Article
Multidisciplinary Sciences
Clement Solie, Alessandro Contestabile, Pedro Espinosa, Stefano Musardo, Sebastiano Bariselli, Chieko Huber, Alan Carleton, Camilla Bellone
Summary: This study shows that the pathway from superior colliculus to ventral tegmental area (VTA) plays a key role in encoding orienting behavior and modulating social interaction. The researchers found that this pathway affects VTA dopamine neurons projecting onto dorsolateral striatum, and the stimulation or inhibition of this pathway can influence social interaction in mice.
NATURE COMMUNICATIONS
(2022)
Article
Multidisciplinary Sciences
Wouter van Elzelingen, Jessica Goedhoop, Pascal Warnaar, Damiaan Denys, Tara Arbab, Ingo Willuhn
Summary: Dopamine signals in the striatum play a critical role in motivated behavior. The release and modulation of dopamine in different regions of the striatum vary, while prediction-error signals are limited to specific regions.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Endocrinology & Metabolism
Stephanie Kullmann, Dominik Blum, Benjamin Assad Jaghutriz, Christoph Gassenmaier, Benjamin Bender, Hans-Ulrich Haering, Gerald Reischl, Hubert Preissl, Christian la Fougere, Andreas Fritsche, Matthias Reimold, Martin Heni
Summary: This study demonstrates that central administration of insulin can impact dopaminergic activity in the striatum, which in turn affects regional brain activity and connectivity. The interaction between insulin and dopamine and the regulation of whole-body metabolism through a complex network are further elucidated by our findings.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Chemistry, Analytical
Sam B. Choi, Abigail M. Polter, Peter Nemes
Summary: The integration of patch-clamp electrophysiology with high-resolution mass spectrometry enables the identification and quantification of proteins within neurons. By improving sample processing and detection methods, the study was able to detect approximately 275 different proteins in somal aspirates from cultured neurons.
ANALYTICAL CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Siamak K. Sorooshyari, Nicholas Ouassil, Sarah J. Yang, Markita P. Landry
Summary: The emergence of new imaging tools has revolutionized our understanding of neurochemistry in brain development and cognition. In this study, near-infrared catecholamine nanosensors were used to image dopamine modulation in brain tissue slices. Machine learning techniques were applied to identify unique features of dopamine modulation related to stimulation strength and specific neuroanatomical regions. The results showed that machine learning could accurately distinguish dopamine release in different regions of the brain, which was not achievable with conventional statistical analysis. The study highlights the potential of machine learning as a powerful tool in differentiating neuroanatomical regions and detecting features not detectable by conventional statistical analysis.
ACS CHEMICAL NEUROSCIENCE
(2023)
Article
Neurosciences
Maria Christensen, Soren Emil Norr, Ulrik Gether, Mattias Rickhag
Summary: The study focuses on the pivotal role of the striatum in controlling voluntary movements and the impact of permanently inhibiting dSPN activity with TeLC on behavioral outcomes. It was found that the observed ipsilateral rotations in TeLC-expressing mice were due to the silencing of dSPN activity in one hemisphere, causing a temporal imbalance in the basal ganglia circuit and resulting in short bursts of rotations, particularly evident during extrinsic dopaminergic modulation.
Article
Multidisciplinary Sciences
Nicolas A. Morgenstern, Ana Filipa Isidro, Inbal Israely, Rui M. Costa
Summary: This study reveals a previously unknown excitatory circuit in the brain, which conveys a delayed second phase of excitation to the striatum through a polysynaptic pathway involving PT neurons, cholinergic interneurons, and glutamate-releasing axons. This circuit mechanism may have important implications for behavior, plasticity, and learning.
Article
Biochemistry & Molecular Biology
Joshua R. Enck, Eric C. Olson
Summary: This study confirms that Cajal-Retzius neurons in the cortical marginal zone can influence the development of cortical projection neurons by releasing glutamate and glycine, providing insight into the observation that many autism-linked genes are expressed in the developing cortex before the appearance of synapses and functional circuits.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Neurosciences
Christine J. Arasaratnam, Jennifer J. Song, Tomoko Yoshida, Maurice A. Curtis, Ann M. Graybiel, Richard L. M. Faull, Henry J. Waldvogel
Summary: The dorsal striatum is a central node of the basal ganglia, which is involved in mood and movement regulation. It connects the neocortex and thalamus with circuits that modulate these functions. Striatal projection neurons, including D1-type and D2-type dopamine receptors, form the direct and indirect output systems of the basal ganglia. Within the striatum, there is a compartmental organization with striosomes embedded within a larger striatal matrix. DARPP-32, a key signaling molecule, is highly concentrated in striosomes in the dorsal human striatum.
