Intracellular and extracellular Hsp70 chaperone as a target for cancer therapy

Tumor response to mTHPC-mediated photodynamic therapy exhibits strong correlation with extracellular release of HSP70

(2015) Soumya Mitra et al.   LASERS IN SURGERY AND MEDICINE

Abrogating HSP Response Augments Cell Death Induced by As2O3 in Glioma Cell Lines

(2014) Xueming Song et al.   CANADIAN JOURNAL OF NEUROLOGICAL SCIENCES

Inhibition of HSP70: A challenging anti-cancer strategy

(2012) Anastasia R. Goloudina et al.   CANCER LETTERS

Lysosomal Rerouting of Hsp70 Trafficking as a Potential Immune Activating Tool for Targeting Melanoma

(2012) Kata Juhasz et al.   CURRENT PHARMACEUTICAL DESIGN

Haematoporphyrin Based Photodynamic Therapy Combined with Hyperthermia Provided Effective Therapeutic Vaccine Effect against Colon Cancer Growth in Mice

(2012) Yaoming He et al.   International Journal of Medical Sciences

Anticancer Drugs Cause Release of Exosomes with Heat Shock Proteins from Human Hepatocellular Carcinoma Cells That Elicit Effective Natural Killer Cell Antitumor Responsesin Vitro

(2012) Li-Hong Lv et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

HSP70 Enhances Immunosuppressive Function of CD4+CD25+FoxP3+ T Regulatory Cells and Cytotoxicity in CD4+CD25− T Cells

(2012) Julian Wachstein et al.   PLoS One

The anti-inflammatory mechanisms of Hsp70

(2012) Thiago J. Borges et al.   Frontiers in Immunology

Heat Shock Proteins: Conditional Mediators of Inflammation in Tumor Immunity

(2012) Stuart K. Calderwood et al.   Frontiers in Immunology

Extracellular HSPA1A promotes the growth of hepatocarcinoma by augmenting tumor cell proliferation and apoptosis-resistance

(2011) Feng-Hua Wu et al.   CANCER LETTERS

Targeting HSP70: The second potentially druggable heat shock protein and molecular chaperone?

(2011) Marissa V. Powers et al.   CELL CYCLE

Heat shock proteins and cancer vaccines: developments in the past decade and chaperoning in the decade to come

(2011) Ayesha Murshid et al.   Expert Review of Vaccines

Nature and nurture in Foxp3+ regulatory T cell development, stability, and function

(2011) Terrence L. Geiger et al.   HUMAN IMMUNOLOGY

KNK437, a benzylidene lactam compound, sensitises prostate cancer cells to the apoptotic effect of hyperthermia

(2011) Emel Sahin et al.   INTERNATIONAL JOURNAL OF HYPERTHERMIA

HSP70 Inhibition by the Small-Molecule 2-Phenylethynesulfonamide Impairs Protein Clearance Pathways in Tumor Cells

(2011) J. I.-J. Leu et al.   MOLECULAR CANCER RESEARCH

Heat shock protein Hsp72 plays an essential role in Her2-induced mammary tumorigenesis

(2011) L Meng et al.   ONCOGENE

Serum HSP70

(2011) Sudhir K. Dutta et al.   PANCREAS

Radiation combined with hyperthermia induces HSP70-dependent maturation of dendritic cells and release of pro-inflammatory cytokines by dendritic cells and macrophages

(2011) Petra Schildkopf et al.   RADIOTHERAPY AND ONCOLOGY

Detection of irradiation-induced, membrane heat shock protein 70 (Hsp70) in mouse tumors using Hsp70 Fab fragment

(2011) Stefan Stangl et al.   RADIOTHERAPY AND ONCOLOGY

Antimyeloma Effects of the Heat Shock Protein 70 Molecular Chaperone Inhibitor MAL3-101

(2011) Marc J. Braunstein et al.   Journal of Oncology

Binding of a Small Molecule at a Protein–Protein Interface Regulates the Chaperone Activity of Hsp70–Hsp40

(2010) Susanne Wisén et al.   ACS Chemical Biology

An investigation into the potential use of serum Hsp70 as a novel tumour biomarker for Hsp90 inhibitors

(2010) Naveen Dakappagari et al.   BIOMARKERS

Heat shock protein 70 is acute phase reactant: response elicited by tumor treatment with photodynamic therapy

(2010) Soroush Merchant et al.   CELL STRESS & CHAPERONES

Identification of diagnostic serum protein profiles of glioblastoma patients

(2010) Anja Elstner et al.   JOURNAL OF NEURO-ONCOLOGY

Heat shock factors: integrators of cell stress, development and lifespan

(2010) Malin Åkerfelt et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Targeting membrane heat-shock protein 70 (Hsp70) on tumors by cmHsp70.1 antibody

(2010) S. Stangl et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Radiation therapy induces circulating serum Hsp72 in patients with prostate cancer

(2010) Mark D. Hurwitz et al.   RADIOTHERAPY AND ONCOLOGY

Heat shock protein 70 is secreted from endothelial cells by a non-classical pathway involving exosomes

(2009) Rui Zhan et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Serum level of soluble 70-kD heat shock protein is associated with high mortality in patients with colorectal cancer without distant metastasis

(2009) Judit Kocsis et al.   CELL STRESS & CHAPERONES

The endogenous danger signals HSP70 and MICA cooperate in the activation of cytotoxic effector functions of NK cells

(2009) Leslie Elsner et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

T Cell Activation by Heat Shock Protein 70 Vaccine Requires TLR Signaling and Scavenger Receptor Expressed by Endothelial Cells-1

(2009) J. Gong et al.   JOURNAL OF IMMUNOLOGY

Myeloid-Derived Suppressor Cells: Linking Inflammation and Cancer

(2009) S. Ostrand-Rosenberg et al.   JOURNAL OF IMMUNOLOGY

Cell-surface expression of Hsp70 on hematopoietic cancer cells after inhibition of HDAC activity

(2009) Helle Jensen et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Differential heat shock protein localization in chronic lymphocytic leukemia

(2009) N. C. Dempsey et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Clinical correlation of circulating heat shock protein 70 in acute leukemia

(2009) Chen-Hsiung Yeh et al.   LEUKEMIA RESEARCH

A Small Molecule Inhibitor of Inducible Heat Shock Protein 70

(2009) J. I-Ju Leu et al.   MOLECULAR CELL

Autologous Hsp70 immunization induces anti-tumor immunity and increases longevity and survival of tumor-bearing mice

(2009) S. Kumar et al.   NEOPLASMA

Increased serum heat-shock protein 70 levels reflect systemic inflammation, oxidative stress and hepatocellular injury in preeclampsia

(2008) Attila Molvarec et al.   CELL STRESS & CHAPERONES

Extracellular heat shock protein 70: A potential prognostic marker for chronic myeloid leukemia

(2008) Jesper Nylandsted   LEUKEMIA RESEARCH

Circulating heat shock protein 70 and progression in patients with chronic myeloid leukemia

(2008) Chen-Hsiung Yeh et al.   LEUKEMIA RESEARCH