Fraction Unbound Using Equilibrium Dialysis

(2011) Li Di et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Structure of a nanobody-stabilized active state of the β2 adrenoceptor

(2011) Søren G. F. Rasmussen et al.   NATURE

Endocytosis Promotes Rapid Dopaminergic Signaling

(2011) Sarah J. Kotowski et al.   NEURON

The Physiology, Signaling, and Pharmacology of Dopamine Receptors

(2011) J.-M. Beaulieu et al.   PHARMACOLOGICAL REVIEWS

Pathway and mechanism of drug binding to G-protein-coupled receptors

(2011) Ron O. Dror et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Discovery of  -Arrestin-Biased Dopamine D2 Ligands for Probing Signal Transduction Pathways Essential for Antipsychotic Efficacy

(2011) J. A. Allen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Moving beyond Rules: The Development of a Central Nervous System Multiparameter Optimization (CNS MPO) Approach To Enable Alignment of Druglike Properties

(2010) Travis T. Wager et al.   ACS Chemical Neuroscience

Attention-Deficit/Hyperactivity Disorder and Attention Networks

(2009) George Bush   NEUROPSYCHOPHARMACOLOGY

Dopamine and inhibitory action control: evidence from spontaneous eye blink rates

(2009) Lorenza Serena Colzato et al.   EXPERIMENTAL BRAIN RESEARCH

Pathophysiology of Parkinsonism

(2008) Adriana Galvan et al.   CLINICAL NEUROPHYSIOLOGY

Dopamine D1receptor ligands: Where are we now and where are we going

(2008) Jing Zhang et al.   MEDICINAL RESEARCH REVIEWS