JOURNAL OF COMPARATIVE NEUROLOGY
(2023)
Article
Cell Biology
Giorgio Rizzi, Zhuoliang Li, Norbert Hogrefe, Kelly R. Tan
Summary: This study explored the involvement of midbrain neurons in conditioned learning and how GABA and glutamate cells affect fear-conditioned learning through specific connections. Inhibiting specific sub-circuits of dmCIN neurons led to varying impairments in learning, with Vglut2-expressing cells and Vgat-positive neurons associating with different stimuli. It suggests that each component of the network carries information relevant to different subdomains of the behavioral strategy.
Article
Neurosciences
Toneisha Stubbs, Andrew Koemeter-Cox, James I. Bingman, Fangli Zhao, Anuradha Kalyanasundaram, Leslie A. Rowland, Muthu Periasamy, Calvin S. Carter, Val C. Sheffield, Candice C. Askwith, Kirk Mykytyn
Summary: A rod-shaped appendage called a primary cilium projects from most central neurons in the mammalian brain. Cilia are important for neuronal signaling and their dysfunction is associated with various neuropathologies. This study demonstrates that disrupting the localization of a specific ciliary GPCR, called dopamine receptor 1 (D-1), in neurons leads to obesity and reduced locomotor activity in male and female mice. Loss of a BBS protein or cilia on D-1-expressing neurons also reduces D-1-mediated signaling. These findings highlight the importance of neuronal cilia for proper GPCR signaling and shed light on the role of cilia in regulating weight and locomotor activity.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Neurosciences
Renchao Chen, Timothy R. Blosser, Mohamed N. Djekidel, Junjie Hao, Aritra Bhattacherjee, Wenqiang Chen, Luis M. Tuesta, Xiaowei Zhuang, Yi Zhang
Summary: The authors utilized single-cell RNA sequencing and multiplexed error-robust FISH to generate a cell census of the mouse nucleus accumbens, revealing a high level of cell heterogeneity. This study demonstrates that the transcriptional and spatial diversity of neuron subtypes underlie the anatomic and functional heterogeneity of the nucleus accumbens.
NATURE NEUROSCIENCE
(2021)
Article
Neurosciences
Ettel Keifman, Camila Coll, Cecilia Tubert, Rodrigo M. Paz, Juan E. Belforte, Mario G. Murer, Barbara Y. Braz
Summary: In Parkinson's disease patients and rodent models, loss of dopaminergic neurons results in severe motor disabilities. However, in rodents, general motility is preserved after early postnatal loss of dopaminergic neurons. This preservation is likely due to functional changes in certain neurons in the brain.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Neurosciences
Klara Danielsson, Oona Lagstrom, Mia Ericson, Bo Soderpalm, Louise Adermark
Summary: The study suggests that repeated amphetamine exposure leads to selective effects on dopamine signaling in striatal subregions, explaining why tolerance develops towards the drug's rewarding effects but not its psychosis inducing properties.
