Effects of oncogenic mutations on the conformational free-energy landscape of EGFR kinase
出版年份 2013 全文链接
标题
Effects of oncogenic mutations on the conformational free-energy landscape of EGFR kinase
作者
关键词
-
出版物
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume 110, Issue 26, Pages 10616-10621
出版商
Proceedings of the National Academy of Sciences
发表日期
2013-06-11
DOI
10.1073/pnas.1221953110
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Architecture and Membrane Interactions of the EGF Receptor
- (2013) Anton Arkhipov et al. CELL
- Conformational Coupling across the Plasma Membrane in Activation of the EGF Receptor
- (2013) Nicholas F. Endres et al. CELL
- Transitions to catalytically inactive conformations in EGFR kinase
- (2013) Y. Shan et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Erlotinib binds both inactive and active conformations of the EGFR tyrosine kinase domain
- (2012) Jin H. Park et al. BIOCHEMICAL JOURNAL
- Oncogenic Mutations Counteract Intrinsic Disorder in the EGFR Kinase and Promote Receptor Dimerization
- (2012) Yibing Shan et al. CELL
- Oncogenic potential is related to activating effect of cancer single and double somatic mutations in receptor tyrosine kinases
- (2012) Kosuke Hashimoto et al. HUMAN MUTATION
- The Different Flexibility of c-Src and c-Abl Kinases Regulates the Accessibility of a Druggable Inactive Conformation
- (2012) Silvia Lovera et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Mechanism of Drug Efficacy Within the EGF Receptor Revealed by Microsecond Molecular Dynamics Simulation
- (2012) S. Wan et al. MOLECULAR CANCER THERAPEUTICS
- Systematic Validation of Protein Force Fields against Experimental Data
- (2012) Kresten Lindorff-Larsen et al. PLoS One
- New advances in metadynamics
- (2012) Ludovico Sutto et al. Wiley Interdisciplinary Reviews-Computational Molecular Science
- Catalytic Control in the EGF Receptor and Its Connection to General Kinase Regulatory Mechanisms
- (2011) Natalia Jura et al. MOLECULAR CELL
- Computational Modeling of Allosteric Communication Reveals Organizing Principles of Mutation-Induced Signaling in ABL and EGFR Kinases
- (2011) Anshuman Dixit et al. PLoS Computational Biology
- COSMIC: mining complete cancer genomes in the Catalogue of Somatic Mutations in Cancer
- (2010) S. A. Forbes et al. NUCLEIC ACIDS RESEARCH
- Enhanced Sampling in the Well-Tempered Ensemble
- (2010) M. Bonomi et al. PHYSICAL REVIEW LETTERS
- PLUMED: A portable plugin for free-energy calculations with molecular dynamics
- (2009) Massimiliano Bonomi et al. COMPUTER PHYSICS COMMUNICATIONS
- Optimized Molecular Dynamics Force Fields Applied to the Helix−Coil Transition of Polypeptides
- (2009) Robert B. Best et al. JOURNAL OF PHYSICAL CHEMISTRY B
- Double EGFR mutants containing rare EGFR mutant types show reduced in vitro response to gefitinib compared with common activating missense mutations
- (2009) I. Y.-S. Tam et al. MOLECULAR CANCER THERAPEUTICS
- The cancer genome
- (2009) Michael R. Stratton et al. NATURE
- GROMACS 4: Algorithms for Highly Efficient, Load-Balanced, and Scalable Molecular Simulation
- (2008) Berk Hess et al. Journal of Chemical Theory and Computation
- Protein Conformational Transitions: The Closure Mechanism of a Kinase Explored by Atomistic Simulations
- (2008) Anna Berteotti et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Comprehensive genomic characterization defines human glioblastoma genes and core pathways
- (2008) Roger McLendon et al. NATURE
- A conserved protonation-dependent switch controls drug binding in the Abl kinase
- (2008) Y. Shan et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The T790M mutation in EGFR kinase causes drug resistance by increasing the affinity for ATP
- (2008) C.-H. Yun et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Publish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn MoreAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started