Forming next-generation antibody–nanoparticle conjugates through the oriented installation of non-engineered antibody fragments

Highly robust and optimized conjugation of antibodies to nanoparticles using quantitatively validated protocols

(2017) Sinyoung Jeong et al.   Nanoscale

Frizzled7 Antibody-Functionalized Nanoshells Enable Multivalent Binding for Wnt Signaling Inhibition in Triple Negative Breast Cancer Cells

(2017) Rachel S. Riley et al.   Small

Antibody fragments as nanoparticle targeting ligands: a step in the right direction

(2017) Daniel A. Richards et al.   Chemical Science

Enabling the controlled assembly of antibody conjugates with a loading of two modules without antibody engineering

(2017) Maximillian T. W. Lee et al.   Chemical Science

Pyridazinediones deliver potent, stable, targeted and efficacious antibody–drug conjugates (ADCs) with a controlled loading of 4 drugs per antibody

(2017) Eifion Robinson et al.   RSC Advances

Understanding How the Stability of the Thiol-Maleimide Linkage Impacts the Pharmacokinetics of Lysine-Linked Antibody–Maytansinoid Conjugates

(2016) Jose F. Ponte et al.   BIOCONJUGATE CHEMISTRY

Click Chemistry Immobilization of Antibodies on Polymer Coated Gold Nanoparticles

(2016) Chiara Finetti et al.   LANGMUIR

Conjugation of 10 kDa Linear PEG onto Trastuzumab Fab′ Is Sufficient to Significantly Enhance Lymphatic Exposure while Preserving in Vitro Biological Activity

(2016) Linda J. Chan et al.   MOLECULAR PHARMACEUTICS

Delivery of siRNAs to Dendritic Cells Using DEC205-Targeted Lipid Nanoparticles to Inhibit Immune Responses

(2016) Joseph A Katakowski et al.   MOLECULAR THERAPY

Nanoparticle-Based Medicines: A Review of FDA-Approved Materials and Clinical Trials to Date

(2016) Daniel Bobo et al.   PHARMACEUTICAL RESEARCH

Next-generation disulfide stapling: reduction and functional re-bridging all in one

(2016) Maximillian T. W. Lee et al.   Chemical Science

The use of 3,6-pyridazinediones in organic synthesis and chemical biology

(2016) Maximillian T. W. Lee et al.   JOURNAL OF CHEMICAL RESEARCH

Antibody fragment-conjugated polymeric micelles incorporating platinum drugs for targeted therapy of pancreatic cancer

(2015) Jooyeon Ahn et al.   BIOMATERIALS

Site-selective multi-porphyrin attachment enables the formation of a next-generation antibody-based photodynamic therapeutic

(2015) Antoine Maruani et al.   CHEMICAL COMMUNICATIONS

Bispecific single-chain diabody-immunoliposomes targeting endoglin (CD105) and fibroblast activation protein (FAP) simultaneously

(2015) Markus Rabenhold et al.   JOURNAL OF CONTROLLED RELEASE

Targeting FR-expressing cells in ovarian cancer with Fab-functionalized nanoparticles: a full study to provide the proof of principle from in vitro to in vivo

(2015) Alessandra Quarta et al.   Nanoscale

mRNA Profiling Reveals Determinants of Trastuzumab Efficiency in HER2-Positive Breast Cancer

(2015) Silvia von der Heyde et al.   PLoS One

Targeting Siglecs with a sialic acid–decorated nanoparticle abrogates inflammation

(2015) Shaun Spence et al.   Science Translational Medicine

A plug-and-play approach to antibody-based therapeutics via a chemoselective dual click strategy

(2015) Antoine Maruani et al.   Nature Communications

Click Conjugation of Peptide to Hydrogel Nanoparticles for Tumor-Targeted Drug Delivery

(2014) Ming Qin et al.   BIOMACROMOLECULES

Ligand-Directed Active Tumor-Targeting Polymeric Nanoparticles for Cancer Chemotherapy

(2014) Yinan Zhong et al.   BIOMACROMOLECULES

Anti-neuropilin 1 antibody Fab′ fragment conjugated liposomal docetaxel for active targeting of tumours