Article
Neurosciences
Keita Sugiyama, Mahomi Kuroiwa, Takahide Shuto, Yoshinori N. Ohnishi, Yukie Kawahara, Yuta Miyamoto, Takaichi Fukuda, Akinori Nishi
Summary: The striatum, the main structure of the basal ganglia, is subdivided into seven subregions with distinct roles in motor and emotional functions. Dopamine D1 receptor signaling is region-specifically regulated in the striatum, with aberrant activation in the IC associated with L-DOPA-induced dyskinesia. Future research focusing on D1 receptor signaling in the IC may lead to novel therapeutics for LID.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Computer Science, Interdisciplinary Applications
Mathew Birdsall Abrams, Jan G. Bjaalie, Samir Das, Gary F. Egan, Satrajit S. Ghosh, Wojtek J. Goscinski, Jeffrey S. Grethe, Jeanette Hellgren Kotaleski, Eric Tatt Wei Ho, David N. Kennedy, Linda J. Lanyon, Trygve B. Leergaard, Helen S. Mayberg, Luciano Milanesi, Roman Moucek, J. B. Poline, Prasun K. Roy, Stephen C. Strother, Tong Boon Tang, Paul Tiesinga, Thomas Wachtler, Daniel K. Wojcik, Maryann E. Martone
Summary: There is a great need for coordination around standards and best practices in neuroscience to address challenges in data science. Developing community standards and gaining their adoption is difficult, as the current landscape is characterized by a lack of robust, validated standards and a plethora of underdeveloped and underutilized standards and best practices. An independent organization, the International Neuroinformatics Coordinating Facility (INCF), is dedicated to promoting data sharing in neuroscience and has implemented procedures for evaluating and endorsing community standards and best practices.
Correction
Computer Science, Interdisciplinary Applications
Mathew Birdsall Abrams, Jan G. Bjaalie, Samir Das, Gary F. Egan, Satrajit S. Ghosh, Wojtek J. Goscinski, Jeffrey S. Grethe, Jeanette Hellgren Kotaleski, Eric Tatt Wei Ho, David N. Kennedy, Linda J. Lanyon, Trygve B. Leergaard, Helen S. Mayberg, Luciano Milanesi, Roman Moucek, J. B. Poline, Prasun K. Roy, Stephen C. Strother, Tong Boon Tang, Paul Tiesinga, Thomas Wachtler, Daniel K. Wojcik, Maryann E. Martone
Review
Behavioral Sciences
Shreyas M. Suryanarayana, Juan Perez-Fernandez, Brita Robertson, Sten Grillner
Summary: Through a detailed comparison between the mammalian forebrain and that of the lamprey, it is suggested that many aspects of the basic design of the vertebrate forebrain had evolved before the lamprey diverged from the evolutionary line leading to mammals. The study proposes a compelling account of a pan-vertebrate schema for basic forebrain structures, indicating a common ancestry of over half a billion years of vertebrate evolution.
BRAIN BEHAVIOR AND EVOLUTION
(2022)
Article
Biology
Jay S. Coggan, Daniel Keller, Henry Markram, Felix Schurmann, Pierre J. Magistretti
Summary: We explored a computational model of astrocytic energy metabolism and demonstrated the theoretical plausibility that this type of pathway might be capable of coding information about stimuli in addition to its known functions in cellular energy and carbon budgets. The simulation results showed that glycogenolytic glycolysis triggered by activation of adrenergic receptors can capture the characteristics of a neuromodulator waveform and respond in a dose-dependent manner. This metabolic pathway has the potential to translate information about external stimuli to production profiles of energy-carrying molecules, impacting the function of the cells.
JOURNAL OF THEORETICAL BIOLOGY
(2022)
Article
Mathematical & Computational Biology
Ilaria Carannante, Yvonne Johansson, Gilad Silberberg, Jeanette Hellgren Kotaleski
Summary: This article presents a new data-driven model for accurately describing the features of excitatory postsynaptic currents in mouse striatum. Compared to traditional methods, this new model uses more time constants and provides a more accurate description, while maintaining low computational costs.
FRONTIERS IN COMPUTATIONAL NEUROSCIENCE
(2022)
Article
Cell Biology
Anna Tokarska, Gilad Silberberg
Summary: The interactions between striatal cholinergic and GABAergic systems play a crucial role in reward-related behavior and reinforcement learning. By studying Chrna2-Cre mice, we discovered that striatal Chrna2-INs have different electrophysiological, morphological, and synaptic properties compared to other brain regions. These INs form inhibitory synaptic connections with striatal projection neurons and other INs and receive excitatory inputs from the primary motor cortex. Some Chrna2-INs respond to nicotinic input, suggesting reciprocal interactions with striatal cholinergic synapses.
Article
Chemistry, Multidisciplinary
Siri C. van Keulen, Juliette Martin, Francesco Colizzi, Elisa Frezza, Daniel Trpevski, Nuria Cirauqui Diaz, Pietro Vidossich, Ursula Rothlisberger, Jeanette Hellgren Kotaleski, Rebecca C. Wade, Paolo Carloni
Summary: This study used simulation tools to uncover the molecular and subcellular mechanisms of AC function, with a focus on the AC5 isoform. The research revealed an inactive state of the enzyme in the presence of an inhibitory G alpha subunit, regardless of the presence of a stimulatory G alpha. The binding of G alpha subunits reshaped the free-energy landscape of the AC5 enzyme.
