Quantitative characterization of all single amino acid variants of a viral capsid-based drug delivery vehicle

Evolution of a designed protein assembly encapsulating its own RNA genome

(2017) Gabriel L. Butterfield et al.   NATURE

Global analysis of protein folding using massively parallel design, synthesis, and testing

(2017) Gabriel J. Rocklin et al.   SCIENCE

Single-mutation fitness landscapes for an enzyme on multiple substrates reveal specificity is globally encoded

(2017) Emily E. Wrenbeck et al.   Nature Communications

A Catalytic Nanoreactor Based on in Vivo Encapsulation of Multiple Enzymes in an Engineered Protein Nanocompartment

(2016) Tobias W. Giessen et al.   CHEMBIOCHEM

Structure of a novel 13 nm dodecahedral nanocage assembled from a redesigned bacterial microcompartment shell protein

(2016) J. Jorda et al.   CHEMICAL COMMUNICATIONS

Bottom-up Construction of a Primordial Carboxysome Mimic

(2016) Raphael Frey et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Biodistribution of Antibody-MS2 Viral Capsid Conjugates in Breast Cancer Models

(2016) Ioana L. Aanei et al.   MOLECULAR PHARMACEUTICS

A Selection for Assembly Reveals That a Single Amino Acid Mutant of the Bacteriophage MS2 Coat Protein Forms a Smaller Virus-like Particle

(2016) Michael A. Asensio et al.   NANO LETTERS

In situ structures of the genome and genome-delivery apparatus in a single-stranded RNA virus

(2016) Xinghong Dai et al.   NATURE

Local fitness landscape of the green fluorescent protein

(2016) Karen S. Sarkisyan et al.   NATURE

Design of a hyperstable 60-subunit protein icosahedron

(2016) Yang Hsia et al.   NATURE

Accurate design of megadalton-scale two-component icosahedral protein complexes

(2016) J. B. Bale et al.   SCIENCE

The Mutational Robustness of Influenza A Virus

(2016) Elisa Visher et al.   PLoS Pathogens

Quantitative Packaging of Active Enzymes into a Protein Cage

(2015) Yusuke Azuma et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A novel method to produce armored double-stranded DNA by encapsulation of MS2 viral capsids

(2015) Lei Zhang et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Influence of Electrostatics on Small Molecule Flux through a Protein Nanoreactor

(2015) Jeff E. Glasgow et al.   ACS Synthetic Biology

High-resolution genetic profile of viral genomes: why it matters

(2015) Hangfei Qi et al.   Current Opinion in Virology

Production and applications of engineered viral capsids

(2014) Jeff Glasgow et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Trimmomatic: a flexible trimmer for Illumina sequence data

(2014) Anthony M. Bolger et al.   BIOINFORMATICS

A Comprehensive, High-Resolution Map of a Gene’s Fitness Landscape

(2014) Elad Firnberg et al.   MOLECULAR BIOLOGY AND EVOLUTION

Structure of a designed protein cage that self-assembles into a highly porous cube

(2014) Yen-Ting Lai et al.   Nature Chemistry

Translating HIV Sequences into Quantitative Fitness Landscapes Predicts Viral Vulnerabilities for Rational Immunogen Design

(2013) Andrew L. Ferguson et al.   IMMUNITY

Analyses of the Effects of All Ubiquitin Point Mutants on Yeast Growth Rate

(2013) Benjamin P. Roscoe et al.   JOURNAL OF MOLECULAR BIOLOGY

Controlled Integration of Gold Nanoparticles and Organic Fluorophores Using Synthetically Modified MS2 Viral Capsids

(2013) Stacy L. Capehart et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Computational design of ligand-binding proteins with high affinity and selectivity

(2013) Christine E. Tinberg et al.   NATURE

Mutational and fitness landscapes of an RNA virus revealed through population sequencing

(2013) Ashley Acevedo et al.   NATURE

Osmolyte-Mediated Encapsulation of Proteins inside MS2 Viral Capsids

(2012) Jeff E. Glasgow et al.   ACS Nano

PET Imaging and Biodistribution of Chemically Modified Bacteriophage MS2

(2012) Michelle E. Farkas et al.   MOLECULAR PHARMACEUTICS

MS2 Viruslike Particles: A Robust, Semisynthetic Targeted Drug Delivery Platform

(2012) Francis A. Galaway et al.   MOLECULAR PHARMACEUTICS

Cell-Specific Delivery of Diverse Cargos by Bacteriophage MS2 Virus-like Particles

(2011) Carlee E. Ashley et al.   ACS Nano

FLASH: fast length adjustment of short reads to improve genome assemblies

(2011) T. Magoc et al.   BIOINFORMATICS

Exploring the Fitness Landscape of an RNA Virus by Using a Universal Barcode Microarray

(2011) A. S. Lauring et al.   JOURNAL OF VIROLOGY

Experimental illumination of a fitness landscape

(2011) R. T. Hietpas et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Thermal Stability of RNA Phage Virus-Like Particles Displaying Foreign Peptides

(2011) Jerri C Caldeira et al.   JOURNAL OF NANOBIOTECHNOLOGY

Dual-Surface Modified Virus Capsids for Targeted Delivery of Photodynamic Agents to Cancer Cells

(2010) Nicholas Stephanopoulos et al.   ACS Nano

Mutually-induced Conformational Switching of RNA and Coat Protein Underpins Efficient Assembly of a Viral Capsid

(2010) Óttar Rolfsson et al.   JOURNAL OF MOLECULAR BIOLOGY

High-resolution mapping of protein sequence-function relationships

(2010) Douglas M Fowler et al.   NATURE METHODS

Genome-Free Viral Capsids as Multivalent Carriers for Taxol Delivery

(2009) Wesley Wu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

The Sequence Alignment/Map format and SAMtools

(2009) H. Li et al.   BIOINFORMATICS

Fast and accurate short read alignment with Burrows-Wheeler transform

(2009) H. Li et al.   BIOINFORMATICS

Analysis of current and alternative phenol based RNA extraction methodologies for cyanobacteria

(2009) Fernando Pinto et al.   BMC MOLECULAR BIOLOGY

Genomewide Patterns of Substitution in Adaptively Evolving Populations of the RNA Bacteriophage MS2

(2009) A. J. Betancourt   GENETICS

Exploring protein fitness landscapes by directed evolution

(2009) Philip A. Romero et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Golden Gate Shuffling: A One-Pot DNA Shuffling Method Based on Type IIs Restriction Enzymes

(2009) Carola Engler et al.   PLoS One

Oxidative coupling of peptides to a virus capsid containing unnatural amino acids

(2008) Zachary M. Carrico et al.   CHEMICAL COMMUNICATIONS