Article
Immunology
Yuejin Liang, Aditi, Florence Onyoni, Hui Wang, Casey Gonzales, Piyanate Sunyakumthorn, Ping Wu, Parimal Samir, Lynn Soong
Summary: Scrub typhus, caused by Orientia tsutsugamushi (Ot), often involves the central nervous system (CNS). This study used a mouse model to investigate the brain transcriptome dynamics during severe scrub typhus and identified activated neuroinflammation pathways. The results revealed excessive immune signaling, inflammation, and blood-brain barrier dysregulation, along with microglial activation and proinflammatory cytokine production.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Tak Shun Fung, Rajarshi Chakrabarti, Jana Kollasser, Klemens Rottner, Theresia E. B. Stradal, Frieda Kage, Henry N. Higgs
Summary: Mitochondrial damage triggers metabolic changes and mitophagy in cells. This study reveals the mechanism of a rapid peri-mitochondrial actin polymerization called acute damage-induced actin (ADA). The activation of ADA involves multiple signaling pathways and proteins, and it inhibits the rapid mitochondrial shape changes that occur upon mitochondrial depolarization.
Article
Cell Biology
Hyungju Jeon, Hoji Lee, Dae-Hyuk Kwon, Jiwon Kim, Keiko Tanaka-Yamamoto, Jang Soo Yook, Linqing Feng, Hye Ran Park, Yong Hoon Lim, Zang-Hee Cho, Sun Ha Paek, Jinhyun Kim
Summary: Researchers used neuroanatomical techniques to construct a comprehensive connectivity map of the subthalamic nucleus (STN) in mice, identifying three types of pathways. The study also confirmed the existence of these pathways in the human STN using MRI tractography. Additionally, the researchers identified two functional types of glutamatergic STN neurons and studied their synaptic connectivity in the indirect and hyperdirect pathways.
Article
Plant Sciences
Xiaochun Wei, Yingying Zhang, Yanyan Zhao, Zhengqing Xie, Mohammad Rashed Hossain, Shuangjuan Yang, Gongyao Shi, Yanyan Lv, Zhiyong Wang, Baoming Tian, Henan Su, Fang Wei, Xiaowei Zhang, Yuxiang Yuan
Summary: This study investigated the transcriptome and metabolome changes in Brassica crops infected with Plasmodiophora brassicae, highlighting the role of plant hormones in defense mechanisms and resistance to clubroot disease. The findings suggest a general model of hormone-mediated defense mechanism in plants and pave the way for enhancing clubroot resistance in Brassica rapa.
FRONTIERS IN PLANT SCIENCE
(2021)
Article
Cell Biology
Alexandra L. Nguyen, Marie Diane Fadel, Iain M. Cheeseman
Summary: Most cell division components are essential for viability across human cell lines, but there are proteins that exhibit cell line-specific essentiality. Understanding the behaviors of these proteins is critical for our understanding of complex biological processes. The differential essentiality approach reveals the contributions of the CENP-O complex, shedding light on the precise functions and interactions within the cell division process.
MOLECULAR BIOLOGY OF THE CELL
(2021)
Article
Plant Sciences
Samrah Afzal Awan, Imran Khan, Rezwan Tariq, Muhammad Rizwan, Xiaoshan Wang, Xinquan Zhang, Linkai Huang
Summary: This study conducted a comparative transcriptome profiling to reveal the differentially expressed transcripts (DETs) associated with salt stress in pearl millet. The results showed that salt stress significantly affected the physiological characteristics of pearl millet and upregulated and downregulated the expression of various transcripts involved in different metabolic functions. The study also identified potential roles of hormones and kinases in enhancing plant tolerance against salt stress. Moreover, various transcription factors were predicted to regulate different transcripts involved in salt stress responses. Overall, this study provides new insights into the salt stress regulation mechanisms in pearl millet and has implications for improving salinity resistance in other cereal crops.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Cell Biology
Mark Dittmar, Jae Seung Lee, Kanupriya Whig, Elisha Segrist, Minghua Li, Brinda Kamalia, Lauren Castellana, Kasirajan Ayyanathan, Fabian L. Cardenas-Diaz, Edward E. Morrisey, Rachel Truitt, Wenli Yang, Kellie Jurado, Kirandeep Samby, Holly Ramage, David C. Schultz, Sara Cherry
Summary: There is an urgent need for antiviral drugs to treat SARS-CoV-2, and screening has identified several potential candidates with different mechanisms of action in lung epithelial cells. Some of these drugs could be used for the treatment of respiratory cells in patients.