(2014) Arehalli S. Manjappa et al.   JOURNAL OF DRUG TARGETING

Efficient Drug Delivery and Induction of Apoptosis in Colorectal Tumors Using a Death Receptor 5-Targeted Nanomedicine

(2014) Daniela Schmid et al.   MOLECULAR THERAPY

Cancer nanotechnology: The impact of passive and active targeting in the era of modern cancer biology

(2013) Nicolas Bertrand et al.   ADVANCED DRUG DELIVERY REVIEWS

Single domain antibody–quantum dot conjugates for ricin detection by both fluoroimmunoassay and surface plasmon resonance

(2013) George P. Anderson et al.   ANALYTICA CHIMICA ACTA

Functionalizing Nanoparticles with Biological Molecules: Developing Chemistries that Facilitate Nanotechnology

(2013) Kim E. Sapsford et al.   CHEMICAL REVIEWS

Carbodiimide versus Click Chemistry for Nanoparticle Surface Functionalization: A Comparative Study for the Elaboration of Multimodal Superparamagnetic Nanoparticles Targeting αvβ3 Integrins

(2013) Julie Bolley et al.   LANGMUIR

Targeted polymeric therapeutic nanoparticles: design, development and clinical translation

(2012) Nazila Kamaly et al.   CHEMICAL SOCIETY REVIEWS

Design, functionalization strategies and biomedical applications of targeted biodegradable/biocompatible polymer-based nanocarriers for drug delivery

(2012) Julien Nicolas et al.   CHEMICAL SOCIETY REVIEWS

Comparison of Strain-Promoted Alkyne-Azide Cycloaddition With Established Methods for Conjugation of Biomolecules to Magnetic Nanoparticles

(2012) Cordula Gruttner et al.   IEEE TRANSACTIONS ON MAGNETICS

Tunable Degradation of Maleimide–Thiol Adducts in Reducing Environments

(2011) Aaron D. Baldwin et al.   BIOCONJUGATE CHEMISTRY

Conatumumab (AMG 655) coated nanoparticles for targeted pro-apoptotic drug delivery

(2011) Francois Fay et al.   BIOMATERIALS

A novel pathway for maytansinoid release from thioether linked antibody–drug conjugates (ADCs) under oxidative conditions

(2011) Nathan Fishkin et al.   CHEMICAL COMMUNICATIONS

Bromopyridazinedione-mediated protein and peptide bioconjugation

(2011) Vijay Chudasama et al.   CHEMICAL COMMUNICATIONS

Treatment of HER2-positive breast cancer: current status and future perspectives

(2011) Carlos L. Arteaga et al.   Nature Reviews Clinical Oncology

To exploit the tumor microenvironment: Passive and active tumor targeting of nanocarriers for anti-cancer drug delivery

(2010) Fabienne Danhier et al.   JOURNAL OF CONTROLLED RELEASE

An Intein-Mediated Site-Specific Click Conjugation Strategy for Improved Tumor Targeting of Nanoparticle Systems

(2010) Drew R. Elias et al.   Small

Synthesis of bombesin-functionalized iron oxide nanoparticles and their specific uptake in prostate cancer cells

(2009) Amanda L. Martin et al.   JOURNAL OF NANOPARTICLE RESEARCH

In VivoTumor Cell Targeting with “Click” Nanoparticles

(2008) Geoffrey von Maltzahn et al.   BIOCONJUGATE CHEMISTRY

Click Chemistry Functionalized Polymeric Nanoparticles Target Corneal Epithelial Cells through RGD-Cell Surface Receptors

(2008) Jiao Lu et al.   BIOCONJUGATE CHEMISTRY

Development of Multivalent Radioimmunonanoparticles for Cancer Imaging and Therapy

(2008) Arutselvan Natarajan et al.   CANCER BIOTHERAPY AND RADIOPHARMACEUTICALS

Targeted delivery of anti-CD19 liposomal doxorubicin in B-cell lymphoma: A comparison of whole monoclonal antibody, Fab′ fragments and single chain Fv

(2007) Wilson W.K. Cheng et al.   JOURNAL OF CONTROLLED RELEASE