Next-generation disulfide stapling: reduction and functional re-bridging all in one

Acetone-Linked Peptides: A Convergent Approach for Peptide Macrocyclization and Labeling

(2015) Naila Assem et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Site-Specific Antibody–Drug Conjugates: The Nexus of Bioorthogonal Chemistry, Protein Engineering, and Drug Development

(2015) Paresh Agarwal et al.   BIOCONJUGATE CHEMISTRY

A mild TCEP-based para-azidobenzyl cleavage strategy to transform reversible cysteine thiol labelling reagents into irreversible conjugates

(2015) Antoine Maruani et al.   CHEMICAL COMMUNICATIONS

Site-selective multi-porphyrin attachment enables the formation of a next-generation antibody-based photodynamic therapeutic

(2015) Antoine Maruani et al.   CHEMICAL COMMUNICATIONS

Functional native disulfide bridging enables delivery of a potent, stable and targeted antibody–drug conjugate (ADC)

(2015) João P. M. Nunes et al.   CHEMICAL COMMUNICATIONS

Advances in Chemical Protein Modification

(2015) Omar Boutureira et al.   CHEMICAL REVIEWS

Developments and recent advancements in the field of endogenous amino acid selective bond forming reactions for bioconjugation

(2015) Oleksandr Koniev et al.   CHEMICAL SOCIETY REVIEWS

Peptide/Protein Stapling and Unstapling: Introduction of s-Tetrazine, Photochemical Release, and Regeneration of the Peptide/Protein

(2015) Stephen P. Brown et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Organic Arsenicals As Efficient and Highly Specific Linkers for Protein/Peptide–Polymer Conjugation

(2015) Paul Wilson et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A plug-and-play approach to antibody-based therapeutics via a chemoselective dual click strategy

(2015) Antoine Maruani et al.   Nature Communications

Regioselective and Stoichiometrically Controlled Conjugation of Photodynamic Sensitizers to a HER2 Targeting Antibody Fragment

(2014) Francesca Bryden et al.   BIOCONJUGATE CHEMISTRY

Next generation maleimides enable the controlled assembly of antibody–drug conjugates via native disulfide bond bridging

(2014) Felix F. Schumacher et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Selective chemical protein modification

(2014) Christopher D. Spicer et al.   Nature Communications

Acid-cleavable thiomaleamic acid linker for homogeneous antibody–drug conjugation

(2013) Lourdes Castañeda et al.   CHEMICAL COMMUNICATIONS

Homogeneous antibody fragment conjugation by disulfide bridging introduces ‘spinostics’

(2013) Felix F. Schumacher et al.   Scientific Reports

Comparative Binding of Disulfide-Bridged PEG-Fabs

(2012) Hanieh Khalili et al.   BIOCONJUGATE CHEMISTRY

Trastuzumab Emtansine for HER2-Positive Advanced Breast Cancer

(2012) Sunil Verma et al.   NEW ENGLAND JOURNAL OF MEDICINE

In Situ Maleimide Bridging of Disulfides and a New Approach to Protein PEGylation

(2011) Felix F. Schumacher et al.   BIOCONJUGATE CHEMISTRY

Tunable reagents for multi-functional bioconjugation: reversible or permanent chemical modification of proteins and peptides by control of maleimide hydrolysis

(2011) Chris P. Ryan et al.   CHEMICAL COMMUNICATIONS

Bromopyridazinedione-mediated protein and peptide bioconjugation

(2011) Vijay Chudasama et al.   CHEMICAL COMMUNICATIONS

Tetrazine Phototriggers: Probes for Peptide Dynamics

(2010) Matthew J. Tucker et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

PEGylation of therapeutic proteins

(2010) Simona Jevševar et al.   Biotechnology Journal

Chemically modified antibodies as diagnostic imaging agents

(2010) Jeffrey J Day et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Protein Modification, Bioconjugation, and Disulfide Bridging Using Bromomaleimides

(2010) Mark E. B. Smith et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Poly(2-methacryloyloxyethyl phosphorylcholine) for Protein Conjugation

(2008) Andrew Lewis et al.   BIOCONJUGATE CHEMISTRY

A Glycoconjugate Antigen Based on the Recognition Motif of a Broadly Neutralizing Human Immunodeficiency Virus Antibody, 2G12, Is Immunogenic but Elicits Antibodies Unable To Bind to the Self Glycans of gp120

(2008) R. D. Astronomo et al.   JOURNAL OF VIROLOGY

Disulfide bridge based PEGylation of proteins

(2007) Steve Brocchini et al.   ADVANCED DRUG DELIVERY REVIEWS