Article
Multidisciplinary Sciences
Hirotada Kobayashi, Karin Amrein, Jessica A. Lasky-Su, Kenneth B. Christopher
Summary: Elevated procalcitonin levels are associated with significant changes in various metabolite classes, including positive associations with short and medium chain acylcarnitines and negative associations with long chain acylcarnitines and lysophosphatidylcholines. This indicates activation of branched chain amino acid dehydrogenase and a metabolic shift in response to inflammation.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Yi Ding, Marielle C. Haks, Gabriel Forn-Cuni, Junling He, Natalia Nowik, Amy C. Harms, Thomas Hankemeier, Muhamed N. H. Eeza, Jorg Matysik, A. Alia, Herman P. Spaink
Summary: This study investigates the effects of leptin deficiency in mice and zebrafish larvae through integration of metabolomics and transcriptomics, revealing similar metabolic alterations and dysregulated gene regulation related to proteolysis and arachidonic acid metabolism in both models.
CELL AND BIOSCIENCE
(2021)
Article
Plant Sciences
Yuru Chang, Yogesh Kumar Ahlawat, Tongjun Gu, Ali Sarkhosh, Tie Liu
Summary: This study explored the variations in morphology, biochemistry, and genetics during berry maturation in two muscadine grape cultivars, Carlos and Noble. The levels of antioxidants, anthocyanins, and titratable acids differed between the two cultivars, and new genes, pathways, and regulatory networks involved in berry ripening were identified. These findings have implications for improving the ripening uniformity and postharvest characteristics of muscadine grapes.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Biochemical Research Methods
Mohammad Ali Moni, Julian M. W. Quinn, Nese Sinmaz, Matthew A. Summers
Summary: The study identified key gene expression pathways altered with infection of the novel coronavirus SARS-CoV-2 through comparative genomic and transcriptomic analysis, including comparisons with SARS-CoV and MERS-CoV, as well as influenza A strains. Validation of SARS-CoV-2 infection response genes as disease-associated and identification of signaling pathway concordance between lung cell and blood cell infection responses were also highlighted in the research.
BRIEFINGS IN BIOINFORMATICS
(2021)
Article
Oncology
Sumeyra Cetinkaya, Ilknur Cinar Ayan, Ipek Suntar, Hatice Gul Dursun
Summary: The study investigates the cellular and molecular mechanisms of Liquidambar orientalis in colorectal cancer cell lines, revealing the leaf methanol extract as having high cytotoxic activity, primarily due to phytochemical compounds like quercetin 3-glucoside and chlorogenic acid. The results demonstrate the in vitro cytotoxic and apoptotic properties of the LM extract.
NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL
(2022)
Article
Genetics & Heredity
Laura Natalia Balarezo-Cisneros, Steven Parker, Marcin G. Fraczek, Soukaina Timouma, Ping Wang, Raymond T. O'Keefe, Catherine B. Millar, Daniela Delneri
Summary: The study revealed the crucial role of non-coding RNAs (ncRNAs) in regulating gene expression by fine-tuning cellular expression through interactions with transcription factors, demonstrating their significant impact on cellular function.
