Pigs expressing the human inhibitory ligand PD-L1 (CD 274) provide a new source of xenogeneic cells and tissues with low immunogenic properties

PD-L1 on tumor cells is sufficient for immune evasion in immunogenic tumors and inhibits CD8 T cell cytotoxicity

(2017) Vikram R. Juneja et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Human IL-6, IL-17, IL-1β, and TNF-α differently regulate the expression of pro-inflammatory related genes, tissue factor, and swine leukocyte antigen class I in porcine aortic endothelial cells

(2017) Hanchao Gao et al.   XENOTRANSPLANTATION

Activation of NK cells and disruption of PD-L1/PD-1 axis: two different ways for lenalidomide to block myeloma progression

(2017) Massimo Giuliani et al.   Oncotarget

LEA29Y expression in transgenic neonatal porcine islet-like cluster promotes long-lasting xenograft survival in humanized mice without immunosuppressive therapy

(2017) L. Wolf-van Buerck et al.   Scientific Reports

Counter-regulation of rejection activity against human liver grafts by donor PD-L1 and recipient PD-1 interaction

(2016) Xiao-Lei Shi et al.   JOURNAL OF HEPATOLOGY

Ubiquitous LEA29Y Expression Blocks T Cell Co-Stimulation but Permits Sexual Reproduction in Genetically Modified Pigs

(2016) Andrea Bähr et al.   PLoS One

PD-L1 Deficiency within Islets Reduces Allograft Survival in Mice

(2016) Dongxia Ma et al.   PLoS One

The production of multi-transgenic pigs: update and perspectives for xenotransplantation

(2016) Heiner Niemann et al.   TRANSGENIC RESEARCH

Human anti-pig NK cell and CD8+T-cell responses in the presence of regulatory dendritic cells

(2016) Natacha Madelon et al.   XENOTRANSPLANTATION

Inhibition of B-cell activation and antibody production by triggering inhibitory signals via the PD-1/PD-ligand pathway

(2016) Anna Buermann et al.   XENOTRANSPLANTATION

TGFβ-dependent expression of PD-1 and PD-L1 controls CD8+ T cell anergy in transplant tolerance

(2016) Marije Baas et al.   eLife

Efficient production of multi-modified pigs for xenotransplantation by ‘combineering’, gene stacking and gene editing

(2016) Konrad Fischer et al.   Scientific Reports

siRNA Mediated Knockdown of Tissue Factor Expression in Pigs for Xenotransplantation

(2015) H. E. Ahrens et al.   AMERICAN JOURNAL OF TRANSPLANTATION

β-Cell-targeted blockage of PD1 and CTLA4 pathways prevents development of autoimmune diabetes and acute allogeneic islets rejection

(2015) M M El Khatib et al.   GENE THERAPY

The role of genetically engineered pigs in xenotransplantation research

(2015) David KC Cooper et al.   JOURNAL OF PATHOLOGY

The immunological barriers to xenotransplantation

(2015) M. Vadori et al.   TISSUE ANTIGENS

T cells Exhibit Reduced Signal Transducer and Activator of Transcription 5 Phosphorylation and Upregulated Coinhibitory Molecule Expression After Kidney Transplantation

(2015) Anne P. Bouvy et al.   TRANSPLANTATION

Progress towards overcoming coagulopathy and hemostatic dysfunction associated with xenotransplantation

(2015) Peter J. Cowan et al.   International Journal of Surgery

Biochemical Signaling of PD-1 on T Cells and Its Functional Implications

(2014) Vassiliki A. Boussiotis et al.   CANCER JOURNAL

PD-1 as an Immune Modulatory Receptor

(2014) Sheng Yao et al.   CANCER JOURNAL

Japanese encephalitis virus expands regulatory T cells by increasing the expression of PD-L1 on dendritic cells

(2014) Nimesh Gupta et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Xenotransplantation: immunological hurdles and progress toward tolerance

(2014) Adam Griesemer et al.   IMMUNOLOGICAL REVIEWS

Interplay between regulatory T cells and PD-1 in modulating T cell exhaustion and viral control during chronic LCMV infection

(2014) Pablo Penaloza-MacMaster et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Programmed Death (PD)-1:PD-Ligand 1/PD-Ligand 2 Pathway Inhibits T Cell Effector Functions during Human Tuberculosis

(2014) J. O. Jurado et al.   JOURNAL OF IMMUNOLOGY

Combination Therapy with Anti–CTLA-4 and Anti–PD-1 Leads to Distinct Immunologic Changes In Vivo

(2014) Rituparna Das et al.   JOURNAL OF IMMUNOLOGY

Impaired selectin-dependent leukocyte recruitment induces T-cell exhaustion and prevents chronic allograft vasculopathy and rejection