WILEY INTERDISCIPLINARY REVIEWS-COMPUTATIONAL MOLECULAR SCIENCE
(2023)
Review
Biology
Olivia Eriksson, Upinder Singh Bhalla, Kim T. Blackwell, Sharon M. Crook, Daniel Keller, Andrei Kramer, Marja-Leena Linne, Ausra Saudargiene, Rebecca C. Wade, Jeanette Hellgren Kotaleski
Summary: Modeling in neuroscience involves hypothesis-driven and data-driven approaches, with models constructed at different biological scales and levels of abstraction. However, a lack of interoperability, transparency, and reusability of models and workflows hinders the integration of models representing different scales and built using different methods. Applying the FAIR principles to models and workflows can facilitate integration and enhance understanding of the brain.
Article
Cell Biology
Yvonne Johansson, Maya Ketzef
Summary: Sensory processing is crucial for appropriate behavior. This study investigates the pathways involved in sensory integration in different types of cells in the external globus pallidus (GPe), a region important for motor control. The results show that prototypic cells in the GPe receive sensory information from the subthalamic nucleus and indirect pathway medium spiny neurons (MSNs), while arkypallidal cells primarily receive sensory information from direct pathway MSNs. These findings highlight the anatomical and functional differences in the GPe's parallel pathways.
Article
Multidisciplinary Sciences
Roberto de la Torre-Martinez, Maya Ketzef, Gilad Silberberg
Summary: This study investigates the influence of motor activity on sensory processing in the dorsolateral striatum (DLS) and how it is modulated by dopamine. Whole-cell recordings in awake mice reveal that whisking affects sensory responses in the DLS, with attenuated responses during ongoing whisking. Dopamine depletion reduces the representation of whisking in direct-pathway neurons and impairs discrimination between ipsilateral and contralateral sensory stimulation in both direct and indirect pathway neurons.
NATURE COMMUNICATIONS
(2023)
Article
Multidisciplinary Sciences
Yichen Zhang, Gan He, Lei Ma, Xiaofei Liu, J. J. Johannes Hjorth, Alexander Kozlov, Yutao He, Shenjian Zhang, Jeanette Hellgren Kotaleski, Yonghong Tian, Sten Grillner, Kai Du, Tiejun Huang
Summary: Biophysically detailed multi-compartment models are powerful tools for exploring brain computational principles and generating AI algorithms. The high computational cost limits their applications. Researchers propose a novel dendritic hierarchical scheduling method that significantly accelerates simulations using GPU computing engine, and demonstrate its applications in neuroscience tasks.
NATURE COMMUNICATIONS
(2023)
Article
Cell Biology
Marta Barandela, Carmen Nunez-Gonzalez, Daichi G. Suzuki, Cecilia Jimenez-Lopez, Manuel A. Pombal, Juan Perez-Fernandez
Summary: Animals constantly adjust their gaze to stabilize their vision, with stabilizing movements appearing before goal-oriented responses during the development of the lamprey visual system. This finding provides valuable insights into the evolutionary and developmental processes of vertebrate vision.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Neurosciences
Ruy Gomez-Ocadiz, Gilad Silberberg
Summary: Corticostriatal pathways are crucial for various motor, sensory, cognitive, and affective functions. Recent studies have revealed their distinct structural and functional properties, as well as their regulatory role in neuromodulation within the striatum.
CURRENT OPINION IN NEUROBIOLOGY
(2023)
Article
Behavioral Sciences
Robert Lindroos, Rohan Raj, Stephen Pierzchajlo, Thomas Horberg, Pawel Herman, Sandra Challma, Thomas Hummel, Maria Larsson, Erika J. Laukka, Jonas K. Olofsson
Summary: Odor identification abilities decline with age, with high-intensity odors being easier to identify overall but more affected by old age. Identification likelihood is proportional to the perceived intensity of the odor, and it is also associated with perceived pleasantness and edibility.