Article
Immunology
Takara L. Stanley, Lindsay T. Fourman, Lai Ping Wong, Ruslan Sadreyev, James M. Billingsley, Meghan N. Feldpausch, Isabel Zheng, Chelsea S. Pan, Autumn Boutin, Hang Lee, Kathleen E. Corey, Martin Torriani, David E. Kleiner, Raymond T. Chung, Colleen M. Hadigan, Steven K. Grinspoon
Summary: This study demonstrated that long-term treatment with a GHRH analog reduced markers of T-cell and monocyte/macrophage activity, suggesting that augmentation of the GH axis may ameliorate immune activation in an HIV population with metabolic dysregulation, systemic and end organ inflammation.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Chemistry, Multidisciplinary
Cindy D. Beyer, Matthew L. Reback, Srinivasa M. Gopal, Kim A. Nolte, John A. Finlay, Anthony S. Clare, Lars V. Schaefer, Nils Metzler-Nolte, Axel Rosenhahn
ACS SUSTAINABLE CHEMISTRY & ENGINEERING
(2020)
Article
Biochemistry & Molecular Biology
Dariusz Smilowicz, Nils Metzler-Nolte
JOURNAL OF INORGANIC BIOCHEMISTRY
(2020)
Article
Green & Sustainable Science & Technology
Kai Junge Puring, Daniel Siegmund, Jana Timm, Florian Moellenbruck, Steffen Schemme, Roland Marschall, Ulf-Peter Apfel
Summary: Gas diffusion electrodes play a crucial role in the electrochemical conversion of CO2, where electrode composition and catalytic layer assembly have a significant impact on the performance. Optimized electrodes show high selectivity and efficiency in producing formate, CO, and H-2 at different current densities and electrolyte concentrations.
ADVANCED SUSTAINABLE SYSTEMS
(2021)
Article
Chemistry, Multidisciplinary
Isabelle Marie Daubit, Svenja Wortmann, Daniel Siegmund, Stephan Hahn, Patrick Nuernberger, Nils Metzler-Nolte
Summary: The synthesis of luminescent Rh-I and Ir-I [M(COD)(NHC)I] complexes with 1,8-naphthalimide-based emitting ligands has been reported, and the complexes were found to predominantly accumulate in the endoplasmic reticulum, providing new insights into the cellular localization of such Ir-I(NHC) complexes.
CHEMISTRY-A EUROPEAN JOURNAL
(2021)
Article
Chemistry, Inorganic & Nuclear
Philipp Gerschel, Anna L. Cordes, Sarah Bimmermann, Daniel Siegmund, Nils Metzler-Nolte, Ulf-Peter Apfel
Summary: The study presents a series of cyclam-based Re complexes and investigates their synthesis, coordination behavior, and performance in the electrochemical reduction of CO2.
ZEITSCHRIFT FUR ANORGANISCHE UND ALLGEMEINE CHEMIE
(2021)
Article
Nanoscience & Nanotechnology
Cindy D. Beyer, Sugina Thavalingam, Tatiana Guseva, Lisa Schardt, Ralf Zimmermann, Carsten Werner, Pascal Dietze, Julia Elisabeth Bandow, Nils Metzler-Nolte, Axel Rosenhahn
Summary: Zwitterionic peptides with histidine and glutamic acid, as well as lysine and glutamic acid, sequences were synthesized and tested for protein and marine organism resistance. A comparison revealed that peptides with lysine performed better against proteins and freshwater bacteria, while sequences containing histidine were more resistant to marine organisms. The influence of amino acid properties and external factors on coating resistance was discussed, providing insights for future biocompatible and sustainable fouling release coatings.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Chemistry, Multidisciplinary
Dianna Truong, Nelson Y. S. Lam, Meder Kamalov, Mie Riisom, Stephen M. F. Jamieson, Paul W. R. Harris, Margaret A. Brimble, Nils Metzler-Nolte, Christian G. Hartinger
Summary: The study presents a novel approach for selectively anchoring transition metal half-sandwich complexes onto peptides with high purity using solid support synthesis. The metalated peptides were evaluated for their anticancer properties against human cancer cell lines, showing no cytotoxic activity but potential for site-selective peptide labelling and ligand design in transition metal catalysts.
CHEMISTRY-A EUROPEAN JOURNAL
(2022)
Article
Chemistry, Inorganic & Nuclear
Marion Graf, Hans-Christian Boettcher, Nils Metzler-Nolte, Sugina Thavalingam, Peter Mayer
Summary: This study describes the synthesis and characterization of eight new bis-cyclometalated compounds. The cytotoxic properties of these compounds were evaluated against prominent cancer cell lines, and it was found that the compounds with 5-chloro-substituted phenanthroline ligands showed the highest cytotoxicity.
