Conformational landscape of the epidermal growth factor receptor kinase reveals a mutant specific allosteric pocket
出版年份 2018 全文链接
标题
Conformational landscape of the epidermal growth factor receptor kinase reveals a mutant specific allosteric pocket
作者
关键词
-
出版物
Chemical Science
Volume 9, Issue 23, Pages 5212-5222
出版商
Royal Society of Chemistry (RSC)
发表日期
2018-05-16
DOI
10.1039/c8sc01262h
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Hydration effects on the efficacy of the Epidermal growth factor receptor kinase inhibitor afatinib
- (2017) Srinivasaraghavan Kannan et al. Scientific Reports
- The International Association for the Study of Lung Cancer Consensus Statement on Optimizing Management of EGFR Mutation–Positive Non–Small Cell Lung Cancer: Status in 2016
- (2016) Daniel S.W. Tan et al. Journal of Thoracic Oncology
- Review on EGFR Inhibitors: Critical Updates
- (2016) Davinder Singh et al. MINI-REVIEWS IN MEDICINAL CHEMISTRY
- Overcoming EGFR(T790M) and EGFR(C797S) resistance with mutant-selective allosteric inhibitors
- (2016) Yong Jia et al. NATURE
- Analysis of different HER-2 mutations in breast cancer progression and drug resistance
- (2015) Zijia Sun et al. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
- Acquired EGFR C797S mutation mediates resistance to AZD9291 in non–small cell lung cancer harboring EGFR T790M
- (2015) Kenneth S Thress et al. NATURE MEDICINE
- Conformational Transition Pathways of Epidermal Growth Factor Receptor Kinase Domain from Multiple Molecular Dynamics Simulations and Bayesian Clustering
- (2014) Yan Li et al. Journal of Chemical Theory and Computation
- The clinical development of MEK inhibitors
- (2014) Yujie Zhao et al. Nature Reviews Clinical Oncology
- COSMIC: exploring the world's knowledge of somatic mutations in human cancer
- (2014) Simon A. Forbes et al. NUCLEIC ACIDS RESEARCH
- The free energy landscape in translational science: how can somatic mutations result in constitutive oncogenic activation?
- (2014) Chung-Jung Tsai et al. PHYSICAL CHEMISTRY CHEMICAL PHYSICS
- Unraveling structural mechanisms of allosteric drug action
- (2014) Ruth Nussinov et al. TRENDS IN PHARMACOLOGICAL SCIENCES
- Activation pathway of Src kinase reveals intermediate states as targets for drug design
- (2014) Diwakar Shukla et al. Nature Communications
- AZD9291, an Irreversible EGFR TKI, Overcomes T790M-Mediated Resistance to EGFR Inhibitors in Lung Cancer
- (2014) D. A. E. Cross et al. Cancer Discovery
- Allostery in Disease and in Drug Discovery
- (2013) Ruth Nussinov et al. CELL
- Effects of oncogenic mutations on the conformational free-energy landscape of EGFR kinase
- (2013) L. Sutto et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Transitions to catalytically inactive conformations in EGFR kinase
- (2013) Y. Shan et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Discovery of a Mutant-Selective Covalent Inhibitor of EGFR that Overcomes T790M-Mediated Resistance in NSCLC
- (2013) A. O. Walter et al. Cancer Discovery
- Oncogenic Mutations Counteract Intrinsic Disorder in the EGFR Kinase and Promote Receptor Dimerization
- (2012) Yibing Shan et al. CELL
- Mechanism of Drug Efficacy Within the EGF Receptor Revealed by Microsecond Molecular Dynamics Simulation
- (2012) S. Wan et al. MOLECULAR CANCER THERAPEUTICS
- The Epidermal Growth Factor Receptor-L861Q Mutation Increases Kinase Activity without Leading to Enhanced Sensitivity Toward Epidermal Growth Factor Receptor Kinase Inhibitors
- (2011) Rama Krishna Kancha et al. Journal of Thoracic Oncology
- The Energy Landscape Analysis of Cancer Mutations in Protein Kinases
- (2011) Anshuman Dixit et al. PLoS One
- Comparison of the EGFR resistance mutation profiles generated by EGFR-targeted tyrosine kinase inhibitors and the impact of drug combinations
- (2008) Egle Avizienyte et al. BIOCHEMICAL JOURNAL
- Activation of tyrosine kinases by mutation of the gatekeeper threonine
- (2008) Mohammad Azam et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- The T790M mutation in EGFR kinase causes drug resistance by increasing the affinity for ATP
- (2008) C.-H. Yun et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Create your own webinar
Interested in hosting your own webinar? Check the schedule and propose your idea to the Peeref Content Team.
Create NowAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started