(2014) B. Sarraj et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pig to rat cell transplantation: reduced cellular and antibody responses to xenografts overexpressing PD-L1

(2014) Annegret Plege-Fleck et al.   XENOTRANSPLANTATION

Regulatory Sequences of the Porcine THBD Gene Facilitate Endothelial-Specific Expression of Bioactive Human Thrombomodulin in Single- and Multitransgenic Pigs

(2013) Annegret Wuensch et al.   TRANSPLANTATION

PD-1 is a novel regulator of human B-cell activation

(2012) Marie-Laure Thibult et al.   INTERNATIONAL IMMUNOLOGY

T-cell-mediated immunological barriers to xenotransplantation

(2012) Joseph Scalea et al.   XENOTRANSPLANTATION

Assessment of Fecundity and Germ Line Transmission in Two Transgenic Pig Lines Produced by Sleeping Beauty Transposition

(2012) Wiebke Garrels et al.   Genes

Essential Role of PDL1 Expression on Nonhematopoietic Donor Cells in Acquired Tolerance to Vascularized Cardiac Allografts

(2011) L. V. Riella et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Human PD-L1-overexpressing porcine vascular endothelial cells induce functionally suppressive human CD4+CD25hiFoxp3+ Treg cells

(2011) Q. Ding et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Clinical xenotransplantation: the next medical revolution?

(2011) Burcin Ekser et al.   LANCET

Transgenic expression of human heme oxygenase-1 in pigs confers resistance against xenograft rejection during ex vivo perfusion of porcine kidneys

(2011) Björn Petersen et al.   XENOTRANSPLANTATION

Role Played by the Programmed Death‐1–Programmed Death Ligand Pathway during Innate Immunity againstMycobacterium tuberculosis

(2010) Ivana B. Alvarez et al.   JOURNAL OF INFECTIOUS DISEASES

Renal tubular PD-L1 (CD274) suppresses alloreactive human T-cell responses

(2010) Astrid Starke et al.   KIDNEY INTERNATIONAL

Downregulation of cytolytic activity of human effector cells by transgenic expression of human PD-ligand-1 on porcine target cells

(2010) Annegret Plege et al.   TRANSPLANT INTERNATIONAL

PD-1/B7-H1 Interaction Contribute to the Spontaneous Acceptance of Mouse Liver Allograft

(2009) M. Morita et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Interactions between PD-1 and PD-L1 promote tolerance by blocking the TCR–induced stop signal

(2009) Brian T Fife et al.   NATURE IMMUNOLOGY

Optimization of square-wave electroporation for transfection of porcine fetal fibroblasts

(2009) Jason W. Ross et al.   TRANSGENIC RESEARCH

Interaction of Programmed Death-1 and Programmed Death-1 Ligand-1 Contributes to Testicular Immune Privilege

(2009) Xuyang Cheng et al.   TRANSPLANTATION

HLA-E/Human β2-Microglobulin Transgenic Pigs: Protection Against Xenogeneic Human Anti-Pig Natural Killer Cell Cytotoxicity

(2009) Elisabeth H. Weiss et al.   TRANSPLANTATION

Suppression of Human T-Cell Activation and Expansion of Regulatory T Cells by Pig Cells Overexpressing PD-Ligands

(2009) Annegret Plege et al.   TRANSPLANTATION

Transgenic expression of the human A20 gene in cloned pigs provides protection against apoptotic and inflammatory stimuli

(2009) Marianne Oropeza et al.   XENOTRANSPLANTATION

Pigs transgenic for human thrombomodulin have elevated production of activated protein C

(2009) Björn Petersen et al.   XENOTRANSPLANTATION

Production and characterization of transgenic pigs expressing porcine CTLA4-Ig

(2009) Carol J. Phelps et al.   XENOTRANSPLANTATION

PD-1 and Its Ligands in Tolerance and Immunity

(2008) Mary E. Keir et al.   Annual Review of Immunology

Peripheral deletional tolerance of alloreactive CD8 but not CD4 T cells is dependent on the PD-1/PD-L1 pathway

(2008) F. Haspot et al.   BLOOD

PD-1-PD-1 ligand interaction contributes to immunosuppressive microenvironment of Hodgkin lymphoma

(2008) R. Yamamoto et al.   BLOOD

Xenotransplantation of solid organs in the pig-to-primate model

(2008) Burcin Ekser et al.   TRANSPLANT IMMUNOLOGY

Characterization of porcine UL16-binding protein 1 endothelial cell surface expression

(2008) Benjamin G. Lilienfeld et al.   XENOTRANSPLANTATION

Development and Validation of a Highly Efficient Protocol of Porcine Somatic Cloning Using Preovulatory Embryo Transfer in Peripubertal Gilts

(2008) Björn Petersen et al.   Cloning Stem Cells