ZEITSCHRIFT FUR ANORGANISCHE UND ALLGEMEINE CHEMIE
(2022)
Article
Chemistry, Multidisciplinary
Daniel Obitz, Karmel S. Gkika, Marvin Heller, Tia E. Keyes, Nils Metzler-Nolte
Summary: A lanthanide(iii) complex connected to a light harvesting antenna was synthesized and tested as a potential photosensitizer in photodynamic therapy. The complex showed significant phototoxic activity on cancer cells upon irradiation, with ROS production identified as the compound's phototoxic mode of action. In cell viability assays, a 10-fold decrease in IC50 value was observed compared to the dark control.
CHEMICAL COMMUNICATIONS
(2023)
Article
Chemistry, Multidisciplinary
James W. Southwell, Reyme Herman, Daniel J. Raines, Justin E. Clarke, Isabelle Boeswald, Thorsten Dreher, Sophie M. Gutenthaler, Nicole Schubert, Jana Seefeldt, Nils Metzler-Nolte, Gavin H. Thomas, Keith S. Wilson, Anne-Kathrin Duhme-Klair
Summary: This study investigates the use of siderophore-linked ruthenium catalysts for the activation of antibacterial prodrugs within cells. It demonstrates that moxifloxacin-based prodrugs can be activated under anaerobic, biologically relevant conditions with the help of these catalysts. Conjugates containing siderophore units based on catechol and azotochelin are found to be the most promising for intracellular prodrug activation.
CHEMISTRY-A EUROPEAN JOURNAL
(2022)
Article
Chemistry, Inorganic & Nuclear
Marion Graf, Jasmine Ochs, Nils Metzler-Nolte, Peter Mayer, Hans-Christian Bottcher
Summary: This paper describes the synthesis and characterization of six new organometallic half-sandwich iridium(III) compounds with modified bipyridine ligands. The cytotoxic properties of the compounds against two cancer cell lines were evaluated, and compound 3 showed the most remarkable biological activity with significantly enhanced toxicity compared to cisplatin.
ZEITSCHRIFT FUR ANORGANISCHE UND ALLGEMEINE CHEMIE
(2023)
Review
Chemistry, Multidisciplinary
Karolina Kaminska, Andrzej Mular, Evgenia Olshvang, Nils Metzler Nolte, Henryk Kozlowski, Elzbieta Wojaczynska, Elzbieta Gumienna-Kontecka
Summary: Siderophores are specific iron chelators produced and secreted by organisms under iron deficiency conditions. These molecules have high affinity and specificity for Fe3+ and other metal ions, and have potential applications in antibiotics delivery. Total synthesis of siderophores is necessary due to their low natural concentrations.
Correction
Chemistry, Multidisciplinary
Christine N. Morrison, Kathleen E. Prosser, Ryjul W. Stokes, Anna Cordes, Nils Metzler-Nolte, Seth M. Cohen
Summary: The study introduces a novel approach using metallofragments as 3D scaffolds for fragment-based drug discovery. This method has great potential in the field of medicinal chemistry and provides a new direction for drug development.
Article
Chemistry, Inorganic & Nuclear
Daniel Obitz, Reece G. Miller, Nils Metzler-Nolte
Summary: The synthesis of bioconjugates of ruthenium(ii) dipyridophenazine complexes with two different cell penetrating peptides (CPPs) was described, with characterization done by various methods. The bioconjugates show similar low vitro cytotoxicity to the parent metal complexes.
DALTON TRANSACTIONS
(2021)
Review
Chemistry, Multidisciplinary
Julian T. Kleinhaus, Florian Wittkamp, Shanika Yadav, Daniel Siegmund, Ulf-Peter Apfel
Summary: This review provides an overview of developments in [FeFe]-hydrogenase research, focusing on synthetic mimics and their application within the native enzymatic environment.
CHEMICAL SOCIETY REVIEWS
(2021)